Compounds > tricyclazole
Page last updated: 2024-11-06

tricyclazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tricyclazole is a fungicide that was first synthesized in the 1970s. It is a broad-spectrum fungicide effective against a wide range of fungal diseases, including rice blast, a major disease affecting rice production worldwide. The compound works by inhibiting the biosynthesis of melanin, a pigment essential for fungal growth and development. Tricyclazole is used extensively in agriculture, particularly in rice cultivation. Its effectiveness and wide spectrum of activity make it a valuable tool in controlling fungal diseases and protecting rice crops. Research on tricyclazole continues to focus on understanding its mechanism of action, its potential environmental impact, and the development of more effective and environmentally friendly fungicides.'

tricyclazole: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tricyclazole : A triazolobenzothiazole that is [1,2,4]triazolo[3,4-b][1,3]benzothiazole which is substituted at position 5 by a methyl group. A fungicide used for the control of rice blast, it is not approved for use within the European Union. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID39040
CHEMBL ID357021
CHEBI ID81783
SCHEMBL ID23082
MeSH IDM0122280

Synonyms (75)

Synonym
AC-12491
41814-78-2
1,2,4-triazolo[3,4-b]benzothiazole, 5-methyl-
tricyclazole
5-methyl-1,2,4-triazolo[3,4-b]benzothiazole
BEA ,
5-methyl-1,2,4-triazolo(3,4-b)benzothiazole
DB02891
beam
tricyclazone
2,7,8,9-tricyclazole
5-methyl-1,2,4-triazolo(3,4-b)(1,3)benzothiazole
NCGC00163820-01
s-triazolo(3,4-b)benzothiazole, 5-methyl-
tizole
5-methyl-1,2,4-triazolo(3,4-b)benzo-1,3-thiazole
tricyclazole [ansi:bsi:iso]
caswell no. 884c
epa pesticide chemical code 120201
blascide
5-methyl-1,2,4-triazole(3,4-b)benzothiazole
einecs 255-559-5
sivic
blas-t
brn 0980261
elanco 291
1,2,4-triazolo(3,4-b)benzothiazole, 5-methyl-
pilarblas
el-291
trizole
chebi:81783 ,
CHEMBL357021
8-methyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole
inchi=1/c9h7n3s/c1-6-3-2-4-7-8(6)12-5-10-11-9(12)13-7/h2-5h,1h3
dqjchoqlcledll-uhfffaoysa-
C18492
dtxcid5017478
cas-41814-78-2
dtxsid7037478 ,
tox21_302419
NCGC00255465-01
5-methylbenzo[4,5]thiazolo[2,3-c][1,2,4]triazole
A825664
AKOS006227856
5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazole
r7u3meu7vr ,
unii-r7u3meu7vr
FT-0630622
tricyclazole [iso]
tricyclazole [mi]
SCHEMBL23082
5-methyl-striazolo-[3,4-b]benzothiazole
W-106294
5-methyl[1,2,4]triazolo[3,4-b][1,3]benzothiazole #
DQJCHOQLCLEDLL-UHFFFAOYSA-N
el 291
12-methyl-7-thia-2,4,5-triazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),3,5,8,10-pentaene
tricyclazol
tricyclazol, pestanal(r), analytical standard
tricyclazole 10 microg/ml in cyclohexane
5-methyl-s-triazolo(3,4-b)benzothiazole
tricyclozole
5-methyl-1,2,4-triazolo[3,4-b]benzothiazole, 9ci
pesticide5_tricyclazole_c9h7n3s_beam
bdbm50182418
mfcd00072466
AS-14881
HY-B0848
Q15632715
AMY22302
E78657
CS-0012862
EN300-365964
12-methyl-7-thia-2,4,5-triazatricyclo[6.4.0.0,2,6]dodeca-1(12),3,5,8,10-pentaene
Z1198150056

Research Excerpts

Overview

Tricyclazole is a commercial fungicide used to control rice blast.

