carbohydrazide

Description

carbohydrazide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

carbohydrazide : A hydrazide consisting of hydrazine carrying one or more carboacyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

carbonyl dihydrazine : A carbohydrazide obtained by formal condensation between hydrazinecarboxylic acid and hydrazine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	73948
CHEBI ID	61308
MeSH ID	M0071636

Synonyms (62)

Synonym
AKOS003193931
hydrazinecarboxamide, n-amino-
hydrazinecarboxylic acid, hydrazide
carbazide
urea,n'-diamino-
carbohydrazide
carbonic dihydrazide
carbazic acid, hydrazide
1,3-diaminourea
nsc1934
urea,3-diamino-
497-18-7
wln: zmvmz
carbodihydrazide
hydrazine, carbonyldi-
carbonohydrazide
semicarbazide, 4-amino-
nsc-1934
carbonic acid, dihydrazide
hydrazine, carbonylbis-
einecs 207-837-2
nsc 1934
1,3-diaminomocovina [czech]
brn 1747069
ai3-52397
urea, n,n'-diamino-
karbazid [czech]
urea, 1,3-diamino-
carbohydrazide, 98%
hydrazide hydrazinecarboxylic acid
carbonylbis-hydrazine
carbonodihydrazide
cabazide
n-aminohydrazinecarboxamide
carbonohydrazid
4-aminosemicarbazide
hydrazinecarbohydrazide
carbonyl dihydrazine
n,n'-diaminourea
n-aminohydrazine carboxamide
CHEBI:61308
A827826
1,3-bis(azanyl)urea
ch6n4o
unii-w8v7fyy4wh
1,3-diaminomocovina
4-03-00-00240 (beilstein handbook reference)
ec 207-837-2
karbazid
w8v7fyy4wh ,
FT-0606617
carbohydrazide [mi]
W-106011
DTXSID5038757
mfcd00007591
E77171
Q5037885
AMY40845
o c (n h n h2)2
carbonyldihydrazide
CS-0149890
EN300-20051

Research Excerpts

Overview

Excerpt	Reference
"New carbohydrazide 3 is an attractive lead for drug development to treat paracoccidioidomycoses."	( A Bueno, PS; Bagatin, MC; Basso, EA; Canduri, F; F Rozada, AM; Gauze, GF; Kioshima, ÉS; Santos, JL; V Rodrigues, FA; V Seixas, FA, 2019)

Treatment

Excerpt	Reference
"The carbohydrazide was treated with differently substituted aromatic carbonyl compounds giving hydrazones."	( Ahmad, M; Anwar, M; Din, G; Hameed, S; Israr, M; Khan, SA; Shah, MA; Tahir, MN, 2016)

Drug Classes (2)

