Page last updated: 2024-11-13

kurarinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

kurarinone: cytotoxic lavandulyl flavanone from Sophora flavescens; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
SophoragenusA plant genus of the family FABACEAE.[MeSH]FabaceaeThe large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

Cross-References

ID SourceID
PubMed CID26209049
MeSH IDM0366826

Synonyms (3)

Synonym
kurarinone
34981-26-5
(2r)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-[(2s)-5-methyl-2-prop-1-en-2-ylhex-4-enyl]-2,3-dihydrochromen-4-one

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The validated method was further successfully applied to a preclinical pharmacokinetic study of kurarinone in dog after a single intravenous (2 mg/kg) and oral (20 mg/kg) administration."( Pharmacokinetic and bioavailability study of kurarinone in dog plasma by UHPLC-MS/MS.
Chen, Y; Huang, X; Huang, Y; Lin, H, 2020
)
1.04

Compound-Compound Interactions

ExcerptReferenceRelevance
"KR combined with IFNalpha-1b shows better effect in treating chronic hepatitis B than that of using either of the two alone."( [Clinical study on treatment of chronic hepatitis B by kurarinone combined with interferon alpha-1b].
Pan, ZS; Yan, H; Yu, QH; Zhang, Y, 2005
)
0.58

Bioavailability

ExcerptReferenceRelevance
" The results revealed that kurarinone was rapidly absorbed into plasma with good bioavailability (38."( Pharmacokinetic and bioavailability study of kurarinone in dog plasma by UHPLC-MS/MS.
Chen, Y; Huang, X; Huang, Y; Lin, H, 2020
)
1.11
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (23.08)29.6817
2010's22 (56.41)24.3611
2020's8 (20.51)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index27.31 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index5.55 (4.65)
Search Engine Demand Index30.30 (26.88)
Search Engine Supply Index2.20 (0.95)

This Compound (27.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.56%)5.53%
Reviews1 (2.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other37 (94.87%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]