Protein Wnt-3a

A protein Wnt-3a that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56704]

Synonyms

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
CCT251545	Homo sapiens (human)	IC50	0.0070	1	1
xav939	Homo sapiens (human)	IC50	0.0780	1	1
nvp-tnks656	Homo sapiens (human)	IC50	0.0035	1	1

Enables

This protein enables 9 target(s):

Target	Category	Definition
transcription coactivator activity	molecular function	A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
co-receptor binding	molecular function	Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. [GOC:bf, GOC:jl]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
receptor ligand activity	molecular function	The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt]
cytokine activity	molecular function	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]
frizzled binding	molecular function	Binding to a frizzled (fz) receptor. [GOC:ceb]

Located In

This protein is located in 10 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
Golgi lumen	cellular component	The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell surface	cellular component	The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm]
endocytic vesicle membrane	cellular component	The lipid bilayer surrounding an endocytic vesicle. [GOC:mah]
early endosome membrane	cellular component	The lipid bilayer surrounding an early endosome. [GOC:pz]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
Wnt-Frizzled-LRP5/6 complex	cellular component	A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]

Involved In

This protein is involved in 67 target(s):

Target	Category	Definition
osteoblast differentiation	biological process	The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid]
in utero embryonic development	biological process	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. [GOC:go_curators, GOC:mtg_sensu]
positive regulation of cytokine production	biological process	Any process that activates or increases the frequency, rate or extent of production of a cytokine. [GOC:add, ISBN:0781735149]
positive regulation of protein phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
heart looping	biological process	The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. [GOC:dph, PMID:12094232]
positive regulation of receptor internalization	biological process	Any process that activates or increases the frequency, rate or extent of receptor internalization. [GOC:hjd]
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
axon guidance	biological process	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
heart development	biological process	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
protein localization	biological process	Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
COP9 signalosome assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. [PMID:17307927]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of neuron projection development	biological process	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:dph, GOC:tb]
spinal cord association neuron differentiation	biological process	The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
hippocampus development	biological process	The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
cell proliferation in forebrain	biological process	The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]
Wnt signaling pathway involved in forebrain neuroblast division	biological process	The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:16226447]
dorsal/ventral neural tube patterning	biological process	The process in which the neural tube is regionalized in the dorsoventral axis. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:11262869]
hemopoiesis	biological process	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. [GOC:dgh, ISBN:0198506732]
neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
extracellular matrix organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]
mammary gland development	biological process	The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. [PMID:9576833]
positive regulation of B cell proliferation	biological process	Any process that activates or increases the rate or extent of B cell proliferation. [GOC:mah]
positive regulation of peptidyl-serine phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
cell proliferation in midbrain	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. [GO_REF:0000021, GOC:dgf]
non-canonical Wnt signaling pathway	biological process	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin. [PMID:37804416]
skeletal muscle cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. [CL:0000188, GOC:BHF, GOC:vk]
post-anal tail morphogenesis	biological process	The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. [GOC:bf, GOC:kmv, Wikipedia:Chordate]
synaptic vesicle recycling	biological process	The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]
B cell proliferation	biological process	The expansion of a B cell population by cell division. Follows B cell activation. [GOC:jl]
inner ear morphogenesis	biological process	The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. [GOC:jl, ISBN:0192801023]
fat cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. [CL:0000136, GOC:go_curators]
myoblast differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
negative regulation of fat cell differentiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators]
positive regulation of DNA-templated transcription	biological process	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
somatic stem cell division	biological process	The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. [GOC:jid, ISBN:0582227089]
positive regulation of mesodermal cell fate specification	biological process	Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. [GOC:dgh]
paraxial mesodermal cell fate commitment	biological process	The process in which a cell becomes committed to become a paraxial mesoderm cell. [GOC:dgh]
positive regulation of skeletal muscle tissue development	biological process	Any process that activates, maintains or increases the rate of skeletal muscle tissue development. [GOC:go_curators]
positive regulation of collateral sprouting in absence of injury	biological process	Any process that activates or increases the frequency, rate or extent of collateral sprouting in the absence of injury. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm]
negative regulation of axon extension involved in axon guidance	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. [GOC:devbiol]
negative regulation of neurogenesis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. [GOC:ai]
modulation of chemical synaptic transmission	biological process	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]
regulation of synapse organization	biological process	Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). [GOC:ai, GOC:dph, GOC:tb]
canonical Wnt signaling pathway	biological process	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]
cardiac muscle cell fate commitment	biological process	The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. [GOC:mtg_heart]
positive regulation of dermatome development	biological process	Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. [GOC:BHF, GOC:dph]
secondary palate development	biological process	The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. [PMID:28784960]
regulation of microtubule cytoskeleton organization	biological process	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]
platelet aggregation	biological process	The adhesion of one platelet to one or more other platelets via adhesion molecules. [GOC:BHF, GOC:vk]
cellular response to retinoic acid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus. [GOC:mah]
axis elongation involved in somitogenesis	biological process	The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis. [GOC:ascb_2009, GOC:dph, GOC:tb]
positive regulation of canonical Wnt signaling pathway	biological process	Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:tb]
calcium ion transmembrane transport via low voltage-gated calcium channel	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel. [GOC:bf, GOC:PARL, PMID:20371816]
presynapse assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a presynapse. [GOC:bf, GOC:dos, GOC:PARL, PMID:24449494]
positive regulation of protein localization to plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
negative regulation of dopaminergic neuron differentiation	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of dopaminergic neuron differentiation. [GO_REF:0000058, GOC:TermGenie, PMID:15522889]
midbrain dopaminergic neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. [GO_REF:0000086, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:17331494, PMID:19122665]
regulation of postsynapse to nucleus signaling pathway	biological process	Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. [GO_REF:0000058, GOC:TermGenie, ISBN:9780071120005]
regulation of presynapse assembly	biological process	Any process that modulates the frequency, rate or extent of presynapse assembly. [GO_REF:0000058, GOC:bc, GOC:PARL, GOC:TermGenie, PMID:25533483]
positive regulation of cell-cell adhesion mediated by cadherin	biological process	Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. [GOC:obol]
positive regulation of neural precursor cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation. [GOC:dph, GOC:yaf]
positive regulation of hepatocyte proliferation	biological process	Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation. [GOC:BHF, GOC:mah]
cell fate commitment	biological process	The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate. [ISBN:0716731185]

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