pyrazines has been researched along with Fibrosis in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 17 (77.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Alharbi, HO; Clerk, A; Cooper, STE; Cull, JJ; Fuller, SJ; Meijles, DN; Sugden, PH | 1 |
| Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY | 1 |
| Cao, W; Chen, W; Ding, M; Guo, H; Lin, T; Wang, T; Wei, H; Yu, H; Zhang, C; Zhao, S; Zhao, X | 1 |
| Chai, J; Jiang, Y; Li, Y; Luo, H; Xiao, X; You, Y; Zhou, Y; Zhu, H; Zuo, X | 1 |
| Chen, L; Kong, D; Lu, Y; Zhang, F; Zhang, X; Zhang, Z; Zheng, S; Zhu, X | 1 |
| Ares-Carrasco, S; Caro-Vadillo, A; Egido, J; Iborra, C; Lorenzo, O; Picatoste, B; Ramírez, E; Tuñón, J | 1 |
| Boutley, H; Karcher, G; Lacolley, P; Lhuillier, M; Louis, H; Marie, PY; Maskali, F; Poussier, S; Thornton, SN | 1 |
| Carmignac, V; Durbeej, M; Fontes-Oliveira, CC; Holmberg, J; Körner, Z | 1 |
| Aziz, M; Bertrand, J; Coëffier, M; Déchelotte, P; Guérin, C; Herranen, A; Loeuillard, E; Marion-Letellier, R; Melchior, C; Savoye, G | 1 |
| Abu Jawdeh, BG; Alloway, RR; Cardi, MA; Ejaz, NS; Sadaka, B; Shields, AR; Wadih, G; Witte, D; Woodle, ES | 1 |
| Bian, H; Li, W; Li, Y; Lin, C; Lu, Y; Qi, X; Wu, X; Yin, Q; Yuan, Y; Zhu, Q | 1 |
| Allanore, Y; Bruni, C; Distler, O; Gabrielli, A; Iannone, F; Matucci-Cerinic, M; Praino, E | 1 |
| Bai, Y; Bian, H; Hu, Y; Ma, LT; Ren, QY; Yang, MH; Zhang, Y; Zheng, J; Zhou, YC | 1 |
| Foley, PW; Hamilton, MS; Leyva, F | 1 |
| Böhm, M; Kazakov, A; Laufs, U; Lenski, M; Marx, N | 1 |
| Dagli, F; Isik, A; Koca, SS; Ozercan, IH; Ozgen, M; Sahin, K; Tuzcu, M | 1 |
| Budinger, GR; Chandel, NS; Chiarella, SE; Ghosh, AK; Go, LH; Jain, M; Kamp, DW; Lam, AP; Mutlu, GM; Pardo, A; Rivera, S; Selman, M; Sznajder, JI; Urich, D; Varga, J; Wu, M; Zirk, A | 1 |
| Fu, Q; Liu, LS; Wang, CX; Yuan, XP | 1 |
| Yang, QQ; Yang, X; Ye, RG | 1 |
| Chen, L; Deng, YL; Du, J; Huang, H; Lin, YZ; Xu, CX | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Argiroffo, CB; Bongiovanni, M; Chizzolini, C; Dayer, JM; Djaafar, S; Donati, Y; Ferrari-Lacraz, S; Fineschi, S; Goffin, L; Naso, F; Pache, JC | 1 |
1 review(s) available for pyrazines and Fibrosis
| Article | Year |
|---|---|
Use of biologics and other novel therapies for the treatment of systemic sclerosis.
Topics: Abatacept; Acetamides; Antibodies, Monoclonal, Humanized; Biological Products; Clinical Trials as Topic; Fibrinolytic Agents; Fibrosis; Humans; Hypertension, Pulmonary; Indoles; Inflammation; Joints; Lisuride; Lung; PubMed; Pyrazines; Pyrazoles; Pyrimidines; Scleroderma, Systemic; Skin | 2017 |
21 other study(ies) available for pyrazines and Fibrosis
| Article | Year |
|---|---|
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
Topics: Alkalies; Animals; Animals, Newborn; Female; Fibrosis; Humans; Hydrogen-Ion Concentration; Hypertrophy; Imidazoles; Insulin; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Receptors, Adrenergic, alpha-1 | 2021 |
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation Mediators; Isoproterenol; Myocytes, Cardiac; Oxidative Stress; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Thiones; Thiophenes; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Fibrosis; Mice; Nanoparticles; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrazines; Reperfusion Injury; Thiones; Thiophenes; Time Factors; Tissue Distribution; Treatment Outcome | 2019 |
MicroRNA-21 in scleroderma fibrosis and its function in TGF-β-regulated fibrosis-related genes expression.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Mice; Mice, Inbred DBA; MicroRNAs; Molecular Targeted Therapy; Pyrazines; RNA, Small Interfering; Scleroderma, Diffuse; Signal Transduction; Skin; Smad7 Protein; Transforming Growth Factor beta | 2013 |
Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways.