ExcerptReferenceRelevance
"Tricyclazole is a commercial fungicide used to control rice blast. "( Synthesis of new compounds related to the commercial fungicide tricyclazole.
Balcer, JL; Dai, D; DeAmicis, CV; Johnson, PL; Klosin, J; Rao, CS; Whiteker, GT, 2011)		2.05

Treatment

ExcerptReferenceRelevance
"Tricyclazole-treated cultures of the fungi were reddish-brown in color and contained typical intermediates of the DHN-melanin pathway, as demonstrated by high-performance liquid chromatography."( Evidence for 1,8-dihydroxynaphthalene melanin in three halophilic black yeasts grown under saline and non-saline conditions.
Gunde-Cimerman, N; Kogej, T; Lanisnik Rizner, T; Wheeler, MH, 2004)		1.04

Bioavailability

ExcerptReferenceRelevance
" Tricyclazole is readily absorbed and highly bioavailable in rodents (>86%) with indication of saturation of absorption at high doses."( The ADME profile of the fungicide tricyclazole in rodent via the oral route: A critical review for human health safety assessment.
Bartels, M; Corvaro, M, 2019)		1.7
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
melanin synthesis inhibitorA depigmentation agent which inhibits the synthesis of melanin.
antifungal agrochemicalAny substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
triazolobenzothiazole
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (7)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
acetylcholinesteraseHomo sapiens (human)Potency51.58790.002541.796015,848.9004AID1347395; AID1347398
AR proteinHomo sapiens (human)Potency47.66950.000221.22318,912.5098AID1259243; AID1259247
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency24.43170.001022.650876.6163AID1224838; AID1224839; AID1224893
pregnane X nuclear receptorHomo sapiens (human)Potency48.73600.005428.02631,258.9301AID1346982; AID720659
aryl hydrocarbon receptorHomo sapiens (human)Potency31.30410.000723.06741,258.9301AID743085; AID743122
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency13.93010.000627.21521,122.0200AID651741; AID720636; AID743202; AID743219
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (6)

Processvia Protein(s)Taxonomy
chromatin remodelingPeregrinHomo sapiens (human)
regulation of DNA-templated transcriptionPeregrinHomo sapiens (human)
positive regulation of DNA-templated transcriptionPeregrinHomo sapiens (human)
regulation of developmental processPeregrinHomo sapiens (human)
regulation of hemopoiesisPeregrinHomo sapiens (human)
regulation of transcription by RNA polymerase IIPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
histone H4K5 acetyltransferase activityPeregrinHomo sapiens (human)
histone H4K8 acetyltransferase activityPeregrinHomo sapiens (human)
histone H4K12 acetyltransferase activityPeregrinHomo sapiens (human)
DNA bindingPeregrinHomo sapiens (human)
protein bindingPeregrinHomo sapiens (human)
acetyltransferase activator activityPeregrinHomo sapiens (human)
metal ion bindingPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
nucleusPeregrinHomo sapiens (human)
nucleoplasmPeregrinHomo sapiens (human)
cytoplasmPeregrinHomo sapiens (human)
cytosolPeregrinHomo sapiens (human)
plasma membranePeregrinHomo sapiens (human)
MOZ/MORF histone acetyltransferase complexPeregrinHomo sapiens (human)
histone acetyltransferase complexPeregrinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (58)

