Disperse Blue 1, also known as C.I. 61500, is a blue anthraquinone dye used primarily in dyeing polyester fibers. It is synthesized through a multi-step process involving the condensation of 1-amino-4-hydroxyanthraquinone with 2-chloro-4-nitroaniline. The dye is characterized by its excellent fastness properties, including good lightfastness and washfastness. It is widely used in the textile industry for dyeing various polyester fabrics, including clothing, upholstery, and carpets. The study of disperse blue 1 focuses on its properties, applications, and potential environmental impact. This includes research on its synthesis methods, dyeing processes, and the development of more sustainable alternatives. Disperse Blue 1 has been found to exhibit some bioaccumulation potential in aquatic organisms, raising concerns regarding its environmental impact. Continued research is essential to minimize its potential risks while maximizing its benefits in textile applications.'
| ID Source | ID |
|---|---|
| PubMed CID | 17190 |
| CHEMBL ID | 87568 |
| CHEBI ID | 82325 |
| SCHEMBL ID | 125495 |
| MeSH ID | M0140330 |
| Synonym |
|---|
| AC-16450 |
| chebi:82325 , |
| 1,4,5,8-tetraamino-anthraquinone |
| CHEMBL87568 |
| 9,10-anthracenedione, 1,4,5,8-tetraamino- |
| NCI60_003723 |
| perliton blue b |
| oracet sapphire blue g |
| microsetile blue eb |
| artisil blue sap conc. |
| 1,5,8-tetraminoanthraquinone |
| amacel blue gg |
| disperse blue 1 |
| grasol blue 2gs |
| 1,5,8-tetraaminoanthraquinone |
| setacyl blue 2gs ii |
| setacyl blue 2gs |
| nacelan blue g |
| nsc39936 |
| celanthrene pure blue brs |
| c.i. 64500 |
| c.i. solvent blue 18 |
| miketon fast blue |
| nyloquinone blue 2j |
| serinyl blue 3g |
| 2475-45-8 |
| brasilazet blue gr |
| solvent blue 18 |
| acetate blue g |
| 9, 1,4,5,8-tetraamino- |
| amacel pure blue b |
| diacelliton fast blue r |
| celliton blue g |
| supracet brilliant blue 2gn |
| nci-c54900 |
| 1,5,8-tetraamino-9,10-anthracenedione |
| acetoquinone blue r |
| fenacet blue g |
| acetylon fast blue g |
| cilla blue extra |
| c.i. disperse blue 1 |
| cibacet sapphire blue g |
| nsc-39936 |
| duranol brilliant blue cb |
| neosetile blue eb |
| serinyl blue 3gn |
| acetoquinone blue l |
| wln: l c666 bv ivj dz gz kz nz |
| kayalon fast blue br |
| cibacete sapphire blue g |
| miketon fast blue b |
| serinyl blue 2g |
| celliton blue extra |
| disperse blue no 1 |
| anthraquinone,4,5,8-tetraamino- |
| celliton blue ga-cf |
| artisil blue sap |
| artisil blue sap conc |
| supracet deep blue r |
| celliton blue bb-cf |
| 1,4,5,8-tetraaminoanthracene-9,10-dione |
| 1,4,5,8-tetraaminoanthra-9,10-quinone |
| 1,4,5,8-tetraamino-9,10-anthracenedione |
| ci disperse blue 1 |
| einecs 219-603-7 |
| ci 64500 |
| acetate blue 6 |
| ci solvent blue 18 |
| diacellition fast blue r |
| brn 0925672 |
| disperse blue no. 1 |
| anthraquinone, 1,4,5,8-tetraamino- |
| ccris 1419 |
| 1,4,5,8-tetraaminoanthraquinone |
| hsdb 4200 |
| 1,4,5,8-tetraamino-9,10-anthraquinone |
| anthraquinone, 1,4,5,8-tetramino- |
| 1,4,5,8-tetraminoanthraquinone |
| nsc 39936 |
| dracet sapphire blue g |
| disperse blue 1, dye content 30 % |
| NCGC00164089-01 |
| AKOS001567886 |
| C19236 |
| 2429naz8wh , |
| unii-2429naz8wh |
| c.i. disperse blue |
| lowadene blue 1 |
| disperse blue 1 [iarc] |
| disperse blue 1 [inci] |
| disperse blue 1 [hsdb] |
| SCHEMBL125495 |
| 1,4,5,8-tetraaminoanthra-9,10-quinone # |
| 1,4,5,8-tetraamino-9,10-dihydroanthracene-9,10-dione |
| DTXSID7020188 , |
| ci disperse blue 1; cl solvent blue 18; 1,4,5,8-tetraaminoanthraquinone; 1,4,5,8-tetraamino-9,10-anthracenedione; 1,4,5,8-tetraaminoanthraquinone |
| J-015656 |
| Q27155877 |
| disperseblue1 |
| disperse blue 1 100 microg/ml in acetonitrile |
| STARBLD0016596 |
| CAA47545 |
| dtxcid10188 |
