An NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial that is encoded in the genome of human. [PRO:DNx]
Complex I-39kD;
CI-39kD;
NADH-ubiquinone oxidoreductase 39 kDa subunit
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| aurapten | Homo sapiens (human) | IC50 | 14.5000 | 2 | 2 |
| marmin | Homo sapiens (human) | IC50 | 30.0000 | 2 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| NADH dehydrogenase activity | molecular function | Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. [RHEA:11356] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| NADH dehydrogenase (ubiquinone) activity | molecular function | Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091] |
| protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| mitochondrial inner membrane | cellular component | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| mitochondrial membrane | cellular component | Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. [GOC:mah, NIF_Subcellular:sao1045389829] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial respiratory chain complex I | cellular component | A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. [GOC:mtg_sensu, ISBN:0198547684] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial electron transport, NADH to ubiquinone | biological process | The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. [ISBN:0716731363] |
| sodium ion transport | biological process | The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| circadian rhythm | biological process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| aerobic respiration | biological process | The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. [GOC:das, GOC:jl, ISBN:0140513590] |
| mitochondrial respiratory chain complex I assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. [GOC:rph] |
| proton motive force-driven mitochondrial ATP synthesis | biological process | The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. [GOC:mtg_sensu, ISBN:0716731363] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| ubiquinone-6 biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of ubiquinone-6. [GOC:TermGenie] |