Page last updated: 2024-11-07

safrole oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

safrole oxide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID101123
CHEMBL ID199838
SCHEMBL ID1262235
MeSH IDM0053692

Synonyms (38)

Synonym
safrole epoxide
2',3'-epoxysafrol [french]
benzene, 4-(2,3-epoxypropyl)-1,2-(methylenedioxy)-
brn 0163628
ai3-33068
1,3-benzodioxole, 5-(2,3-epoxypropyl)-
safrole-2',3'-oxide
safrole oxide
2',3'-epoxysafrole
nsc 402793
5-(oxiranylmethyl)-1,3-benzodioxole
1,3-benzodioxole, 5-(oxiranylmethyl)-
nsc-402793
nsc402793
7470-44-2
1, 5-(oxiranylmethyl)-
5-(oxiran-2-ylmethyl)-1,3-benzodioxole
CHEMBL199838
AKOS006273156
safrole 2',3'-oxide
1-(3',4'-methylenedioxyphenyl)-2,3-epoxypropane
1x8lby54mv ,
unii-1x8lby54mv
2',3'-epoxysafrol
5-19-09-00191 (beilstein handbook reference)
KZYXVVGEWCXONF-UHFFFAOYSA-N
SCHEMBL1262235
(+/-)-safrole oxide
2-piperonyloxirane
1,3-benzodioxole, 5-(2-oxiranylmethyl)-
5-glycidyl-1,3-benzodioxole
5-(oxiran-2-ylmethyl)benzo[d][1,3]dioxole
Q27253030
STARBLD0003132
EN300-1996371
5-[(oxiran-2-yl)methyl]-1,3-dioxaindane
DTXSID401032715
5-(2-oxiranylmethyl)-1,3-benzodioxole

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID307214Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as neurites degeneration at 70 ug/mL after 10 hrs2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258400Effect on caspase 3 activation to initiate apoptosis in A549 human lung cancer cell line2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
AID307218Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as DNA fragmentation at 70 ug/mL after 10 hrs2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307213Induction of apoptosis in neural stem cells assessed as cell viability at 10 to 100 ug/mL by MTT assay2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258402Effect on caspase 9 activation to initiate apoptosis in A549 human lung cancer cell line2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
AID307215Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as inhibition of cell differentiation at 70 ug/mL after 10 hrs2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307217Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as nuclear condensation at 70 ug/mL after 10 hrs2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307219Increase in apoptosis rate in neural stem cells co-cultured with vascular endothelial cells assessed as cell survival at 70 ug/mL after 10 hrs2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307216Induction of necrosis in neural stem cells co-cultured with vascular endothelial cells assessed as LDH release at 70 ug/mL after 10 hrs relative to control2007Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11
Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258401Effect on caspase 8 activation to initiate apoptosis in A549 human lung cancer cell line2006Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1
Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.00)18.7374
1990's2 (8.00)18.2507
2000's11 (44.00)29.6817
2010's6 (24.00)24.3611
2020's4 (16.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.84 (24.57)
Research Supply Index3.30 (2.92)
Research Growth Index5.14 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (4.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (96.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]