isoproterenol has been researched along with Fibrosis in 249 studies
Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions." | 8.98 | Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. ( Allawadhi, P; Godugu, C; Khurana, A; Kumari, P; Sayed, N, 2018) |
| " Hemodynamics, lipid profile, liver enzymes, urea, and creatinine were assessed in conjunction with heart failure markers (serum NT-proANP and cTnI)." | 8.31 | Inhibition of transglutaminase 2 (TG2) ameliorates ventricular fibrosis in isoproterenol-induced heart failure in rats. ( Abusara, S; Al-Dwairi, A; Al-Shboul, O; Al-U'datt, DGF; AlQudah, M; Altuntas, Y; Alu'datt, M; Alzoubi, KH; Hiram, R; Jaradat, S; Tranchant, CC, 2023) |
| "We investigated the effects of pravastatin (PRAVA) on isoprenaline (ISP) induced cardiac fibrosis using four groups of mice: untreated control, PRAVA, ISP, ISP + PRAVA groups." | 8.31 | Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model. ( Gari, M; Kumar Mariappan, A; Kumar, A; Kumar, D; Kumar, T; Lingaraju, MC; Parida, S; Rana, A; Sharma, M; Singh, TU, 2023) |
| "To evaluate the cardioprotective effects and the potential mechanisms of the ethanol extracts of SD-3 against isoproterenol (ISO)-induced heart failure (HF) in rats." | 8.12 | Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics. ( Bai, X; Fu, DN; Liu, MJ; Na, RS; Wang, Y; Wei, CX; Yu, LJ; Zhen, D, 2022) |
| " However, its effects on isoproterenol-induced myocardial fibrosis in mice remain unknown." | 8.12 | Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. ( Li, C; Niu, G; Sun, K; Wang, F; Weng, J; Xie, M; Zhang, J; Zhang, Q, 2022) |
| "Gallic acid has been reported to mitigate cardiac hypertrophy, fibrosis and arterial hypertension." | 8.12 | Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg. ( Bai, L; Han, X; Jeong, MH; Kee, HJ, 2022) |
| "Inflammation can contribute to the initiation and progression of atrial fibrillation (AF), and pinocembrin can suppress downstream inflammatory cytokine production by inhibiting the inflammation pathway." | 8.12 | Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats. ( Chen, X; Liu, Z; Wan, W; Yang, B; Ye, T; Yu, Y; Zhang, C, 2022) |
| "To study the effect of sinomenine (Sin) on isoproterenol (Iso, β-agonist)-induced cardiac hypertrophy (CH), we set up four mouse groups: control, Iso model, Iso+metoprolol (Met, β blocker) 60 mg/kg and Iso+Sin 120 mg/kg." | 8.02 | Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice. ( Chen, J; Fang, P; Li, L; Tao, H; Zhang, C, 2021) |
| "To evaluate the effects of Huoxin Pill (, HXP) on cardiac fibrosis and heart failure (HF) in isoproterenol (ISO)-induced HF rats." | 8.02 | Huoxin Pill () Attenuates Cardiac Fibrosis by Suppressing TGF-β1/Smad2/3 Pathway in Isoproterenol-Induced Heart Failure Rats. ( Chu, JF; Huang, B; Li, Q; Lu, Y; Peng, J; Peng, MZ; Shen, AL; Shen, ZQ; Yang, ML; Zhou, XL, 2021) |
| "8%) alleviated myocardial fibrosis when compared with the isoproterenol group (10." | 8.02 | Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway. ( Fu, W; Sui, D; Wang, Q; Wang, Y; Xu, H; Yu, X, 2021) |
| "As rats develop myocardial infarction (MI) like lesions when injected with large doses of isoproterenol (ISO), this investigation was designed to evaluate the dose-dependent effects of thymoquinone (TQ) on ISO-induced myocardial injury in rats." | 8.02 | Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis, autophagy, and fibrosis. ( Elhadidy, WF; Farag, MM; Khalifa, AA; Rashad, RM, 2021) |
| "This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism." | 7.96 | Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020) |
| " acuta ameliorated cardiac function and inhibited isoproterenol (ISO)‑induced myocardial fibrosis in rats." | 7.96 | The aqueous extract of Gentianella acuta improves isoproterenol‑induced myocardial fibrosis via inhibition of the TGF‑β1/Smads signaling pathway. ( Li, AY; Li, YF; Liu, Y; Song, JN; Sun, JH; Xu, GR; Yang, HX; Zhang, C; Zhang, Y, 2020) |
| " This study evaluated whether LCZ696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (ISO)-treated rats compared with valsartan alone." | 7.91 | Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. ( Akagi, S; Ito, H; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Yoshida, M, 2019) |
| "Stevioside, a natural glycoside compound, has many beneficial biological activities, but its protective effect on myocardial fibrosis has not been reported yet." | 7.91 | Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway. ( Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY, 2019) |
| " Furthermore, the effects of 2-ME on blood pressure and cardiovascular remodeling in the constricted aorta (CA) rat model and on isoproterenol-induced (ISO) cardiac hypertrophy and fibrosis were examined." | 7.91 | 2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury. ( Bastacky, SI; Jackson, EK; Salah, E; Tofovic, SP, 2019) |