Class	Description
carbohydrazide	A hydrazide consisting of hydrazine carrying one or more carboacyl groups.
one-carbon compound	An organic molecular entity containing a single carbon atom (C1).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (101)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (0.99)	18.7374
1990's	1 (0.99)	18.2507
2000's	17 (16.83)	29.6817
2010's	59 (58.42)	24.3611
2020's	23 (22.77)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (0.95%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	104 (99.05%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Classes	Roles
hydrazine	[no description available]	medium	101	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
triazoles	[no description available]	medium	5	1,2,3-triazole
pyridine	[no description available]	medium	2	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
colchicine	[no description available]	medium	1	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
adamantane	[no description available]	medium	2	adamantanes; polycyclic alkane
bismuth	[no description available]	medium	1	metal atom; pnictogen
ruthenium	[no description available]	medium	1	iron group element atom; platinum group metal atom
silver	[no description available]	medium	1	copper group element atom; elemental silver	Escherichia coli metabolite
vanadates	[no description available]	medium	1	trivalent inorganic anion; vanadium oxoanion	EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor
bismuth orthovanadate	[no description available]	medium	1
isatin	[no description available]	medium	3	indoledione	EC 1.4.3.4 (monoamine oxidase) inhibitor; plant metabolite
adipic dihydrazide	[no description available]	medium	1
succinic dihydrazide	[no description available]	medium	1
pyridoxal	[no description available]	medium	1	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
nickel	[no description available]	medium	3	metal allergen; nickel group element atom	epitope; micronutrient
1,3,4-oxadiazole	[no description available]	medium	2
piperidines	[no description available]	medium	1
piperidine	[no description available]	medium	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
oxadiazoles	[no description available]	medium	5
urea	[no description available]	medium	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
imidazolidines	[no description available]	medium	1	azacycloalkane; imidazolidines; saturated organic heteromonocyclic parent
amphotericin b	[no description available]	medium	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
allopurinol	[no description available]	medium	1	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger
pyrazole	[no description available]	medium	2	pyrazole
acetophenone	[no description available]	medium	1	acetophenones	animal metabolite; photosensitizing agent; xenobiotic
benzaldehyde	[no description available]	medium	1	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
chiniofon	[no description available]	medium	1
1,1-diphenyl-2-picrylhydrazyl	[no description available]	medium	2
fluorine	[no description available]	medium	2	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
dimethyl sulfoxide	[no description available]	medium	3	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
thiophene-2-carboxylic acid hydrazide	[no description available]	medium	1
thiophenes	[no description available]	medium	3	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
salicylaldehyde	[no description available]	medium	2	hydroxybenzaldehyde	nematicide; plant metabolite
lactic acid	[no description available]	medium	1	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
adenosine diphosphate	[no description available]	medium	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
arachidonic acid	[no description available]	medium	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
tryptoline	[no description available]	medium	1	beta-carbolines
methyl gallate	[no description available]	medium	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
gallic acid	[no description available]	medium	1	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
1,2,4-triazole	[no description available]	medium	1	1,2,4-triazole
adamantyl isothiocyanate	[no description available]	medium	1
pyrazines	[no description available]	medium	2	diazine; pyrazines	Daphnia magna metabolite
benzimidazole	[no description available]	medium	2	benzimidazole; polycyclic heteroarene
carbamylhydrazine	[no description available]	medium	2	carbohydrazide; monocarboxylic acid amide; one-carbon compound; ureas
pimagedine	[no description available]	medium	1	guanidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor; EC 1.4.3.4 (monoamine oxidase) inhibitor
5-amino-1h-tetrazole	[no description available]	medium	1
ammonium hydroxide	[no description available]	medium	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
phloroglucinol	[no description available]	medium	1	benzenetriol; phenolic donor	algal metabolite
pyrroles	[no description available]	medium	3	pyrrole; secondary amine
l-873724	[no description available]	medium	1
balicatib	[no description available]	medium	1
odanacatib	[no description available]	medium	1
pyrazinamide	[no description available]	medium	1	monocarboxylic acid amide; N-acylammonia; pyrazines	antitubercular agent; prodrug
cerium	[no description available]	medium	1	f-block element atom; lanthanoid atom
cobalt	[no description available]	medium	2	cobalt group element atom; metal allergen	micronutrient
nalidixic acid	[no description available]	medium	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
indoline	[no description available]	medium	1	indoles
quinoline	[no description available]	medium	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines
