fluorouracil has been researched along with Fibrosis in 62 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy and 5-Fluorouracil combination had a synergic effect." | 7.80 | The effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model. ( Ercan, S; Firat, U; Kemaloglu, S; Osun, A; Ozkan, U; Samancioglu, A, 2014) |
| "This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model." | 7.74 | Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007) |
| "To report the outcome of 5-fluorouracil (5-FU)-augmented bleb needling revision of failed and failing filtration blebs and to identify risk factors for failure, indicators for success, and any complications of the procedure." | 7.72 | Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis. ( Bloom, PA; Broadway, DC; Bunce, C; Khaw, PT; Thiagarajan, M, 2004) |
| "To determine the prevalence of tearing and canalicular fibrosis in patients receiving systemic 5-fluorouracil (5-FU) therapy and the reversibility of the symptoms when treatment is stopped." | 7.70 | Epiphora in patients receiving systemic 5-fluorouracil therapy. ( Burkes, RL; Hassan, A; Hurwitz, JJ, 1998) |
| "With the increased use of intraoperative antifibrotic (eg, mitomycin and fluorouracil) as an adjunct to standard trabeculectomy, an increased incidence is seen of late-onset filtering bleb-related infections." | 4.82 | Glaucoma-filtering bleb infections. ( Mac, I; Soltau, JB, 2003) |
| "The use of antifibrotic agents, namely, 5-fluorouracil and mitomycin C, in conjunction with glaucoma surgery has resulted in lower postoperative intraocular pressures after trabeculectomy or combined cataract and glaucoma surgery." | 4.82 | Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. ( Singh, K; Yoon, PS, 2004) |
| "Ocular side effects of systemic fluorouracil include excessive lacrimation, due to punctal and canalicular stenosis and fibrosis." | 4.79 | Punctal and canalicular stenosis associated with systemic fluorouracil therapy. Report of five cases and review of the literature. ( Beex, LV; Brink, HM, 1995) |
| "Rabbit model studies suggested better morphology blebs with equal intraocular pressure (IOP) efficacy as a standard mitomycin C (MMC) trabeculectomy using a novel slow-release drug delivery antifibrotic system delivering small quantities of MMC and 5-fluorouracil (5-FU)." | 3.91 | Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model. ( Ayyala, RS; Blake, D; Fullerton, M; Greenberg, E; John, V; Le, C; Mancera, N; Margo, C; Muddasani, N; Satija, C; Singh, S; Swann, FB; Wall, J; Zhang, Z; Zurakowski, D, 2019) |
| " Antimetabolites, such as mitomycin C and 5-fluorouracil, have been used for many years to increase survival time of filtration surgeries by preventing bleb fibrosis and scarring." | 3.83 | A role for antimetabolites in glaucoma tube surgery: current evidence and future directions. ( Amoozgar, B; Han, Y; Kuo, J; Lin, SC, 2016) |
| "Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy and 5-Fluorouracil combination had a synergic effect." | 3.80 | The effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model. ( Ercan, S; Firat, U; Kemaloglu, S; Osun, A; Ozkan, U; Samancioglu, A, 2014) |
| "Structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis." | 3.80 | The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil. ( Al-Hamdany, MZ; Al-Hubaity, AY, 2014) |
| " We conducted molecular dynamics simulations to study the dissolution process of tablets derived from two drugs that can inhibit fibrosis after GFS, 5-fluorouracil (5-FU) and the matrix metalloprotease inhibitor (MMPi), ilomastat." | 3.79 | Molecular dynamic simulations of ocular tablet dissolution. ( Brocchini, S; Fadda, HM; Khaw, PT; Li, C; Paul, D; Ru, Q; Zloh, M, 2013) |