| " To assess the effects of phosphodiesterase type 3 and phosphodiesterase type 5 inhibitors on cardiac function and left ventricular myocardial fibrosis in catecholamine-induced myocardial injury, sildenafil and pimobendan were administered to male Wistar rats 24 hours after isoproterenol injection." | 7.91 | Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction. ( Nakata, TM; Shimada, K; Suzuki, K; Tanaka, R; Uemura, A, 2019) |
| "We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy." | 7.91 | Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019) |
| " The aim of the present study was to investigate the role of curcumin in regulating autophagy and mammalian target of rapamycin (mTOR) signaling in isoproterenol-induced cardiac hypertrophy and fibrosis in the rat." | 7.88 | Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR. ( Li, CL; Liu, JX; Liu, R; Wang, JR; Yang, J; Zhang, HB, 2018) |
| "To evaluate the effect of oltipraz (OPZ) on isoproterenol-induced heart failure (HF) and heart function." | 7.88 | Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. ( Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY, 2018) |
| "There may be cardio-renal interactions in rats of isoproterenol-induced heart failure, which may be associated with renal fibrosis and endothelial-to-mesenchymal transition (EndMT)." | 7.85 | Relaxin Ameliorates Renal Fibrosis and Expression of Endothelial Cell Transition Markers in Rats of Isoproterenol-Induced Heart Failure. ( Cai, J; Chen, L; Chen, X; Ge, W; Zheng, G; Zhou, H; Zhou, X, 2017) |
| "Male Sprague Dawley rats were treated with isoproterenol (ISO) to induce cardiac remodeling and fibrosis and treated with either miR-30e agomir (AG) or antagomir and respective controls." | 7.85 | MiR-30e Attenuates Isoproterenol-induced Cardiac Fibrosis Through Suppressing Snai1/TGF-β Signaling. ( Chang, H; Zhang, H; Zhang, L; Zhang, W, 2017) |
| "To study the effect of curcumin on fibroblasts in rats with cardiac fibrosis." | 7.85 | Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1. ( Ding, CH; Ma, J; Ma, SY, 2017) |
| "Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure model by subcutaneous injection." | 7.85 | Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. ( Ma, P; Wang, Y; Xiong, A; Xu, Q; Xu, Y; Zhou, R, 2017) |
| "Isoproterenol infusions generated significant cardiac fibrosis (p < 0." | 7.83 | Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016) |
| "Cardiac fibrosis was induced by subcutaneous isoproterenol (ISO) injection, and rapamycin was simultaneously administered orally for 14 days." | 7.81 | Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: the role of autophagy. ( Dong, RQ; Gu, HR; Hu, ZW; Wang, ZF; Wu, YQ; Xie, J; Zhao, C, 2015) |
| "In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice." | 7.81 | Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. ( Li, J; Liu, J; Lu, P; Qi, Z; Ren, J; Tian, W; Yang, L; Zhu, M, 2015) |
| " The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 7.81 | Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. ( Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA, 2015) |
| "Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process." | 7.81 | Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015) |
| "RDN can effectively attenuate the left atrial fibrosis in rats with isoproterenol induced chronic heart failure." | 7.81 | [Effects of renal denervation on left atrial fibrosis in rats with isoproterenol induced chronic heart failure]. ( Li, Z; Liu, Q; Lu, D; Shan, Q; Wang, K; Wang, S; Zhang, Q, 2015) |
| "The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood." | 7.80 | Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide. ( Chen, LL; Hong, HS; Li, YH; Lin, XH; Zhu, XQ, 2014) |
| "Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis." | 7.80 | Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. ( Cai, J; Chen, L; Chen, X; Huang, W; Zhang, H; Zheng, G; Zhou, H; Zhou, X, 2014) |
| "To explore the effects of glutamine (Gln) induced heat shock protein 70(Hsp70) overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline(ISO)treated rats and related mechanisms." | 7.79 | [Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline-treated rats]. ( Bao, HG; Chen, YQ; Li, T; Ma, L; Wang, F; Zhang, WZ, 2013) |
| "Persistent β-adrenergic receptor stimulation with isoproterenol is associated with cardiac hypertrophy as well as cardiac synthesis of angiotensin II." | 7.78 | Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. ( Ballesteros, S; Cachofeiro, V; Davel, AP; de las Heras, N; Lahera, V; Martín-Fernández, B; Miana, M; Rossoni, LV; Valero-Muñoz, M; Vassallo, D, 2012) |
