triazoles has been researched along with Malaria, Falciparum in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 18 (69.23) | 24.3611 |
| 2020's | 6 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Andrade, JL; Bueno, LL; Camara, CA; Costa Souza, RM; Dantas, WM; De Andrade-Neto, VF; De Medeiros Brito, RM; De Oliveira, RN; Ferreira, LKM; Fujiwara, RT; Montenegro Pimentel, LML; Pena, L; Pereira, VRA; Rathi, B; Santos, ACDS; Silva Junior, VA; Silva, CJO | 1 |
| Hasbullah, SA; Hassan, NI; Rakesh, KP; Ravindar, L | 1 |
| Babu, PP; Mudiraj, A; Ommi, NB; Sujatha, K; Vedula, RR | 1 |
| Ballard, E; Chalon, S; Collins, KA; Elliott, SL; Griffin, P; Marquart, L; McCarthy, JS; Möhrle, JJ; Rückle, T | 1 |
| Gamo, FJ; Lafuente-Monasterio, MJ; Lukens, AK; Luth, MR; Magan, N; Mandt, REK; Ottilie, S; Pablos-Tanarro, A; Sakata-Kato, T; Segura, D; Viera, S; Winzeler, EA; Wirth, DF | 1 |
| Agrahari, AK; Bose, P; Mishra, N; Singh, AS; Singh, SK; Tiwari, VK | 1 |
| Akakpo, S; Chalon, S; Chughlay, MF; Csermak-Renner, K; Djeriou, E; Gaur, AH; Leboulleux, D; McCarthy, J; Odedra, A; Shanks, GD; Winnips, C | 1 |
| Aguiar, ACC; Albuquerque, MG; Boechat, N; Campos, VR; de Souza, JO; Guido, RVC; Hoelz, LVB; Jabor, VAP; Nonato, MC; Pinheiro, LCS; Silveira, FF | 1 |
| Cherkaoui, M; Dini, S; Gobeau, N; Kümmel, A; McCarthy, JS; Moehrle, JJ; Price, DJ; Simpson, JA; Zaloumis, SG | 1 |
| Brückner, S; Calle, CL; Chalon, S; Gebru, T; Gobeau, N; Granados, P; Held, J; Hoffman, SL; Ibáñez, J; Kerr, N; Kremsner, PG; Lalremruata, A; Mengue, J; Möhrle, JJ; Mordmüller, B; Mürbeth, RE; Nguetse, C; Roth, A; Rückle, T; Samec, SS; Sim, BKL; Sulyok, M; Sulyok, Z | 1 |
| Andenmatten, N; Chalon, S; Chang, M; Duke, ER; Duparc, S; Ferguson, S; Fishbaugher, M; Fong, Y; Fritzen, E; Gillespie, K; Hanron, AE; Janes, HE; Jensen, RL; Kappe, SH; Kerr, N; Kublin, JG; Marcsisin, SR; Möhrle, JJ; Murphy, SC; Rinn, L; Rueckle, T; Seilie, AM; Shipman, KJ; Sousa, JC; VonGoedert, T | 1 |
| Betz, W; Bial, J; Billman, Z; Camargo, N; Campo, B; Charman, SA; Chuenchob, V; Fishbaugher, M; Flannery, EL; Foquet, L; Kappe, SH; Lee, J; Mikolajczak, SA; Murphy, SC; Navarro, MJ; Nguyen, T; Olsen, TM; Phillips, MA; Sack, BK; Saunders, J; Schafer, C; Wilson, EM | 1 |
| Andenmatten, N; Araeipour, N; Arch, RH; Baker, M; Bath, J; Casapia, M; Chuquiyauri, R; Cowell, AN; Duparc, S; Fidock, DA; Gobeau, N; Hinojosa, JC; Hooft van Huijsduijnen, R; Kerr, N; Llanos-Cuentas, A; Möhrle, JJ; Ng, CL; Phillips, MA; Rosario, M; Rozenberg, FD; Rückle, T; Toovey, S; Winzeler, EA | 1 |
| Bélard, S; Ramharter, M | 1 |