| "FOLFOX-4 (folinic acid/5-fluorouracil/oxaliplatin) chemotherapy is used to treat patients with colorectal liver metastases." | 3.74 | The pathological response to neoadjuvant chemotherapy with FOLFOX-4 for colorectal liver metastases: a comparative study. ( Aithal, GP; Aloysius, MM; Beckingham, IJ; Bessell, EM; Lobo, DN; Neal, KR; Zaitoun, AM, 2007) |
| "To evaluate long-term outcomes after Ahmed valve implantation in patients with glaucoma when using adjunctive intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU)." | 3.74 | Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes. ( Alvarado, JA; Hollander, DA; Juster, RP; Lee, LC, 2008) |
| "This study examined the preventive effects of the local application of mitomycin C (MMC), 5-fluorouracil (5-FU), and cyclosporine A (CsA) in minimizing spinal epidural fibrosis in a rat laminectomy model." | 3.74 | Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model. ( Cukur, S; Dosoglu, M; Gezen, F; Is, M; Yildiz, KH, 2007) |
| "To determine the preference of members of the American Glaucoma Society for the use of antifibrotic agents (mitomycin C or 5-fluorouracil or both) and glaucoma drainage devices in ten clinical settings." | 3.73 | 2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use. ( Feuer, WF; Joshi, AB; Parrish, RK, 2005) |
| "To report the outcome of 5-fluorouracil (5-FU)-augmented bleb needling revision of failed and failing filtration blebs and to identify risk factors for failure, indicators for success, and any complications of the procedure." | 3.72 | Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis. ( Bloom, PA; Broadway, DC; Bunce, C; Khaw, PT; Thiagarajan, M, 2004) |
| "To determine the prevalence of tearing and canalicular fibrosis in patients receiving systemic 5-fluorouracil (5-FU) therapy and the reversibility of the symptoms when treatment is stopped." | 3.70 | Epiphora in patients receiving systemic 5-fluorouracil therapy. ( Burkes, RL; Hassan, A; Hurwitz, JJ, 1998) |
| "To evaluate intraocular pressure (IOP) control and surgical complications following trabeculectomy with 5-fluorouracil (5-FU) or mitomycin at the inferior limbus." | 3.69 | Trabeculectomy at the inferior limbus. ( Caronia, RM; Cohen, H; Friedman, R; Liebmann, JM; Ritch, R, 1996) |
| "Administration of subconjunctival 5-fluorouracil (5-FU) and topical mitomycin-C (MMC) has been shown to improve the success rate of glaucoma-filtering surgery." | 3.69 | A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies. ( Akata, RF; Gökçe, M; Kiremitçi-Gümüşderelioglu, M, 1996) |
| " Preferences for either no antifibrosis agent (up to 39%) or 5-fluorouracil (up to 29%) were highest in primary trabeculectomy." | 3.69 | Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies. ( Chen, PP; Kitazawa, Y; Parrish, RK; Sawada, A; Yamamoto, T, 1997) |
| "A minority of early invasive breast cancers show a pattern of central necrosis and fibrosis (CNF)." | 2.75 | Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy. ( Castiglione-Gertsch, M; Coates, AS; Colleoni, M; Gelber, RD; Goldhirsch, A; Maiorano, E; Mastropasqua, MG; Price, KN; Regan, MM; Viale, G, 2010) |
| "Patients with resectable advanced squamous cell carcinoma of the larynx (tumor stage T3-T4) or hypopharynx (T2-T4), with regional lymph nodes in the neck staged as N0-N2 and with no metastasis, were randomly assigned to treatment in the sequential (or control) or the alternating (or experimental) arm." | 2.74 | Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy. ( Bardet, E; Barzan, L; Bernier, J; Bogaerts, J; Chevalier, D; de Raucourt, D; Geoffrois, L; Horiot, JC; Hupperets, P; Lacombe, D; Leemans, CR; Lefebvre, JL; Licitra, L; Lunghi, F; Rolland, F; Stupp, R; Tesselaar, M; Vermorken, JB, 2009) |
