allosamidin profile

Allosamidin is a natural product isolated from the culture broth of the bacterium Streptomyces griseus. It is a potent and selective inhibitor of chitin synthase, an enzyme involved in the synthesis of chitin. Chitin is a major structural component of the cell walls of fungi and the exoskeletons of insects and crustaceans. Allosamidin exhibits antifungal and insecticidal activities. Its unique mechanism of action and potential for agricultural applications have made it a subject of extensive research.'

allosamidin: Anti-Asthmatic [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	119339
CHEMBL ID	1230997
SCHEMBL ID	118668
MeSH ID	M0154700

Synonym
CHEMBL1230997 ,
103782-08-7
allosamidine
C05346
DB04628
allosamidin
a 82516
beta-d-allopyranoside, 2-(dimethylamino)-3a,5,6,6a-tetrahydro-4-hydroxy-6-(hydroxymethyl)-4h-cyclopentoxazol-5-yl 2-(acetylamino)-4-o-(2-(acetylamino)-2-deoxy-beta-d-allopyranosyl)-2-deoxy-, (3aalpha,4beta,5beta,6alpha,6aalpha)-
a82516
a-82516
1,2-dideoxy-2'-dimethylamino-alpha-d-glucopyranoso-[2,1-d]-delta2'-thiazoline
n-[(2s,3r,4s,5s,6r)-2-[(2r,3s,4s,5r,6r)-6-[[(3ar,4r,5r,6s,6as)-2-(dimethylamino)-4-hydroxy-6-(hydroxymethyl)-4,5,6,6a-tetrahydro-3ah-cyclopenta[d][1,3]oxazol-5-yl]oxy]-5-acetamido-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxa
bdbm50331851
5udj46528k ,
unii-5udj46528k
n-[(2s,3r,4s,5s,6r)-2-[(2r,3s,4s,5r,6r)-6-[[(3ar,4r,5r,6s,6as)-2-(dimethylamino)-4-hydroxy-6-(hydroxymethyl)-4,5,6,6a-tetrahydro-3ah-cyclopenta[d]oxazol-5-yl]oxy]-5-acetamido-4-hydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-4,5-dihydroxy-6-(hydroxymeth
{(3ar,4r,5r,6s,6as)-2-(dimethylamino)-4-hydroxy-6-(hydroxymethyl)-4,5,6,6a-tetrahydro-3ah-cyclopenta[d][1,3]oxazol-5-yl}-2-(acetylamino)-4-o-[2-(acetylamino)-2-deoxy-beta-d-allopyranosyl]-2-deoxy-beta-d-allopyranoside
SCHEMBL118668
W-200706
(3ar,4r,5r,6s,6as)-2-(dimethylamino)-4-hydroxy-6-(hydroxymethyl)-4,5,6,6a-tetrahydro-3ah-cyclopenta[d][1,3]oxazol-5-yl 2-(acetylamino)-4-o-[2-(acetylamino)-2-deoxy-beta-d-allopyranosyl]-2-deoxy-beta-d-allopyranoside
DTXSID90883122
Q27095365
(-)-allosamidine
allosamidin [iso]
.beta.-d-allopyranoside, (3ar,4r,5r,6s,6as)-2-(dimethylamino)-3a,5,6,6a-tetrahydro-4-hydroxy-6-(hydroxymethyl)-4h-cyclopentoxazol-5-yl 2-(acetylamino)-4-o-(2-(acetylamino)-2-deoxy-.beta.-d-allopyranosyl)-2-deoxy-
(3ar,4r,5r,6s,6as)-2-(dimethylamino)-3a,5,6,6a-tetrahydro-4-hydroxy-6-(hydroxymethyl)-4h-cyclopentoxazol-5-yl 2-(acetylamino)-4-o-(2-(acetylamino)-2-deoxy-.beta.-d-allopyranosyl)-2-deoxy-.beta.-d-allopyranoside
(-)-allosamidin
HY-120827
CS-0079267
AKOS040747793

