Proteins > Cytochrome P450 11B2, mitochondrial
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Cytochrome P450 11B2, mitochondrial
A cytochrome P450 11B that is a translation product of the Cyp11b2 gene in mouse. [PRO:DAN, UniProtKB:P15539]
Synonyms
Aldosterone synthase;
ALDOS;
Aldosterone-synthesizing enzyme;
CYPXIB2;
Corticosterone 18-monooxygenase, CYP11B2;
1.14.15.5;
Cytochrome P-450Aldo;
Cytochrome P-450C18;
Cytochrome P450C11;
Steroid 11-beta-hydroxylase, CY
Research
Bioassay Publications (1)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
fadrozole | Mus musculus (house mouse) | IC50 | 0.1900 | 1 | 1 |
osilodrostat | Mus musculus (house mouse) | IC50 | 0.2100 | 1 | 1 |
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015
Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys.Journal of medicinal chemistry, , Oct-22, Volume: 58, Issue:20, 2015