Page last updated: 2024-12-07
1,4-dioxin
Description
You're likely thinking of **1,4-dioxane**, not 1,4-dioxin. 1,4-dioxin is a highly reactive and unstable molecule, while 1,4-dioxane is a stable, cyclic ether.
**1,4-Dioxane (C4H8O2)** is a colorless, odorless liquid that is commonly used as a solvent in a variety of industrial and consumer products. It is also found as a contaminant in some products, such as cosmetics and personal care products.
**Here's why 1,4-dioxane is important for research:**
* **Environmental concerns:** 1,4-dioxane is a potential human carcinogen and can persist in the environment. Research is conducted to understand its environmental fate and potential risks to human health and ecosystems.
* **Toxicity and safety:** Studies are carried out to evaluate the toxicity of 1,4-dioxane, including its effects on different organs and systems. This information is crucial for establishing safe exposure limits and mitigating risks.
* **Analytical chemistry:** 1,4-dioxane is a challenging analyte due to its volatility and lack of strong chromophores. Researchers develop new and improved analytical methods for its detection and quantification in various matrices, such as water, food, and consumer products.
* **Industrial applications:** Despite its potential hazards, 1,4-dioxane remains widely used in various industrial processes. Research focuses on developing safer alternatives and finding ways to minimize its release into the environment.
* **Pharmaceutical and chemical synthesis:** 1,4-dioxane is a versatile solvent and reagent used in various chemical reactions, including pharmaceutical synthesis. Research explores its use in novel synthetic methodologies and investigates its potential applications in drug development.
**It's important to note that 1,4-dioxane is a potential health hazard, and research aims to find ways to minimize its exposure and protect human health.**
1,4-dioxine : An oxacycle that is 4H-pyran in which the methylene group at position 4 is replaced by an oxygen. Non-aromatic. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
ID Source | ID |
PubMed CID | 78968 |
CHEBI ID | 134044 |
MeSH ID | M0116834 |
Synonyms (12)
Synonym |
unii-zd32358xmg |
zd32358xmg , |
1,4-dioxin |
p-dioxin |
CHEBI:134044 |
1,4-dioxine |
290-67-5 |
KVGZZAHHUNAVKZ-UHFFFAOYSA-N |
1,4-dioxame |
DTXSID10183191 |
Q161534 |
1,4-dioxacyclohexa-2,5-diene |
Research Excerpts
Toxicity
Excerpt | Reference | Relevance |
"The aryl hydrocarbon receptor (AHR) plays an essential role in the toxic response to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin), in the adaptive up-regulation of xenobiotic metabolizing enzymes, and in hepatic vascular development." | ( The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. Bradfield, CA; Glover, E; Kennedy, GD; Lin, BC; Moran, SM; Nukaya, M, 2010) | 0.36 |
"The dioxin congener 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes a wide range of toxic effects in rodent species, all of which are mediated by a ligand-dependent transcription-factor, the aryl hydrocarbon receptor (AHR)." | ( Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity. Boutros, PC; Moffat, ID; Okey, AB; Pohjanvirta, R; Prokopec, SD; Smith, AB; Watson, JD; Wu, AH; Yao, CQ, 2011) | 0.37 |
Dosage Studied
Drug Classes (1)
Class | Description |
oxacycle | Any organic heterocyclic compound containing at least one ring oxygen atom. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (20)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 2 (10.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (15.00) | 29.6817 |
2010's | 12 (60.00) | 24.3611 |
2020's | 3 (15.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 34.47
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 34.47 (24.57) | Research Supply Index | 3.09 (2.92) | Research Growth Index | 4.49 (4.65) | Search Engine Demand Index | 42.91 (26.88) | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 0 (0.00%) | 5.53% |
Reviews | 1 (4.76%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 20 (95.24%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |