Periostitis

Inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis. (Dorland, 27th ed)

Synonym
Periostitis

Excerpt	Reference
"Isolated periostitis is a rare skeletal manifestation of systemic vasculitis that could be misdiagnosed as neoplastic or traumatic periosteal reaction."	( Cheon, JE; Kim, IO; Kim, WS; Yeon, KM, 2010)
"Periostitis is increasingly reported and should be considered in patients taking voriconazole who present with bone pain and/or alkaline phosphatase elevation."	( Adwan, MH, 2017)
"Isolated periostitis is a very rare skeletal manifestation of systemic vasculitis and easily could be misdiagnosed."	( Bogaert, B; Brys, P; Peers, K, 2018)

Excerpt	Reference
"Drug-induced periostitis has recently been reported in patients on long-term voriconazole therapy after lung transplantation for prophylaxis and treatment of Aspergillus infection."	( Wilson, MA; Wise, SM, 2011)
"While drug-related periostitis has been known of for many years, the specific association of diffuse periostitis with voriconazole (most frequently in transplant patients) has only been recently explicitly addressed in the literature."	( Bucknor, MD; Gross, AJ; Link, TM, 2013)

Excerpt	Reference
"The reactive periostitis affected the volar aspect of two adjacent phalanges with sparing of the intervening joint, confirming that this is a reactive process rather than a benign neoplasm."	( Correa-Gracian, H; Craver, RD; Heinrich, S, 1997)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	131 (48.88)	23.3326
1990's	33 (12.31)	12.5806
2000's	29 (10.82)	18.1394
2010's	61 (22.76)	28.8240
2020's	14 (5.22)	9.53

Drug	Relationship Strength	Studies	Trials
carbamates	low	1	0
citric acid, anhydrous	low	1	0
salicylic acid	low	2	0
dimethyl sulfoxide	low	2	0
methanol	low	1	0
melatonin	medium	1	1
phenol	low	1	0
thiamine	low	1	0
alendronate	low	1	0
azathioprine	low	1	0
aztreonam	low	1	0
chloroquine	low	1	0
ciprofloxacin	low	1	0
clofazimine	low	1	0
dapsone	low	1	0
etidronate	low	1	0
fluconazole	low	1	0
hydroxychloroquine	low	1	0
lidocaine	low	2	0
methoxyflurane	low	1	0
ofloxacin	low	1	0
phenylbutazone	low	3	0
procaine	low	2	0
sodium fluoride	low	1	0
sulfanilamide	low	1	0
prednisolone	low	3	0
estriol	low	1	0
thymidine	low	1	0
hydroxyproline	low	1	0
penicillamine	low	1	0
prednisone	low	6	0
estrone	low	1	0
penicillin g	low	6	0
chloramphenicol	low	2	0
colchicine	low	2	0
oxacillin	low	2	0
triamcinolone acetonide	low	1	0
methylprednisolone	low	4	0
thiophenes	low	1	0
cyclopentane	low	1	0
betamethasone	low	3	0
spectinomycin	low	1	0
octyl 2-cyanoacrylate	low	1	0
mercury	low	1	0
technetium	low	4	0
gadolinium	low	1	0
gold	low	1	0
barium sulfate	low	1	0
calcium phosphate, dibasic, anhydrous	low	1	0
calcium phosphate, monobasic, anhydrous	low	1	0
tricalcium phosphate	low	1	0
fluorine	low	2	0
radon	low	1	0
trolamine salicylate	low	45	0
cephalexin	low	1	0
fluorides	low	14	0
cetylpyridinium chloride anhydrous	low	1	0
cefazolin	low	1	0
amoxicillin	low	1	0
propiconazole	low	15	0
raloxifene hydrochloride	low	1	0
itraconazole	low	3	0
cephalosporin c	low	3	0
triazoles	low	17	0
fluorodeoxyglucose f18	low	2	0
zoledronic acid	low	1	0
voriconazole	low	48	0
ethyl 2-cyanoacrylate	low	1	0
prednisolone tebutate	low	1	0
foxes	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
methotrexate	low	4	0
moxifloxacin	low	1	0
calcium pyrophosphate	low	1	0
cortisone	low	4	0
glycogen	low	1	0
clindamycin	low	1	0
zithromax	low	1	0
posaconazole	low	3	0
micafungin	low	1	0
lincomycin	low	2	0
osteoprotegerin	low	1	0
alprostadil	low	8	0
rutin	medium	1	1
amphotericin b	low	2	0
clavulanic acid	low	1	0
sf 837	low	1	0
codeine	low	1	0
morphine	low	1	0
strontium	low	1	0
desomorphine	low	1	0
cefuzonam	low	1	0
carumonam	low	1	0
amoxicillin-potassium clavulanate combination	low	1	0
mocetinostat	low	1	0
enerbol	low	1	0
acid phosphatase	low	1	0
jaw	low	9	0
chitosan	medium	1	1
ro13-9904	low	2	0
tetracycline	low	3	0
salicylates	low	2	0
piroxicam	medium	1	1
acenocoumarol	low	1	0
lornoxicam	medium	1	1
saxitoxin	low	1	0
hyaluronoglucosaminidase	low	1	0
technetium tc 99m medronate	low	12	0
rifampin	low	1	0