Assay IDTitleYearJournalArticle
AID1103131Antifungal activity against Thielaviopsis basicola assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1112832Fungicidal activity against Magnaporthe oryzae assessed as germination of conidia at 0.01 to 1 mg/l at 26 degC measured after 7 days2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1103119Antifungal activity against Penicillium italicum ATCC 48952 assessed as bleaching of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103155Antifungal activity against Trichoderma harzianum (Pers.)-Tul assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103127Antifungal activity against Botryotinia fuckeliana assessed as appearance of numerous vacuoles in hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103156Antifungal activity against Magnaporthe grisea assessed as growth inhibition at 50 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103148Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition at 50 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1102626Antifungal activity against Magnaporthe grisea infested rice plant grown under greenhouse condition assessed as reduction in lesion formation on second leaves at 100 ug/ml sprayed at eight-leaf stage 1 day prior inoculation measured after 5 days post inoc2004Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4
Antifungal activity of beta-asarone from rhizomes of Acorus gramineus.
AID1103140Antifungal activity against Penicillium italicum ATCC 48952 assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1090851Antifungal activity against logarithmic phase of Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 50 ug/ml measured at 5 days post-drug treatment2007Journal of agricultural and food chemistry, Dec-12, Volume: 55, Issue:25
Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
AID1103389In vitro antifungal activity against Magnaporthe grisea on eight-leaf stage rice plant assessed as reduction of blast disease at 10 to 500 ug/mL2005Journal of agricultural and food chemistry, Oct-05, Volume: 53, Issue:20
Isolation and antifungal activity of 4-phenyl-3-butenoic acid from Streptomyces koyangensis strain VK-A60.
AID1112836Fungicidal activity against Magnaporthe oryzae assessed as inhibition of mycelium growth at 26 degC measured after 7 days2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1103144Antifungal activity against Trichoderma harzianum (Pers.)-Tul assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103135Antifungal activity against Sclerotinia minor assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1101921Antifungal activity against Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 200 ug/ml after 5 days2002Journal of agricultural and food chemistry, Aug-14, Volume: 50, Issue:17
Development of new fungicides against Magnaporthe grisea: synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine, and pyrazolo[3,4-d]pyrimidine derivatives.
AID1112833Fungicidal activity against Magnaporthe oryzae assessed as inhibition of sporulation at 5 mg/l at 26 degC measured after 7 days2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1099276Fungicidal activity against Magnaporthe oryzae infected on foliar spray based compound pre-treated second-leaf stage rice plants assessed as rice blast disease control level at 250 ppm measured 5 days post fungal exposure relative to untreated control1999Bioscience, biotechnology, and biochemistry, , Volume: 63, Issue:3
Synthesis and Fungicidal Activities of 4,5-Dihydro-7H-pyrano[3,4-c]isoxazole Derivatives.
AID1103118Antifungal activity against Penicillium crustosum assessed as bleaching of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103132Antifungal activity against Thielaviopsis basicola assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103142Antifungal activity against Hypocrea rufa assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1112835Fungicidal activity against Magnaporthe oryzae assessed as inhibition of sporulation at 26 degC measured after 7 days2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1101919Antifungal activity against Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 50 ug/ml after 5 days2002Journal of agricultural and food chemistry, Aug-14, Volume: 50, Issue:17
Development of new fungicides against Magnaporthe grisea: synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine, and pyrazolo[3,4-d]pyrimidine derivatives.
AID1112827Fungicidal activity against Magnaporthe oryzae in five leaf stage carnaroli plants assessed as decrease in frequency of type 3 lesions at 0.01 to 1 mg/l2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1090850Antifungal activity against logarithmic phase of Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 100 ug/ml measured at 5 days post-drug treatment2007Journal of agricultural and food chemistry, Dec-12, Volume: 55, Issue:25
Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
AID1308809Binding affinity to recombinant GST-tagged human BRPF1 expressed in Escherichia coli BL21 (DE3) after 1 hr by qPCR-based BromoScan assay2016Journal of medicinal chemistry, 06-09, Volume: 59, Issue:11
Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
AID1103128Antifungal activity against Botryotinia fuckeliana assessed as disorganized hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1099269Fungicidal activity against Magnaporthe oryzae infected on foliar spray based compound pre-treated second-leaf stage rice plants assessed as rice blast disease control level at 10 ppm measured 5 days post fungal exposure relative to untreated control1999Bioscience, biotechnology, and biochemistry, , Volume: 63, Issue:3
Synthesis and Fungicidal Activities of 4,5-Dihydro-7H-pyrano[3,4-c]isoxazole Derivatives.
AID1103122Antifungal activity against Alternaria solani Nees assessed as color variation of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103137Antifungal activity against Penicillium crustosum assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1080705Antifungal activity against Magnaporthe grisea infected compound pre-treated rice plant seedlings assessed as rice blast disease control efficacy at 10 ug/mL under greenhouse conditions2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi.
