Page last updated: 2024-09-27

Necrotizing Pneumonia

Severe complication of pneumonia characterized by liquefaction of lung tissue.

Synonyms(2)

Synonym
Pneumonia, Necrotizing
Necrotizing Pneumonia

Research Excerpts

Research

Studies (13)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's7 (53.85)28.8240
2020's6 (46.15)9.53
DrugIndicatedRelationship StrengthStudiesTrials
ciprofloxacin0low10
fluconazole0low10
gentamicin0low10
methicillin0low20
oxacillin0low20
vancomycin0low30
trolamine salicylate0low10
piperacillin0low10
fenoxaprop ethyl0low10
itraconazole0low10
triazoles0low10
tazobactam0low10
meropenem0low10
linezolid0low10
clindamycin0low10
posaconazole0low10
amphotericin b0low20
ro13-99040low10
clozapine0low10

Protein Targets (483)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, Cruzipain3003
interleukin 82002
phosphopantetheinyl transferase1001
GLS protein2002
glucocorticoid receptor [Homo sapiens]5005
farnesoid X nuclear receptor3003
peroxisome proliferator-activated receptor delta6006
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA1001
nuclear factor erythroid 2-related factor 2 isoform 17007
peripheral myelin protein 222002
lamin isoform A-delta105005
Cytochrome P450 1A20304
Cytochrome P450 3A40608
Cytochrome P450 2D60305
Cytochrome P450 2C9 0608
Cytochrome P450 2C190305
Nuclear receptor ROR-gamma1001
Potassium voltage-gated channel subfamily H member 20708
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20404
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE1001
Chain A, 2-oxoglutarate Oxygenase2002
TDP1 protein5005
aldehyde dehydrogenase 1 family, member A12002
EWS/FLI fusion protein5005
cytochrome P450 2C9 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Gamma-aminobutyric acid receptor subunit pi2204
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Bile salt export pump010010
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0204
DNA gyrase subunit B0204
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
Gamma-aminobutyric acid receptor subunit beta-12204
Gamma-aminobutyric acid receptor subunit delta2204
Gamma-aminobutyric acid receptor subunit gamma-22204
Gamma-aminobutyric acid receptor subunit alpha-52204
Gamma-aminobutyric acid receptor subunit alpha-32204
DNA gyrase subunit A0102
Gamma-aminobutyric acid receptor subunit gamma-12204
Gamma-aminobutyric acid receptor subunit alpha-22204
Gamma-aminobutyric acid receptor subunit alpha-42204
Gamma-aminobutyric acid receptor subunit gamma-32204
Gamma-aminobutyric acid receptor subunit alpha-62204
Multidrug resistance protein MdtK0011
Histamine H2 receptor3003
Gamma-aminobutyric acid receptor subunit alpha-12204
Gamma-aminobutyric acid receptor subunit beta-32204
Gamma-aminobutyric acid receptor subunit beta-22204
DNA gyrase subunit B0202
DNA gyrase subunit A0303
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
GABA theta subunit2204
Canalicular multispecific organic anion transporter 10909
Gamma-aminobutyric acid receptor subunit epsilon2204
Protein-arginine deiminase type-40101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, JmjC domain-containing histone demethylation protein 3A2002
5-hydroxytryptamine receptor 3E0101
Luciferase2002
acetylcholinesterase2002
thioredoxin reductase2002
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
ATAD5 protein, partial2002
Fumarate hydratase3003
NFKB1 protein, partial1001
GLI family zinc finger 34004
Microtubule-associated protein tau2002
AR protein5005
caspase 7, apoptosis-related cysteine protease2002
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor3003
cytochrome P450 family 3 subfamily A polypeptide 44004
retinoic acid nuclear receptor alpha variant 15005
estrogen-related nuclear receptor alpha4004
estrogen nuclear receptor alpha7007
G6006
cytochrome P450 2D62002
polyprotein3003
Beta-1 adrenergic receptor 0101
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B1001
caspase-32002
IDH11001
Adenylate cyclase type 1 0101
Histone H2A.x1001
Bloom syndrome protein isoform 11001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
D(1A) dopamine receptor1001
chromobox protein homolog 12002
potassium voltage-gated channel subfamily H member 2 isoform d2002
thyroid hormone receptor beta isoform 23003
DNA polymerase beta2002
mitogen-activated protein kinase 11001
atrial natriuretic peptide receptor 2 precursor1001
DNA polymerase iota isoform a (long)2002
nuclear receptor ROR-gamma isoform 11001
short transient receptor potential channel 6 isoform 10011
survival motor neuron protein isoform d1001
cytochrome P450 3A4 isoform 12002
M-phase phosphoprotein 81001
transient receptor potential cation channel subfamily V member 11001
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1F0303
Bile salt export pump0404
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 40202
Voltage-dependent calcium channel gamma-2 subunit3003
5-hydroxytryptamine receptor 3B0101
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 6006
Albumin0011
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20213
Muscarinic acetylcholine receptor M40213
ATP-dependent translocase ABCB10103
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0202
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0303
Calmodulin-10101
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10213
Angiotensin-converting enzyme0202
D(2) dopamine receptor0205
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0314
Alpha-2B adrenergic receptor0202
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0314
Glutamate receptor 23003
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30213
Endothelin receptor type B0101
D(1A) dopamine receptor0203
D(4) dopamine receptor0204
D(1B) dopamine receptor0102
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0314
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0314
Alpha-1D adrenergic receptor0314
