Page last updated: 2024-12-11

pachymic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pachymic acid: inhibits phospholipase A2; isolated from Poria cocos; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5484385
CHEMBL ID468034
CHEBI ID80885
MeSH IDM0268320

Synonyms (26)

Synonym
nsc-244427
pachymic acid
29070-92-6
C17044
CHEMBL468034 ,
chebi:80885 ,
bdbm50292363
ccris 7792
lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy-24-methylene-, (3beta,16alpha)-
nsc 244427
x2fck16qah ,
unii-x2fck16qah
(3b,16a)-3-(acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid
CS-5368
HY-N0371
AC-33955
Q-100369
pachymic-acid
lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy-24-methylene-, (3.beta.,16.alpha.)-
lanost-8-en-21-oic acid, 3.beta.,16.alpha.-dihydroxy-24-methylene-, 3-acetate
3-o-acetyltumulosic acid
eburica-8,24(28)-dien-21-oic acid, 3.beta.,16.alpha.-dihydroxy-, 3-acetate
AKOS030526129
mfcd00238657
A912692
BS-42182

Research Excerpts

Overview

Pachymic acid (PA) is a lanostane-type triterpenoid derived from Poria cocos mushroom. It possesses various biological effects such as anti-cancer, antiinflammatory and anti-metastasis effects.

ExcerptReferenceRelevance
"Pachymic acid (PA) is a lanolin triterpene compound from"( Pachymic acid inhibits inflammation and cell apoptosis in lipopolysaccharide (LPS)-induced rat model with pneumonia by regulating NF-κB and MAPK pathways.
Gui, Y; Liu, R; Luo, J; Sun, L, 2021
)
2.79
"Pachymic acid (PA) is an active ingredient found in Poria cocos."( Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis.
Wu, L; Wu, Y; Xu, C; Ying, J; Zhu, X, 2023
)
3.07
"Pachymic acid (PA) is a lanostane type triterpenoid isolated from Poria cocos, which possesses an anti-tumor effect in breast cancer, prostate cancer, lung cancer, and bladder cancer cells. "( The anti-tumor effect of pachymic acid on osteosarcoma cells by inducing PTEN and Caspase 3/7-dependent apoptosis.
Dong, Q; Guo, G; Hu, H; Lu, J; Wen, H; Wu, Y; Wu, Z; Yang, G, 2018
)
2.23
"Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. "( Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress.
Cheng, S; Eliaz, I; McClintick, JN; Sandusky, GE; Sliva, D; Swanson, K, 2015
)
3.3
"Pachymic acid (PA) is a lanostane-type triterpenoid derived from Poria cocos mushroom that possess various biological effects such as anti-cancer, antiinflammatory and anti-metastasis effects. "( Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members.
Baek, JY; Choi, YH; Go, SI; Jeong, JW; Kim, GS; Kim, GY; Kim, HJ; Kwon, TK; Lee, JD; Lee, SJ; Lee, WS; Nagappan, A; Park, C; Ryu, CH; Shin, SC, 2015
)
3.3
"Pachymic acid (PA) is a bioactive lanostrane-type triterpenoid from Poria cocos."( Determination and Pharmacokinetic Study of Pachymic Acid by LC-MS/MS.
Han, L; Lv, WS; Wang, FY, 2015
)
1.4
"Pachymic acid (PA) is a natural triterpenoid known to inhibit the phospholipase A2 (PLA(2)) family of arachidonic acid (AA)-producing enzymes. "( Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos.
Gapter, L; Glinski, J; Ng, KY; Wang, Z, 2005
)
2.02

Effects

Pachymic acid has various pharmacological effects, including anti-inflammatory, antioxidant, immunomodulatory, and antitumor.

