Page last updated: 2024-12-08

25-hydroxyprotopanaxadiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

25-hydroxyprotopanaxadiol: anti-cancer ginsenoside; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID158501
CHEMBL ID1669124
MeSH IDM0522422

Synonyms (11)

Synonym
dammarane-3,12,20,25-tetrol, (3beta,12beta,20r)-
(3s,5r,8r,9r,10r,12r,13r,14r,17s)-17-[(2r)-2,6-dihydroxy-6-methylheptan-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene-3,12-diol
25-hydroxyprotopanaxadiol
CHEMBL1669124
83349-37-5
25(r)-hydroxyprotopanaxadiol
25-oh-ppd
dammarane-3,12,20,25-tetrol
DTXSID601003342
AKOS040760204
FS-6985

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" These results indicate that this novel anti-cancer ginsenoside has relatively favorable pharmacokinetic properties and provide a basis for further development of this compound as a chemotherapeutic agent."( Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors.
Hao, M; Wang, H; Wang, W; Zhang, R; Zhao, Y, 2011
)
0.63

Bioavailability

ExcerptReferenceRelevance
" The absolute oral bioavailability of 25-OH-PPD was relatively high, compared with other ginsenosides."( Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors.
Hao, M; Wang, H; Wang, W; Zhang, R; Zhao, Y, 2011
)
0.63
"The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of the poorly water-soluble compound 20(S)-25-methoxydammarane-3β;12β;20-triol (25-OCH3-PPD)."( Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: preparation and evaluation.
Cai, S; Shi, CH; Suo, H; Tang, X; Yang, L; Zhang, X; Zhao, Y, 2014
)
0.4

Dosage Studied

ExcerptRelevanceReference
"The viability of GMC and the total protein content were decreased in HG group, different dosage PPD group could increase these indexes (P<0."( Inhibitory effects and mechanism of 25-OH-PPD on glomerular mesangial cell proliferation induced by high glucose.
Li, Z; Liu, C; Liu, X; Wang, Z; Yu, J; Zhang, C, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (41)

Assay IDTitleYearJournalArticle
AID675020Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Sep, Volume: 55Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
AID1582255Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1582257Cytotoxicity against human IOSE-144 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID675021Antiproliferative activity against human A549 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Sep, Volume: 55Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
AID1571184Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID675023Antiproliferative activity against human IOSE-144 cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Sep, Volume: 55Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
AID1436621Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1571181Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID1436619Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1172947Antiproliferative activity against human U87 cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
AID1571185Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID1172946Antiproliferative activity against human MCF7 cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
AID1582268Induction of apoptosis in human A549 cells assessed as nuclear condensation at 10 to 20 uM measured after 12 hrs by DAPI staining based fluorescence microscopic analysis2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1436618Antiproliferative activity against human A549 cells after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1436624Antiproliferative activity against human BGC823 cells assessed as cell viability at 40 uM after 48 hrs by MTT assay relative to control2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1571186Cytotoxicity against human IOSE-144 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID568819Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities.
AID1436620Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1582252Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1337332Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis of novel 25-hydroxyprotopanaxadiol derivatives by methylation and methoxycarbonylation using dimethyl carbonate as a environment-friendly reagent and their anti-tumor evaluation.
AID568823Cytotoxicity against human HL60 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities.
AID1436622Antiproliferative activity against human IOSE-144 cells after 48 hrs by MTT assay2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID675022Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay2012European journal of medicinal chemistry, Sep, Volume: 55Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
AID1571183Cytotoxicity against human 8901 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID568822Cytotoxicity against human A549 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities.
AID568818Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities.
AID1582267Induction of apoptosis in human A549 cells assessed as appearance of fragmented apoptotic bodies at 10 to 20 uM measured after 12 hrs by DAPI staining based fluorescence microscopic analysis2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID675024Antiproliferative activity against human MCF7 cells assessed as cell viability at 30 uM after 48 hrs by MTT assay2012European journal of medicinal chemistry, Sep, Volume: 55Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives.
AID1582253Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1337331Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis of novel 25-hydroxyprotopanaxadiol derivatives by methylation and methoxycarbonylation using dimethyl carbonate as a environment-friendly reagent and their anti-tumor evaluation.
AID1337333Cytotoxicity against human IOSE-144 cells assessed as reduction in cell viability after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 10-01, Volume: 26, Issue:19
Synthesis of novel 25-hydroxyprotopanaxadiol derivatives by methylation and methoxycarbonylation using dimethyl carbonate as a environment-friendly reagent and their anti-tumor evaluation.
AID568821Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3
Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities.
AID1172945Antiproliferative activity against human HeLa cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
AID1172944Antiproliferative activity against human BGC823 cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
AID1436623Antiproliferative activity against human A549 cells assessed as cell viability at 20 uM after 48 hrs by MTT assay relative to control2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Sulfamic and succinic acid derivatives of 25-OH-PPD and their activities to MCF-7, A-549, HCT-116, and BGC-823 cell lines.
AID1571182Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay2018MedChemComm, Nov-01, Volume: 9, Issue:11
Synthesis, characterization and cytotoxic activity evaluation of ginsengdiol oxidation and nitrogen hybrid derivatives.
AID1582269Induction of apoptosis in human A549 cells assessed as nuclear shrinkage at 10 to 20 uM measured after 12 hrs by DAPI staining based fluorescence microscopic analysis2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1582254Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1172949Antiproliferative activity against human LoVo cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
AID1582256Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay2020European journal of medicinal chemistry, Feb-01, Volume: 187Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives.
AID1172948Antiproliferative activity against human HCT116 cells assessed as cell-growth inhibition after 48 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's15 (71.43)24.3611
2020's4 (19.05)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index5.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]