Protein Targets (992)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Luciferase	8	0	0	8
RAR-related orphan receptor gamma	22	0	0	22
retinoid X nuclear receptor alpha	24	0	0	24
G	17	0	0	17
peroxisome proliferator activated receptor gamma	21	0	0	21
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
thyroid stimulating hormone receptor	6	0	0	6
chromobox protein homolog 1	16	0	0	16
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
geminin	21	0	0	21
muscleblind-like protein 1 isoform 1	9	0	0	9
Interferon beta	23	0	0	23
HLA class I histocompatibility antigen, B alpha chain	17	0	0	17
Guanine nucleotide-binding protein G	4	0	0	4
Inositol hexakisphosphate kinase 1	17	0	0	17
cytochrome P450 2C9, partial	17	0	0	17
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
Acetylcholinesterase	0	5	0	5
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	3	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
TDP1 protein	26	0	0	26
AR protein	33	0	0	33
glucocorticoid receptor [Homo sapiens]	31	0	0	31
estrogen nuclear receptor alpha	37	0	0	37
ATP-binding cassette sub-family C member 3	0	28	0	28
Multidrug resistance-associated protein 4	0	28	0	31
Bile salt export pump	0	41	0	41
Cellular tumor antigen p53	18	0	0	18
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	27	0	27
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Beta-lactamase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	12	0	0	12
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
Bile salt export pump	0	11	0	11
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase SHV-1	0	2	0	4
Cytochrome P450 2C9	0	10	0	10
Beta-lactamase	0	1	0	3
Kappa-type opioid receptor	0	2	0	4
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	4	0	4
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Solute carrier family 15 member 2	0	4	0	5
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, Cruzipain	4	0	0	4
interleukin 8	10	0	0	10
phosphopantetheinyl transferase	13	0	0	13
GLS protein	5	0	0	5
farnesoid X nuclear receptor	14	0	0	14
peroxisome proliferator-activated receptor delta	17	0	0	17
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	26	0	0	26
peripheral myelin protein 22	8	0	0	8
lamin isoform A-delta10	20	0	0	20
Cytochrome P450 1A2	0	3	0	3
Cytochrome P450 3A4	0	16	1	17
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C19	0	4	0	4
Nuclear receptor ROR-gamma	8	0	0	8
Potassium voltage-gated channel subfamily H member 2	0	15	0	17
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Ferritin light chain	7	0	0	7
acetylcholinesterase	6	0	0	6
thioredoxin reductase	13	0	0	13
SMAD family member 2	8	0	0	8
ATAD5 protein, partial	8	0	0	8
Fumarate hydratase	6	0	0	6
SMAD family member 3	8	0	0	8
GLI family zinc finger 3	28	0	0	28
Microtubule-associated protein tau	11	0	0	11
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
EWS/FLI fusion protein	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
estrogen-related nuclear receptor alpha	25	0	0	25
pregnane X nuclear receptor	22	0	0	22
polyprotein	6	0	0	6
P53	1	0	0	1
arylsulfatase A	4	0	0	4
IDH1	10	0	0	10
aryl hydrocarbon receptor	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
activating transcription factor 6	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	7	0	0	7
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	21	0	0	21
heat shock protein beta-1	10	0	0	10
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	12	0	0	12
M-phase phosphoprotein 8	7	0	0	7
muscarinic acetylcholine receptor M1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	12	2	0	14
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-1	12	2	0	14
Gamma-aminobutyric acid receptor subunit delta	12	2	0	14
Gamma-aminobutyric acid receptor subunit gamma-2	12	2	0	14
Glutamate receptor 2	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-5	12	2	0	14
Gamma-aminobutyric acid receptor subunit alpha-3	12	2	0	14
Gamma-aminobutyric acid receptor subunit gamma-1	12	2	0	14
Gamma-aminobutyric acid receptor subunit alpha-2	12	2	0	14
Gamma-aminobutyric acid receptor subunit alpha-4	12	2	0	14
Gamma-aminobutyric acid receptor subunit gamma-3	12	2	0	14
Gamma-aminobutyric acid receptor subunit alpha-6	12	2	0	14
Gamma-aminobutyric acid receptor subunit alpha-1	12	2	0	14
Gamma-aminobutyric acid receptor subunit beta-3	12	2	0	14
