Small conductance calcium-activated potassium channel protein 3

A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9UGI6]

SK3;
SKCa 3;
SKCa3;
KCa2.3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dequalinium chloride	Homo sapiens (human)	IC50	1.6500	2	2
n-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine	Homo sapiens (human)	IC50	0.0397	3	3
n-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine	Homo sapiens (human)	IC50	0.2860	3	3

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
(r)-n-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine	Homo sapiens (human)	EC50	1.3000	2	2
(r)-n-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine	Homo sapiens (human)	Kd	0.1000	1	1

This protein enables 3 target(s):

Target	Category	Definition
inward rectifier potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
small conductance calcium-activated potassium channel activity	molecular function	Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, OMIM:602754]

This protein is located in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is active in 3 target(s):

Target	Category	Definition
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

This protein is involved in 1 target(s):

Target	Category	Definition
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]