AID1103153Antifungal activity against Magnaporthe grisea assessed as color variation of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1080704Antifungal activity against Magnaporthe grisea infected compound pre-treated rice plant seedlings assessed as rice blast disease control efficacy at 0.5 ug/mL under greenhouse conditions2009Journal of agricultural and food chemistry, Jul-08, Volume: 57, Issue:13
Antifungal activity of CHE-23C, a dimeric sesquiterpene from Chloranthus henryi.
AID1103120Antifungal activity against Trichoderma harzianum (Pers.)-Tul assessed as bleaching of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103150Antifungal activity against Magnaporthe grisea assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103147Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103151Antifungal activity against Magnaporthe grisea assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103138Antifungal activity against Penicillium crustosum assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103136Antifungal activity against Sclerotinia minor assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1090852Antifungal activity against logarithmic phase of Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 10 ug/ml measured at 5 days post-drug treatment2007Journal of agricultural and food chemistry, Dec-12, Volume: 55, Issue:25
Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
AID1099268Fungicidal activity against Magnaporthe oryzae infected on foliar spray based compound pre-treated second-leaf stage rice plants assessed as rice blast disease control level at 2 ppm measured 5 days post fungal exposure relative to untreated control1999Bioscience, biotechnology, and biochemistry, , Volume: 63, Issue:3
Synthesis and Fungicidal Activities of 4,5-Dihydro-7H-pyrano[3,4-c]isoxazole Derivatives.
AID1103133Antifungal activity against Alternaria solani assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103146Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID214624Compound was evaluated for its inhibition constant against Trihydroxynaphthalene reductase [3H]-NR)2000Bioorganic & medicinal chemistry letters, Mar-06, Volume: 10, Issue:5
Selection of a potent inhibitor of trihydroxynaphthalene reductase by sorting disease control data.
AID1103152Antifungal activity against Magnaporthe grisea assessed as growth inhibition at 10 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103139Antifungal activity against Penicillium italicum ATCC 48952 assessed as growth inhibition at 200 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1102625Antifungal activity against Magnaporthe grisea infested rice plant grown under greenhouse condition assessed as reduction in lesion formation on second leaves at 500 ug/ml sprayed at eight-leaf stage 1 day prior inoculation measured after 5 days post inoc2004Journal of agricultural and food chemistry, Feb-25, Volume: 52, Issue:4
Antifungal activity of beta-asarone from rhizomes of Acorus gramineus.
AID1101920Antifungal activity against Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 100 ug/ml after 5 days2002Journal of agricultural and food chemistry, Aug-14, Volume: 50, Issue:17
Development of new fungicides against Magnaporthe grisea: synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine, and pyrazolo[3,4-d]pyrimidine derivatives.
AID1103123Antifungal activity against Sclerotinia minor assessed as bleaching/decolorization of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103121Antifungal activity against Hypocrea rufa assessed as bleaching of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103141Antifungal activity against Botryotinia fuckeliana assessed as color variation of hyphae at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103134Antifungal activity against Alternaria solani assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1099270Fungicidal activity against Magnaporthe oryzae infected on foliar spray based compound pre-treated second-leaf stage rice plants assessed as rice blast disease control level at 50 ppm measured 5 days post fungal exposure relative to untreated control1999Bioscience, biotechnology, and biochemistry, , Volume: 63, Issue:3
Synthesis and Fungicidal Activities of 4,5-Dihydro-7H-pyrano[3,4-c]isoxazole Derivatives.
AID1103129Antifungal activity against Botryotinia fuckeliana assessed as appearance of electron dense stacks in nucleus at 200 ug/ml after 5 days by electron microscopy2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1101918Antifungal activity against Magnaporthe grisea ATCC 64413 assessed as growth inhibition at 10 ug/ml after 5 days2002Journal of agricultural and food chemistry, Aug-14, Volume: 50, Issue:17
Development of new fungicides against Magnaporthe grisea: synthesis and biological activity of pyrazolo[3,4-d][1,3]thiazine, pyrazolo[1,5-c][1,3,5]thiadiazine, and pyrazolo[3,4-d]pyrimidine derivatives.
AID1090847Antifungal activity against logarithmic phase of Magnaporthe grisea ATCC 64413 assessed as growth inhibition measured at 5 days post-drug treatment2007Journal of agricultural and food chemistry, Dec-12, Volume: 55, Issue:25
Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
AID1112828Fungicidal activity against Magnaporthe oryzae in five leaf stage carnaroli plants assessed as decrease in disease incidence at 0.01 to 1 mg/l2013Pest management science, Feb, Volume: 69, Issue:2
Impact of tricyclazole and azoxystrobin on growth, sporulation and secondary infection of the rice blast fungus, Magnaporthe oryzae.
AID1103143Antifungal activity against Hypocrea rufa assessed as growth inhibition at 100 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
AID1103149Antifungal activity against Botryotinia fuckeliana assessed as growth inhibition at 10 ug/ml after 5 days2004Journal of agricultural and food chemistry, Apr-07, Volume: 52, Issue:7
Synthesis and antifungal action of new tricyclazole analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (76)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (3.95)18.7374
1990's4 (5.26)18.2507
2000's29 (38.16)29.6817
2010's28 (36.84)24.3611
2020's12 (15.79)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 52.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index52.72 (24.57)
Research Supply Index4.39 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index111.48 (26.88)
Search Engine Supply Index2.70 (0.95)

