Proteins > Protein O-GlcNAcase
Page last updated: 2024-08-07 23:04:28

Protein O-GlcNAcase

A protein O-GlcNAcase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60502]

Synonyms

OGA;
EC 3.2.1.169;
Beta-N-acetylglucosaminidase;
Beta-N-acetylhexosaminidase;
Beta-hexosaminidase;
Meningioma-expressed antigen 5;
N-acetyl-beta-D-glucosaminidase;
N-acetyl-beta-glucosaminidase;
Nuclear cytoplasmic O-GlcNA

Research

Bioassay Publications (12)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's8 (66.67)24.3611
2020's2 (16.67)2.80

Compounds (4)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
2-acetamido-1,5-imino-1,2,5-trideoxy-d-glucitolHomo sapiens (human)Ki12.070012
n-acetylglucosamine thiazolineHomo sapiens (human)Ki0.086733
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oximeHomo sapiens (human)Ki0.050011
thiamet gHomo sapiens (human)IC500.001722
thiamet gHomo sapiens (human)Ki0.014466

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
thiamet gHomo sapiens (human)EC500.021011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
hyalurononglucosaminidase activitymolecular functionCatalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activitymolecular functionCatalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine. [EC:3.2.1.169]
beta-N-acetylglucosaminidase activitymolecular functionCatalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]

Located In

This protein is located in 3 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 5 target(s):

TargetCategoryDefinition
N-acetylglucosamine metabolic processbiological processThe chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]
protein O-linked glycosylationbiological processA protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
glycoprotein catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]
protein deglycosylationbiological processThe removal of sugar residues from a glycosylated protein. [GOC:mah]
glycoprotein metabolic processbiological processThe chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]