Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7

A bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P0C870]

EC 1.14.11.63;
EC 3.4.-.-;
JmjC domain-containing protein 7;
Jumonji domain-containing protein 7;
L-lysine (3S)-hydroxylase JMJD7

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
vidofludimus	Homo sapiens (human)	IC50	7.1600	1	1

This protein enables 8 target(s):

Target	Category	Definition
endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
aminopeptidase activity	molecular function	Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]
monooxygenase activity	molecular function	Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
methylated histone binding	molecular function	Binding to a histone in which a residue has been modified by methylation. [GOC:bf, PMID:14585615]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
peptidyl-lysine 3-dioxygenase activity	molecular function	Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2. [GOC:al, PMID:29915238, RHEA:57152]
2-oxoglutarate-dependent dioxygenase activity	molecular function	Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 2 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
protein hydroxylation	biological process	The addition of a hydroxy group to a protein amino acid. [GOC:ai]