ciprofloxacin	[no description available]	medium	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
pyoluteorin	[no description available]	medium	1	aromatic ketone; beta-hydroxy ketone; diol; organochlorine compound; organochlorine pesticide; polyketide; pyrroles; resorcinols	antibacterial agent; antifungal agent; apoptosis inducer; bacterial metabolite; marine metabolite
thienopyrimidine	[no description available]	medium	1
pentylenetetrazole	[no description available]	medium	1	organic heterobicyclic compound; organonitrogen heterocyclic compound
folic acid	[no description available]	medium	1	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient
methotrexate	[no description available]	medium	1	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent
phosgene	[no description available]	medium	1	acyl chloride
isoxazoles	[no description available]	medium	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
transforming growth factor beta	[no description available]	medium	1
warfarin	[no description available]	medium	2	benzenes; hydroxycoumarin; methyl ketone
phosphatidylcholines	[no description available]	medium	1	1,2-diacyl-sn-glycero-3-phosphocholine
formaldehyde	[no description available]	medium	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cesium	[no description available]	medium	1	alkali metal atom
lithium	[no description available]	medium	1	alkali metal atom
gossypol	[no description available]	medium	1
deoxycytidine	[no description available]	medium	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
4-hydroxybenzoic acid hydrazide	[no description available]	low	0	carbohydrazide; phenols
am 251	[no description available]	low	0	amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles	antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist
benserazide	[no description available]	low	0	carbohydrazide; catechols; primary alcohol; primary amino compound	antiparkinson drug; dopaminergic agent; EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor
iproniazid	[no description available]	low	0	carbohydrazide; pyridines
isoniazid	[no description available]	low	0	carbohydrazide	antitubercular agent; drug allergen
benzoylhydrazine	[no description available]	low	0	carbohydrazide
acetylhydrazine	[no description available]	low	0	carbohydrazide; carbohydrazonic acid	drug metabolite
bumadizone	[no description available]	low	0	carbohydrazide; monocarboxylic acid	antipyretic; non-steroidal anti-inflammatory drug
nifursol	[no description available]	low	0	carbohydrazide; dinitrophenol; nitrofuran antibiotic
oxadixyl	[no description available]	low	0	anilide fungicide; aromatic amide; carbohydrazide; ether; oxazolidinone	agrochemical
acetylisoniazid	[no description available]	low	0	carbohydrazide	metabolite
n,n'-diacetylhydrazine	[no description available]	low	0	carbohydrazide
tebufenozide	[no description available]	low	0	carbohydrazide	ecdysone agonist; environmental contaminant; xenobiotic
sr141716	[no description available]	low	0	amidopiperidine; carbohydrazide; dichlorobenzene; monochlorobenzenes; pyrazoles	anti-obesity agent; appetite depressant; CB1 receptor antagonist
methoxyfenozide	[no description available]	low	0	carbohydrazide; monomethoxybenzene	environmental contaminant; insecticide; xenobiotic
atazanavir	[no description available]	low	0	carbohydrazide	antiviral drug; HIV protease inhibitor
famoxadone	[no description available]	low	0	aromatic ether; carbohydrazide; oxazolidinone
elesclomol	[no description available]	low	0	carbohydrazide; thiocarbonyl compound	antineoplastic agent; apoptosis inducer
agaritine	[no description available]	low	0	amino acid zwitterion; benzyl alcohols; carbohydrazide; L-glutamic acid derivative; non-proteinogenic L-alpha-amino acid
N'-[1-oxo-2-(4-propan-2-ylphenoxy)ethyl]-2-pyrazinecarbohydrazide	[no description available]	low	0	carbohydrazide; pyrazines
N'-[2-(4-bromo-2-methylphenoxy)-1-oxoethyl]-2-pyrazinecarbohydrazide	[no description available]	low	0	carbohydrazide; pyrazines
2-(1-adamantylcarbonyl)hydrazine-1-carbothioamide	[no description available]	low	0	carbohydrazide
fenamidone	[no description available]	low	0	carbohydrazide; imidazole fungicide; imidazolone; organic sulfide	antifungal agrochemical; mitochondrial cytochrome-bc1 complex inhibitor; quinone outside inhibitor
sid 26681509	[no description available]	low	0	carbohydrazide; L-tryptophan derivative; secondary carboxamide; tert-butyl ester; thioester	antiplasmodial drug; cathepsin L (EC 3.4.22.15) inhibitor
carbamic acid	[no description available]	low	0	carbon oxoacid; one-carbon compound; organonitrogen compound	Escherichia coli metabolite
carbamyl phosphate	[no description available]	low	0	acyl monophosphate; one-carbon compound	Escherichia coli metabolite; mouse metabolite
carbon monoxide	[no description available]	low	0	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
methane	[no description available]	low	0	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
cyanic acid	[no description available]	low	0	one-carbon compound; pseudohalogen oxoacid
formamide	[no description available]	low	0	carboximidic acid; formamides; monocarboxylic acid amide; one-carbon compound	solvent
hydrogen cyanide	[no description available]	low	0	hydracid; one-carbon compound	Escherichia coli metabolite; human metabolite; poison
thiocyanic acid	[no description available]	low	0	hydracid; one-carbon compound; organosulfur compound	Escherichia coli metabolite
methanol	[no description available]	low	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
foscarnet	[no description available]	low	0	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
