Compounds > cucurbitacin-I-2-O-beta-D-glucopyranoside

cucurbitacin-I-2-O-beta-D-glucopyranoside and Fibrosis

cucurbitacin-I-2-O-beta-D-glucopyranoside has been researched along with Fibrosis* in 1 studies

Other Studies

1 other study(ies) available for cucurbitacin-I-2-O-beta-D-glucopyranoside and Fibrosis

Article	Year
In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten Cucs demonstrated protective activity on human hepatocyte-derived HepG2 cells exposed to CCl(4) (EC(50)=2.4-45.3 μM) with good margin to toxicity (T/A). All Cucs exhibited anti-proliferative effect on serum-activated rat stellate cells, HSC-T6 (EC(50)=0.02-4.12 μM) with high T/A. While silybin is nontoxic, its protection is lower compared to Cuc D (3), iso-D (4), I (5), B (11), E (12), I-Me (6), L-Me (7), and E-Me (13) on both cell lines. Strong correlations were found for lipophilicity with both protection and toxicity on HepG2. Lipophilicity correlated only with toxicity on HSC-T6. Consequently, we suggest that Cucs are potential hepatoprotective agents against fibrosis that deserve further examination. Topics: Animals; Cell Line; Cell Proliferation; Cucurbitacins; Fibrosis; Hep G2 Cells; Hepatic Stellate Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liver; Protective Agents; Quantitative Structure-Activity Relationship; Rats	2011

Article

Year

In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines.

Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants and eight prepared by C2-alkylation or C16-acylation. Ten Cucs demonstrated protective activity on human hepatocyte-derived HepG2 cells exposed to CCl(4) (EC(50)=2.4-45.3 μM) with good margin to toxicity (T/A). All Cucs exhibited anti-proliferative effect on serum-activated rat stellate cells, HSC-T6 (EC(50)=0.02-4.12 μM) with high T/A. While silybin is nontoxic, its protection is lower compared to Cuc D (3), iso-D (4), I (5), B (11), E (12), I-Me (6), L-Me (7), and E-Me (13) on both cell lines. Strong correlations were found for lipophilicity with both protection and toxicity on HepG2. Lipophilicity correlated only with toxicity on HSC-T6. Consequently, we suggest that Cucs are potential hepatoprotective agents against fibrosis that deserve further examination.

Topics: Animals; Cell Line; Cell Proliferation; Cucurbitacins; Fibrosis; Hep G2 Cells; Hepatic Stellate Cells; Humans; Hydrophobic and Hydrophilic Interactions; Liver; Protective Agents; Quantitative Structure-Activity Relationship; Rats

2011