This Compound (52.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other78 (97.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
formic acid
formic acid: RN given refers to parent cpd. formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.		2.110monocarboxylic acidantibacterial agent;
astringent;
metabolite;
protic solvent;
solvent
guaiacol
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.		2.4110guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		210alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
indoleacetic acid
indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.		2.3110indole-3-acetic acids;
monocarboxylic acid		auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite
dihydroxyphenylalanine
Dihydroxyphenylalanine: A beta-hydroxylated derivative of phenylalanine. The D-form of dihydroxyphenylalanine has less physiologic activity than the L-form and is commonly used experimentally to determine whether the pharmacological effects of LEVODOPA are stereospecific.. dopa : A hydroxyphenylalanine carrying hydroxy substituents at positions 3 and 4 of the benzene ring.		2.3820hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative		human metabolite
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		2.110pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)		2.0510monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
phenanthrene
phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'		7.0410ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes		environmental contaminant;
mouse metabolite
pyridine
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.		2.0710azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
juglone
juglone: structure. juglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.		1.9610hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
thiabendazole
Tresaderm: dermatologic soln containing dexamethasone, thiabendazole & neomycin sulfate		2.21101,3-thiazoles;
benzimidazole fungicide;
benzimidazoles		antifungal agrochemical;
antinematodal drug
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		7.3110organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.4320alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
uridine
[no description available]		2.0810uridinesdrug metabolite;
fundamental metabolite;
human metabolite
levodopa
Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease		2.0510amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
dithionitrobenzoic acid
Dithionitrobenzoic Acid: A standard reagent for the determination of reactive sulfhydryl groups by absorbance measurements. It is used primarily for the determination of sulfhydryl and disulfide groups in proteins. The color produced is due to the formation of a thio anion, 3-carboxyl-4-nitrothiophenolate.. dithionitrobenzoic acid : An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups.		2.0310nitrobenzoic acid;
organic disulfide		indicator
2-toluidine
2-toluidine: RN given refers to parent cpd. o-toluidine : An aminotoluene in which the amino substituent is ortho to the methyl group.		2.7220aminotoluenecarcinogenic agent
carveol
carveol: structure given in first source; prolongs tumor latency and decreases tumor yield. carveol : A limonene monoterpenoid that is cyclohex-2-en-1-ol substituted by a methyl group at position 2 and a prop-1-en-2-yl group at position 5.		2.1510limonene monoterpenoidplant metabolite;
volatile oil component
carvone
carvone: an oxidized derivative of limonene; RN given refers to cpd without isomeric designation; L-carvone has spearmint flavor, D-carvone has dill/caraway flavor. carvone : A p-menthane monoterpenoid that consists of cyclohex-2-enone having methyl and isopropenyl substituents at positions 2 and 5, respectively.		2.1510botanical anti-fungal agent;
carvones		allergen
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.110mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		3.88120naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
thiazoles
[no description available]		7.186601,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
isocarbostyril
isoquinolinone : An isoquinoline containing one or more oxo groups.		2.1310isoquinolines
4-phenylpyridine
[no description available]		2.1310phenylpyridine
2,6-dichloroindophenol
2,6-Dichloroindophenol: A dye used as a reagent in the determination of vitamin C.. 2,6-dichloroindophenol : A quinone imine that is indophenol substituted by chloro groups at positions 2 and 6.. N-3,5-dichloro-4-hydroxyphenyl-1,4-benzoquinone imine : 1,4-benzoquinone imine having a 3,5-dichloro-4-hydroxyphenyl substituent attached to the nitrogen atom.		2.1510dichlorobenzene;
quinone imine
tetrachloroisophthalonitrile
tetrachloroisophthalonitrile: structure. chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops.		2.7230aromatic fungicide;
