chloroquine has been researched along with Fibrosis in 8 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine (CQ) is an anti-inflammatory and disease-modifying anti-rheumatic drug (DMARD) utilized in treating autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus." | 5.91 | Chloroquine inhibits NLRP3 inflammasomes activation and alleviates renal fibrosis in mouse model of hyperuricemic nephropathy with aggravation by a high-fat-diet. ( Cui, J; Hong, P; Li, Z; Lin, J; Nie, K; Wan, J; Wu, X; Zhang, X, 2023) |
| "Chloroquine (CQ) is an anti-inflammatory and disease-modifying anti-rheumatic drug (DMARD) utilized in treating autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus." | 1.91 | Chloroquine inhibits NLRP3 inflammasomes activation and alleviates renal fibrosis in mouse model of hyperuricemic nephropathy with aggravation by a high-fat-diet. ( Cui, J; Hong, P; Li, Z; Lin, J; Nie, K; Wan, J; Wu, X; Zhang, X, 2023) |
| " The dosing regimen used in preclinical models of nephrotoxicity may impact the success of therapeutic candidates in clinical trials." | 1.72 | Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury. ( Beverly, LJ; Doll, MA; Feng, JL; Krueger, AM; Orwick, A; Sears, SM; Shah, PP; Siskind, LJ; Vega, AA, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 4 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, Z | 1 |
| Wang, H | 1 |
| Zhang, X | 2 |
| Song, M | 1 |
| Yao, S | 1 |
| Jiang, P | 1 |
| Liu, D | 1 |
| Wang, Z | 1 |
| Lv, H | 1 |
| Li, R | 1 |
| Hong, Y | 1 |
| Dai, J | 1 |
| Hu, Y | 1 |
| Zhao, G | 1 |
| Sears, SM | 1 |
| Feng, JL | 1 |
| Orwick, A | 1 |
| Vega, AA | 1 |
| Krueger, AM | 1 |
| Shah, PP | 1 |
| Doll, MA | 1 |
| Beverly, LJ | 1 |
| Siskind, LJ | 1 |
| Cui, J | 1 |
| Hong, P | 1 |
| Li, Z | 1 |
| Lin, J | 1 |
| Wu, X | 1 |
| Nie, K | 1 |
| Wan, J | 1 |
| Yang, C | 1 |
| Wu, HL | 1 |
| Li, ZH | 1 |
| Chen, XC | 1 |
| Su, HY | 1 |
| Guo, XY | 1 |
| An, N | 1 |
| Jing, KP | 1 |
| Pan, QJ | 1 |
| Liu, HF | 1 |
| Fox, C | 1 |
| Cocchiaro, P | 1 |
| Oakley, F | 1 |
| Howarth, R | 1 |
| Callaghan, K | 1 |
| Leslie, J | 1 |
| Luli, S | 1 |
| Wood, KM | 1 |
| Genovese, F | 1 |
| Sheerin, NS | 1 |
| Moles, A | 1 |
| Gupta, SS | 1 |
| Zeglinski, MR | 1 |
| Rattan, SG | 1 |
| Landry, NM | 1 |
| Ghavami, S | 1 |
| Wigle, JT | 1 |
| Klonisch, T | 1 |
| Halayko, AJ | 1 |
| Dixon, IM | 1 |
| Kossard, S | 1 |
| Lee, MS | 1 |
| Wilkinson, B | 1 |
| Jedynak, U | 1 |
| Ciezarek, M | 1 |
| Kopiński, P | 1 |
8 other studies available for chloroquine and Fibrosis
| Article | Year |
|---|---|
Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions.
Topics: Actins; Adenosine; AMP-Activated Protein Kinases; Animals; Autophagy; Cadherins; Cathepsin D; Chloro | 2022 |
Pharmacological inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Autophagy; Chloroquine; Cisplatin; Fibrosis; In | 2022 |
Chloroquine inhibits NLRP3 inflammasomes activation and alleviates renal fibrosis in mouse model of hyperuricemic nephropathy with aggravation by a high-fat-diet.
Topics: Animals; Chloroquine; Creatinine; Diet, High-Fat; Fibrosis; Hyperuricemia; Inflammasomes; Kidney; Ki | 2023 |
Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-β).
Topics: Autophagy; Cell Line; Cell Proliferation; Chloroquine; Cyclin-Dependent Kinase 4; Cyclin-Dependent K | 2020 |
Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.
Topics: Animals; Cathepsin D; Chloroquine; Collagen; Dipeptides; Disease Models, Animal; Extracellular Matri | 2016 |
Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.
Topics: Actins; Animals; Autophagy; Cardiomyopathies; Cell Movement; Cells, Cultured; Chloroquine; Fibroblas | 2016 |
Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alopecia; Antimalarials; Biopsy; Chloroquine; Dermato | 1997 |
Pulmonary infiltrates with masto- and lymphocytosis in BALF associated with arechine.
Topics: Adult; Bronchoalveolar Lavage Fluid; Cell Movement; Chloroquine; Fibrosis; Humans; Lung; Lymphocytos | 1997 |