guanidine	[no description available]	low	0	carboxamidine; guanidines; one-carbon compound
hydroxyurea	[no description available]	low	0	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent
guanidine hydrochloride	[no description available]	low	0	one-carbon compound; organic chloride salt	protein denaturant
chloroform	[no description available]	low	0	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
methylamine	[no description available]	low	0	methylamines; one-carbon compound; primary aliphatic amine	mouse metabolite
isocyanic acid	[no description available]	low	0	hydracid; one-carbon compound
carbon disulfide	[no description available]	low	0	one-carbon compound; organosulfur compound
methanesulfonic acid	[no description available]	low	0	alkanesulfonic acid; one-carbon compound	Escherichia coli metabolite
methyl sulfate	[no description available]	low	0	alkyl sulfate; one-carbon compound
chloropicrin	[no description available]	low	0	C-nitro compound; one-carbon compound; organochlorine compound	antifungal agrochemical; fumigant insecticide; nematicide
sodium cyanide	[no description available]	low	0	cyanide salt; one-carbon compound; sodium salt	EC 1.15.1.1 (superoxide dismutase) inhibitor
monomethylarsonic acid	[no description available]	low	0	arsonic acids; one-carbon compound; organoarsonic acid
potassium cyanide	[no description available]	low	0	cyanide salt; one-carbon compound; potassium salt	EC 1.15.1.1 (superoxide dismutase) inhibitor; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; neurotoxin
bromochlorodifluoromethane	[no description available]	low	0	one-carbon compound; organobromine compound; organochlorine compound; organofluorine compound
cyanamide	[no description available]	low	0	nitrile; one-carbon compound	EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor
carbonyl sulfide	[no description available]	low	0	one-carbon compound; organosulfur compound
thiophosgene	[no description available]	low	0	one-carbon compound; thiocarbonyl compound
limestone	[no description available]	low	0	calcium salt; carbonate salt; inorganic calcium salt; one-carbon compound	antacid; fertilizer; food colouring; food firming agent
magnesium carbonate	[no description available]	low	0	carbonate salt; magnesium salt; one-carbon compound; organic magnesium salt	antacid; fertilizer
siderite	[no description available]	low	0	carbonate mineral; carbonate salt; iron molecular entity; one-carbon compound
methylphosphate	[no description available]	low	0	monoalkyl phosphate; one-carbon compound	algal metabolite; epitope; phosphoantigen
methylphosphonic acid	[no description available]	low	0	one-carbon compound; phosphonic acids
1-aminomethylphosphonic acid	[no description available]	low	0	one-carbon compound; phosphonic acids
clodronic acid	[no description available]	low	0	1,1-bis(phosphonic acid); one-carbon compound; organochlorine compound	antineoplastic agent; bone density conservation agent
clodronate disodium	[no description available]	low	0	one-carbon compound; organic sodium salt	bone density conservation agent
foscarnet sodium	[no description available]	low	0	one-carbon compound; organic sodium salt	antiviral drug
trifluoromethanesulfonic acid	[no description available]	low	0	one-carbon compound; perfluoroalkanesulfonic acid
isothiocyanic acid	[no description available]	low	0	hydracid; one-carbon compound
1h-tetrazole	[no description available]	low	0	one-carbon compound; tetrazole
formamidine	[no description available]	low	0	carboxamidine; formamidines; one-carbon compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
trithiocarbonic acid	[no description available]	low	0	chalcocarbonic acid; one-carbon compound; thiocarbonyl compound
methylene glycol	[no description available]	low	0	aldehyde hydrate; methanediols; one-carbon compound
hydroxyguanidine	[no description available]	low	0	guanidines; one-carbon compound	antineoplastic agent; antiviral agent
methyleneimine	[no description available]	low	0	aldimine; one-carbon compound
hypothiocyanite ion	[no description available]	low	0	one-carbon compound; sulfur oxoacid	antibacterial agent; antifungal agent; antiviral agent; human metabolite; oxidising agent; rat metabolite
carbazic acid	[no description available]	low	0	monocarboxylic acid; one-carbon compound
methanearsonous acid	[no description available]	low	0	arsonous acids; one-carbon compound	carcinogenic agent; human xenobiotic metabolite; poison
methylselenic acid	[no description available]	low	0	one-carbon compound; organoselenium compound	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor; human xenobiotic metabolite
formyl phosphate	[no description available]	low	0	acyl monophosphate; one-carbon compound
carboxy phosphate	[no description available]	low	0	acyclic mixed acid anhydride; one-carbon compound; organic phosphate
methylmercuric chloride	[no description available]	low	0	chlorine molecular entity; mercury coordination entity; one-carbon compound
sodium bicarbonate	[no description available]	low	0	one-carbon compound; organic sodium salt	antacid; food anticaking agent
sodium cyanate	[no description available]	low	0	cyanate salt; one-carbon compound
thiourea	[no description available]	low	0	one-carbon compound; thioureas; ureas	antioxidant; chromophore
isoselenocyanic acid	[no description available]	low	0	hydracid; one-carbon compound
potassium cyanate	[no description available]	low	0	cyanate salt; one-carbon compound	herbicide
bismuth subcarbonate	[no description available]	low	0	bismuth coordination entity; one-carbon compound
nitroguanidine	[no description available]	low	0	nitroguanidine; one-carbon compound