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0202
5-hydroxytryptamine receptor 3A0101
Endothelin receptor type B0101
Histamine H2 receptor0202
Adenosine receptor A10101
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0204
5-hydroxytryptamine receptor 2C0213
5-hydroxytryptamine receptor 1B0202
5-hydroxytryptamine receptor 1D0202
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0202
5-hydroxytryptamine receptor 2B0213
Histamine H1 receptor0101
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0202
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0226
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0204
5-hydroxytryptamine receptor 3A0101
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2B0213
Alpha-1A adrenergic receptor0314
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60203
Cytochrome P450 2J20102
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
Spike glycoprotein5005
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Calmodulin 0011
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Sodium-dependent dopamine transporter 0101
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Transporter0101
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0202
5-hydroxytryptamine receptor 3D0101
Adenylyl cyclase 7 0101
5-hydroxytryptamine receptor 3C0101
Inositol hexakisphosphate kinase 16006
D0202
ATPase family AAA domain-containing protein 52002
Ataxin-22002
Sigma non-opioid intracellular receptor 10101
Histamine H4 receptor0112
5-hydroxytryptamine receptor 3B0101
Sigma non-opioid intracellular receptor 10101
Transporter0202
Histamine H3 receptor0101
cytochrome P450 2C9, partial6006
retinoid X nuclear receptor alpha6006
pregnane X nuclear receptor5005
peroxisome proliferator activated receptor gamma3003
aryl hydrocarbon receptor2002
thyroid hormone receptor beta isoform a1001
Chain A, BCL-2-RELATED PROTEIN A10011
apical membrane antigen 1, AMA11001
unnamed protein product0101
transcriptional regulator ERG isoform 31001
heat shock protein HSP 90-alpha isoform 20001
geminin3003
bcl-2-like protein 11 isoform 10011
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 31001
Chymotrypsinogen A0101
Beta-lactamase0202
Cellular tumor antigen p532002
Steroid 17-alpha-hydroxylase/17,20 lyase0202
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10101
Lanosterol 14-alpha demethylase0123
Aromatase0202
Cytochrome P450 11B1, mitochondrial0202
Cytochrome P450 11B2, mitochondrial0202
ATP-dependent translocase ABCB10101
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Cytochrome P450 1440022
Steroid C26-monooxygenase0022
Steroid C26-monooxygenase0022
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
TAR DNA-binding protein 431001
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0213
Sterol 14-alpha demethylase0022
Sterol 14-alpha demethylase0224
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0022
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
heat shock protein 90, putative0001
likely tRNA 2'-phosphotransferase0101
GALC protein1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
heat shock protein beta-11001
euchromatic histone-lysine N-methyltransferase 22002
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
histone acetyltransferase KAT2A isoform 11001
streptokinase A precursor0033
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Multidrug and toxin extrusion protein 10101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Estrogen receptor0011
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0202
Prostaglandin G/H synthase 10101
Amine oxidase [flavin-containing] B0101
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Estrogen receptor beta0011
Renin0101
Beta-lactamase 0002
Beta-lactamase 0103
Metallo-beta-lactamase type 20013
Metallo-beta-lactamase VIM-11 0001
Metallo-beta-lactamase VIM-20001
Metallo-beta-lactamase VIM-19 0002
Beta-lactamase 0002
Metallo-beta-lactamase0001
Beta-lactamase0204
Beta-lactamase SHV-10204
Beta-lactamase0103
Beta-lactamase TEM0203
B2 metallo-beta-lactamase 0001
Metallo-beta-lactamase VIM-130002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0103
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0103
Beta-lactamase 0001
Beta-lactamase 0012
Metallo-b-lactamase 0003
Beta-lactamase IMP-1 0001
BlaVIM-1 0002
Beta-lactamase 0102
Carbapenem-hydrolyzing beta-lactamase KPC0204
Histamine H3 receptor0002
Beta-lactamase class B VIM-2 0014
Beta-lactamase 0001
Beta-lactamase VIM-1 0002
Solute carrier family 22 member 80202
Beta-lactamase OXA-70002
Solute carrier family 15 member 10202
Solute carrier family 15 member 20101
Class D beta-lactamase0103
Solute carrier family 15 member 20101
MecA 0101
Beta-lactamase 0102
Beta-lactamase 0202
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase SHV-10102
Kappa-type opioid receptor0001
Beta-lactamase 0102
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0001
Sterol 14-alpha-demethylase0011
SMAD family member 21001
SMAD family member 31001
thyroid stimulating hormone receptor1001
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 2B1 0202
Albumin0022
NH(3)-dependent NAD(+) synthetase0101
60 kDa heat shock protein, mitochondrial0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cytochrome P450 2B60112
Arylacetamide deacetylase0102
Caspase-10101
Alpha-synuclein0101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20101
10 kDa heat shock protein, mitochondrial0202
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10203
Beta-lactamase 0101
Beta-lactamase 0101
B2 bradykinin receptor0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase0101
Beta-lactamase OXA-10102
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Metallo-beta-lactamase L1 type 30101
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
D-alanyl-D-alanine dipeptidase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]