| "Castration significantly increased cardiomyocyte apoptosis and fibrosis that was normally induced by isoproterenol (P<0." | 7.78 | Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. ( Cao, JX; Fu, L; Han, Y; Kang, NN; Sun, JF; Xu, J; Zheng, M, 2012) |
| "To explore the effects of Sini Decoction (SD) on the expressions of Samd2 and Smad7 isoproterenol (Iso) induced myocardial fibrosis rats." | 7.78 | [Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats]. ( Liao, HC; Liu, Y; Zhou, B, 2012) |
| "To investigate the therapeutic effect of PI3Kgamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by Isoproterenol in rats." | 7.77 | [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. ( Hu, XH; Jiang, W; Li, Y; Qing, Y; Song, LF; Tong, QY; Wu, XH, 2011) |
| "The aim of this study was to clarify the effects of renin-angiotensin system (RAS) blockade by captopril, an angiotensin converting enzyme inhibitor, and telmisartan, an angiotensin II type 1 receptor antagonist, on matrix metalloproteinase (MMP)-2 and MMP-9 expressions and development of left ventricular (LV) fibrosis induced by isoprenaline in rats." | 7.76 | Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats. ( Hara, Y; Hoshino, Y; Kosaka, N; Okada, M; Yamawaki, H, 2010) |
| "Our study demonstrates the contribution of IL-17 to myocardial fibrosis in isoproterenol-induced HF." | 7.75 | IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. ( Feng, W; Li, W; Li, Y; Liu, W; Wang, F; Yan, W, 2009) |
| "Isoproterenol treatment of Brown Norway and Lewis rats (high and low plasma angiotensin-I-converting enzyme activity, respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown Norway rats." | 7.74 | Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism. ( Copaja Soto, M; Díaz-Araya, G; Jalil, JE; Lavandero, S; Lijnen, P; Ordenes, GE; Paz Ocaranza, M; Saldaña, A; Valenzuela, R; Vio, C; Vivar Sanchez, R, 2008) |
| "To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO)." | 7.74 | Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. ( Bu, DF; Li, YG; Liu, BG; Pang, YZ; Tan, XR; Tang, CS; Wang, DM; Wei, RH; Zhang, YG, 2007) |
| " The aim of the present study was to evaluate the role of aldosterone and angiotensin II on formation of left ventricular fibrosis induced by chronic beta-adrenergic stimulation with isoproterenol (iso) in the rat heart failure model induced by myocardial infarction (MI)." | 7.73 | Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist. ( Bos, R; Findji, L; Lechat, P; Médiani, O; Mougenot, N; Vanhoutte, PM, 2005) |
| "These findings indicated that celiprolol attenuates cardiac myocyte hypertrophy both in vitro and in vivo and halts the process leading from hypertrophy to heart failure." | 7.72 | Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice. ( Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Kitamura, S; Liao, Y; Minamino, T; Ogai, A; Sanada, S; Shintani, Y; Takashima, S; Tomoike, H, 2004) |
| "This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ventricular hypertrophy (LVH) and myocardial fibrosis." | 7.71 | Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis. ( Chiong, M; Díaz-Araya, G; Ebensperger, R; Irarrázaval, P; Jalil, JE; Lavandero, S; Muñoz, D; Ocaranza, MP; Riveros, JP; Sabat, S, 2002) |
| "By preventing isoprenaline induced myocardial injury and fibrosis, amiodarone may have a cardioprotective role." | 7.69 | Amiodarone protection against myocardial injury and fibrosis induced by isoprenaline is abolished by thyroid hormone. ( Cespedes, C; Dussaillant, G; Jalil, JE, 1994) |
| "A study was designed to determine whether phenytoin (PHE) prevents the myocardial necrosis and subsequent fibrosis produced by isoproterenol (ISO)." | 7.68 | Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats. ( Besbasi, FS; Hamlin, RL, 1990) |
| "Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 7.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
| "A study of isoproterenol-induced (1 mg/kg) myocardial fibrosis in the rat was undertaken, taking advantage of the differential colorization provided by thick and thin collagen fibers to picrosirius red and polarization microscopy." | 7.67 | The fibrillar nature and structure of isoproterenol-induced myocardial fibrosis in the rat. ( Jalil, JE; Janicki, JS; Pick, R; Weber, KT, 1989) |
| "Cardiac fibrosis is an essential structural remodeling associated with HF; therefore, preventing cardiac fibrosis is crucial to decelerating the progression of HF." | 5.91 | Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38. ( Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J, 2023) |
| "Myocardial fibrosis is a pathological hallmark of cardiac dysfunction." | 5.91 | Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis. ( Buigues, M; Dekker, N; García, NA; González-King, H; Sepúlveda, P; Silva, AM; Tejedor, S, 2023) |