Gamma-aminobutyric acid receptor subunit beta-2	12	2	0	14
GABA theta subunit	12	2	0	14
ATPase family AAA domain-containing protein 5	11	0	0	11
Ataxin-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit epsilon	12	2	0	14
Protein-arginine deiminase type-4	0	5	0	5
pregnane X receptor	7	0	0	7
progesterone receptor	16	0	0	16
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	14	2	21
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Smad3	5	0	0	5
cytochrome P450 2D6	9	0	0	9
Solute carrier family 22 member 6	0	7	0	7
Solute carrier family 22 member 6	0	5	0	6
Solute carrier family 22 member 8	0	6	0	8
Solute carrier family 22 member 11	0	2	0	4
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase Toho-1	0	0	0	2
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
mitogen-activated protein kinase 1	7	0	0	7
hypoxia-inducible factor 1 alpha subunit	8	0	0	8
USP1 protein, partial	5	0	0	5
caspase 7, apoptosis-related cysteine protease	4	0	0	4
estrogen receptor 2 (ER beta)	12	0	0	12
67.9K protein	6	0	0	6
caspase-3	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Caspase-2	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
streptokinase A precursor	0	0	6	6
lethal factor (plasmid)	4	0	0	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Methionine--tRNA ligase, mitochondrial	0	0	1	1
PPM1D protein	6	0	0	6
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	6	0	0	6
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	1	4
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	3	2	5
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	3	2	5
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	0	2
Serine/threonine-protein kinase mTOR	0	1	0	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	8	1	2	11
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
cytochrome P450 2C9 precursor	6	0	0	6
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	3	0	7
DNA gyrase subunit B	0	3	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
DNA topoisomerase 2-alpha	0	1	0	5
DNA gyrase subunit A	0	2	0	3
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	9	0	0	9
DNA gyrase subunit B	0	4	0	6
DNA gyrase subunit A	0	4	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	2	0	3
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Cytochrome P450 2B6	0	2	1	3
Beta-lactamase TEM	0	3	0	5
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	2
Class D beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	2	0	3
Beta-lactamase class B VIM-2	0	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6 isoform 1	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
transcriptional regulator ERG isoform 3	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	1	1	2
ATP-dependent translocase ABCB1	0	7	0	8
5-hydroxytryptamine receptor 1A	0	0	1	1
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	1	1	2
Solute carrier family 22 member 1	0	3	0	4
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	2
Delta-type opioid receptor	0	3	0	4
Kappa-type opioid receptor	0	3	1	5
Mu-type opioid receptor	0	4	2	7
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	2	2
endonuclease IV	4	0	0	4
PAX8	0	0	0	1
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	8	0	0	8
glucocerebrosidase	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	3	0	0	3
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
neuropeptide S receptor isoform A	4	0	0	4
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
ATP-dependent phosphofructokinase	8	0	0	8
dopamine D1 receptor	2	0	0	2
regulator of G-protein signaling 4	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	9	0	0	9
Multidrug and toxin extrusion protein 1	0	4	0	4
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Myeloperoxidase	0	2	0	2
Dihydrofolate reductase	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	3	0	0	3
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Albumin	0	2	5	7
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Cytochrome P450 1B1	0	3	0	3
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	3	1	4
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Estrogen receptor	0	7	1	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Androgen receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	4	0	4
Alpha-synuclein	1	4	0	5
Solute carrier organic anion transporter family member 1A1	0	4	0	4
