maytansine has been researched along with Fibrosis* in 1 studies
1 other study(ies) available for maytansine and Fibrosis
Article | Year |
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Antibody-drug conjugates targeting CD248
Myofibroblasts, or activated fibroblasts, play a critical role in the process of renal fibrosis. Targeting myofibroblasts to inhibit their activation or induce specific cell death has been considered to be an effective strategy to attenuate renal fibrosis. However, specific biomarkers for myofibroblasts are needed to ensure the efficacy of these strategies. Here, we verified that CD248 was mainly expressed in myofibroblasts in patients with chronic kidney disease, which was inversely correlated with renal function. The same result was also confirmed in renal fibrotic mice induced by unilateral ureteral obstruction and aristolochic acid nephropathy. By using an antibody-drug conjugate (ADC) named IgG78-DM1, in which maytansinoid (DM1) was linked to a fully human antibody IgG78 through an uncleavable SMCC linker, we demonstrated that it could effectively bind with and kill CD248 Topics: Animals; Antigens, CD; Antigens, Neoplasm; Drug Delivery Systems; Fibrosis; Immunoconjugates; Male; Maytansine; Mice; Myofibroblasts; Renal Insufficiency, Chronic | 2022 |