| "For patients with squamous cell carcinoma of the head and neck (HNSCC), persistence of cervical adenopathy following organ-preservation therapy is a strong predictor of locoregional failure." | 2.69 | Squamous cell granulomas of the neck: histologic regression of metastatic squamous cell carcinoma following chemotherapy and/or radiotherapy. ( Eisele, DW; Forastiere, AA; Lee, DJ; Westra, WH, 1998) |
| "When comparing the different types of open angle glaucoma, no difference was found in terms of reduction in IOP, number of patients requiring antiglaucoma medications, or success rate." | 2.69 | Deep sclerectomy with collagen implant: medium term results. ( Karlen, ME; Mermoud, A; Sanchez, E; Schnyder, CC; Sickenberg, M, 1999) |
| "5 h for the recovery half-life of sublethal damage repair." | 2.67 | Dose and volume effects on fibrosis after breast conservation therapy. ( Bartelink, H; Borger, JH; Hart, A; Kemperman, H; Lebesque, J; Smitt, HS; van Dongen, J, 1994) |
| " The recommended dosage schedule with this technique is cisplatin 25 mg/m2 and FU 750 mg total dose IP with FU 500 mg/m2 as a continuous 24-hour infusion daily for days 1 to 4." | 2.67 | Phase II trial of postoperative adjuvant intraperitoneal cisplatin and fluorouracil and systemic fluorouracil chemotherapy in patients with resected gastric cancer. ( Atiq, OT; Brennan, M; Kelsen, DP; Lin, S; Niedzwiecki, D; Saltz, L; Shiu, MH; Tong, W; Toomasi, F; Trochanowski, B, 1993) |
| "Chronic pancreatitis is characterized by chronic inflammation and fibrosis, processes heightened by activated pancreatic stellate cells (PSCs)." | 1.91 | 5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro. ( Almanzar, VMD; Bialkowska, AB; Cheung, J; Ju, J; LaComb, JF; Mojumdar, A; Patel, HR; Shah, K; Tang, M, 2023) |
| "To evaluate the prognostic value of posttreatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, to the standard contrast agent, Gd-DOTA, for their abilities to identify FOLFIRINOX-induced fibrosis in a murine model of PDAC." | 1.56 | Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI. ( Arora, G; Axtell, AL; Bardeesy, N; Caravan, P; Chawla, A; Chen, YI; Deshpande, V; Erstad, DJ; Farrar, CT; Ferreira, DS; Ferrone, CR; Fuchs, BC; Ghoshal, S; Graham-O'Regan, KA; Humblet, V; Jones, C; Jordan, VC; Kontos, F; Lanuti, M; Li, S; Michelakos, T; Qadan, M; Rotile, NJ; Sojoodi, M; Tanabe, KK; Taylor, MS, 2020) |
| "8mg/kg) in different dosing schedules." | 1.40 | Adverse effects on cardiovascular status and lipid levels of albino Wistar rats treated with cisplatin and oxaliplatin in combination with 5 Fluorouracil. ( Bano, N; Hassan, S; Mirza, T; Najam, R, 2014) |
| "Locoregional treatment of inflammatory breast cancer (IBC) is crucial because local relapses may be highly symptomatic and are commonly associated with distant metastasis." | 1.38 | Exclusive alternating chemotherapy and radiotherapy in nonmetastatic inflammatory breast cancer: 20 years of follow-up. ( Arriagada, R; Bourgier, C; Dunant, A; Heymann, S; Marsiglia, H; Mathieu, MC; Pessoa, EL; Spielmann, M; Uzan, C, 2012) |
| "Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P < ." | 1.30 | Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents. ( Budenz, DL; Gordon, J; Keates, EU; Piltz-Seymour, J; Pyfer, M; Singh, K, 1999) |
| "To study the effect of tissue plasminogen activator (t-PA) in combination with 5-fluorouracil (5-Fu) polyphase liposome on the prevention of scar formation in filtration surgery." | 1.30 | [The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery]. ( Chen, R; Jing, M; Xi, S, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.61) | 18.7374 |
| 1990's | 18 (29.03) | 18.2507 |
| 2000's | 21 (33.87) | 29.6817 |
| 2010's | 19 (30.65) | 24.3611 |