| Afanador, GA; Bath, J; Deng, X; Dhingra, SK; El Mazouni, F; Fidock, DA; Lawong, A; Lee, MCS; Ng, CL; Phillips, MA; Rathod, PK; Tomchick, DR; White, J | 1 |
| Anvikar, AR; Batra, N; Nath, M; Prasad, D; Srivastava, K; Valecha, N; Wadi, I | 1 |
| Bättig, S; Nasiri Sovari, S; Nikodinovic-Runic, J; Pavic, A; Rossier, J; Smith, GS; Stringer, T; Vojnovic, S; Zobi, F | 1 |
| Alonso, LM; Angulo-Barturen, I; Avery, VM; Bathhurst, I; Bazaga, SF; Benito, FJ; Bhatia, SN; Burrows, JN; Campo, B; Charman, SA; Cui, Y; Dayan, A; Dechering, K; Delves, M; Deng, X; Ding, X; Duffy, S; El Mazouni, F; Fidock, DA; Gahagen, J; Haselden, JN; Iyer, L; Jimenez-Diaz, MB; Kocken, C; Kokkonda, S; Lafuente-Monasterio, M; Laird, T; Lao, Y; Leroy, D; Lotharius, J; Louttit, J; March, S; Marsh, K; Martinez, MS; Mirsalis, J; Ng, CL; Njoroge, JW; Phillips, MA; Rathod, PK; Riccio, E; Rochford, R; Rogers, MJ; Ruecker, A; Rueckle, T; Sauerwein, R; Sinden, R; Sridhar, A; Tomchick, DR; White, J; White, KL; Wickham, KS; Wittlin, S; Zeeman, AM | 1 |
| Angulo-Barturen, Í; Bahamontes-Rosa, N; Ballell-Pages, L; Berry, NG; Biagini, GA; Blackman, MJ; Calderón, F; Castañeda, P; Crespo, B; de Cózar, C; de Mercado, J; Fernández, J; Frigerio, M; Guijarro, L; Jiménez-Díaz, MB; Martínez-Martínez, MS; McConville, M; Nixon, GL; O'Neill, PM; Santos-Villarejo, Á; Sanz, LM; Ward, SA; Washbourn, G | 1 |
| Chhabra, S; Devender, N; Gunjan, S; Jaiswal, S; Kumar, Y; Lal, J; Pasam, VR; Sharma, A; Shukla, SK; Singh, K; Singh, SK; Tripathi, R; Tripathi, RP; Trivedi, AK | 1 |
| Angulo-Barturen, I; Bazaga, SF; Burrows, JN; Charman, SA; Chen, G; Coteron, JM; de Las Heras, L; Deng, X; El Mazouni, F; Jimenez-Diaz, MB; Kaminsky, W; Kokkonda, S; Leroy, D; Manjalanagara, K; Marco, M; Martínez-Martínez, MS; Matthews, D; Morizzi, J; Phillips, MA; Rathod, PK; Rudra, KR; Ryan, E; Tomchick, DR; Waterson, D; White, J; White, KL | 1 |
| Amante, F; Cooper, MA; Dwyer, PJ; Faleiro, R; Horne-Debets, JM; Huang, JX; Karunarathne, DS; Lee, JS; Leow, CY; McCarthy, JS; Miles, JJ; Poh, CM; Rénia, L; Richard, D; Sharpe, AH; Stacey, KJ; Watkins, TS; Wykes, MN; Yarski, M | 1 |
| Eberhardt, R; Ebinger, D; Eckerle, I; Eisenbach, C; Gotthardt, D; Junghanss, T; Schnabel, PA; Stremmel, W | 1 |
| Deng, X; El Mazouni, F; Goldsmith, EJ; Gujjar, R; Kaminsky, W; Malmquist, NA; Phillips, MA; Rathod, PK | 1 |
| Chibale, K; Gut, J; Hans, RH; Rosenthal, PJ | 1 |
| Crandall, IE; Mitu, S; Patricia Rodriguez, E; Roman, G; Szarek, WA; Vlahakis, JZ | 1 |
2 review(s) available for triazoles and Malaria, Falciparum
| Article | Year |
|---|---|
Triazole hybrid compounds: A new frontier in malaria treatment.
