3-hydroxybutyric acid has been researched along with Fibrosis in 7 studies
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.
3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal interstitial fibrosis is characterized by increased extracellular matrix (ECM) synthesis." | 1.38 | Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways. ( Chang, SY; Chen, PY; Chuang, LY; Guh, JY; Hsieh, PF; Hung, CY; Hung, TJ; Hung, YJ; Lee, TC; Liu, SF; Yang, YL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Lecoutre, S | 1 |
| Merabtene, F | 1 |
| El Hachem, EJ | 1 |
| Gamblin, C | 1 |
| Rouault, C | 1 |
| Sokolovska, N | 1 |
| Soula, H | 1 |
| Lai, WS | 1 |
| Blackshear, PJ | 1 |
| Clément, K | 1 |
| Dugail, I | 1 |
| Torres, JA | 1 |
| Kruger, SL | 1 |
| Broderick, C | 1 |
| Amarlkhagva, T | 1 |
| Agrawal, S | 1 |
| Dodam, JR | 1 |
| Mrug, M | 1 |
| Lyons, LA | 1 |
| Weimbs, T | 1 |
| Deng, Y | 1 |
| Xie, M | 1 |
| Li, Q | 1 |
| Xu, X | 1 |
| Ou, W | 1 |
| Zhang, Y | 1 |
| Xiao, H | 1 |
| Yu, H | 1 |
| Zheng, Y | 1 |
| Liang, Y | 1 |
| Jiang, C | 1 |
| Chen, G | 1 |
| Du, D | 1 |
| Zheng, W | 1 |
| Wang, S | 1 |
| Gong, M | 1 |
| Chen, Y | 1 |
| Tian, R | 1 |
| Li, T | 1 |
| Xu, S | 1 |
| Tao, H | 1 |
| Cao, W | 1 |
| Cao, L | 1 |
| Lin, Y | 1 |
| Zhao, SM | 1 |
| Xu, W | 1 |
| Cao, J | 1 |
| Zhao, JY | 1 |
| Qi, H | 1 |
| Gu, L | 1 |
| Xu, D | 1 |
| Liu, K | 1 |
| Zhou, M | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Li, Y | 1 |
| Qi, J | 1 |
| Perry, HM | 1 |
| Huang, L | 1 |
| Wilson, RJ | 1 |
| Bajwa, A | 1 |
| Sesaki, H | 1 |
| Yan, Z | 1 |
| Rosin, DL | 1 |
| Kashatus, DF | 1 |
| Okusa, MD | 1 |
| Liu, SF | 1 |
| Chang, SY | 1 |
| Lee, TC | 1 |
| Chuang, LY | 1 |
| Guh, JY | 1 |
| Hung, CY | 1 |
| Hung, TJ | 1 |
| Hung, YJ | 1 |
| Chen, PY | 1 |
| Hsieh, PF | 1 |
| Yang, YL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Short Term Induction of Ketosis in PKD[NCT04472624] | 10 participants (Actual) | Interventional | 2020-07-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for 3-hydroxybutyric acid and Fibrosis
| Article | Year |
|---|---|
Beta-hydroxybutyrate dampens adipose progenitors' profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms.
Topics: 3-Hydroxybutyric Acid; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Fib | 2022 |
Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease.
Topics: 3-Hydroxybutyric Acid; Animals; Cats; Cysts; Diet, Ketogenic; Disease Models, Animal; Disease Progre | 2019 |
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF.
Topics: 3-Hydroxybutyric Acid; 3T3 Cells; Acetyl Coenzyme A; Acetylation; Aged; Animals; Anti-Inflammatory A | 2021 |
Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis.
Topics: 3-Hydroxybutyric Acid; Acetylation; Animals; Apoptosis; Diet, Ketogenic; Disease Models, Animal; Fas | 2021 |
β-Hydroxybutyrate inhibits cardiac microvascular collagen 4 accumulation by attenuating oxidative stress in streptozotocin-induced diabetic rats and high glucose treated cells.
Topics: 3-Hydroxybutyric Acid; Animals; Antioxidants; Cells, Cultured; Collagen Type IV; Coronary Vessels; D | 2021 |
Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI.
Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Animals; Apoptosis; Disease Progression; Dynamins; Fibro | 2018 |
Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways.
Topics: 3-Hydroxybutyric Acid; Animals; Cadherins; Cell Line; Cell Survival; Drugs, Chinese Herbal; Epitheli | 2012 |