**1',3',3'-trimethyl-6-nitroindolene-2-spiro-2-benzopyran** is a complex organic compound with a unique molecular structure.
**Structure and Properties:**
* **Indole Core:** The molecule contains an indole ring system, a common structural motif in many bioactive compounds.
* **Nitro Group:** The presence of a nitro group (NO2) on the indole ring suggests potential for electron-withdrawing effects and reactivity.
* **Spirocyclic System:** The spiro nomenclature refers to the presence of a spirocyclic system, where two rings share a single atom. In this case, the indole ring is fused to a benzopyran ring through a spiro carbon atom.
* **Methyl Groups:** Three methyl groups are attached to the indole ring, potentially affecting its steric and electronic properties.
**Research Significance:**
The specific biological activity and potential research applications of 1',3',3'-trimethyl-6-nitroindolene-2-spiro-2-benzopyran are not readily available in public databases. However, based on its structural features, it could be of interest for research in various areas:
* **Medicinal Chemistry:** The indole ring system is frequently found in pharmaceuticals, and the nitro group can enhance its reactivity and binding affinity. The unique spirocyclic system could potentially contribute to novel pharmacological properties.
* **Organic Synthesis:** The complex molecular structure of this compound could serve as a valuable synthetic target for developing new synthetic methods and exploring new chemical reactions.
* **Materials Science:** The presence of both aromatic and spirocyclic units suggests that this compound could exhibit interesting optical or electronic properties, potentially relevant for materials applications.
**Finding More Information:**
To understand the specific research significance of 1',3',3'-trimethyl-6-nitroindolene-2-spiro-2-benzopyran, further research is needed. Searching scientific databases such as PubMed, Scopus, or Reaxys for publications that mention this compound could provide valuable insights into its current research context.
It's important to note that without specific research findings, the exact significance of this compound remains speculative.
1',3',3'-trimethyl-6-nitroindolene-2-spiro-2-benzopyran: photochromic dye [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 99766 |
| SCHEMBL ID | 79311 |
| MeSH ID | M0143292 |
| Synonym |
|---|
| nsc 206176 |
| 1,3,3-trimethyl-6'-nitroindoline-2-spiro-2'-benzopyran |
| einecs 216-102-5 |
| 6'-nitro-1,3,3-trimethylindolinobenzopyrylspiran |
| spiro(2h-1-benzopyran-2,2'-indoline), 1',3',3'-trimethyl-6-nitro- |
| 1',3',3'-trimethyl-6-nitroindolene-2-spiro-2-benzopyran |
| spiro(2h-1-benzopyran-2,2'-(2h)indole), 1',3'-dihydro-1',3',3'-trimethyl-6-nitro- |
| 1',3'-dihydro-1',3',3'-trimethyl-6-nitrospiro(2h-1-benzopyran-2,2'-(2h)indole) |
| brn 0040498 |
| 1',3',3'-trimethyl-6-nitrospiro(2h-1-benzopyran-2,2'-indoline) |
| spiro(2h-1-benzopyran-2,2'-indoline), 6-nitro-1',3',3'-trimethyl- |
| 1',3',3'-trimethyl-6-nitro-spiro[chromene-2,2'-indoline] |
| spiro[2h-1-benzopyran-2,2'-[2h]indole], 1',3'-dihydro-1',3',3'-trimethyl-6-nitro- |
| spiro[2h-1-benzopyran-2,2'-indoline], 1',3',3'-trimethyl-6-nitro- |
| spiro[2h-1-benzopyran-2, 1',3'-dihydro-1',3',3'-trimethyl-6-nitro- |
| 1498-88-0 |
| 1,3-trimethyl-6'-nitroindoline-2-spiro-2'-benzopyran |
| 6'-nitro-1,3-trimethylindolinobenzopyrylspiran |
| 1',3'-trimethyl-6-nitrospiro[2h-1-benzopyran-2,2'-indoline] |
| spiro(2h-1-benzopyran-2, 6-nitro-1',3',3'-trimethyl- |
| nsc206176 |
| wln: t66 boxj hnw c-& ct56 bnx dhj b1 d1 d1 |
| spiro[2h-1-benzopyran-2, 1',3',3'-trimethyl-6-nitro- |
| nsc-206176 |
| OPREA1_432405 , |
| 1',3'-dihydro-1',3',3'-trimethyl-6-nitrospiro[2h-1-benzopyran-2,2'-(2h)-indole], 98% |
| AKOS000279513 |
| 1',3',3'-trimethyl-6-nitro-1',3'-dihydrospiro[chromene-2,2'-indole] |
| STK830351 |
| 1',3',3'-trimethyl-6-nitrospiro[chromene-2,2'-indole] |
| 1,3,3-trimethylindolino-6'-nitrobenzopyrylospiran |
| T0366 |
| 1',3',3'-trimethyl-6-nitrospiro[1(2h)-benzopyran-2,2'-indoline] |
| 1,3,3-trimetylindolino-6-nitro benzopyrylospiran |
| 4-27-00-01460 (beilstein handbook reference) |
| SCHEMBL79311 |
| AKOS016875037 |
| PSXPTGAEJZYNFI-UHFFFAOYSA-N |
| 1',3',3'-trimethyl-6-nitrospiro[2h-1-benzopyran-2,2'-indoline] |
| mfcd00059175 |
| 1',3',3'-trimethyl-6-nitrospiro[chromene-2,2'-indoline] |
| J-008639 |
| Z56763048 |
| 1,3,3-trimethylindolino-6-nitrobenzopyrylospiran |
| DS-3551 |
| DTXSID70871845 |
| 1',3'-dihydro-1',3',3'-trimethyl-6-nitrospiro[2h-1-benzopyran-2,2'-(2h)-indole] |
| 6'-nitro-1,3,3-trimethylspiro[indoline-2,2'-2'h-chromene] |
| 1,3,3-trimethylindolino-6'-nitrobenzopyrylospiran, [photochromic compound] |
| 1',3',3'-trimethyl-6-nitrospiro[chromene-2,2'indoline] |
| C72849 |
| CS-0153809 |
| A910353 |
| 1 inverted exclamation mark ,3 inverted exclamation mark ,3 inverted exclamation mark -trimethyl-6-nitrospiro[chromene-2,2 inverted exclamation mark -indoline] |
| SY073113 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.43) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||