| 2020's | 3 (4.84) | 2.80 |
| Authors | Studies |
|---|---|
| Almanzar, VMD | 1 |
| Shah, K | 1 |
| LaComb, JF | 1 |
| Mojumdar, A | 1 |
| Patel, HR | 1 |
| Cheung, J | 1 |
| Tang, M | 1 |
| Ju, J | 1 |
| Bialkowska, AB | 1 |
| Zhang, X | 1 |
| Su, J | 1 |
| Lin, J | 1 |
| Liu, L | 1 |
| Wu, J | 1 |
| Yuan, W | 1 |
| Zhang, Y | 2 |
| Chen, Q | 1 |
| Su, ZJ | 1 |
| Xu, G | 1 |
| Sun, M | 1 |
| Chen, X | 1 |
| Zhang, W | 1 |
| Erstad, DJ | 1 |
| Sojoodi, M | 1 |
| Taylor, MS | 1 |
| Jordan, VC | 1 |
| Farrar, CT | 1 |
| Axtell, AL | 1 |
| Rotile, NJ | 1 |
| Jones, C | 1 |
| Graham-O'Regan, KA | 1 |
| Ferreira, DS | 1 |
| Michelakos, T | 1 |
| Kontos, F | 1 |
| Chawla, A | 1 |
| Li, S | 1 |
| Ghoshal, S | 1 |
| Chen, YI | 1 |
| Arora, G | 1 |
| Humblet, V | 1 |
| Deshpande, V | 1 |
| Qadan, M | 1 |
| Bardeesy, N | 1 |
| Ferrone, CR | 1 |
| Lanuti, M | 1 |
| Tanabe, KK | 1 |
| Caravan, P | 1 |
| Fuchs, BC | 1 |
| Swann, FB | 1 |
| Singh, S | 1 |
| Blake, D | 1 |
| John, V | 1 |
| Le, C | 1 |
| Fullerton, M | 1 |
| Margo, C | 1 |
| Zhang, Z | 1 |
| Muddasani, N | 1 |
| Wall, J | 1 |
| Satija, C | 1 |
| Greenberg, E | 1 |
| Mancera, N | 1 |
| Zurakowski, D | 1 |
| Ayyala, RS | 1 |
| Tsukada, T | 1 |
| Fushida, S | 1 |
| Harada, S | 1 |
| Terai, S | 1 |
| Yagi, Y | 1 |
| Kinoshita, J | 1 |
| Oyama, K | 1 |
| Tajima, H | 1 |
| Ninomiya, I | 1 |
| Fujimura, T | 1 |
| Ohta, T | 1 |
| Ru, Q | 1 |
| Fadda, HM | 1 |
| Li, C | 1 |
| Paul, D | 1 |
| Khaw, PT | 2 |
| Brocchini, S | 1 |
| Zloh, M | 1 |
| Welling, TH | 1 |
| Feng, M | 1 |
| Wan, S | 1 |
| Hwang, SY | 1 |
| Volk, ML | 1 |
| Lawrence, TS | 1 |
| Zalupski, MM | 1 |
| Sonnenday, CJ | 1 |
| Ozgonul, C | 1 |
| Mumcuoglu, T | 1 |
| Gunal, A | 1 |
| Ozkan, U | 1 |
| Osun, A | 1 |
| Samancioglu, A | 1 |
| Ercan, S | 1 |
| Firat, U | 1 |
| Kemaloglu, S | 1 |
| Uyeturk, U | 1 |
| Gucuk, A | 1 |
| Firat, T | 1 |
| Kemahli, E | 1 |
| Kukner, A | 1 |
| Ozyalvacli, ME | 1 |
| Najam, R | 1 |
| Bano, N | 1 |
| Mirza, T | 1 |
| Hassan, S | 1 |
| Al-Hamdany, MZ | 1 |
| Al-Hubaity, AY | 1 |
| Qu, K | 1 |
| Yan, Z | 1 |
| Wu, Y | 1 |
| Chen, Y | 1 |
| Qu, P | 1 |
| Xu, X | 1 |
| Yuan, P | 1 |
| Huang, X | 1 |
| Xing, J | 1 |
| Zhang, H | 1 |
| Liu, C | 1 |
| Zhang, J | 1 |
| Amoozgar, B | 1 |
| Lin, SC | 1 |
| Han, Y | 1 |
| Kuo, J | 1 |
| Serrablo, A | 1 |
| Paliogiannis, P | 1 |
| Pulighe, F | 1 |
| Moro, SS | 1 |
| Borrego-Estella, V | 1 |
| Attene, F | 1 |
| Scognamillo, F | 1 |
| Hörndler, C | 1 |
| Alvarado, JA | 1 |
| Hollander, DA | 1 |
| Juster, RP | 1 |
| Lee, LC | 1 |
| Law, SK | 1 |
| Lefebvre, JL | 1 |
| Rolland, F | 1 |
| Tesselaar, M | 1 |
| Bardet, E | 1 |
| Leemans, CR | 1 |
| Geoffrois, L | 1 |
| Hupperets, P | 1 |
| Barzan, L | 1 |
| de Raucourt, D | 1 |
| Chevalier, D | 1 |
| Licitra, L | 1 |
| Lunghi, F | 1 |
| Stupp, R | 1 |
| Lacombe, D | 1 |
| Bogaerts, J | 1 |
| Horiot, JC | 1 |
| Bernier, J | 1 |
| Vermorken, JB | 1 |
| Memarzadeh, F | 1 |
| Varma, R | 1 |
| Lin, LT | 1 |
| Parikh, JG | 1 |
| Dustin, L | 1 |
| Alcaraz, A | 1 |
| Eliott, D | 1 |
| Maiorano, E | 1 |
| Regan, MM | 1 |
| Viale, G | 1 |
| Mastropasqua, MG | 1 |
| Colleoni, M | 1 |
| Castiglione-Gertsch, M | 1 |
| Price, KN | 1 |
| Gelber, RD | 1 |
| Goldhirsch, A | 1 |
| Coates, AS | 1 |
| How, A | 1 |
| Chua, JL | 1 |
| Charlton, A | 1 |
| Su, R | 1 |
| Lim, M | 1 |
| Kumar, RS | 1 |
| Crowston, JG | 1 |
| Wong, TT | 1 |
| Hoehn, R | 1 |
| Lamparter, J | 1 |
| Pfeiffer, N | 1 |
| Vossmerbaeumer, U | 1 |
| Knape, RM | 1 |
| Smith, MF | 1 |
| Bourgier, C | 1 |
| Pessoa, EL | 1 |
| Dunant, A | 1 |
| Heymann, S | 1 |
| Spielmann, M | 1 |
| Uzan, C | 1 |
| Mathieu, MC | 1 |
| Arriagada, R | 1 |
| Marsiglia, H | 1 |
| Duman, L | 1 |
| Büyükyavuz, BI | 1 |
| Altuntas, I | 1 |
| Gökcimen, A | 1 |
