Anemia With Multinucleated Erythroblasts

A familial disorder characterized by ANEMIA with multinuclear ERYTHROBLASTS, karyorrhexis, asynchrony of nuclear and cytoplasmic maturation, and various nuclear abnormalities of bone marrow erythrocyte precursors (ERYTHROID PRECURSOR CELLS). Type II is the most common of the 3 types; it is often referred to as HEMPAS, based on the Hereditary Erythroblast Multinuclearity with Positive Acidified Serum test.

Synonym
Anemia, Congenital Dyserythropoietic, Type II
Anemia, Dyserythropoietic Congenital, Type I
Dyserythropoietic Anemia, Congenital Type 2
Anemia, Dyserythropoietic Congenital, Type II
Anemia, Dyserythropoietic Congenital, Type III
Anemia, Dyserythropoietic, Congenital
Anemia, Dyserythropoietic, Congenital Type 1
Anemia, Dyserythropoietic, Congenital Type 2
Anemia, Dyserythropoietic, Congenital, Type I
Anemia, Dyserythropoietic, Congenital, Type II
Anemia, Dyserythropoietic, Congenital, Type III
HEMPAS Anemia
HEMPAS
Dyserythropoietic Anemia, Congenital
Hereditary Erythroblastic Multinuclearity with Positive Acidified-Serum Test
Hereditary Erythroblast Multinuclearity with Positive Acidified Serum
Dyserythropoietic Anemia, Congenital, Type I
Dyserythropoietic Anemia, Congenital, Type II
Congenital Dyserythropoietic Anemia, Type III
Dyserythropoietic Anemia, HEMPAS Type
Dyserythropoietic Anemia, Congenital, Type III
Dyserythropoietic Anemia, Congenital Type 1
Type I Congenital Dyserythropoietic Anemia
Anemia With Multinucleated Erythroblasts
Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic
Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type II
Congenital Dyserythropoietic Anemia, Type I

Excerpt	Reference
"Congenital dyserythropoietic anemia type II is a rare disorder that is often diagnosed in patients before age 20 years."	( Burns, CP; Dick, FR; Greiner, TC; Henry, KM; Mahmood, I, 1992)
"HEMPAS is therefore genetically heterogeneous."	( Fukuda, MN, 1999)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	34 (32.38)	23.3326
1990's	26 (24.76)	12.5806
2000's	24 (22.86)	18.1394
2010's	14 (13.33)	28.8240
2020's	7 (6.67)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	1	0
glycine	low	1	0
phenylacetic acid	low	1	0
pyridoxal phosphate	low	1	0
deferoxamine	low	11	0
pamidronate	low	1	0
stearic acid	low	1	0
prednisolone	low	1	0
thymidine	low	1	0
dehydroepiandrosterone	low	1	0
serine	low	1	0
sucrose	low	1	0
uridine	low	1	0
galactose	low	1	0
colchicine	low	1	0
asparagine	low	2	0
valine	low	1	0
tryptophan	low	1	0
arginine	low	1	0
deoxyuridine	low	1	0
acetylthiocholine	low	1	0
trolamine salicylate	low	2	0
transferrin	low	4	0
swainsonine	low	1	0
thomsen-friedenreich antigen	low	1	0
triazoles	medium	2	1
methotrexate	low	1	0
deferasirox	medium	2	1
leupeptins	low	1	0
glycogen	low	1	0
fibrin	low	1	0
ouabain	low	1	0
keratan sulfate	low	1	0
afimoxifene	low	1	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	low	1	0
tamoxifen	low	1	0
ace-011	low	1	0
alpha-chymotrypsin	low	1	0
sodium borohydride	low	1	0
bilirubin	low	5	0
coenzyme q10	low	1	0
dolichols	low	1	0
sincalide	low	1	0
losartan potassium	low	8	0
jaw	low	1	0
cytochrome c-t	low	1	0
oligonucleotides	low	1	0
ubiquinone	low	1	0
glycolipids	low	3	0
heme	low	1	0
vitamin b 12	low	3	0
folic acid	low	2	0