dinitrile;
tetrachlorobenzene		antifungal agrochemical
fluorescein
Fluorescein: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.. fluorescein (lactone form) : A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy.		2.31102-benzofurans;
gamma-lactone;
organic heteropentacyclic compound;
oxaspiro compound;
polyphenol;
xanthene dye		fluorescent dye;
radioopaque medium
carboxin
Carboxin: A systemic agricultural fungicide and seed treatment agent.. carboxin : An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment.		2.0510anilide fungicide;
anilide;
enamide;
organosulfur heterocyclic compound;
oxacycle;
secondary carboxamide		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
mercury
Mercury: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.. mercury(0) : Elemental mercury of oxidation state zero.		2.0310elemental mercury;
zinc group element atom		neurotoxin
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.8730copper group element atom;
elemental silver		Escherichia coli metabolite
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		7.1310cadmium molecular entity;
zinc group element atom
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		7.3110copper group element atom;
elemental gold
benomyl
[no description available]		2.0510aromatic amide;
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		acaricide;
anthelminthic drug;
antifungal agrochemical;
microtubule-destabilising agent;
tubulin modulator
4,5,6,7-tetrachlorophthalide
4,5,6,7-tetrachlorophthalide: a fungicide. 4,5,6,7-tetrachloro-2-benzofuran-1(3H)-one : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one in which all or the hydrogens attached to the benzene ring are replaced by chlorines. A fungicide used for the control of rice blast, it is not approved for use within the European Union.		210gamma-lactone;
organic heterobicyclic compound;
propan-1-ol;
tetrachlorobenzene		antifungal agrochemical;
melanin synthesis inhibitor
metalaxyl
metalaxyl: RN given refers to (DL-Ala)-isomer. metalaxyl : A racemate comprising equal amounts of (R)- and (S)-metalaxyl. A systemic fungicide, it is active against phytopathogens of the order Peronosporales and is used to conrtrol Pythium in a number of vegetable crops.. methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate : An alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group.		2.4320alanine derivative;
aromatic amide;
carboxamide;
ether;
methyl ester
itraconazole
Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.		2.1710aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles		EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.0110D-glucopyranoseepitope;
mouse metabolite
salicylhydroxamic acid
[no description available]		1.9610hydroxamic acid;
phenols		antibacterial drug;
EC 1.11.2.2 (myeloperoxidase) inhibitor;
EC 3.5.1.5 (urease) inhibitor;
trypanocidal drug
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.02101,2,3-triazole
1,8-dihydroxynaphthalene
1,8-dihydroxynaphthalene: isolated from mutant of Wangiella dermatitidis; structure given in first source. naphthalene-1,8-diol : A member of the class of naphthalenediols that is naphthalene in which the hydrogens at positions 1 and 8 are replaced by hydroxy groups.		2.7130naphthalenediolfungal metabolite
3,4-diaminobenzoic acid
3,4-diaminobenzoic acid: RN given refers to parent cpd		1.9610
thifensulfuron methyl
thifensulfuron methyl: structure in first source. thifensulfuron-methyl : A methyl ester resulting from the formal condensation of the carboxy group of thifensulfuron with methanol. It is used as a post-emergence herbicide for the control of grass and broad-leaved weeds.		2.1101,3,5-triazines;
methyl ester;
N-sulfonylurea;
thiophenes		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
dimethomorph
[no description available]		2.0510mixture;
morpholine fungicide		antifungal agrochemical;
environmental contaminant;
xenobiotic
fludioxonil
fludioxonil: structure in first source. fludioxonil : A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.		2.0510benzodioxoles;
nitrile;
organofluorine compound;
pyrroles		androgen antagonist;
antifungal agrochemical;
estrogen receptor agonist
flaviolin
flaviolin: isolated from mutants of Wangiella dermatitidis; structure given in first source. flaviolin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone having three hydroxy substituents placed at the 2-, 5- and 7-positions.		2.3820
scytolone
scytolone: intermediate in melanin biosynthesis by Verticillium dahliae. scytalone : A cyclic ketone that is 3,4-dihydronaphthalen-1(2H)-one substituted by hydroxy groups at positions 3, 6, and 8.		3.2460
erythritol
[no description available]		2.0110butane-1,2,3,4-tetrolantioxidant;
human metabolite;
plant metabolite