| Ceyhan, L | 1 |
| Darici, H | 1 |
| Aylak, F | 1 |
| Tomruk, O | 1 |
| Roy, S | 1 |
| Mermoud, A | 2 |
| Moreno, A | 1 |
| Escobedo, A | 1 |
| Benito, E | 1 |
| Serra, JM | 1 |
| Gumà, A | 1 |
| Riu, F | 1 |
| Pescosolido, N | 1 |
| Scarsella, G | 1 |
| Risuleo, G | 1 |
| Mac, I | 1 |
| Soltau, JB | 1 |
| Higginbotham, EJ | 1 |
| Yoon, PS | 1 |
| Singh, K | 2 |
| Broadway, DC | 1 |
| Bloom, PA | 1 |
| Bunce, C | 1 |
| Thiagarajan, M | 1 |
| Sasson, AR | 1 |
| Wetherington, RW | 1 |
| Hoffman, JP | 1 |
| Ross, EA | 1 |
| Cooper, H | 1 |
| Meropol, NJ | 1 |
| Freedman, G | 1 |
| Pingpank, JF | 1 |
| Eisenberg, BL | 1 |
| Pasternack, JJ | 1 |
| Wand, M | 1 |
| Shields, MB | 1 |
| Abraham, D | 1 |
| Francis, BA | 1 |
| Du, LT | 1 |
| Najafi, K | 1 |
| Murthy, R | 1 |
| Kurumety, U | 1 |
| Rao, N | 1 |
| Minckler, DS | 1 |
| Joshi, AB | 1 |
| Parrish, RK | 2 |
| Feuer, WF | 1 |
| Cincik, H | 2 |
| Güngör, A | 2 |
| Cekin, E | 2 |
| Saglam, O | 2 |
| Yildirim, S | 2 |
| Poyrazoglu, E | 2 |
| Candan, H | 1 |
| Rubbia-Brandt, L | 1 |
| Giostra, E | 1 |
| Brezault, C | 1 |
| Roth, AD | 1 |
| Andres, A | 1 |
| Audard, V | 1 |
| Sartoretti, P | 1 |
| Dousset, B | 1 |
| Majno, PE | 1 |
| Soubrane, O | 1 |
| Chaussade, S | 1 |
| Mentha, G | 1 |
| Terris, B | 1 |
| Yildiz, KH | 1 |
| Gezen, F | 1 |
| Is, M | 1 |
| Cukur, S | 1 |
| Dosoglu, M | 1 |
| Johansen, J | 1 |
| Overgaard, J | 1 |
| Overgaard, M | 1 |
| Aloysius, MM | 1 |
| Zaitoun, AM | 1 |
| Beckingham, IJ | 1 |
| Neal, KR | 1 |
| Aithal, GP | 1 |
| Bessell, EM | 1 |
| Lobo, DN | 1 |
| Milivojević, M | 1 |
| Vukosavljević, M | 1 |
| Aleksić, P | 1 |
| Stojković, R | 1 |
| Dimitrijević, J | 1 |
| Latković, Z | 1 |
| Avramović, S | 1 |
| Austin, JR | 1 |
| Wong, FC | 1 |
| Kim, EE | 1 |
| Lee, DA | 2 |
| Borger, JH | 1 |
| Kemperman, H | 1 |
| Smitt, HS | 1 |
| Hart, A | 1 |
| van Dongen, J | 1 |
| Lebesque, J | 1 |
| Bartelink, H | 1 |
| Gould, L | 1 |
| Trope, G | 1 |
| Cheng, YL | 1 |
| Heathcote, JG | 1 |
| Sheardown, H | 1 |
| Rootman, D | 1 |
| Liu, GS | 1 |
| Menon, IA | 1 |
| Atiq, OT | 1 |
| Kelsen, DP | 1 |
| Shiu, MH | 1 |
| Saltz, L | 1 |
| Tong, W | 1 |
| Niedzwiecki, D | 1 |
| Trochanowski, B | 1 |
| Lin, S | 1 |
| Toomasi, F | 1 |
| Brennan, M | 1 |
| Brink, HM | 1 |
| Beex, LV | 1 |
| Caronia, RM | 1 |
| Liebmann, JM | 1 |
| Friedman, R | 1 |
| Cohen, H | 1 |
| Ritch, R | 1 |
| Kiremitçi-Gümüşderelioglu, M | 1 |
| Gökçe, M | 1 |
| Akata, RF | 1 |
| Chen, PP | 1 |
| Yamamoto, T | 1 |
| Sawada, A | 1 |
| Kitazawa, Y | 1 |
| Chang, MR | 1 |
| Cheng, Q | 1 |
| Hassan, A | 1 |
| Hurwitz, JJ | 1 |
| Burkes, RL | 1 |
| Westra, WH | 1 |
| Forastiere, AA | 1 |
| Eisele, DW | 1 |
| Lee, DJ | 1 |
| Gillies, MC | 1 |
| Brooks, AM | 1 |
| Young, S | 1 |
| Gillies, B | 1 |
| Simpson, JM | 1 |
| Goldberg, I | 1 |
| Karlen, ME | 1 |
| Sanchez, E | 1 |
| Schnyder, CC | 1 |
| Sickenberg, M | 1 |
| Budenz, DL | 1 |
| Pyfer, M | 1 |
| Gordon, J | 1 |
| Piltz-Seymour, J | 1 |
| Keates, EU | 1 |
| Jing, M | 1 |
| Xi, S | 1 |
| Chen, R | 1 |
| Allen, DC | 1 |
| Fon, LJ | 1 |
| McAleer, JJ | 1 |
| Irwin, ST | 1 |
| Hefetz, L | 1 |
| Naveh, N | 1 |
| Kopel, J | 1 |
| Demailly, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE II STUDY ON LARYNX PRESERVATION COMPARING INDUCTION CHEMOTHERAPY AND RADIOTHERAPY VERSUS ALTERNATING CHEMO-RADIOTHERAPY IN RESECTABLE HYPOPHARYNX AND LARYNX CANCERS[NCT00002839] | Phase 3 | 564 participants (Anticipated) | Interventional | 1996-07-31 | Completed | ||
| Efficacy and Safety of Trabeculectomy With Subconjunctival Bevacizumab Versus Trabeculectomy With Mitomycin C.[NCT01310764] | 36 participants (Actual) | Interventional | 2009-04-30 | Completed | |||
