Protein O-GlcNAcase

A protein O-GlcNAcase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60502]

Synonyms

OGA;
EC 3.2.1.169;
Beta-N-acetylglucosaminidase;
Beta-N-acetylhexosaminidase;
Beta-hexosaminidase;
Meningioma-expressed antigen 5;
N-acetyl-beta-D-glucosaminidase;
N-acetyl-beta-glucosaminidase;
Nuclear cytoplasmic O-GlcNA

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (16.67)	29.6817
2010's	8 (66.67)	24.3611
2020's	2 (16.67)	2.80

Compounds (4)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-acetamido-1,5-imino-1,2,5-trideoxy-d-glucitol	Homo sapiens (human)	Ki	12.0700	1	2
n-acetylglucosamine thiazoline	Homo sapiens (human)	Ki	0.0867	3	3
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime	Homo sapiens (human)	Ki	0.0500	1	1
thiamet g	Homo sapiens (human)	IC50	0.0017	2	2
thiamet g	Homo sapiens (human)	Ki	0.0144	6	6

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
thiamet g	Homo sapiens (human)	EC50	0.0210	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
hyalurononglucosaminidase activity	molecular function	Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	molecular function	Catalysis of the reaction: 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl/L-threonyl-[protein] + H2O = L-seryl//L-threonyl-[protein] + N-acetyl-D-glucosamine. [EC:3.2.1.169]
beta-N-acetylglucosaminidase activity	molecular function	Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
N-acetylglucosamine metabolic process	biological process	The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. [ISBN:0198506732]
protein O-linked glycosylation	biological process	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212]
glycoprotein catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]
protein deglycosylation	biological process	The removal of sugar residues from a glycosylated protein. [GOC:mah]
glycoprotein metabolic process	biological process	The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. [GOC:go_curators, ISBN:0198506732]

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