pomolic-acid and Fibrosis

pomolic-acid has been researched along with Fibrosis* in 2 studies

Other Studies

2 other study(ies) available for pomolic-acid and Fibrosis

Article	Year
Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways. Molecules (Basel, Switzerland), 2018, Sep-03, Volume: 23, Issue:9 Fibrosis is a common pathological feature in most kinds of chronic kidney disease. Transforming growth factor β1 (TGF-β1) signaling is the master pathway regulating kidney fibrosis pathogenesis, in which mothers against decapentaplegic homolog 3 (SMAD3) with signal transducer and activator of transcription 3 (STAT3) act as the integrator of various pro-fibrosis signals. We examine the effects of pomolic acid (PA) on mice with unilateral ureteral obstruction (UUO) and TGF-β1 stimulated kidney fibroblast cells. UUO mice were observed severe tubular atrophy, and tubulointerstitial fibrosis and extracellular matrix (ECM) deposition at seven days postoperatively. However, PA-treated UUO mice demonstrated only moderate injury, minimal fibrosis, and larger reductions in the expression of ECM protein and epithelial-mesenchymal transition (EMT) progress. PA inhibited the SMAD-STAT phosphorylation in UUO mice. PA effects were also confirmed in TGF-β1 stimulated kidney fibroblast cells. In this study, we first demonstrated that PA ameliorates fibroblast activation and renal interstitial fibrosis. Our results indicate that PA may be useful as a potential candidate in the prevention of chronic kidney disease. Topics: Animals; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice; Oleanolic Acid; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; STAT Transcription Factors; Transforming Growth Factor beta1	2018
Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells. Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:6 In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 microM. Topics: Animals; Cell Line; Cell Proliferation; Fibrosis; Hepatic Stellate Cells; Magnoliopsida; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Plant Leaves; Plant Stems; Rats; Triterpenes	2009

Article

Year

Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.

Molecules (Basel, Switzerland), 2018, Sep-03, Volume: 23, Issue:9

Fibrosis is a common pathological feature in most kinds of chronic kidney disease. Transforming growth factor β1 (TGF-β1) signaling is the master pathway regulating kidney fibrosis pathogenesis, in which mothers against decapentaplegic homolog 3 (SMAD3) with signal transducer and activator of transcription 3 (STAT3) act as the integrator of various pro-fibrosis signals. We examine the effects of pomolic acid (PA) on mice with unilateral ureteral obstruction (UUO) and TGF-β1 stimulated kidney fibroblast cells. UUO mice were observed severe tubular atrophy, and tubulointerstitial fibrosis and extracellular matrix (ECM) deposition at seven days postoperatively. However, PA-treated UUO mice demonstrated only moderate injury, minimal fibrosis, and larger reductions in the expression of ECM protein and epithelial-mesenchymal transition (EMT) progress. PA inhibited the SMAD-STAT phosphorylation in UUO mice. PA effects were also confirmed in TGF-β1 stimulated kidney fibroblast cells. In this study, we first demonstrated that PA ameliorates fibroblast activation and renal interstitial fibrosis. Our results indicate that PA may be useful as a potential candidate in the prevention of chronic kidney disease.

Topics: Animals; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Male; Mice; Oleanolic Acid; Renal Insufficiency, Chronic; Signal Transduction; Smad Proteins; STAT Transcription Factors; Transforming Growth Factor beta1

2018

Antifibrotic activity of triterpenoids from the aerial parts of Euscaphis japonica on hepatic stellate cells.

Journal of enzyme inhibition and medicinal chemistry, 2009, Volume: 24, Issue:6

In the course of screening antifibrotic activity of natural products employing HSC-T6, a rat hepatic stellate cell line, as an in vitro assay system, the methanolic extract of aerial parts of Euscaphis japonica (Tunb.) Kantiz (Staphyleaceae) showed significant inhibitory activity on HSC proliferation. Activity-guided fractionation led to the isolation of four triterpenoids, friedeline (1), glut-5-en-ol (2), pomolic acid (3), and methylrotundate (4). Among the triterpenoids isolated, pomolic acid (3) significantly inhibited the proliferation of HSCs at concentrations 10 and 100 microM.

Topics: Animals; Cell Line; Cell Proliferation; Fibrosis; Hepatic Stellate Cells; Magnoliopsida; Oleanolic Acid; Plant Components, Aerial; Plant Extracts; Plant Leaves; Plant Stems; Rats; Triterpenes

2009