| A Pilot Study Using Neoadjuvant Proton Beam Radiation Therapy and Chemotherapy for Marginally Resectable Carcinoma of the Pancreas[NCT00763516] | 8 participants (Actual) | Interventional | 2009-02-28 | Completed | |||
| Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Primary Open Angle Glaucoma: a Three-year Comparative Study[NCT01633775] | 100 participants (Actual) | Observational | 2007-12-31 | Completed | |||
| Randomized Phase 2 Study Comparing Pathological Responses on Colorectal Cancer Metastases After Preoperative Treatment Combining Bevacizumab With FOLFOX or FOLFIRI[NCT01858649] | Phase 2 | 60 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Randomised Phase 2 Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected After Preoperative Treatment Combining Cetuximab With FOLFOX or FOLFIRI in RAS and B-RAF WT Tumors[NCT01858662] | Phase 2 | 4 participants (Actual) | Interventional | 2014-01-31 | Terminated (stopped due to due to poor recrutment) | ||
| TWICE-IRI: Optimization of Second-line Therapy With Aflibercept, Irinotecan (Day 1 or Day 1,3), 5-Fluorouracile and Folinic Acid in Patients With Metastatic Colorectal Cancer. A Randomized Phase III Study.[NCT04392479] | Phase 3 | 202 participants (Anticipated) | Interventional | 2020-09-02 | Active, not recruiting | ||
| Analysis of Effect of Low Level Laser Therapy in Spinal Surgery[NCT02529657] | 48 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for fluorouracil and Fibrosis
| Article | Year |
|---|---|
Deep sclerectomy.
Topics: Conjunctiva; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Immunosuppressive Agents; | 2012 |
Glaucoma-filtering bleb infections.
Topics: Anti-Bacterial Agents; Drug Administration Schedule; Endophthalmitis; Fibrosis; Filtering Surgery; F | 2003 |
Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery.
Topics: Antimetabolites, Antineoplastic; Cataract Extraction; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Dra | 2004 |
Antifibrosis agents and glaucoma surgery.
Topics: Animals; Conjunctiva; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomycin | 1994 |
Punctal and canalicular stenosis associated with systemic fluorouracil therapy. Report of five cases and review of the literature.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neopla | 1995 |
Basic science and clinical aspects of wound healing in glaucoma filtering surgery.
Topics: Culture Techniques; Fibroblasts; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Humans; Mitomy | 1998 |
[Use of drugs inhibiting fibrosis after trabeculectomy].
Topics: Adrenal Cortex Hormones; Aminopropionitrile; Fibrosis; Fluorouracil; Humans; Mitomycin; Postoperativ | 1992 |
8 trials available for fluorouracil and Fibrosis
| Article | Year |
|---|---|
Phase 3 randomized trial on larynx preservation comparing sequential vs alternating chemotherapy and radiotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, | 2009 |
Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2010 |
Pathologic changes related to CMF primary chemotherapy in breast cancer. Pathological evaluation of response predicts clinical outcome.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Br | 2002 |
Dose and volume effects on fibrosis after breast conservation therapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Breast Neoplasms; Cispla | 1994 |
Phase II trial of postoperative adjuvant intraperitoneal cisplatin and fluorouracil and systemic fluorouracil chemotherapy in patients with resected gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; | 1993 |
Squamous cell granulomas of the neck: histologic regression of metastatic squamous cell carcinoma following chemotherapy and/or radiotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; | 1998 |
A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy.
