arecoline has been researched along with Fibrosis in 9 studies
Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands.
arecoline : A tetrahydropyridine that is 1,2,5,6-tetrahydropyridine with a methyl group at position 1, and a methoxycarbonyl group at position 3. An alkaloid found in the areca nut, it acts as an agonist of muscarinic acetylcholine.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Arecoline induced the gradual atrophy and thinning of rat oral mucosal, collagen accumulation, the increase expressions of fibrosis-related proteins and Th17/Treg ratio." | 4.31 | Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS). ( Dai, Y; Qin, Y; Tan, J; Tan, Y; Wang, Z; Wu, D; Xiao, Y; Zhou, L; Zhu, K, 2023) |
| " Thus, we studied the effects of arecoline, a major alkaloid of AN, on proximal tubule (LLC-PK1) cells in terms of cytotoxicity, fibrosis, transforming growth factor-β (TGF-β) and c-Jun N-terminal kinase (JNK)." | 3.83 | Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase. ( Chiou, SJ; Chuang, CT; Chuang, LY; Guh, JY; Ho, WT; Lin, SH, 2016) |
| "Arecoline treatment upregulated the expression of phosphorylated extracellular signal-regulated kinase through epithelial mesenchymal transition and renal fibrosis in HK2 cells." | 1.56 | Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway. ( Cheng, CW; Hsieh, YH; Lee, CC; Lee, CH; Lin, SH; Syu, RJ; Tsai, JP, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 6 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ho, DC | 1 |
| Chen, SH | 1 |
| Fang, CY | 1 |
| Hsieh, CW | 1 |
| Hsieh, PL | 1 |
| Liao, YW | 1 |
| Yu, CC | 1 |
| Tsai, LL | 1 |
| Gupta, AA | 1 |
| Kheur, S | 1 |
| Varadarajan, S | 1 |
| Rajkumar, C | 1 |
| Patil, VR | 1 |
| Wang, L | 1 |
| Tang, Z | 1 |
| Huang, J | 1 |
| Zhou, L | 1 |
| Tan, J | 1 |
| Dai, Y | 1 |
| Zhu, K | 1 |
| Xiao, Y | 1 |
| Wu, D | 1 |
| Wang, Z | 1 |
| Tan, Y | 1 |
| Qin, Y | 1 |
| Krishnakumar, K | 1 |
| Ramadoss, R | 1 |
| Krishnan, R | 1 |
| Sukhija, H | 1 |
| Hsieh, YH | 1 |
| Syu, RJ | 1 |
| Lee, CC | 1 |
| Lin, SH | 2 |
| Lee, CH | 1 |
| Cheng, CW | 1 |
| Tsai, JP | 1 |
| Kuo, TM | 1 |
| Luo, SY | 1 |
| Chiang, SL | 1 |
| Yeh, KT | 1 |
| Hsu, HT | 1 |
| Wu, CT | 1 |
| Lu, CY | 1 |
| Tsai, MH | 1 |
| Chang, JG | 1 |
| Ko, YC | 1 |
| Chiou, SJ | 1 |
| Ho, WT | 1 |
| Chuang, CT | 1 |
| Chuang, LY | 1 |
| Guh, JY | 1 |
| Hsu, HJ | 1 |
| Chang, KL | 1 |
| Yang, YH | 1 |
| Shieh, TY | 1 |
9 other studies available for arecoline and Fibrosis
| Article | Year |
|---|---|
Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts.
Topics: Acetophenones; Areca; Arecoline; Cell Transdifferentiation; Cells, Cultured; Collagen Type I; Fibrob | 2022 |
In-vitro analysis on the potential use of dental pulp mesenchymal stem cells on arecoline-induced oral epithelial cells.
Topics: Apoptosis; Arecoline; Cells, Cultured; Cellular Senescence; Dental Pulp; Epithelial Cells; Epithelia | 2022 |
Interleukin-13 contributes to the occurrence of oral submucosal fibrosis.
Topics: Arecoline; Fibroblasts; Fibrosis; Humans; Interleukin-13; Mouth Mucosa; Oral Submucous Fibrosis | 2023 |
Jiawei Danxuan Koukang Alleviates Arecoline Induced Oral Mucosal Lesions: Network Pharmacology and the Combined Ultra-High Performance Liquid Chromatography (UPLC) and Mass Spectrometry (MS).
Topics: Animals; Arecoline; Chromatography, High Pressure Liquid; Collagen; Fibroblasts; Fibrosis; Humans; M | 2023 |
In vitro Quantification of Collagen and Snail1 Gene Expression in Experimentally Induced Fibrosis by Arecoline and Commercial Smokeless Tobacco Products.
Topics: Arecoline; Cells, Cultured; Cholinergic Agonists; Coculture Techniques; Collagen; Fibroblasts; Fibro | 2020 |
Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway.
Topics: Actins; Antigens, CD; Areca; Arecoline; Cadherins; Cell Cycle; Cell Line; Cell Movement; Dose-Respon | 2020 |
Fibrotic Effects of Arecoline N-Oxide in Oral Potentially Malignant Disorders.
Topics: Animals; Areca; Arecoline; Cells, Cultured; Cyclic N-Oxides; Fibroblasts; Fibrosis; Fruit; Humans; I | 2015 |
Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase.
Topics: Animals; Arecoline; Cell Death; Dose-Response Relationship, Drug; Fibronectins; Fibrosis; Humans; JN | 2016 |
The effects of arecoline on the release of cytokines using cultured peripheral blood mononuclear cells from patients with oral mucous diseases.
Topics: Arecoline; Carcinoma, Squamous Cell; Cells, Cultured; Cytokines; Fibrosis; Humans; Leukocytes, Monon | 2001 |