safrole oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

safrole oxide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	101123
CHEMBL ID	199838
SCHEMBL ID	1262235
MeSH ID	M0053692

Synonyms (38)

Synonym
safrole epoxide
2',3'-epoxysafrol [french]
benzene, 4-(2,3-epoxypropyl)-1,2-(methylenedioxy)-
brn 0163628
ai3-33068
1,3-benzodioxole, 5-(2,3-epoxypropyl)-
safrole-2',3'-oxide
safrole oxide
2',3'-epoxysafrole
nsc 402793
5-(oxiranylmethyl)-1,3-benzodioxole
1,3-benzodioxole, 5-(oxiranylmethyl)-
nsc-402793
nsc402793
7470-44-2
1, 5-(oxiranylmethyl)-
5-(oxiran-2-ylmethyl)-1,3-benzodioxole
CHEMBL199838
AKOS006273156
safrole 2',3'-oxide
1-(3',4'-methylenedioxyphenyl)-2,3-epoxypropane
1x8lby54mv ,
unii-1x8lby54mv
2',3'-epoxysafrol
5-19-09-00191 (beilstein handbook reference)
KZYXVVGEWCXONF-UHFFFAOYSA-N
SCHEMBL1262235
(+/-)-safrole oxide
2-piperonyloxirane
1,3-benzodioxole, 5-(2-oxiranylmethyl)-
5-glycidyl-1,3-benzodioxole
5-(oxiran-2-ylmethyl)benzo[d][1,3]dioxole
Q27253030
STARBLD0003132
EN300-1996371
5-[(oxiran-2-yl)methyl]-1,3-dioxaindane
DTXSID401032715
5-(2-oxiranylmethyl)-1,3-benzodioxole

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID307214	Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as neurites degeneration at 70 ug/mL after 10 hrs	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258400	Effect on caspase 3 activation to initiate apoptosis in A549 human lung cancer cell line	2006	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1	Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
AID307218	Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as DNA fragmentation at 70 ug/mL after 10 hrs	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307213	Induction of apoptosis in neural stem cells assessed as cell viability at 10 to 100 ug/mL by MTT assay	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258402	Effect on caspase 9 activation to initiate apoptosis in A549 human lung cancer cell line	2006	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1	Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
AID307215	Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as inhibition of cell differentiation at 70 ug/mL after 10 hrs	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307217	Induction of apoptosis in neural stem cells co-cultured with vascular endothelial cells assessed as nuclear condensation at 70 ug/mL after 10 hrs	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307219	Increase in apoptosis rate in neural stem cells co-cultured with vascular endothelial cells assessed as cell survival at 70 ug/mL after 10 hrs	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID307216	Induction of necrosis in neural stem cells co-cultured with vascular endothelial cells assessed as LDH release at 70 ug/mL after 10 hrs relative to control	2007	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 17, Issue:11	Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro.
AID258401	Effect on caspase 8 activation to initiate apoptosis in A549 human lung cancer cell line	2006	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 16, Issue:1	Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (25)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (8.00)	18.7374
1990's	2 (8.00)	18.2507
2000's	11 (44.00)	29.6817
2010's	6 (24.00)	24.3611
2020's	4 (16.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.84 (24.57)
Research Supply Index	3.30 (2.92)
Research Growth Index	5.14 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.84)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (4.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (96.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
safrole Safrole: A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).. safrole : A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted by an allyl group at position 5. It is found in several plants, including black pepper, cinnamon and nutmeg, and is present in several essential oils, notably that of sassafras. It has insecticidal properties and has been used as a topical antiseptic. Although not thought to pose a significant carcinogenic risk to humans, findings of weak carcinogenicity in rats have resulted in the banning of its (previously widespread) use in perfumes and soaps, and as a food additive.	6.85	24	1	benzodioxoles	flavouring agent; insecticide; metabolite; plant metabolite
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	4.62	1	1	penicillin allergen; penicillin	antibacterial drug
cloxacillin Cloxacillin: A semi-synthetic antibiotic that is a chlorinated derivative of OXACILLIN.. cloxacillin : A semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6.	4.62	1	1	penicillin allergen; penicillin; semisynthetic derivative	antibacterial agent; antibacterial drug
estragole estragole : A phenylpropanoid that is chavicol in which the hydroxy group is replaced by a methoxy group.	1.96	1	0	alkenylbenzene; monomethoxybenzene; phenylpropanoid	carcinogenic agent; flavouring agent; genotoxin; insect attractant; plant metabolite
fluorides [no description available]	2.6	1	0	halide anion; monoatomic fluorine
allylbenzene 2',3'-epoxide allylbenzene 2',3'-epoxide: structure given in first source	1.99	1	0
fosfomycin Fosfomycin: An antibiotic produced by Streptomyces fradiae.. fosfomycin : A phosphonic acid having an (R,S)-1,2-epoxypropyl group attached to phosphorus.	4.62	1	1	epoxide; phosphonic acids	antimicrobial agent; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor
silver diammine [no description available]	2.6	1	0	silver coordination entity
sepharose agarose : A linear polysaccharide made up from alternating D-galactose and 3,6-anhydro-alpha-L-galactopyranose residues joined by alpha-(1->3)- and beta-(1->4)-linkages.	2.02	1	0
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.77	3	0
deoxyguanosine [no description available]	1.99	1	0	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanine [no description available]	7.57	2	0	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	1.99	1	0	guanosines; purines D-ribonucleoside	fundamental metabolite
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.98	1	0

Condition	Relationship Strength	Studies	Trials
Innate Inflammatory Response [description not available]	2.03	1	0
Cancer of Lung [description not available]	2.72	3	0
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.03	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.72	3	0
Infections, Staphylococcal [description not available]	4.62	1	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	4.62	1	1
Bacteremia The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.	4.62	1	1
Cirrhosis [description not available]	2.1	1	0
Benign Neoplasms [description not available]	2.1	1	0
Fibrosis Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	2.1	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.1	1	0
Atheroma [description not available]	2.08	1	0

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