Condition	Relationship Strength	Studies
Absence Seizure	low	1
Absence Seizures	low	1
Acute Confusional Senile Dementia	low	3
Alloxan Diabetes	low	2
Alzheimer Dementia	low	3
Alzheimer Disease	low	3
Alzheimer Disease, Early Onset	low	3
Alzheimer Disease, Late Onset	low	3
Alzheimer Sclerosis	low	3
Alzheimer Syndrome	low	3
Alzheimer Type Senile Dementia	low	3
Alzheimer-Type Dementia (ATD)	low	3
Alzheimer's Disease	low	3
Alzheimer's Disease, Focal Onset	low	3
Alzheimer's Diseases	low	3
American Trypanosomiasis	low	1
Anasarca	low	1
Appetite Disorders	low	1
Atonic Absence Seizure	low	1
Atonic Absence Seizures	low	1
Atonic Seizure	low	1
Atonic Seizures	low	1
Bacterial Disease	low	1
Bacterial Infection	low	1
Bacterial Infections	low	1
Becker Muscular Dystrophy	low	1
Becker's Muscular Dystrophy	low	1
Benign Neoplasms	low	1
Benign Neoplasms, Brain	low	1
Blastomyces brasiliensis Infection	low	1
Blastomyces brasiliensis Infections	low	1
Blastomycosis, South American	low	1
Body Weight	low	2
Brain Cancer	low	1
Brain Metastases	low	1
Brain Neoplasm, Primary	low	1
Brain Neoplasms	low	1
Brain Neoplasms, Benign	low	1
Brain Neoplasms, Malignant	low	1
Brain Neoplasms, Malignant, Primary	low	1
Brain Neoplasms, Primary Malignant	low	1
Brain Tumor, Primary	low	1
Brain Tumor, Recurrent	low	1
Brain Tumors	low	1
Cancer	low	1
Cancer of Brain	low	1
Cancer of Liver	low	2
Cancer of Lung	low	3
Cancer of Mouth	low	1
Cancer of the Brain	low	1
Cancer of the Liver	low	2
Cancer of the Lung	low	3
Cancer of the Mouth	low	1
Cancer, Hepatocellular	low	2
Carcinoma, Ehrlich Tumor	low	1
Carcinoma, Hepatocellular	low	2
Carcinoma, Non-Small Cell Lung	low	2
Carcinoma, Non-Small-Cell Lung	low	2
Cardiomyopathy, Dilated, 3B	low	1
Cardiomyopathy, Dilated, X-Linked	low	1
Cell Transformation, Neoplastic	low	1
Chagas Disease	low	1
Chagas' Disease	low	1
Childhood Muscular Dystrophy, Pseudohypertrophic	low	1
Childhood Pseudohypertrophic Muscular Dystrophy	low	1
Clonic Seizure	low	1
Clonic Seizures	low	1
Colorectal Cancer	low	1
Colorectal Carcinoma	low	1
Colorectal Neoplasms	low	1
Colorectal Tumors	low	1
Complex Partial Seizure	low	1
Complex Partial Seizures	low	1
Convulsion	low	1
Convulsion, Non-Epileptic	low	1
Convulsions	low	1
Convulsive Seizure	low	1
Convulsive Seizures	low	1
Dementia, Alzheimer Type	low	3
Dementia, Presenile	low	3
Dementia, Primary Senile Degenerative	low	3
Dementia, Senile	low	3
Diabetes Mellitus	low	2
Diabetes Mellitus, Adult-Onset	low	1
Diabetes Mellitus, Experimental	low	2
Diabetes Mellitus, Ketosis-Resistant	low	1
Diabetes Mellitus, Maturity-Onset	low	1
Diabetes Mellitus, Non Insulin Dependent	low	1
Diabetes Mellitus, Non-Insulin-Dependent	low	1
Diabetes Mellitus, Noninsulin Dependent	low	1
Diabetes Mellitus, Noninsulin-Dependent	low	1
Diabetes Mellitus, Slow-Onset	low	1
Diabetes Mellitus, Stable	low	1
Diabetes Mellitus, Type 2	low	1
Diabetes Mellitus, Type II	low	1
Dropsy	low	1
Duchenne and Becker Muscular Dystrophy	low	1
Duchenne Muscular Dystrophy	low	1
Duchenne-Becker Muscular Dystrophy	low	1
Duchenne-Type Progressive Muscular Dystrophy	low	1
Early Onset Alzheimer Disease	low	3
