Page last updated: 2024-12-11

conophylline

Description

conophylline: isolated from the leaves of Ervatamia microphylla; a ras function inhibitor; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9853848
MeSH IDM0260358

Synonyms (10)

Synonym
cid 9853848
conophylline
142741-24-0
dimethyl 14,25-diethyl-24,33-dihydroxy-31,32-dimethoxy-12,22-dioxa-1,9,18,29-tetrazadodecacyclo[23.13.1.16,9.02,23.03,21.05,19.06,17.011,13.028,36.030,35.036,39.014,40]tetraconta-3,5(19),16,20,27,30,32,34-octaene-16,27-dicarboxylate
MS-31463
HY-N3619
CS-0023949
cophylline
B0005-166147
AKOS040740754

Research Excerpts

Overview

Conophylline (CNP) is a vinca alkaloid isolated from the leaves of Ervatamia microphylla and related plants. It inhibits activation of pancreatic stellate cells.

ExcerptReferenceRelevance
"Conophylline (CNP) is a vinca alkaloid extracted from the "( Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline.
Hatanaka, T; Hosoi, T; Kakegawa, J; Ohtsuka, S; Ozawa, K; Yokoyama, M, 2021
)
2.28
"Conophylline is an alkaloid isolated from the leaves of Ervatamia microphylla and related plants."( Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.
Fukatsu, H; Koide, N; Kojima, I; Lin, Y; Nakade, Y; Simizu, S; Umezawa, K; Yoneda, M, 2018
)
1.46
"Conophylline (CnP) is a vinca alkaloid purified from a tropical plant and inhibits activation of pancreatic stellate cells. "( Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats.
Aoki, F; Hamano, K; Kojima, I; Kubo, N; Kuwano, H; Nagasawa, M; Saito, R; Takei, I; Umezawa, K, 2014
)
3.29
"Conophylline (CnP) is a natural compound, which reproduces the effect of activin on β-cell differentiation and promotes β-cell neogenesis when administered in vivo."( Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats.
Hara, A; Kimura, F; Kodera, T; Kojima, I; Saito, R; Takei, I; Tanaka, Y; Umezawa, K; Yamada, S; Yamamoto, Y, 2012
)
2.54
"Conophylline is a vinca alkaloid extracted from the tropical plant Ervatamia microphylla and has been shown to induce differentiation of pancreatic AR42J cells. "( Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas.
Kojima, I; Li, L; Ogata, T; Takei, I; Tanaka, Y; Umezawa, K; Yamada, S; Yamamoto, Y, 2004
)
2.03

Actions

Conophylline did not inhibit the development of myocardial fibrosis in the presence of JNK activator anisomycin. It was found to suppress secretions of various inflammatory cytokines by pancreatic cancer-associated fibroblasts.

ExcerptReferenceRelevance
"Conophylline did not inhibit the development of myocardial fibrosis in the presence of JNK activator anisomycin."( Conophylline Suppresses Angiotensin II-Induced Myocardial Fibrosis In Vitro via the BMP4/JNK Pathway.
Bao, YN; Du, XH; Lv, LY; Wang, YC; Zhang, SQ, 2021
)
2.79
"Conophylline was found to suppress secretions of various inflammatory cytokines by pancreatic cancer-associated fibroblasts."( Direct and Indirect Anticancer Activity of Plant-Derived Alkaloid Conophylline.
Shirabe, K; Umezawa, K, 2021
)
1.58
"Conophylline was found to activate autophagy in cultured neural cells."( Therapeutic activity of plant-derived alkaloid conophylline on metabolic syndrome and neurodegenerative disease models.
Fukatsu, H; Koide, N; Kojima, I; Lin, Y; Nakade, Y; Simizu, S; Umezawa, K; Yoneda, M, 2018
)
1.46
"Conophylline did not inhibit nuclear translocation of Smad2."( Suppression of TGF-beta signaling by conophylline via upregulation of c-Jun expression.
Atsumi, S; Kowithayakornd, T; Koyano, T; Nagasawa, A; Umezawa, K, 2003
)
1.31
"Conophylline did not increase expression of fibronectin but induced E-cadherin expression in K-ras-NIH3T3 cells."( Inhibition of cellular chemotactic invasion by a vinca alkaloid, conophylline.
Amino, N; Koyano, T; Ohse, T; Umezawa, K,
)
1.09

Treatment

Conophylline significantly reduced the plasma glucose concentration and improved glucose tolerance in response to glucose loading.

ExcerptReferenceRelevance
"Conophylline-treated cells were found to express insulin as measured at both mRNA and protein levels."( Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline.
Hiroki, A; Kam, TS; Kawakami, M; Kojima, I; Kowithayakorn, T; Koyano, T; Naka, H; Ogata, T; Pang, HS; Takei, I; Umezawa, K, 2003
)
1.27
"Treatment with conophylline significantly reduced the plasma glucose concentration and improved glucose tolerance in response to glucose loading."( Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas.
Kojima, I; Li, L; Ogata, T; Takei, I; Tanaka, Y; Umezawa, K; Yamada, S; Yamamoto, Y, 2004
)
0.93
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (3.57)18.2507
2000's10 (35.71)29.6817
2010's13 (46.43)24.3611
2020's4 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.79 (24.57)
Research Supply Index3.43 (2.92)
Research Growth Index5.55 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
chemdatabank.com