sulforaphane has been researched along with Fibrosis in 11 studies
sulforaphane: from Cardaria draba L.
sulforaphane : An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to examine the efficacy of sulforaphane (SFN) in preventing radiation-induced muscle fibrosis (RIMF) and the potential role in nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant stress." | 9.51 | Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis. ( Bian, C; Jiang, X; Su, J; Wang, B; Wang, H; Wei, J; Xin, Y; Zheng, Z, 2022) |
| "The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity." | 8.02 | Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7. ( Cheng, H; Cui, Y; Kong, L; Li, C; Liu, L; Wang, H; Zhao, Y, 2021) |
| "BACKGROUND The aim of this study was to investigate the effects of sulforaphane (SFN), a natural isothiocyanate compound, in a rabbit ascending aortic cerclage model of chronic heart failure (CHF)." | 7.88 | Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure. ( Chen, D; Dong, H; Lu, H; Ma, T; Wu, G; Wu, W; Zhang, Q; Zhu, D, 2018) |
| "This study aimed to examine the efficacy of sulforaphane (SFN) in preventing radiation-induced muscle fibrosis (RIMF) and the potential role in nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant stress." | 5.51 | Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis. ( Bian, C; Jiang, X; Su, J; Wang, B; Wang, H; Wei, J; Xin, Y; Zheng, Z, 2022) |
| "Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)." | 5.38 | Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. ( Harris, RA; Kim, HJ; Kim, JY; Lee, IK; Min, AK; Oh, CJ; Park, KG, 2012) |
| "The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity." | 4.02 | Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7. ( Cheng, H; Cui, Y; Kong, L; Li, C; Liu, L; Wang, H; Zhao, Y, 2021) |
| "BACKGROUND The aim of this study was to investigate the effects of sulforaphane (SFN), a natural isothiocyanate compound, in a rabbit ascending aortic cerclage model of chronic heart failure (CHF)." | 3.88 | Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure. ( Chen, D; Dong, H; Lu, H; Ma, T; Wu, G; Wu, W; Zhang, Q; Zhu, D, 2018) |
| "Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2)." | 1.56 | Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function. ( Cai, L; Guo, H; Li, J; Li, Z; Ma, T; Miao, L; Zhang, Z; Zhou, S, 2020) |
| "Sulforaphane was unable to modulate autophagy." | 1.43 | Sulforaphane effects on postinfarction cardiac remodeling in rats: modulation of redox-sensitive prosurvival and proapoptotic proteins. ( Barbosa, S; Belló-Klein, A; Bonetto, JH; Campos-Carraro, C; da Rosa Araujo, AS; De Castro, AL; Fernandes, RO; Khaper, N; Müller, DD; Neves, LT; Ortiz, VD; Schenkel, PC; Singal, P; Xavier, LL, 2016) |
| "Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)." | 1.38 | Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. ( Harris, RA; Kim, HJ; Kim, JY; Lee, IK; Min, AK; Oh, CJ; Park, KG, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 4 |
| Wang, B | 3 |
| Wei, J | 3 |
| Zheng, Z | 3 |
| Su, J | 3 |
| Bian, C | 3 |
| Xin, Y | 4 |
| Jiang, X | 3 |
| Li, Z | 1 |
| Guo, H | 1 |
| Li, J | 1 |
| Ma, T | 2 |
| Zhou, S | 1 |
| Zhang, Z | 2 |
| Miao, L | 1 |
| Cai, L | 3 |
| Kong, L | 1 |
| Li, C | 1 |
| Cheng, H | 1 |
| Cui, Y | 1 |
| Liu, L | 1 |
| Zhao, Y | 1 |
| Bai, Y | 2 |
| Chen, Q | 2 |
| Sun, YP | 1 |
| Wang, X | 1 |
| Lv, L | 1 |
| Zhang, LP | 1 |
| Liu, JS | 1 |
| Zhao, S | 1 |
| Wang, XL | 1 |
| Zhu, D | 1 |
| Chen, D | 1 |
| Zhang, Q | 1 |
| Dong, H | 1 |
| Wu, W | 1 |
| Lu, H | 1 |
| Wu, G | 1 |
| Wang, Y | 1 |
| Sun, W | 1 |
| Tan, Y | 2 |
| Liu, Y | 1 |
| Zheng, Y | 2 |
| Liu, Q | 1 |
| Sun, J | 1 |
| Sun, C | 1 |
| Li, S | 1 |
| Li, D | 1 |
| Fernandes, RO | 1 |
| De Castro, AL | 1 |
| Bonetto, JH | 1 |
| Ortiz, VD | 1 |
| Müller, DD | 1 |
| Campos-Carraro, C | 1 |
| Barbosa, S | 1 |
| Neves, LT | 1 |
| Xavier, LL | 1 |
| Schenkel, PC | 1 |
| Singal, P | 1 |
| Khaper, N | 1 |
| da Rosa Araujo, AS | 1 |
| Belló-Klein, A | 1 |
| Shin, DH | 1 |
| Park, HM | 1 |
| Jung, KA | 1 |
| Choi, HG | 1 |
| Kim, JA | 1 |
| Kim, DD | 1 |
| Kim, SG | 1 |
| Kang, KW | 1 |
| Ku, SK | 1 |
| Kensler, TW | 1 |
| Kwak, MK | 1 |
| Oh, CJ | 1 |
| Kim, JY | 1 |
| Min, AK | 1 |
| Park, KG | 1 |
| Harris, RA | 1 |
| Kim, HJ | 1 |
| Lee, IK | 1 |
| Cui, W | 1 |
| Miao, X | 1 |
| Barati, MT | 1 |
| Zhang, C | 1 |
| Cui, T | 1 |
1 trial available for sulforaphane and Fibrosis
| Article | Year |
|---|---|
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
Sulforaphane regulates Nrf2-mediated antioxidant activity and downregulates TGF-β1/Smad pathways to prevent radiation-induced muscle fibrosis.
Topics: Animals; Antioxidants; Collagen; Fibrosis; Glycogen Synthase Kinase 3 beta; Mice; Mice, Inbred C57BL | 2022 |
10 other studies available for sulforaphane and Fibrosis
| Article | Year |
|---|---|
Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Nephropath | 2020 |
Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7.
Topics: Animals; Bone Morphogenetic Protein 7; Diabetes Mellitus, Experimental; Epigenesis, Genetic; Fibrosi | 2021 |
Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation.
Topics: Animals; Cardiotoxicity; Cell Line; Chronic Disease; Collagen; Disease Models, Animal; Doxorubicin; | 2017 |
Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Chronic Disease; Collagen; Cytokines; Female; Fibrosi | 2018 |
Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.
Topics: Animals; Aorta; Apoptosis; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2014 |
Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-β/Smad signaling.
Topics: Actins; Animals; Collagen Type I; Fibronectins; Fibrosis; Interleukin-6; Isothiocyanates; Leukocyte | 2016 |
Sulforaphane effects on postinfarction cardiac remodeling in rats: modulation of redox-sensitive prosurvival and proapoptotic proteins.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Biomarkers; Fibrosis; He | 2016 |
The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis.
Topics: Animals; Cyclosporine; Epithelial Cells; Fibrosis; Heme Oxygenase-1; Isothiocyanates; Kidney; Male; | 2010 |
Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Enzyme Induction; Extracellular Matrix Proteins; | 2012 |
Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation.
Topics: Animals; Catalase; Cell Line; Connective Tissue Growth Factor; Diabetes Mellitus, Experimental; Diab | 2013 |