1,3,6,8-tetrahydroxynaphthalene
1,3,6,8-tetrahydroxynaphthalene: intermediate in polyketide biosynthesis. naphthalene-1,3,6,8-tetrol : A naphthalenetetrol that is naphthalene substituted by hydroxy groups at positions 1, 3, 6 and 8.		210naphthalenetetrol
ochratoxin a
ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.		7.610isochromanes;
monocarboxylic acid amide;
N-acyl-L-phenylalanine;
organochlorine compound;
phenylalanine derivative		Aspergillus metabolite;
calcium channel blocker;
carcinogenic agent;
mycotoxin;
nephrotoxin;
Penicillium metabolite;
teratogenic agent
validamycin a
validamycin A : A member of the class of validamycins that is (1R,2S,3S,4S,6R)-4-amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol in which the hydroxy group at position 1 has been converted to its beta-D-glucoside and in which one of the hydrogens attached to the nitrogen is replaced by a (1R,4R,5R,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl group. It is the major validamycin produced by Streptomyces hygroscopicus.		2.0510antibiotic fungicide;
polyol;
secondary amino compound;
validamycins		antifungal agrochemical;
EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitor;
EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitor;
EC 3.2.1.28 (alpha,alpha-trehalase) inhibitor
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.0310cyclodextrin
terbinafine
[no description available]		2.1310acetylenic compound;
allylamine antifungal drug;
enyne;
naphthalenes;
tertiary amine		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor;
sterol biosynthesis inhibitor
2,8-dimercapto-6-hydroxypurine
[no description available]		2.1310
nadp
[no description available]		2.3920
azoxystrobin
azoxystrobin: a methoxyacrylate analog; a strobilurin fungicide; structure given in first source. azoxystrobin : An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.		7.0810aryloxypyrimidine;
enoate ester;
enol ether;
methoxyacrylate strobilurin antifungal agent;
methyl ester;
nitrile		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
quinone outside inhibitor;
xenobiotic
sodium dodecyl sulfate
Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.		7.7220organic sodium saltdetergent;
protein denaturant
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		2.6830
beta-asarone
beta-asarone : The cis-isomer of asarone.		2.0210asaroneGABA modulator
4-phenyl-3-butenoic acid
4-phenyl-3-butenoic acid: an inhibitor of peptidyl glycine hydroxylase (peptide amidating enzyme); RN given refers to cpd without isomeric designation		2.0210
pyrachlostrobin
pyraclostrobin : A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres.		2.0310aromatic ether;
carbamate ester;
carbanilate fungicide;
methoxycarbanilate strobilurin antifungal agent;
monochlorobenzenes;
pyrazoles		antifungal agrochemical;
environmental contaminant;
mitochondrial cytochrome-bc1 complex inhibitor;
xenobiotic
pymetrozine
pymetrozine: an anti-feedant against aphids, whiteflies, and leaf hoppers. pymetrozine : A member of the class of 1,2,4-triazines that is 4,5-dihydro-1,2,4-triazin-3(2H)-one substituted by a methyl group at position 6 and a (pyridin-3-ylmethylidene)amino group at position 4.		2.1101,2,4-triazines;
pyridines		antifeedant;
environmental contaminant;
TRPV channel modulator;
xenobiotic
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.1310aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
granite
granite: crystalline rock of quartz, orthoclase, muscovite & biotite		2.0810triazolopyrimidines
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.1510organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.5720chlorophyll;
methyl ester		cofactor
clay
Clay: A naturally-occurring rock or soil constituent characterized by particles with a diameter of less than 0.005 mm. It is composed primarily of hydrous aluminum silicates, trace amounts of metal OXIDES, and organic matter.		2.1110
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0410
ConditionIndicatedRelationship StrengthStudiesTrials
Chromoblastomycosis
Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)		02.2110
Acute Liver Injury, Drug-Induced
[description not available]		02.2110
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		02.2110
Sporothrix brasiliensis Infection
[description not available]		02.1310
Sporotrichosis
The commonest and least serious of the deep mycoses, characterized by nodular lesions of the cutaneous and subcutaneous tissues. It is caused by inhalation of contaminated dust or by infection of a wound with SPOROTHRIX.		02.1310
Aspergillus Infection
[description not available]		02.0510
Aspergillosis
Infections with fungi of the genus ASPERGILLUS.		02.0510
Dermatomycoses
Superficial infections of the skin or its appendages by any of various fungi.		0210