poricoic acid a profile

poricoic acid A: from Poria cocos (Polyporaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

poricoic acid A : A tricyclic triterpenoid isolated from Poria cocos. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Cocos	genus	A plant genus of the family ARECACEAE. It is a tropical palm tree that yields a large, edible hard-shelled fruit from which oil and fiber are also obtained.[MeSH]	Arecaceae	The palm family of order Arecales, subclass Arecidae, class Liliopsida.[MeSH]

ID Source	ID
PubMed CID	5471851
CHEMBL ID	461483
CHEBI ID	68353
SCHEMBL ID	22200216
MeSH ID	M0425215

Synonym
nsc715080
nsc-715080
NCI60_039753
poricoic acid a
(2r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxyethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-1,2,3,4,7,8-hexahydrocyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylene-heptanoic acid
(r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxy-ethyl)-2-hydroxy-7-isopropenyl-3a,6,9b-trimethyl-2,3,3a,4,6,7,8,9b-octahydro-1h-benz[e]inden-3-yl]-6-methyl-5-methylene-heptanoic acid
16.alpha.-hydroxy-3,7,9(11),24(24(sup 1))-tetraene-3,21-dioic acid
CHEMBL461483
chebi:68353 ,
(2r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,7,8-hexahydrocyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid
(2r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,6,7,8,9b-octahydro-1h-cyclopenta[a]naphthalen-3-yl]-6-methyl-5-methylideneheptanoic acid
AC-34216
poricoic acid a(f)
137551-38-3
AKOS027326667
HY-N2995
Q27136850
SCHEMBL22200216
CS-0023654
MS-29260
(2r,3r,3ar,6s,7s,9br)-3-[(1r)-1-carboxy-5-methyl-4-methylenehexyl]-2,3,3a,4,6,7,8,9b-octahydro-2-hydroxy-3a,6,9b-trimethyl-7-(1-methylethenyl)-1h-benz[e]indene-6-propanoic acid
A903857
poricoicacida
DTXSID401346653

Role	Description
fungal metabolite	Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
tricyclic triterpenoid
dicarboxylic acid	Any carboxylic acid containing two carboxy groups.
secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (20)

Assay ID	Title	Year	Journal	Article
AID591404	Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID591407	Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338909	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591402	Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338913	Growth inhibition of human NCI60 cells after 48 hrs by sulforhodamine B assay	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID1427863	Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay	2016	Journal of natural products, 11-23, Volume: 79, Issue:11	Cytotoxic Lanostanoids from Poria cocos.
AID338907	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591408	Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338911	Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID1427862	Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay	2016	Journal of natural products, 11-23, Volume: 79, Issue:11	Cytotoxic Lanostanoids from Poria cocos.
AID1427865	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	2016	Journal of natural products, 11-23, Volume: 79, Issue:11	Cytotoxic Lanostanoids from Poria cocos.
AID591405	Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID1427864	Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay	2016	Journal of natural products, 11-23, Volume: 79, Issue:11	Cytotoxic Lanostanoids from Poria cocos.
AID591406	Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID472364	Cytotoxicity against human CRL1579 cells after 48 hrs by MTT assay	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
AID591403	Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338908	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID338910	Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA	2002	Journal of natural products, Apr, Volume: 65, Issue:4	Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591409	Cytotoxicity in human CRL1579 cells assessed as cell viability after 48 hrs by MTT assay	2011	Journal of natural products, Feb-25, Volume: 74, Issue:2	Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID472363	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	2009	Journal of natural products, Oct, Volume: 72, Issue:10	Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (14.29)	29.6817
2010's	5 (35.71)	24.3611
2020's	7 (50.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	2.21	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
melatonin [no description available]	7.21	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.06	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
acrylamide [no description available]	2.31	1	acrylamides; N-acylammonia; primary carboxamide	alkylating agent; carcinogenic agent; Maillard reaction product; mutagen; neurotoxin
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	2.31	1	aldehyde; furans	Maillard reaction product; metabolite
fructosamine Fructosamine: An amino sugar formed when glucose non-enzymatically reacts with the N-terminal amino group of proteins. The fructose moiety is derived from glucose by the classical Amadori rearrangement.	2.31	1
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.25	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	2.31	1	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product
lanosterol [no description available]	2.01	1	14alpha-methyl steroid; 3beta-sterol; tetracyclic triterpenoid	bacterial metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
gingerol gingerol: an active ingredient in GINGER along with SHOGAOL. a nonvolatile methoxy phenyl decanone. gingerol : A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.	2.31	1	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.31	1
beta carotene beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.	2.43	2	carotenoid beta-end derivative; cyclic carotene	antioxidant; biological pigment; cofactor; ferroptosis inhibitor; human metabolite; mouse metabolite; plant metabolite; provitamin A
poricoic acid g poricoic acid G: from Poria cocos (Polyporaceae); structure in first source. poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos.	2.73	3	dicarboxylic acid; secondary alcohol; tricyclic triterpenoid	fungal metabolite
polyporenic acid c [no description available]	2.45	2
dehydroeburicoic acid dehydroeburicoic acid: structure in first source	2.13	1	bile acid

Condition	Relationship Strength	Studies
Benign Neoplasms, Brain [description not available]	2.01	1
Cancer of Colon [description not available]	2.01	1
Cancer of Kidney [description not available]	2.01	1
Granulocytic Leukemia [description not available]	2.01	1
Cancer of Lung [description not available]	2.01	1
Malignant Melanoma [description not available]	2.01	1
Cancer of Ovary [description not available]	2.47	2
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.01	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.01	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	2.01	1
Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	2.01	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.01	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.01	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.47	2
Leukemia, Lymphoblastic, Acute, T Cell [description not available]	2.41	1
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.	2.41	1
Cirrhosis [description not available]	3.63	6
Ureteral Obstruction Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.	3.57	5
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	3.63	6
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	3.57	5
Chronic Kidney Diseases [description not available]	2.61	2
Acute Kidney Failure [description not available]	2.21	1
Injury, Ischemia-Reperfusion [description not available]	2.21	1
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.21	1
Renal Insufficiency, Chronic Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)	2.61	2
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	2.21	1
Disbacteriosis [description not available]	2.21	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.21	1
Blood Pressure, High [description not available]	2.21	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	2.21	1

poricoic acid a

Description

Cross-References

Synonyms (24)

Roles (1)

Drug Classes (3)

Bioassays (20)

Research

Studies (14)

Study Types

poricoic acid a

Description

Related Flora

Cross-References

Synonyms (24)

Roles (1)

Drug Classes (3)

Bioassays (20)

Research

Studies (14)

Study Types

Related Drugs (15)

Related Conditions (30)