acetaldehyde has been researched along with Fibrosis in 7 studies
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.
aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.
acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by the metabolism of ethanol to acetaldehyde and/or the generation of oxidant stress within the cells." | 3.70 | Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. ( Apte, MV; Darby, SJ; Fahmy, RG; Korsten, MA; McCaughan, GW; Naidoo, D; Phillips, PA; Pirola, RC; Rodgers, SC; Wilson, JS, 2000) |
| "Hepatic fibrosis is due to the increased synthesis and deposition of type I collagen." | 1.32 | Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter. ( Mezey, E; Novitskiy, G; Potter, JJ; Rennie-Tankersley, L, 2004) |
| "Malondialdehyde levels were determined as an indicator of lipid peroxidation." | 1.31 | Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. ( Apte, MV; Darby, SJ; Fahmy, RG; Korsten, MA; McCaughan, GW; Naidoo, D; Phillips, PA; Pirola, RC; Rodgers, SC; Wilson, JS, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, X | 1 |
| Wang, Y | 1 |
| Wang, S | 1 |
| Xu, R | 1 |
| Lv, X | 1 |
| Lawrencia, C | 1 |
| Charrier, A | 1 |
| Huang, G | 1 |
| Brigstock, DR | 1 |
| Novitskiy, G | 1 |
| Potter, JJ | 2 |
| Rennie-Tankersley, L | 1 |
| Mezey, E | 2 |
| Lugea, A | 1 |
| Gukovsky, I | 1 |
| Gukovskaya, AS | 1 |
| Pandol, SJ | 1 |
| Apte, MV | 1 |
| Phillips, PA | 1 |
| Fahmy, RG | 1 |
| Darby, SJ | 1 |
| Rodgers, SC | 1 |
| McCaughan, GW | 1 |
| Korsten, MA | 1 |
| Pirola, RC | 1 |
| Naidoo, D | 1 |
| Wilson, JS | 1 |
| Friedman, SL | 1 |
1 review available for acetaldehyde and Fibrosis
| Article | Year |
|---|---|
Acetaldehyde and alcoholic fibrogenesis: fuel to the fire, but not the spark.
Topics: Acetaldehyde; Adipose Tissue; Animals; Ethanol; Fibrosis; Humans; Liver; Liver Cirrhosis, Alcoholic | 1990 |
6 other studies available for acetaldehyde and Fibrosis
| Article | Year |
|---|---|
Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway.
Topics: Acetaldehyde; Adenosine Triphosphate; Animals; Cells, Cultured; Fibrosis; Glycogen Synthase Kinase 3 | 2017 |
Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells.
Topics: Acetaldehyde; Animals; Base Sequence; Cells, Cultured; Connective Tissue Growth Factor; DNA Primers; | 2009 |
Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter.
Topics: Acetaldehyde; Animals; Binding Sites; Cell Nucleus; Cells, Cultured; Collagen; Collagen Type I; DNA; | 2004 |
Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas.
Topics: Acetaldehyde; Animals; Cells, Cultured; Collagen; Ethanol; Extracellular Matrix Proteins; Fatty Acid | 2003 |
Acetaldehyde increases endogenous adiponectin and fibrogenesis in hepatic stellate cells but exogenous adiponectin inhibits fibrogenesis.
Topics: Acetaldehyde; Adiponectin; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Drug Intera | 2007 |
Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.
Topics: Acetaldehyde; Actins; Animals; Ascorbic Acid; Cell Division; Cells, Cultured; Collagen; Drug Combina | 2000 |