4,4-dimethyloxazoline profile

4,4-Dimethyloxazoline is a heterocyclic compound commonly used as a protecting group for carboxylic acids. It is synthesized by the reaction of an amino alcohol with a carboxylic acid, often in the presence of a dehydrating agent like DCC. The oxazoline ring is stable and readily removed by hydrolysis under acidic conditions, making it a versatile protecting group for carboxylic acids. 4,4-Dimethyloxazoline is also studied as a reagent in organic synthesis for its ability to promote various reactions, including cycloadditions and ring-opening metathesis. Its importance lies in its ability to enhance reactivity, selectivity, and efficiency in chemical transformations.'

4,4-dimethyl-2-oxazoline: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	121630
SCHEMBL ID	4794993
MeSH ID	M0160977

Synonym
4,4-dimethyl-2-oxazoline
4,4-dimethyloxazoline
30093-99-3
D90109
inchi=1/c5h9no/c1-5(2)3-7-4-6-5/h4h,3h2,1-2h3
koamxhrrvfdwrq-uhfffaoysa-
D2742
4,4-dimethyl-5h-1,3-oxazole
AKOS005206768
t6z768e669 ,
oxazole, 4,5-dihydro-4,4-dimethyl-
4,5-dihydro-4,4-dimethyloxazole
einecs 250-045-7
unii-t6z768e669
4,4-dimethyl-4,5-dihydrooxazole
FT-0617082
SCHEMBL4794993
4,4-dimethyl-4,5-dihydro-1,3-oxazole
DTXSID60184178
mfcd00014507
ethyl-6-chloro-3-nicotinate
A853656

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (10.34)	18.7374
1990's	5 (17.24)	18.2507
2000's	11 (37.93)	29.6817
2010's	9 (31.03)	24.3611
2020's	1 (3.45)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (3.33%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (96.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.02	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
3-nitropropionic acid 3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.	2.15	1	C-nitro compound	antimycobacterial drug; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor; mycotoxin; neurotoxin
piperidine [no description available]	2.11	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	4.73	29	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
2-amino-2-methyl-1-propanol 2-amino-2-methyl-1-propanol: RN given refers to parent cpd	2.43	2
dimethyl disulfide [no description available]	2.01	1	organic disulfide	xenobiotic metabolite
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.02	1	cobalt group element atom
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	7.69	3	copper group element atom; elemental silver	Escherichia coli metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2	1	dihydrogen
alkenes [no description available]	2.4	2
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	1.99	1	1,2,3-triazole
4-methyl-1,2,4-triazoline-3,5-dione 4-methyl-1,2,4-triazoline-3,5-dione: structure given in ifrst source	1.99	1
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.48	2	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
eicosapentaenoic acid icosapentaenoic acid : Any straight-chain, C20 polyunsaturated fatty acid having five C=C double bonds.. all-cis-5,8,11,14,17-icosapentaenoic acid : An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.	2.06	1	icosapentaenoic acid; omega-3 fatty acid	anticholesteremic drug; antidepressant; antineoplastic agent; Daphnia galeata metabolite; fungal metabolite; micronutrient; mouse metabolite; nutraceutical
alpha-linolenic acid linolenic acid : A two-membered subclass of octadecatrienoic acid comprising the (9Z,12Z,15Z)- and (6Z,9Z,12Z)-isomers. Linolenic acids are nutrients essential to the formation of prostaglandins and are also used in making paints and synthetic resins.. linolenate : A polyunsaturated fatty acid anion obtained by deprotonation of the carboxy group of either alpha- or gamma-linolenic acid.	2.03	1	linolenic acid; omega-3 fatty acid	micronutrient; mouse metabolite; nutraceutical
9,11-linoleic acid 9,11-linoleic acid: a conjugated dienoic linoleate (CLA); RN given refers to cpd without isomeric designation in Chemline. (9E,11E)-octadecadienoic acid : An octadeca-9,11-dienoic acid having 9-trans,11-trans-stereochemistry.	2.42	2	octadeca-9,11-dienoic acid	anti-inflammatory agent; antiatherogenic agent; antineoplastic agent; apoptosis inducer; bacterial xenobiotic metabolite; human metabolite
octadecadienoic acid octadecadienoic acid: location of unsaturation not specified. octadecadienoate : A long-chain, unsaturated fatty acid anion formed by deprotonation of the carboxy group of any octadecadienoic acid; major species at pH 7.3.. octadecadienoic acid : Any straight-chain, C18 polyunsaturated fatty acid having two C=C double bonds.	1.99	1
stearidonic acid [no description available]	2.07	1	long-chain fatty acid; octadecatetraenoic acid; omega-3 fatty acid	Daphnia galeata metabolite; mouse metabolite; plant metabolite
eleostearic acid eleostearic acid: RN given refers to cpd with unspecified isomeric designation	2.01	1	octadecatrienoic acid
docosapentaenoic acid docosapentaenoic acid : Any straight-chain, C22 fatty acid having five C=C double bonds.. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid : The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.	2.48	2	docosapentaenoic acid; omega-3 fatty acid	algal metabolite; human metabolite
tetracosahexaenoic acid tetracosahexaenoic acid: RN given refers to (all-Z)-isomer. tetracosahexaenoic acid : Any C24 straight-chain fatty acid containing six C=C double bonds.	2.01	1
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.05	1	1,2-diacyl-sn-glycero-3-phosphocholine
piperidines Piperidines: A family of hexahydropyridines.	2.11	1
5,9-eicosadienoic acid 5,9-eicosadienoic acid: structure in first source	2.07	1

Condition	Relationship Strength	Studies
Encephalopathy, Toxic [description not available]	2.15	1
Allergic Contact Dermatitis [description not available]	2.05	1
Diseases, Occupational [description not available]	2.05	1
Hand Dermatosis [description not available]	2.05	1
Hand Dermatoses Skin diseases involving the HANDS.	2.05	1
Dermatitis, Allergic Contact A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.	2.05	1
Age-Related Macular Degeneration [description not available]	2.05	1
Autosomal Chromosome Disorders [description not available]	2.05	1
Macular Degeneration Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.	2.05	1

4,4-dimethyloxazoline

Description

Cross-References

Synonyms (22)

Research

Studies (29)

Market Indicators

Research Demand Index: 11.32

Study Types