Protein Targets (694)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
thioredoxin reductase	6	0	0	6
regulator of G-protein signaling 4	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	11	0	0	11
TDP1 protein	11	0	0	11
AR protein	13	0	0	13
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	12	0	0	12
estrogen-related nuclear receptor alpha	13	0	0	13
pregnane X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
heat shock protein beta-1	5	0	0	5
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
lamin isoform A-delta10	9	0	0	9
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Bile salt export pump	0	10	0	10
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	9	0	0	9
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	7	0	0	7
Chain A, Beta-lactamase	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, Ferritin light chain	6	0	0	6
acetylcholinesterase	3	0	0	3
glp-1 receptor, partial	2	0	0	2
pregnane X receptor	2	0	0	2
phosphopantetheinyl transferase	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
SMAD family member 2	6	0	0	6
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	10	0	0	10
Microtubule-associated protein tau	6	0	0	6
Smad3	3	0	0	3
apical membrane antigen 1, AMA1	4	0	0	4
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	9	0	0	9
progesterone receptor	8	0	0	8
nonstructural protein 1	2	0	0	2
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	8	0	0	8
67.9K protein	5	0	0	5
glucocerebrosidase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
caspase-3	2	0	0	2
IDH1	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
thyroid stimulating hormone receptor	7	0	0	7
activating transcription factor 6	6	0	0	6
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	4	0	0	4
Caspase-7	2	0	0	2
thyroid hormone receptor beta isoform a	4	0	0	4
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	8	0	0	8
ubiquitin-conjugating enzyme E2 N	0	2	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
geminin	9	0	0	9
neuropeptide S receptor isoform A	2	0	0	2
Phospholipase D2	0	1	0	1
Estrogen receptor	0	5	1	8
Cellular tumor antigen p53	9	0	0	9
Aromatase	0	2	0	2
Estrogen-related receptor gamma	0	2	1	3
Phospholipase D1	0	2	0	2
Estrogen receptor beta	0	5	1	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	1	0	0	1
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	5	0	0	5
alpha-galactosidase	3	0	0	3
chromobox protein homolog 1	8	0	0	8
flap endonuclease 1	4	0	0	4
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	4	0	0	4
Cytochrome P450 3A4	0	3	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	5	0	0	5
Carbonic anhydrase 1	0	0	0	2
Carbonic anhydrase 2	0	1	2	5
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	2	0	2
Proteasome subunit beta type-11	0	1	0	1
Fumarate hydratase	4	0	0	4
PPM1D protein	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
EWS/FLI fusion protein	4	0	0	4
polyprotein	4	0	0	4
vitamin D3 receptor isoform VDRA	5	0	0	5
survival motor neuron protein isoform d	4	0	0	4
Calpain-9	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Interferon beta	6	0	0	6
Cathepsin B	0	1	0	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Calpain-2 catalytic subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	2
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
NF-kappa-B inhibitor alpha	0	0	1	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Proteasome subunit beta type-10	0	1	0	1
Cathepsin K	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	2	0	2
Proteasome subunit alpha type-6	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
Gamma-secretase subunit PEN-2	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, Cruzipain	1	0	0	1
USP1 protein, partial	7	0	0	7
DNA polymerase kappa isoform 1	4	0	0	4
caspase-1 isoform alpha precursor	3	0	0	3
Caspase-7	2	0	0	2
Inositol monophosphatase 1	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	5
Solute carrier organic anion transporter family member 1B1	0	2	0	3
peripheral myelin protein 22	6	0	0	6
Luciferase	3	0	0	3
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
PAX8	0	0	0	1
ATAD5 protein, partial	4	0	0	4
Thrombopoietin	1	0	0	1
aryl hydrocarbon receptor	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
cytochrome P450 3A4 isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	9
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	2
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	1	0	1
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	1	6
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
ATP-dependent translocase ABCB1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Histamine H2 receptor	3	0	0	3
Nuclear receptor ROR-gamma	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
GABA theta subunit	3	0	0	3
CREB-binding protein	1	0	0	1
Canalicular multispecific organic anion transporter 1	0	6	0	6
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Tubulin beta-1 chain	0	2	2	5
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	2	1	3
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
cytochrome P450 2D6	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
Alpha-synuclein	3	0	0	3
G-protein coupled bile acid receptor 1	0	0	1	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Thymidine kinase, cytosolic	0	2	0	5
Thymidine phosphorylase	0	0	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	4
Dihydrofolate reductase	0	2	3	5
Aldo-keto reductase family 1 member B1	0	3	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	4
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2B	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	4
Large neutral amino acids transporter small subunit 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Proton-coupled amino acid transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
ClpP	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bloom syndrome protein isoform 1	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Spike glycoprotein	2	0	1	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Mcl-1	0	1	0	1
G	1	0	0	1
huntingtin isoform 2	1	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	4
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	4
Cytochrome P450 2C9	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	3
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Bombesin receptor subtype-3	0	0	1	1
Cytochrome P450 2C19	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	4
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	3
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	3
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
STAT3, partial	0	1	0	1
Kruppel-like factor 5	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Geranylgeranyl pyrophosphate synthase	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	1	0	1
Olfactory receptor class A-like protein 1	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	2	1	8
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Acetylcholinesterase	0	3	0	3
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	1	2
Cholecystokinin receptor type A	0	2	2	4
Gastrin/cholecystokinin type B receptor	0	2	2	4
Delta-type opioid receptor	0	2	1	3
Gastrin/cholecystokinin type B receptor	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
Fatty acid-binding protein, adipocyte	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase 9	0	1	1	3
Chain A, Alpha-mannosidase Ii	0	1	0	1
Chain A, ALPHA-MANNOSIDASE II	0	1	0	1
Chain A, Alpha-mannosidase Ii	0	1	0	1
Lysosomal alpha-mannosidase	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA	0	2	0	2
Alpha-mannosidase 2	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Glycoside hydrolase family 92	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase, putative	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Putative alpha-1,2-mannosidase	0	1	0	1
Alpha-1,2-mannosidase family protein	0	1	0	1
alpha-1,2-Mannosidase	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
arylsulfatase A	2	0	0	2
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
interferon gamma precursor	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Cytochrome P450 2B6	0	1	0	1
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Carbonic anhydrase 12	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Carbonic anhydrase 3	0	0	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Carbonic anhydrase 4	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Substance-P receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Protein cereblon	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Anemia With Multinucleated Erythroblasts

Synonyms(29)

Research Excerpts

Overview

Research

Studies (105)

Protein Targets (694)

Anemia With Multinucleated Erythroblasts

Synonyms(29)

Research Excerpts

Overview

Research

Studies (105)

Drugs Studied (66)

Protein Targets (694)