Topics: Animals; Biomarkers; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Gene Expression Regulation; Glucose; Hepatic Stellate Cells; Homeostasis; Insulin; Male; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyrazines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction | 2014 |
Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms.
Topics: Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Fibronectins; Fibrosis; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Insulin; Male; Metformin; Myocardium; Myocytes, Cardiac; PPAR delta; Protein Isoforms; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2013 |
Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET.
Topics: Animals; Arterial Pressure; Cardiac Catheterization; Disease Models, Animal; Fibrosis; Fluorodeoxyglucose F18; Heart Failure; Heart Ventricles; Hypertension; Imaging, Three-Dimensional; Lipid Metabolism; Male; Positron-Emission Tomography; Predictive Value of Tests; Pyrazines; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Remodeling | 2014 |
Bortezomib partially improves laminin α2 chain-deficient muscular dystrophy.
Topics: Animals; Apoptosis; Body Weight; Boronic Acids; Bortezomib; Cells, Cultured; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Laminin; Locomotion; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Muscles; Muscular Dystrophy, Animal; Organ Specificity; Proteasome Endopeptidase Complex; Pyrazines; Survival Analysis | 2014 |
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Colitis; Colon; Disease Models, Animal; Fibrosis; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Tight Junction Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2014 |
A Banff Component Scoring-based Histologic Assessment of Bortezomib-based Antibody-mediated Rejection Therapy.
Topics: Acute Disease; Adult; Atrophy; Biomarkers; Biopsy; Boronic Acids; Bortezomib; Chi-Square Distribution; Chronic Disease; Complement C4b; Drug Monitoring; Female; Fibrosis; Graft Rejection; Humans; Immunity, Humoral; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Middle Aged; Peptide Fragments; Predictive Value of Tests; Pyrazines; Time Factors; Treatment Outcome | 2015 |
Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro.
Topics: Animals; Cardiotonic Agents; Cell Proliferation; Cell Shape; Collagen Type I; Collagen Type III; Down-Regulation; Doxorubicin; Fibroblasts; Fibrosis; Hydroxyproline; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardium; Myocytes, Cardiac; Pyrazines; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2016 |
Anti-fibrotic effects of Salvia miltiorrhiza and Ligustrazine Injection on LX-2 cells involved with increased N-myc downstream-regulated gene 2 expression.
Topics: Apoptosis; beta Catenin; Cell Line; Cell Proliferation; Fibrosis; Gene Expression Regulation; Humans; Injections; Plant Extracts; Pyrazines; Salvia miltiorrhiza; Tumor Suppressor Proteins | 2017 |
Myocardial scarring following chemotherapy for multiple myeloma detected using late gadolinium hyperenhancement cardiovascular magnetic resonance.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Fatal Outcome; Female; Fibrosis; Gadolinium; Heart Failure; Humans; Magnetic Resonance Imaging; Middle Aged; Multiple Myeloma; Myocardium; Pyrazines | 2010 |
Effects of DPP-4 inhibition on cardiac metabolism and function in mice.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Body Weight; CD36 Antigens; Cell Membrane; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Fibrosis; Glucose Tolerance Test; Glucose Transporter Type 4; Glycation End Products, Advanced; Guanine; Heart; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phosphorylation; Protein Transport; Pyrazines; Sitagliptin Phosphate; Triazoles; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2011 |
Proteasome inhibition prevents development of experimental dermal fibrosis.
Topics: Actins; Animals; Bleomycin; Boronic Acids; Bortezomib; Collagen Type I; Female; Fibrosis; Inflammation; Interleukin-4; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 8; NF-kappa B; Proteasome Inhibitors; Pyrazines; Random Allocation; Scleroderma, Localized; Skin; Transforming Growth Factor beta1 | 2012 |
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.
Topics: Animals; Autocrine Communication; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; PPAR gamma; Proteasome Inhibitors; Pulmonary Fibrosis; Pyrazines; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta1 | 2012 |
Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis.
Topics: Actins; Animals; Bone Morphogenetic Protein 7; Cell Line; Collagen; Connective Tissue Growth Factor; Cytokines; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Hydroxyproline; Keratin-18; Kidney Tubules; Ligusticum; Macrophages; Male; Models, Animal; Myofibroblasts; Pyrazines; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Ureteral Obstruction; Vasodilator Agents | 2012 |
[Effect of ligustrazine peritoneal dialysate on CD40 expression of rat peritoneal mesothellial cells].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD40 Antigens; Cells, Cultured; Dialysis Solutions; Epithelium; Fibrosis; Male; Peritoneal Dialysis; Peritoneum; Pyrazines; Rats; RNA, Messenger | 2001 |
[Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing].
Topics: Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Dogs; Female; Fibrosis; Heart Atria; Heart Failure; Male; Pyrazines; Random Allocation | 2006 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis.
Topics: Animals; Bleomycin; Boronic Acids; Bortezomib; Cells, Cultured; Collagen Type I; Fibrosis; Hydroxyproline; Leupeptins; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Pulmonary Fibrosis; Pyrazines; Scleroderma, Systemic; Signal Transduction; Skin; Transforming Growth Factor beta | 2008 |