A protein-serine O-palmitoleoyltransferase porcupine that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9H237]
EC 2.3.1.250;
Protein MG61
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)thio]acetamide | Homo sapiens (human) | IC50 | 0.1570 | 1 | 1 |
| lgk974 | Homo sapiens (human) | IC50 | 0.0004 | 2 | 2 |
| wnt-c59 | Homo sapiens (human) | IC50 | 0.0005 | 2 | 2 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| palmitoleoyltransferase activity | molecular function | Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule. [PMID:17141155, PMID:25731175] |
| Wnt-protein binding | molecular function | Binding to a Wnt-protein, a secreted growth factor involved in signaling. [GOC:jl] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| AMPA glutamate receptor complex | cellular component | An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. [GOC:ef] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| protein lipidation | biological process | The covalent attachment of lipid groups to an amino acid in a protein. [GOC:jl] |
| glycoprotein metabolic process | biological process | The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732] |
| Wnt signaling pathway | biological process | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of a target cell and ending with a change in cell state. [PMID:11532397] |
| protein palmitoleylation | biological process | The covalent attachment of a palmitoleyl group to a protein. [GOC:ai] |
| regulation of postsynaptic membrane neurotransmitter receptor levels | biological process | Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. [GOC:dos] |
| lipid modification | biological process | The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. [GOC:mah] |
| protein palmitoylation | biological process | The covalent attachment of a palmitoyl group to a protein. [GOC:jl, PMID:15520806] |
| Wnt protein secretion | biological process | The controlled release of a Wnt protein from a cell. [GOC:bf, PMID:19223472] |