| 1,4,5,8-tetraamino anthraquinone |
| sapphire8145 |
| disperse blue 1 (iarc) |
Disperse Blue 1 is an anthraquinone dye used at low levels in semipermanent hair color formulations.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Disperse Blue 1 is an anthraquinone dye used at low levels in semipermanent hair color formulations. " | ( Two approaches for assessing human safety of disperse blue 1. Dressler, WE; Haws, LC; Jackson, BA; Turnbull, D, 1994) | 1.99 |
Disperse Blue 1 has been tested in a variety of in vivo and in vitro genotoxicity assays and was negative in vivo. It produced a weak and mixed pattern of genotoxic responses in vitro which may be attributable to a constituent of the commercial preparations.
| Excerpt | Reference | Relevance |
|---|---|---|
| "disperse blue 1 (1), has been investigated under UV light irradiation in the presence of TiO2 and H2O2 under a variety of conditions." | ( Photocatalytic degradation of disperse blue 1 using UV/TiO2/H2O2 process. Abu Tariq, M; Haque, MM; Muneer, M; Saquib, M, 2008) | 1.36 |
| "Disperse Blue 1 has been tested in a variety of in vivo and in vitro genotoxicity assays and was negative in vivo but produced a weak and mixed pattern of genotoxic responses in vitro which may be attributable to a constituent of the commercial preparations." | ( Two approaches for assessing human safety of disperse blue 1. Dressler, WE; Haws, LC; Jackson, BA; Turnbull, D, 1994) | 1.27 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " With this approach, an uncertainty factor of 1000 applied to the no-observed-adverse-effect level in the NTP bioassay yielded a safe exposure level of 45-56 micrograms/kg/day." | ( Two approaches for assessing human safety of disperse blue 1. Dressler, WE; Haws, LC; Jackson, BA; Turnbull, D, 1994) | 0.55 |
| Class | Description |
|---|---|
| anthraquinone | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 44.6684 | 0.0002 | 29.3054 | 16,493.5996 | AID588513 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 42.4600 | 0.0100 | 39.5371 | 1,122.0200 | AID1469; AID1479 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.4973 | 0.0006 | 27.2152 | 1,122.0200 | AID651741; AID720636 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 7.9433 | 0.0023 | 19.5956 | 74.0614 | AID651743 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.6003 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.6306 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0006 | 1.5257 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.7472 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.7411 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.7411 | 10.0000 | AID144609; AID144610 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 (µMol) | 1,000.0000 | 0.0007 | 1.7411 | 10.0000 | AID144609; AID144610 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| AID437515 | Binding affinity to tau stem-loop RNA assessed as inhibition of RNA stem-loop unfolding | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. |
| AID437514 | Displacement of fluorescent pyrene-neomycin conjugate from tau stem-loop RNA | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21 | Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. |
| AID144609 | Displacement of [3H]MK-801 from N-methyl-D-aspartate glutamate receptor | 2000 | Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23 | Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. |
| AID144610 | Displacement of [3H]-SPD from N-methyl-D-aspartate glutamate receptor | 2000 | Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23 | Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (30.55) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (6.67%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (93.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||