Excerpt	Reference	Relevance
"Allosamidin is a strong inhibitor of family 18 chitinases. "	( Nucleotide sequences of genes encoding allosamidin-sensitive and -insensitive chitinases produced by allosamidin-producing Streptomyces. Anamnart, S; Kuzuyama, T; Matsuura, H; Nagasawa, H; Nakayama, J; Nihira, T; Okamoto, S; Sakuda, S; Seto, H; Suzuki, A; Wang, Q; Yamada, Y; Zhou, ZY, 2003)	2.03
"Allosamidin is a family 18 chitinase inhibitor produced by Streptomyces. "	( Chitinase inhibitor allosamidin promotes chitinase production of Streptomyces generally. Furihata, K; Horinouchi, S; Miyamoto, K; Nagasawa, H; Nakanishi, E; Ohnishi, Y; Sakuda, S; Suzuki, S; Tsujibo, H; Watanabe, T, 2008)	2.11
"Allosamidin is a substrate analog that strongly inhibits the class 18 enzymes."	( The X-ray structure of a chitinase from the pathogenic fungus Coccidioides immitis. Bortone, K; Cox, R; Ernst, S; Hollis, T; Monzingo, AF; Robertus, JD, 2000)	1.03
"Allosamidin was found to be a competitive inhibitor with a K(i) of 3.1 microM."	( Enzyme kinetics of hevamine, a chitinase from the rubber tree Hevea brasiliensis. Barends, T; Beintema, JJ; Bokma, E; Dijkstr, BW; Terwissch van Scheltingab, AC, 2000)	1.03
"Allosamidin is a known inhibitor of class 18 chitinases. "	( The structure of an allosamidin complex with the Coccidioides immitis chitinase defines a role for a second acid residue in substrate-assisted mechanism. Bortone, K; Ernst, S; Monzingo, AF; Robertus, JD, 2002)	2.08

Excerpt	Reference	Relevance
"Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms."	( Novel biological activities of allosamidins. Inoue, H; Nagasawa, H; Sakuda, S, 2013)	1.4

Excerpt	Reference	Relevance
"Allosamidin is likely to enhance abiotic stress tolerance, probably through crosstalk between the two signaling pathways for biotic and abiotic stress responses."	( Chitinase gene expression in response to environmental stresses in Arabidopsis thaliana: chitinase inhibitor allosamidin enhances stress tolerance. Fukamizo, T; Nakano, S; Sakuda, S; Takenaka, Y; Tamoi, M, 2009)	1.29

Pathway	Proteins	Compounds
chitin degradation III (Serratia)	5	10
chitin degradation II (Vibrio)	8	7

