Page last updated: 2024-12-07

1,4-dioxin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

You're likely thinking of **1,4-dioxane**, not 1,4-dioxin. 1,4-dioxin is a highly reactive and unstable molecule, while 1,4-dioxane is a stable, cyclic ether.

**1,4-Dioxane (C4H8O2)** is a colorless, odorless liquid that is commonly used as a solvent in a variety of industrial and consumer products. It is also found as a contaminant in some products, such as cosmetics and personal care products.

**Here's why 1,4-dioxane is important for research:**

* **Environmental concerns:** 1,4-dioxane is a potential human carcinogen and can persist in the environment. Research is conducted to understand its environmental fate and potential risks to human health and ecosystems.
* **Toxicity and safety:** Studies are carried out to evaluate the toxicity of 1,4-dioxane, including its effects on different organs and systems. This information is crucial for establishing safe exposure limits and mitigating risks.
* **Analytical chemistry:** 1,4-dioxane is a challenging analyte due to its volatility and lack of strong chromophores. Researchers develop new and improved analytical methods for its detection and quantification in various matrices, such as water, food, and consumer products.
* **Industrial applications:** Despite its potential hazards, 1,4-dioxane remains widely used in various industrial processes. Research focuses on developing safer alternatives and finding ways to minimize its release into the environment.
* **Pharmaceutical and chemical synthesis:** 1,4-dioxane is a versatile solvent and reagent used in various chemical reactions, including pharmaceutical synthesis. Research explores its use in novel synthetic methodologies and investigates its potential applications in drug development.

**It's important to note that 1,4-dioxane is a potential health hazard, and research aims to find ways to minimize its exposure and protect human health.**

1,4-dioxine : An oxacycle that is 4H-pyran in which the methylene group at position 4 is replaced by an oxygen. Non-aromatic. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID78968
CHEBI ID134044
MeSH IDM0116834

Synonyms (12)

Synonym
unii-zd32358xmg
zd32358xmg ,
1,4-dioxin
p-dioxin
CHEBI:134044
1,4-dioxine
290-67-5
KVGZZAHHUNAVKZ-UHFFFAOYSA-N
1,4-dioxame
DTXSID10183191
Q161534
1,4-dioxacyclohexa-2,5-diene

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development."( The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes.
Bradfield, CA; Glover, E; Kennedy, GD; Lin, BC; Moran, SM; Nukaya, M, 2010
)
0.36
"The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR)."( Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity.
Boutros, PC; Moffat, ID; Okey, AB; Pohjanvirta, R; Prokopec, SD; Smith, AB; Watson, JD; Wu, AH; Yao, CQ, 2011
)
0.37

Dosage Studied

ExcerptRelevanceReference
"5 x 10(-4), which enabled the assay of dosage forms of the drug at microquantities."( Spectrophotometric determination of nikethamide by charge--transfer complexation with chloranilic acid.
Ajali, U; Odoh, UE; Okide, GB,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
oxacycleAny organic heterocyclic compound containing at least one ring oxygen atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (10.00)18.7374
1990's0 (0.00)18.2507
2000's3 (15.00)29.6817
2010's12 (60.00)24.3611
2020's3 (15.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.47 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.49 (4.65)
Search Engine Demand Index42.91 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]