ap-10 has been researched along with Fibrosis* in 1 studies
1 other study(ies) available for ap-10 and Fibrosis
| Article | Year |
|---|---|
Synthesis and anti-fibrosis activity study of 14-deoxyandrographolide-19-oic acid and 14-deoxydidehydroandrographolide-19-oic acid derivatives.
A series of 14-deoxyandrographolide-19-oic acid and 14-deoxy-11,12 (or 14,15)-didehydroandrographolide-19-oic acid derivatives were designed, synthesized and screened in vitro against the mouse fibroblast cell lines NIH-3T3. Thirteen compounds 8a-f, 14a-c, 14e-f, and 18a-b were found to exhibit better anti-fibrotic activities than andrographolide, with compounds 8b and 14e displaying best activity with IC Topics: Animals; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Fibrosis; Human Umbilical Vein Endothelial Cells; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Structure-Activity Relationship | 2018 |