Eating and Feeding Disorders	low	1
Eating Disorders	low	1
Edema	low	1
Ehrlich Ascites Tumor	low	1
Embolism, Pulmonary	low	1
Embolisms, Pulmonary	low	1
Epileptic Seizure	low	1
Epileptic Seizures	low	1
Experimental Diabetes Mellitus	low	2
Extravascular Hemolysis	low	1
Familial Alzheimer Disease (FAD)	low	3
Feeding and Eating Disorders	low	1
Feeding Disorders	low	1
Focal Onset Alzheimer's Disease	low	3
Fungal Diseases	low	1
Fungal Infections	low	1
Fungus Diseases	low	1
Fungus Infections	low	1
Generalized Absence Seizure	low	1
Generalized Absence Seizures	low	1
Generalized Tonic-Clonic Seizures	low	1
Haemolysis	low	1
Hemolysis	low	1
Hepatic Cancer	low	2
Hepatic Neoplasms	low	2
Hepatocellular Cancer	low	2
Hepatocellular Carcinoma	low	2
Hepatoma	low	2
Hydrops	low	1
Hyperglycemia	low	1
Hyperglycemia, Postprandial	low	1
Infection, Bacterial	low	1
Infections, Bacterial	low	1
Infections, Orthomyxoviridae	low	1
Infections, Orthomyxovirus	low	1
Intracranial Neoplasms	low	1
Intravascular Hemolysis	low	1
Invasiveness, Neoplasm	low	1
Jacksonian Seizure	low	1
Koch's Disease	low	3
Kochs Disease	low	3
Late Onset Alzheimer Disease	low	3
Leishmania Infection	low	2
Leishmaniasis	low	2
Leishmaniasis, American	low	1
Leishmaniasis, Cutaneous	low	1
Leishmaniasis, New World	low	1
Leishmaniasis, Old World	low	1
Liver Cancer	low	2
Liver Cancer, Adult	low	2
Liver Cell Carcinoma	low	2
Liver Cell Carcinoma, Adult	low	2
Liver Neoplasms	low	2
Lung Cancer	low	3
Lung Neoplasms	low	3
Malaria, Falciparum	low	1
Malignancy	low	1
Malignant Neoplasms	low	1
Malignant Neoplasms, Brain	low	1
Malignant Primary Brain Neoplasms	low	1
Malignant Primary Brain Tumors	low	1
Maturity-Onset Diabetes	low	1
Maturity-Onset Diabetes Mellitus	low	1
MODY	low	1
Mouth Cancer	low	1
Mouth Neoplasms	low	1
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type	low	1
Muscular Dystrophy, Becker	low	1
Muscular Dystrophy, Becker Type	low	1
Muscular Dystrophy, Childhood, Pseudohypertrophic	low	1
Muscular Dystrophy, Duchenne	low	1
Muscular Dystrophy, Duchenne and Becker Types	low	1
Muscular Dystrophy, Duchenne Type	low	1
Muscular Dystrophy, Pseudohypertrophic	low	1
Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type	low	1
Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type	low	1
Muscular Dystrophy, Pseudohypertrophic, Childhood	low	1
Mycobacterium tuberculosis Infection	low	3
Mycoses	low	1
Myoclonic Seizure	low	1
Myoclonic Seizures	low	1
Neoplasia	low	1
Neoplasm	low	1
Neoplasm Invasion	low	1
Neoplasm Invasiveness	low	1
Neoplasms	low	1
Neoplasms, Benign	low	1
Neoplasms, Brain	low	1
Neoplasms, Brain, Benign	low	1
Neoplasms, Brain, Malignant	low	1
Neoplasms, Brain, Primary	low	1
Neoplasms, Colorectal	low	1
Neoplasms, Hepatic	low	2
Neoplasms, Intracranial	low	1
Neoplasms, Liver	low	2
Neoplasms, Lung	low	3
Neoplasms, Mouth	low	1
Neoplasms, Oral	low	1
Neoplasms, Pulmonary	low	3
Neoplastic Cell Transformation	low	1
Neoplastic Transformation, Cell	low	1
NIDDM	low	1
Non-Epileptic Seizure	low	1
Non-Epileptic Seizures	low	1
Non-Small Cell Lung Cancer	low	2
Non-Small Cell Lung Carcinoma	low	2