Topics: Adult; Aged; Aged, 80 and over; Cataract; Cataract Extraction; Connective Tissue; Double-Blind Metho | 1999 |
Deep sclerectomy with collagen implant: medium term results.
Topics: Aged; Collagen; Female; Fibrosis; Fluorouracil; Glaucoma, Open-Angle; Humans; Male; Postoperative Co | 1999 |
47 other studies available for fluorouracil and Fibrosis
| Article | Year |
|---|---|
5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro.
Topics: Animals; Cell Proliferation; Fibrosis; Fluorouracil; Mice; MicroRNAs; Pancreatic Stellate Cells; Pan | 2023 |
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Topics: Animals; Bleomycin; Fibrosis; Fluorouracil; Idiopathic Pulmonary Fibrosis; Janus Kinase 2; Rats; Sig | 2023 |
Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and Is Measurable with Collagen-Targeted Molecular MRI.
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Li | 2020 |
Effect of 2 Novel Sustained-release Drug Release Systems on Bleb Fibrosis: An In Vivo Trabeculectomy Study in a Rabbit Model.
Topics: Absorbable Implants; Animals; Drug Delivery Systems; Drug Implants; Drug Liberation; Endophthalmitis | 2019 |
Low-dose paclitaxel modulates tumour fibrosis in gastric cancer.
Topics: Actins; Antigens, CD; Antineoplastic Agents, Phytogenic; Cadherins; Cell Line, Tumor; Cell Shape; Ci | 2013 |
Molecular dynamic simulations of ocular tablet dissolution.
Topics: Aqueous Humor; Conjunctiva; Diffusion; Fibrosis; Fluorouracil; Humans; Hydrophobic and Hydrophilic I | 2013 |
Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma.
Topics: Aged; Antineoplastic Agents; Capecitabine; Chemoradiotherapy; Cholangiocarcinoma; Cholangitis, Scler | 2014 |
The effect of bevacizumab on wound healing modulation in an experimental trabeculectomy model.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Disease Models, An | 2014 |
The effect of bevacizumab and 5-Fluorouracil combination on epidural fibrosis in a rat laminectomy model.
Topics: Animals; Antibodies, Monoclonal, Humanized; Bevacizumab; Drug Therapy, Combination; Epidural Space; | 2014 |
Effect of mitomycin, bevacizumab, and 5-Fluorouracil to inhibit urethral fibrosis in a rabbit model.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; Collagen; Disease | 2014 |
Adverse effects on cardiovascular status and lipid levels of albino Wistar rats treated with cisplatin and oxaliplatin in combination with 5 Fluorouracil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aorta; Biomarkers; Cardiovascular Diseases; | 2014 |
The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Case-Control Studies; Female; Fibrosis; Fluorouracil; Inje | 2014 |
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Topics: Adult; Aged; Animals; Carcinoma, Hepatocellular; Cell Hypoxia; Chemoembolization, Therapeutic; Disea | 2015 |
A role for antimetabolites in glaucoma tube surgery: current evidence and future directions.
Topics: Animals; Antimetabolites; Fibrosis; Fluorouracil; Glaucoma; Humans; Mitomycin; Trabeculectomy | 2016 |
Impact of novel histopathological factors on the outcomes of liver surgery for colorectal cancer metastases.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; C | 2016 |
Ahmed valve implantation with adjunctive mitomycin C and 5-fluorouracil: long-term outcomes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkylating Agents; Cataract Extraction; Combined Modalit | 2008 |
A modified technique of Ahmed glaucoma valve implantation with adjunctive use of antifibrotic agents.
Topics: Alkylating Agents; Combined Modality Therapy; Fibrosis; Fluorouracil; Glaucoma; Glaucoma Drainage Im | 2008 |
Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet | 2009 |
Combined treatment with bevacizumab and 5-fluorouracil attenuates the postoperative scarring response after experimental glaucoma filtration surgery.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimet | 2010 |
Seizures following subconjunctival 5-FU therapy.
Topics: Aged; Alkylating Agents; Antimetabolites; Combined Modality Therapy; Conjunctiva; Fibrosis; Fluorour | 2011 |
Antimetabolite application technique in trabeculectomy surgery.
Topics: Antimetabolites; Drug Delivery Systems; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraoperative Car | 2011 |
Exclusive alternating chemotherapy and radiotherapy in nonmetastatic inflammatory breast cancer: 20 years of follow-up.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brachial Plexus Neuropathies; Carcinoma | 2012 |
The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn.
Topics: Animals; Burns, Chemical; Caustics; Cell Differentiation; Cell Division; Cicatrix; Drug Evaluation, | 2011 |
An in vitro model for post-trabeculectomy: evaluation of drugs differently controlling cell proliferation.