Lanosterol 14-alpha demethylase	0	0	2	2
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
NFKB1 protein, partial	2	0	0	2
GALC protein	2	0	0	2
nonstructural protein 1	6	0	0	6
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Steryl-sulfatase	0	1	0	1
Aromatase	0	4	0	4
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	6	2	11
5-hydroxytryptamine receptor 2B	0	2	0	2
Mu-type opioid receptor	0	3	1	4
Estrogen receptor beta	0	4	1	6
Ghrelin O-acyltransferase	0	1	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	3	0	3
Chymotrypsinogen A	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	3	4
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	2	0	2
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	3	0	3
Sterol 14-alpha demethylase	0	0	3	3
Sterol 14-alpha demethylase	0	2	2	4
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
14-alpha sterol demethylase	0	0	3	3
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Carbonic anhydrase 1	0	10	0	11
Carbonic anhydrase 2	0	10	2	13
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase 15	0	4	0	4
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Genome polyprotein	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	5	0	5
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	5
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Adenosine receptor A1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	6	1	7
Prostaglandin G/H synthase 2	0	3	0	3
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Nicotinate phosphoribosyltransferase	0	3	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	5	0	7
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	3	0	3
Sodium channel protein type 9 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
DNA polymerase beta	3	0	0	3
ClpP	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
15-lipoxygenase, partial	4	0	0	4
Thymidylate synthase	0	1	0	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	3
Integrin alpha-IIb	2	0	0	2
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	4	1	6
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
DNA gyrase subunit B	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase OXA-7	0	0	0	1
MecA	0	1	0	1
Cystathionine gamma-lyase	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Lysozyme	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Polyphenol oxidase 2	0	2	0	4
Carbonic anhydrase 12	0	4	0	4
Endolysin	0	0	1	1
Carbonic anhydrase 3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Cannabinoid receptor 1	0	1	0	1
Carbonic anhydrase 6	0	6	0	6
Carbonic anhydrase 5A, mitochondrial	0	4	0	5
Carbonic anhydrase 7	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Carbonic anhydrase	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 9	0	5	0	5
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 13	0	3	0	3
Carbonic anhydrase 14	0	4	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
Estrogen receptor 1	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
glp-1 receptor, partial	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Prolyl 4-hydroxylase, beta polypeptide	0	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
huntingtin isoform 2	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Gastric inhibitory polypeptide receptor	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
B-cell lymphoma 6 protein	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Neuraminidase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Lysine-specific histone demethylase 1A	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Albumin	0	1	0	1
Neuraminidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Sialidase	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Substance-K receptor	0	1	0	1
Neuromedin-U receptor 2	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Carbonic anhydrase	0	2	0	2
Eyes absent homolog 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Protein argonaute-2	0	0	1	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
twin arginine protein translocation system - TatA protein	0	0	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Matrix metalloproteinase-9	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (268)

Protein Targets (992)

Periostitis

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Research

Studies (268)

Drugs Studied (124)

Protein Targets (992)