Non-Small-Cell Lung Carcinoma	low	2
Nonepileptic Seizure	low	1
Nonepileptic Seizures	low	1
Noninsulin-Dependent Diabetes Mellitus	low	1
Nonsmall Cell Lung Cancer	low	2
Oral Cancer	low	1
Oral Neoplasms	low	1
Oriental Sore	low	1
Orthomyxoviridae Infections	low	1
Orthomyxovirus Infections	low	1
Paracoccidioidal Granuloma	low	1
Paracoccidioides brasiliensis Infection	low	1
Paracoccidioides Infection	low	1
Paracoccidioides Infections	low	1
Paracoccidioidomycoses	low	1
Paracoccidioidomycosis	low	1
Partial Seizure	low	1
Partial Seizures	low	1
Petit Mal Convulsion	low	1
Plasmodium falciparum Malaria	low	1
Postprandial Hyperglycemia	low	1
Presenile Alzheimer Dementia	low	3
Primary Brain Neoplasms	low	1
Primary Malignant Brain Neoplasms	low	1
Primary Malignant Brain Tumors	low	1
Primary Senile Degenerative Dementia	low	3
Progressive Muscular Dystrophy, Duchenne Type	low	1
Pseudohypertrophic Childhood Muscular Dystrophy	low	1
Pseudohypertrophic Muscular Dystrophy, Childhood	low	1
Pulmonary Cancer	low	3
Pulmonary Embolism	low	1
Pulmonary Embolisms	low	1
Pulmonary Neoplasms	low	3
Pulmonary Thromboembolism	low	1
Pulmonary Thromboembolisms	low	1
Seizure	low	1
Seizures	low	1
Seizures, Auditory	low	1
Seizures, Clonic	low	1
Seizures, Convulsive	low	1
Seizures, Epileptic	low	1
Seizures, Focal	low	1
Seizures, Generalized	low	1
Seizures, Gustatory	low	1
Seizures, Motor	low	1
Seizures, Olfactory	low	1
Seizures, Sensory	low	1
Seizures, Somatosensory	low	1
Seizures, Tonic	low	1
Seizures, Tonic-Clonic	low	1
Seizures, Vertiginous	low	1
Seizures, Vestibular	low	1
Seizures, Visual	low	1
Senile Dementia, Acute Confusional	low	3
Senile Dementia, Alzheimer Type	low	3
Sensitivity and Specificity	low	2
Single Seizure	low	1
Streptozocin Diabetes	low	2
Streptozotocin Diabetes	low	2
Swine Influenza	low	1
Thromboembolism, Pulmonary	low	1
Thromboembolisms, Pulmonary	low	1
Tonic Clonic Seizure	low	1
Tonic Seizure	low	1
Tonic Seizures	low	1
Tonic-Clonic Seizure	low	1
Tonic-Clonic Seizures	low	1
Transformation, Neoplastic Cell	low	1
Trypanosoma cruzi Infection	low	1
Trypanosomiasis, South American	low	1
Tuberculosis	low	3
Tumorigenic Transformation	low	1
Tumors	low	1
Type 2 Diabetes	low	1
Type 2 Diabetes Mellitus	low	1

Research Highlights

Safety/Toxicity (1)

Article	Year
Synthesis, antichagasic in vitro evaluation, cytotoxicity assays, molecular modeling and SAR/QSAR studies of a 2-phenyl-3-(1-phenyl-1H-pyrazol-4-yl)-acrylic acid benzylidene-carbohydrazide series. Bioorganic & medicinal chemistry, Jan-01, Volume: 17, Issue: 1	2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

Article	Year
Synthesis and structure-activity relationships of carbohydrazides and 1,3,4-oxadiazole derivatives bearing an imidazolidine moiety against the yellow fever and dengue vector, Aedes aegypti. Pest management science, Volume: 74, Issue: 2	2018
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue: 22	2006
N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II. Bioorganic & medicinal chemistry letters, Nov-15, Volume: 16, Issue: 22	2006
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]