Proteins > S-methyl-5'-thioadenosine phosphorylase
Page last updated: 2024-08-07 17:04:26
S-methyl-5'-thioadenosine phosphorylase
An S-methyl-5-thioadenosine phosphorylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13126]
Synonyms
EC 2.4.2.28;
5'-methylthioadenosine phosphorylase;
MTA phosphorylase;
MTAP;
MTAPase
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.Journal of medicinal chemistry, , Jul-14, Volume: 48, Issue:14, 2005
Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.Bioorganic & medicinal chemistry letters, , Jun-02, Volume: 15, Issue:11, 2005
Tight binding enantiomers of pre-clinical drug candidates.Bioorganic & medicinal chemistry, , Sep-01, Volume: 23, Issue:17, 2015
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.Bioorganic & medicinal chemistry, , Sep-01, Volume: 20, Issue:17, 2012
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.ACS chemical biology, , Nov-20, Volume: 2, Issue:11, 2007
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| 1,4-alpha-oligoglucan phosphorylase activity | molecular function | Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. [EC:2.4.1.1] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| S-methyl-5-thioadenosine phosphorylase activity | molecular function | Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. [EC:2.4.2.28] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| nucleobase-containing compound metabolic process | biological process | Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai] |
| purine ribonucleoside salvage | biological process | Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. [GOC:jl] |
| L-methionine salvage from methylthioadenosine | biological process | The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. [GOC:jl, MetaCyc:PWY-4361] |
| methylation | biological process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |
| response to testosterone | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus. [GOC:sl] |