An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of thymidine phosphorylase (EC 2.4.2.4).
ChEBI ID: 90878
| Member | Definition | Class |
|---|---|---|
| 5-chloro-6-(1-(2-iminopyrrolidinyl) methyl)uracil hydrochloride | A hydrochloride obtained by combining tipiracil with one equivalent of hydrochloric acid. Used in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. | tipiracil hydrochloride |
| ma-1 | A member of the class of pyrimidones that is uracil substituted by chloro and (2-iminopyrrolidin-1-yl)methyl groups at positions 5 and 6 respectively. Used (as the hydrochloride salt) in combination with trifluridine, a nucleoside metabolic inhibitor, for treatment of advanced/relapsed unresectable colorectal cancer. | tipiracil |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (6.30) | 29.6817 |
| 2010's | 29 (22.83) | 24.3611 |
| 2020's | 90 (70.87) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 31 (24.22%) | 5.53% |
| Reviews | 7 (5.47%) | 6.00% |
| Case Studies | 7 (5.47%) | 4.05% |
| Observational | 8 (6.25%) | 0.25% |
| Other | 75 (58.59%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Thymidine phosphorylase | Escherichia coli K-12 | IC50 | 0.0227 | 5 | 5 |
| Thymidine phosphorylase | Homo sapiens (human) | IC50 | 0.0311 | 12 | 12 |
| Thymidine phosphorylase | Escherichia coli K-12 | Ki | 0.0350 | 1 | 1 |
| Thymidine phosphorylase | Homo sapiens (human) | Ki | 0.0115 | 9 | 9 |