Topics: Antimalarials; Humans; Malaria; Malaria, Falciparum; Plasmodium; Plasmodium falciparum; Triazoles | 2023 |
Invasive Aspergillus fumigatus infection after Plasmodium falciparum malaria in an immuno-competent host: case report and review of literature.
Topics: Antifungal Agents; Aspergillus fumigatus; Caspofungin; Echinocandins; Humans; Invasive Pulmonary Aspergillosis; Lipopeptides; Malaria, Falciparum; Male; Middle Aged; Pyrimidines; Triazoles; Voriconazole | 2009 |
4 trial(s) available for triazoles and Malaria, Falciparum
| Article | Year |
|---|---|
A Single-Dose Combination Study with the Experimental Antimalarials Artefenomel and DSM265 To Determine Safety and Antimalarial Activity against Blood-Stage Plasmodium falciparum in Healthy Volunteers.
Topics: Adamantane; Administration, Oral; Adult; Antimalarials; Drug Combinations; Female; Healthy Volunteers; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Pyrimidines; Triazoles; Young Adult | 2019 |
DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection.
Topics: Administration, Intravenous; Adolescent; Adult; Antimalarials; Chemoprevention; Double-Blind Method; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Plasmodium falciparum; Pyrimidines; Sporozoites; Triazoles; Volunteers | 2017 |
A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.
Topics: Adolescent; Adult; Animals; Antimalarials; Chemoprevention; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Placebos; Plasmodium falciparum; Pyrimidines; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Young Adult | 2018 |
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study.
Topics: Adult; Antimalarials; Cohort Studies; Dihydroorotate Dehydrogenase; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Oxidoreductases Acting on CH-CH Group Donors; Peru; Plasmodium falciparum; Pyrimidines; Triazoles | 2018 |
20 other study(ies) available for triazoles and Malaria, Falciparum
| Article | Year |
|---|---|
Biological activity of 1,2,3-triazole-2-amino-1,4-naphthoquinone derivatives and their evaluation as therapeutic strategy for malaria control.
Topics: Animals; Antimalarials; Chlorocebus aethiops; Humans; Malaria; Malaria, Falciparum; Mammals; Mice; Naphthoquinones; Plasmodium berghei; Plasmodium falciparum; Triazoles; Vero Cells | 2023 |
Synthesis of thiazolyl hydrazonothiazolamines and 1,3,4-thiadiazinyl hydrazonothiazolamines as a class of antimalarial agents.
Topics: Animals; Antimalarials; Cell Line; Cell Survival; Hydrazones; Inhibitory Concentration 50; Macrophages; Malaria, Falciparum; Mice; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Triazoles | 2019 |
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
Topics: Animals; Dihydroorotate Dehydrogenase; Disease Models, Animal; Drug Resistance; Enzyme Inhibitors; Female; Malaria, Falciparum; Mice, SCID; Oxidoreductases Acting on CH-CH Group Donors; Parasites; Phenotype; Plasmodium falciparum; Point Mutation; Pyrimidines; Triazoles | 2019 |
Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors.
Topics: Antimalarials; Aspartic Acid Endopeptidases; Catalysis; Cinchona Alkaloids; Click Chemistry; Copper; Drug Design; Humans; Malaria, Falciparum; Molecular Docking Simulation; Molecular Structure; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Triazoles | 2020 |
Liver Enzyme Elevations in
Topics: Acrylamides; Adamantane; Adult; Alanine Transaminase; Aminopyridines; Aminoquinolines; Antimalarials; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Erythrocyte Transfusion; Erythrocytes; Female; Ferrous Compounds; Healthy Volunteers; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Isoquinolines; Malaria, Falciparum; Male; Metallocenes; Parasitemia; Peroxides; Piperazines; Plasmodium falciparum; Primaquine; Pyrimidines; Quinolines; Spiro Compounds; Sulfones; Triazoles; Young Adult | 2020 |
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors.
Topics: Antimalarials; Chloroquine; Dihydroorotate Dehydrogenase; Drug Design; Enzyme Inhibitors; Hep G2 Cells; Humans; Malaria, Falciparum; Molecular Docking Simulation; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Protein Binding; Pyrimidines; Quinolines; Structure-Activity Relationship; Triazoles | 2021 |
Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria.