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chitinase B	Serratia marcescens	IC50 (µMol)	0.0900	0.0034	2.9492	6.4000	AID1227265
Endochitinase	Saccharomyces cerevisiae S288C	Ki	0.6100	0.6100	1.9050	3.2000	AID539001
Acidic mammalian chitinase	Homo sapiens (human)	IC50 (µMol)	0.0400	0.0400	2.2700	4.5000	AID539003
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
polysaccharide catabolic process	Acidic mammalian chitinase	Homo sapiens (human)
immune system process	Acidic mammalian chitinase	Homo sapiens (human)
production of molecular mediator involved in inflammatory response	Acidic mammalian chitinase	Homo sapiens (human)
chitin metabolic process	Acidic mammalian chitinase	Homo sapiens (human)
chitin catabolic process	Acidic mammalian chitinase	Homo sapiens (human)
apoptotic process	Acidic mammalian chitinase	Homo sapiens (human)
positive regulation of chemokine production	Acidic mammalian chitinase	Homo sapiens (human)
polysaccharide digestion	Acidic mammalian chitinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
chitinase activity	Acidic mammalian chitinase	Homo sapiens (human)
protein binding	Acidic mammalian chitinase	Homo sapiens (human)
kinase binding	Acidic mammalian chitinase	Homo sapiens (human)
chitin binding	Acidic mammalian chitinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
extracellular region	Acidic mammalian chitinase	Homo sapiens (human)
extracellular space	Acidic mammalian chitinase	Homo sapiens (human)
cytoplasm	Acidic mammalian chitinase	Homo sapiens (human)
extracellular region	Acidic mammalian chitinase	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID1227265	Inhibition of Serratia marcescens chitinase ChiB assessed as reduction in chitinolytic activity using 4MU-(GlcNAc)2 substrate by fluorescence based assay	2015	Journal of medicinal chemistry, Jun-25, Volume: 58, Issue:12	Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.
AID539001	Inhibition of Saccharomyces cerevisiae CTS1	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Acetazolamide-based fungal chitinase inhibitors.
AID610637	Inhibition of Trichoderma chitinase T1 using [4MU-(GlcNAc)3] as substrate	2011	Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10	Preparation of allosamidin and demethylallosamidin photoaffinity probes and analysis of allosamidin-binding proteins in asthmatic mice.
AID539002	Inhibition of Aspergillus fumigatus ChiA1 expressed in Pichia pastoris after 70 mins	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Acetazolamide-based fungal chitinase inhibitors.
AID539003	Inhibition of human chitinase	2010	Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23	Acetazolamide-based fungal chitinase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (5.68)	18.7374
1990's	29 (32.95)	18.2507
2000's	37 (42.05)	29.6817
2010's	16 (18.18)	24.3611
2020's	1 (1.14)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	8 (9.09%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	80 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	2.45	2	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
caffeine [no description available]	2.04	1	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
diethyl pyrocarbonate Diethyl Pyrocarbonate: Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.. diethyl pyrocarbonate : The diethyl ester of dicarbonic acid.	1.98	1	acyclic carboxylic anhydride
guanidine Guanidine: A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.. guanidine : An aminocarboxamidine, the parent compound of the guanidines.	2.01	1	carboxamidine; guanidines; one-carbon compound
kinetin Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.. cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.	2.45	2	6-aminopurines; furans	cytokinin; geroprotector
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.4	2	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	4.04	4	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.01	1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
8-chlorotheophylline [no description available]	2.05	1	organochlorine compound; purines	central nervous system stimulant
erythromycin Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.. erythromycin : Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus).. erythromycin A : An erythromycin that consists of erythronolide A having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively.	2.11	1	cyclic ketone; erythromycin
phenylglyoxal [no description available]	1.98	1	phenylacetaldehydes
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	1.99	1
ethyldimethylaminopropyl carbodiimide Ethyldimethylaminopropyl Carbodiimide: Carbodiimide cross-linking reagent.	1.98	1
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	8.61	86	N-acetyl-D-glucosamine	epitope
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2	1	dihydrogen
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.4	2	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.01	1	D-glucopyranose	epitope; mouse metabolite
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	1.99	1	cephalosporin	fungal metabolite
5-Methyl-1,3,4-thiadiazol-2-amine [no description available]	2.05	1	thiadiazoles
5-amino-1,3,4-thiadiazole-2-sulfonamide 5-amino-1,3,4-thiadiazole-2-sulfonamide: structure in first source	2.05	1
chitotriose chitotriose : An amino trisaccharide comprising of three 2-amino-2-deoxy-D-glucopyranose units joined by beta-(1->4) linkages.	1.99	1
n,n',n''-triacetylchitotriose N,N',N''-triacetylchitotriose: used for affinity chromatography of potato lectin when coupled to Sepharose; structure	2.03	1	N-acyl-hexosamine
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	3.12	1	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	6.99	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	3.23	6	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
argadin argadin: a chitinase inhibitor, produced by Clonostachys sp. FO-7314; structure in first source	3.56	2
argifin argifin: possible lead insecticide; isolated from Gliocladium; structure in first source	3.56	2
glycosides [no description available]	2.41	2
chitotetrose chitotetrose: isolated from acid hydrolysates of chitin	2	1
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.47	2
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	2.93	4	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
psammaplin a psammaplin A: isolated from marine sponges Poecillastra and Jaspis; structure in second source	3.83	3
allosamine allosamine: structure in first source	2.41	2
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime N-acetylglucosaminono-1,5-lactone O-(phenylcarbamoyl)oxime: structure given in first source	1.99	1
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	2.01	1	glycoside
chitosan [no description available]	2	1
aflastatin a aflastatin A: inhibitor of aflatoxin production by aflatoxigenic fungi; from Streptomyces sp.; structure given in first source	2.01	1
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	3.09	5
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	2	1

Condition	Relationship Strength	Studies
Asthma, Bronchial [description not available]	3.9	4
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	3.9	4
Bacterial Disease [description not available]	2.11	1
Infections, Serratia [description not available]	2.11	1
Bacterial Infections Infections by bacteria, general or unspecified.	2.11	1
Infections, Plasmodium [description not available]	3.66	3
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	3.66	3
Atherogenesis [description not available]	2.08	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.08	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Cirrhosis [description not available]	2.1	1
Atopic Hypersensitivity [description not available]	2.1	1
Chronic Esophagitis, Eosinophilic [description not available]	2.1	1
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2.1	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	2.1	1
Eosinophilic Esophagitis Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.	2.1	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.05	1
Pneumonia Infection of the lung often accompanied by inflammation.	2.05	1
Uveitis Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)	2.04	1
Aspergillus Infection [description not available]	2	1
Aspergillosis Infections with fungi of the genus ASPERGILLUS.	2	1

allosamidin

Description

Cross-References

Synonyms (30)

Research Excerpts

Overview

Effects

Actions

Pathways (2)

Protein Targets (4)

Inhibition Measurements

Biological Processes (8)

Molecular Functions (4)

Ceullar Components (3)

Bioassays (5)

Research

Studies (88)

Market Indicators

Research Demand Index: 22.26

Study Types