ExcerptReferenceRelevance
"Pachymic acid has various pharmacological effects, including anti-inflammatory, antioxidant, immunomodulatory, and antitumor. "( Antitumor activity of pachymic acid in cervical cancer through inducing endoplasmic reticulum stress, mitochondrial dysfunction, and activating the AMPK pathway.
Ji, J; Tian, S; Wang, Y; Yang, T; Zhao, J, 2022
)
2.48
"Pachymic acid (PA) has various biological activities such as anti-inflammatory, antioxidant and anti-cancer."( Pachymic acid protects hepatic cells against oxygen-glucose deprivation/reperfusion injury by activating sirtuin 1 to inhibit HMGB1 acetylation and inflammatory signaling.
Liu, Z; Xu, Z; Xue, C; Ye, Q; Zeng, C,
)
2.3

Actions

ExcerptReferenceRelevance
"Pachymic acid (PA) plays a neuroprotective role during cerebral ischemia/reperfusion. "( Pachymic acid prevents neuronal cell damage induced by hypoxia/reoxygenation via miR‑155/NRF2/HO‑1 axis.
Liu, B; Mei, X; Mo, X; Wu, L; Zhai, Y; Zou, M, 2022
)
3.61

Toxicity

ExcerptReferenceRelevance
" Pachymic acid could be a viable therapeutic agent to overcome the potential adverse effects associated with root canal sealers."( A Comparative Evaluation of the Effect of the Addition of Pachymic Acid on the Cytotoxicity of 4 Different Root Canal Sealers-An In Vitro Study.
Arun, S; Mahalaxmi, S; Rajkumar, K; Sampath, V, 2017
)
1.61

Pharmacokinetics

ExcerptReferenceRelevance
" Furthermore, a randomized, open-label, three-arm, three-period, crossover study using 21 subjects was conducted to determine the amounts of exposure and pharmacokinetic parameters of nine ingredients derived from rikkunshito (atractylodin, atractylodin carboxylic acid, pachymic acid, 3,3',4',5,6,7,8-heptamethoxyflavone, naringenin, nobiletin, liquiritigenin, isoliquiritigenin, and 18β-glycyrrhetinic acid) after oral administration of rikkunshito at three different doses (2."( Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study.
Aoki, K; Fukutake, M; Hanazaki, K; Hattori, T; Inui, A; Kase, Y; Kitagawa, H; Maemura, K; Matsumoto, T; Munekage, M; Sadakane, C; Uezono, Y; Watanabe, J, 2015
)
0.6

Compound-Compound Interactions

ExcerptReferenceRelevance
"A simple, rapid and reliable microwave-assisted extraction (MAE) combined with ultra performance liquid chromatography tandem mass spectrometry method was developed for simultaneous determination of the seven bioactive constituents in Guizhi Fuling capsule (GFC), namely gallic acid, amygdalin, albiflorin, paeoniflorin, paeonol, cinnamic acid and pachymic acid, respectively."( Simultaneous determination of seven bioactive components in Guizhi Fuling capsule by microwave-assisted extraction combined with ultra performance liquid chromatography tandem mass spectrometry.
Sui, Y; Wang, ZZ; Xiao, W; Xiong, ZL; Zhao, LS; Zhao, YT, 2016
)
0.61

Dosage Studied

ExcerptRelevanceReference
" Animals were randomly divided into 5 groups: a sham group, a CLP group, and three PA-treated groups, which received intraperitoneal injection of PA at the dosage of 5, 20 and 50 mg/kg."( Pachymic acid ameliorates sepsis-induced acute kidney injury by suppressing inflammation and activating the Nrf2/HO-1 pathway in rats.
Cai, ZY; Sheng, ZX; Yao, H, 2017
)
1.9
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID355103Inhibition of snake venom phospholipase A2 assessed as oxygen consumption for 3 mins1996Journal of natural products, Oct, Volume: 59, Issue:10
Two fungal lanostane derivatives as phospholipase A2 inhibitors.
AID288566Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 1000 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288567Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 500 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288569Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 10 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288568Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 100 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288570Cell viability of Raji cells2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID355104Inhibition of snake venom phospholipase A2 at 3.700 mM assessed as oxygen consumption for 3 mins1996Journal of natural products, Oct, Volume: 59, Issue:10
Two fungal lanostane derivatives as phospholipase A2 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (61)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (1.64)18.2507
2000's8 (13.11)29.6817
2010's33 (54.10)24.3611
2020's19 (31.15)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.02 (24.57)
Research Supply Index4.17 (2.92)
Research Growth Index5.40 (4.65)
Search Engine Demand Index31.58 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (27.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (1.59%)5.53%
Reviews2 (3.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other60 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]