Page last updated: 2024-12-06

1,1-cyclopropanedicarboxylate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

There's no compound called 1,1-cyclopropanedicarboxylate because it's chemically impossible. Here's why:

* **Cyclopropane:** This is a three-carbon ring structure. Each carbon in the ring needs to be bonded to two other carbon atoms to form the closed ring.
* **Carboxylate:** This functional group (-COO-) is attached to a carbon atom.
* **1,1-** This indicates two substituents are attached to the same carbon atom.

The problem arises when trying to combine these elements:

* You cannot have two carboxylate groups attached to the same carbon atom in a cyclopropane ring. This would violate the valency rules of carbon (carbon can only form four bonds).

**What Might be the Intended Compound?**

It's likely there's a typo or misunderstanding in the compound's name. Some possibilities include:

* **1,1-Cyclopropanedicarboxylate:** This would be the anion form of 1,1-cyclopropanedicarboxylic acid. This compound exists and can be synthesized, but it's not commonly studied.
* **1,2-Cyclopropanedicarboxylate:** This is a common diacid and its salts. It's an important intermediate in organic synthesis and has potential applications in the development of new drugs and materials.

**Importance in Research**

While 1,1-cyclopropanedicarboxylate doesn't exist, cyclopropane-based compounds are often used in research due to:

* **Strain:** The small ring size of cyclopropane creates significant ring strain, leading to unique reactivity.
* **Chirality:** Some cyclopropane derivatives can be chiral, which is important for developing enantioselective reactions and pharmaceuticals.
* **Bioactivity:** Cyclopropane rings are found in some natural products and synthetic drugs, demonstrating their potential biological activity.

If you can provide more context or the intended compound, I can provide a more specific answer regarding its importance in research.

cyclopropane-1,1-dicarboxylic acid: inhibits 1-aminocyclopropane-1-carboxylic acid oxidase; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID69017
CHEMBL ID1993862
SCHEMBL ID106415
MeSH IDM0188869

Synonyms (37)

Synonym
AC-1893
nsc-626865
NCI60_008490
1,1-cyclopropanedicarboxylic acid
cyclopropane-1,1-dicarboxylic acid
nsc626865
cyclopropane-1,1-dicarboxylic acid, 97%
1,1-cyclopropanedicarboxylate
598-10-7
cyclopropane, 3
bdbm82142
A8394
cyclopropane-1,1-dicarboxylicacid
einecs 209-917-2
cyclopropanedicarboxylic acid
FT-0606081
AM20100460
AKOS009158920
cyclopropane 1,1-dicarboxylic acid
SCHEMBL106415
PS-5731
CHEMBL1993862
W-105298
cycloprpopane-1,1-dicarboxylic acid
ethylenemalonic acid
vinyl-malonic acid
propene-3,3-dicarboxylic acid
vinaconic acid
DTXSID20208526
mfcd00013727
CS-W002094
9ty ,
Z877371762
BCP26949
SY014841
trans-cyclopropanedicarboxylic acid
EN300-58851
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
isoleucine biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
valine biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
pantothenate biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
amino acid biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
branched-chain amino acid biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
isoleucine biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
valine biosynthetic processKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
magnesium ion bindingKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
ketol-acid reductoisomerase activityKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
2-dehydropantoate 2-reductase activityKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
oxidoreductase activityKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
identical protein bindingKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
metal ion bindingKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
NADP bindingKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
cytoplasmKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
cytosolKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
protein-containing complexKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
cytosolKetol-acid reductoisomerase (NADP(+))Escherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1799596Enzyme Inhibition Assay from Article 10.1111/j.1747-0285.2009.00924.x: \\High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors.\\2010Chemical biology & drug design, Feb, Volume: 75, Issue:2
High throughput receptor-based virtual screening under ZINC database, synthesis, and biological evaluation of ketol-acid reductoisomerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's2 (18.18)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.18 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.74 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]