Topics: Animals; Cell Division; Cell Survival; Chromans; Cyclosporine; Drug Evaluation; Fibroblasts; Fibrosi | 2002 |
The case against glaucoma drainage implant surgery in patients with a poor prognosis for standard filtering procedure.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Fibrosis; Fluorouracil; Glaucoma; Glau | 2004 |
Needle revision of failing and failed trabeculectomy blebs with adjunctive 5-fluorouracil: survival analysis.
Topics: Adult; Aged; Aged, 80 and over; Blister; Chemotherapy, Adjuvant; Conjunctiva; Female; Fibrosis; Fluo | 2004 |
Neoadjuvant chemoradiotherapy for adenocarcinoma of the pancreas: analysis of histopathology and outcome.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Deox | 2003 |
Needle revision of failed filtering blebs using 5-Fluorouracil and a combined ab-externo and ab-interno approach.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Conjunctiva; Fe | 2005 |
Histopathologic features of conjunctival filtering blebs.
Topics: Cell Count; Conjunctiva; Epithelial Cells; Fibrosis; Fluorouracil; Glaucoma; Goblet Cells; Humans; M | 2005 |
2002 survey of the American Glaucoma Society: practice preferences for glaucoma surgery and antifibrotic use.
Topics: Antineoplastic Agents; Drug Utilization; Fibrosis; Filtering Surgery; Fluorouracil; Glaucoma; Glauco | 2005 |
Effects of topical application of mitomycin-C and 5-fluorouracil on myringotomy in rats.
Topics: Administration, Topical; Animals; Antimetabolites; Fibrosis; Fluorouracil; Middle Ear Ventilation; M | 2005 |
Effective dose of 5-fluorouracil for myringotomy in rats.
Topics: Animals; Antimetabolites; Dose-Response Relationship, Drug; Fibrosis; Fluorouracil; Inflammation; Mi | 2005 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemot | 2007 |
Mitomycin C, 5-fluorouracil, and cyclosporin A prevent epidural fibrosis in an experimental laminectomy model.
Topics: Animals; Antibiotics, Antineoplastic; Cell Count; Cyclosporine; Epidural Space; Fibroblasts; Fibrosi | 2007 |
Effect of adjuvant systemic treatment on cosmetic outcome and late normal-tissue reactions after breast conservation.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast | 2007 |
The pathological response to neoadjuvant chemotherapy with FOLFOX-4 for colorectal liver metastases: a comparative study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; | 2007 |
[Comparison of the suppressing capecitabine and 5-fluorouracil effects on the pronounce of inflammatory cells score in the induction of episcleral fibrosis after trabeculectomy].
Topics: Animals; Capecitabine; Deoxycytidine; Fibrosis; Fluorouracil; Glaucoma; Inflammation; Rabbits; Scler | 2007 |
Positron emission tomography in the detection of residual laryngeal carcinoma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma, | 1995 |
Fifty:fifty poly (DL glycolic acid-lactic acid) copolymer as a drug delivery system for 5-fluorouracil: a histopathological evaluation.
Topics: Animals; Biocompatible Materials; Conjunctiva; Drug Delivery Systems; Fibrosis; Fluorouracil; Glycol | 1994 |
Trabeculectomy at the inferior limbus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Chemotherapy, Adjuvant; Child; Chi | 1996 |
A novel MMC-loaded pHEMA drainage device for the treatment of glaucoma: in vitro and in vivo studies.
Topics: Administration, Topical; Animals; Antibiotics, Antineoplastic; Conjunctiva; Cornea; Delayed-Action P | 1996 |
Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies.
Topics: Chemotherapy, Adjuvant; Data Collection; Dose-Response Relationship, Drug; Drainage; Fibrosis; Fluor | 1997 |
Epiphora in patients receiving systemic 5-fluorouracil therapy.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Fib | 1998 |
Comparison of phacotrabeculectomy with 5-fluorouracil, mitomycin-C, and without antifibrotic agents.
Topics: Aged; Cataract; Chemotherapy, Adjuvant; Fibrosis; Fluorouracil; Glaucoma; Humans; Intraocular Pressu | 1999 |
[The inhibitory effect of tissue plasminogen activator combined with 5-fluorouracil polyphase liposome on the scar formation in experimental filtration surgery].
Topics: Animals; Cicatrix; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Female; Fibrosis; Fluor | 1997 |
Pathology of rectal adenocarcinoma following preoperative adjuvant radiotherapy and chemotherapy.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biopsy; Female; Fibrosis; | 1999 |
[Use of 5-fluorouracil in the surgery of glaucoma].
Topics: Conjunctiva; Female; Fibrosis; Fluorouracil; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressu | 1987 |