Page last updated: 2024-11-13

(Z)-6,6',7,3'a-Diligustilide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

(Z)-6,6',7,3'a-Diligustilide is a **natural product** isolated from the *Ligusticum lucidum* plant. It is a **lignan**, a class of organic compounds characterized by the presence of two phenylpropanoid units linked through a **dibenzyl ether** bridge.

Here's why it's important for research:

* **Pharmacological Activity:**
* (Z)-6,6',7,3'a-Diligustilide has demonstrated a variety of **pharmacological activities**, including:
* **Antioxidant:** It exhibits strong antioxidant properties, which can help protect cells from damage caused by free radicals.
* **Anti-inflammatory:** It has been shown to reduce inflammation in animal models.
* **Neuroprotective:** Studies suggest it may protect against neuronal damage and have potential for treating neurodegenerative diseases.
* **Anticancer:** Some research indicates it could possess anti-cancer activity by inhibiting cancer cell growth.

* **Chemical Structure and Synthesis:**
* The unique structure of (Z)-6,6',7,3'a-Diligustilide, particularly the presence of the **dibenzyl ether** bridge and the **stereochemistry** of the molecule, has sparked interest in understanding its **biosynthetic pathways** and exploring potential **synthetic strategies**.

* **Potential for Drug Development:**
* The promising pharmacological activities of (Z)-6,6',7,3'a-Diligustilide make it a potential candidate for developing new drugs. Researchers are currently investigating its therapeutic potential and exploring its safety and efficacy in clinical trials.

**In summary, (Z)-6,6',7,3'a-Diligustilide is a naturally occurring compound with significant pharmacological potential. Its antioxidant, anti-inflammatory, neuroprotective, and anticancer properties make it a promising lead compound for drug development. Further research is ongoing to understand its mechanisms of action and explore its therapeutic applications.**

levistilide A: isolated from Angelica sinensis, inhibits hepatic stellate cell proliferation; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID70698035
CHEBI ID68231

Synonyms (27)

Synonym
CHEBI:68231
(z)-6,6',7,3'a-diligustilide
S9201
(z,z)-di(butylidene)[?]dione
1h-5,10c-ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (5s,8z,10cs)-
levistolide a
e,z'-6,6',7,3'a-diligustilide
88182-33-6
diligustilide
29mrt0h4ce ,
levistolid a
unii-29mrt0h4ce
1h-5,10c-ethanonaphtho(1,2-c:7,8-c')difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1z,5s,5as,8z,10bs,10cs)-
z,z'-6,6',7,3'a-diligustilide
(z,z)-diligustilide
levistilide a
levistilide-a
levistolide a [inci]
142797-35-1
senkyunolide o
AKOS037514718
Q27136724
HY-N1472
(1s,2s,6z,10s,11s,16z)-6,16-di(butylidene)-5,15-dioxapentacyclo[9.5.2.01,13.02,10.03,7]octadeca-3(7),12-diene-4,14-dione
CS-0016970
DTXSID601317628
levistilidea

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" In this study, the developed method is successfully applied to the comparative pharmacokinetic study of LA in rats after oral administration of LA alone, Rhizoma Chuanxiong, and Danggui-Shaoyao-San along with the bioavailability study of LA in rats."( Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.
He, WQ; Huang, XT; Li, WR; Liu, CH; Lv, WS; Qu, Z; Wang, Q; Wei, RR; Zhang, L; Zhang, Y; Zhou, XX, 2015
)
0.42

Bioavailability

ExcerptReferenceRelevance
" In this study, the developed method is successfully applied to the comparative pharmacokinetic study of LA in rats after oral administration of LA alone, Rhizoma Chuanxiong, and Danggui-Shaoyao-San along with the bioavailability study of LA in rats."( Study on Pharmacokinetics of Three Preparations from Levistolide A by LC-MS-MS.
He, WQ; Huang, XT; Li, WR; Liu, CH; Lv, WS; Qu, Z; Wang, Q; Wei, RR; Zhang, L; Zhang, Y; Zhou, XX, 2015
)
0.42
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
butenolideA gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (23.81)29.6817
2010's10 (47.62)24.3611
2020's6 (28.57)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]