Topics: Antimalarials; Bayes Theorem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Pyrimidines; Triazoles | 2021 |
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo.
Topics: Animals; Antimalarials; Atovaquone; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Liver; Malaria, Falciparum; Mice; Plasmodium falciparum; Proguanil; Pyrimidines; Triazoles | 2018 |
DSM265: a novel drug for single-dose cure of Plasmodium falciparum malaria.
Topics: Antimalarials; Dihydroorotate Dehydrogenase; Humans; Malaria, Falciparum; Malaria, Vivax; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrimidines; Triazoles | 2018 |
Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; CRISPR-Cas Systems; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Drug Resistance; Gene Editing; Humans; Malaria, Falciparum; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Point Mutation; Pyrimidines; Triazoles | 2019 |
Targeting Asexual and Sexual Blood Stages of the Human Malaria Parasite P. falciparum with 7-Chloroquinoline-Based 1,2,3-Triazoles.
Topics: Antimalarials; Chloroquine; Humans; Inhibitory Concentration 50; Life Cycle Stages; Malaria, Falciparum; Plasmodium falciparum; Structure-Activity Relationship; Triazoles | 2019 |
Antiplasmodial Activity and In Vivo Bio-Distribution of Chloroquine Molecules Released with a 4-(4-Ethynylphenyl)-Triazole Moiety from Organometallo-Cobalamins.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Molecular Structure; Organometallic Compounds; Plasmodium falciparum; Triazoles; Vitamin B 12 | 2019 |
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
Topics: Administration, Oral; Animals; Antimalarials; Area Under Curve; Caco-2 Cells; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Dogs; Drug Evaluation, Preclinical; Enzyme Inhibitors; Haplorhini; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Mice, Inbred NOD; Mice, SCID; Molecular Sequence Data; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Pyrimidines; Rabbits; Substrate Specificity; Triazoles | 2015 |
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.
Topics: Animals; Antimalarials; High-Throughput Screening Assays; Humans; In Vitro Techniques; Malaria; Malaria, Falciparum; Mice; Mice, SCID; Microsomes, Liver; Plasmodium berghei; Plasmodium falciparum; Serine Proteinase Inhibitors; Structure-Activity Relationship; Triazoles | 2015 |
Identification of β-Amino alcohol grafted 1,4,5 trisubstituted 1,2,3-triazoles as potent antimalarial agents.
Topics: Amino Alcohols; Animals; Antimalarials; Chlorocebus aethiops; Humans; Malaria, Falciparum; Male; MCF-7 Cells; Mice; Plasmodium falciparum; Rats, Sprague-Dawley; Triazoles; Tumor Suppressor Protein p53; Up-Regulation; Vero Cells | 2016 |
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity.
Topics: Animals; Antimalarials; Dihydroorotate Dehydrogenase; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Malaria, Falciparum; Mice; Mice, SCID; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyrimidines; Rats; Structure-Activity Relationship; Triazoles | 2016 |
Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity.
Topics: Adamantane; Adult; Animals; Antimalarials; B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cells, Cultured; Clinical Trials as Topic; Dendritic Cells; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Malaria, Falciparum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Parasitemia; Peroxides; Plasmodium falciparum; Programmed Cell Death 1 Ligand 2 Protein; Programmed Cell Death 1 Receptor; Pyrimidines; Triazoles; Young Adult | 2016 |
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Humans; Hydrogen Bonding; Malaria, Falciparum; Models, Molecular; Molecular Sequence Data; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Plasmodium falciparum; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Protozoan Proteins; Pyrimidines; Sequence Homology, Amino Acid; Structure-Activity Relationship; Triazoles | 2009 |
Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.
Topics: Antimalarials; Chalcone; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Isatin; Lactones; Malaria, Falciparum; Plasmodium falciparum; Triazoles | 2010 |
The anti-malarial activity of bivalent imidazolium salts.
Topics: Animals; Antimalarials; Disease Models, Animal; Erythrocytes; Imidazoles; Magnetic Resonance Spectroscopy; Malaria, Falciparum; Mass Spectrometry; Mice; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship; Triazoles | 2011 |