| "Cardiac fibrosis is a common cause of most cardiovascular diseases." | 5.72 | Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway. ( Chen, K; Li, Z; Zhu, YZ, 2022) |
| "Lycorine is an alkaloid with several beneficial biological properties." | 5.62 | Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis. ( Fu, Y; Li, P; Wang, ZH; Wu, J; Wu, YX; Wu, ZX, 2021) |
| "Cardiac fibrosis is a pathological hallmark of progressive heart diseases currently lacking effective treatment." | 5.62 | Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation. ( Li, B; Li, J; Lin, Q; Liu, N; Liu, Q; Tu, T; Wu, K; Xiao, Y; Xu, W; Zhang, B; Zuo, W, 2021) |
| "Crocin treatment suppressed these inflammatory cytokine expressions." | 5.56 | Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. ( Cheng, J; Chu, L; Chu, X; Guan, S; Han, X; Jin, W; Li, Z; Ma, Z; Sun, S; Xue, Y; Zhang, X; Zhang, Y, 2020) |
| "Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases." | 5.56 | Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis. ( Abdel-Kader, MS; Albaqami, FF; Alharthy, KM; Althurwi, HN; Salkini, MA, 2020) |
| "Piperine pretreatment significantly prevented these changes in ISO treated group." | 5.56 | The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity. ( Aliev, G; Beeraka, NM; Chubarev, VN; Dhivya, V; Gavryushova, LV; Huang, CY; Mikhaleva, LM; Minyaeva, NN; Tarasov, VV; Viswanadha, VP, 2020) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 5.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Cardiac fibrosis is a crucial factor of heart failure." | 5.48 | MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel. ( Feng, K; Liu, T; Liu, Y; Lu, C; Pan, Y; Tang, Y; Wang, X; Wu, Y; Xu, H, 2018) |
| "Cardiac fibrosis is a common feature of many cardiac pathophysiologic conditions." | 5.48 | Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. ( Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M, 2018) |
| "Pretreatment with GW9662, a specific inhibitor of peroxisome proliferator activated receptor-γ (PPAR-γ), reversed the effect elicited by piperine in vitro." | 5.46 | Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways. ( Ma, ZG; Tang, QZ; Wang, SS; Xu, SC; Yuan, YP; Zhang, X, 2017) |
| "Cardiac fibrosis is a significant global health problem with limited treatment choices." | 5.46 | Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model. ( Chen, GX; Fan, T; Hou, J; Liang, MY; Wang, LX; Wu, ZK; Yang, X; Yue, Y, 2017) |
| "Fusaric acid (FA) is a novel compound derived from a class of nicotinic acid derivatives, exhibiting activity against cancers." | 5.46 | Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. ( Li, X; Wang, HF; Zhang, ZL, 2017) |
| "Isoproterenol (ISO) has been widely used to establish cardiac injury in vivo and in vitro." | 5.46 | Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress. ( Chen, DL; Wang, Z; Yang, J, 2017) |
| "Gallic acid pretreatment attenuated concentric cardiac hypertrophy." | 5.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
| "Treatment with allopurinol to ISO induced rats prevented the elevated activities of AST, ALT, and ALP enzymes, and the levels of lipid peroxidation products and increased reduced glutathione concentration." | 5.42 | Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. ( Alam, MA; Potol, MA; Sagor, MA; Tabassum, N, 2015) |
| "Cryptotanshinone is an active ingredient of Salvia miltiorrhiza that has been used in traditional Chinese medicine for treating cardiovascular disorders." | 5.38 | Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2. ( Li, D; Ma, S; Tang, B; Wang, K; Yang, D; Yang, Y, 2012) |
| "Cardiac fibrosis was evaluated via histopathological analysis." | 5.35 | Doxycycline attenuates isoproterenol-induced myocardial fibrosis and matrix metalloproteinase activity in rats. ( Hara, Y; Higuchi, S; Hori, Y; Hoshi, F; Itoh, N; Kanai, K; Kunihiro, S; Sato, S; Yoshioka, K, 2009) |
| "Isoproterenol (ISO) was given to C57BL mice with or without ARB (olmesartan) treatment and to AT1aR(-/-) mice by a subcutaneously implanted osmotic mini-pump for 11 days at a rate of 15 mg/kg/day." | 5.34 | Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. ( Abe, Y; Fujisawa, Y; Kimura, S; Nagai, Y; Nishiyama, A; Ohmori, K; Zhang, GX, 2007) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 5.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| " Here, we have investigated the effects and potential mechanisms of action of MgIG, with respect to myocardial fibrosis induced by isoproterenol (ISO) in mice." | 4.98 | Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice. ( Chu, L; Han, X; Ma, D; Song, T; Zhang, J; Zhang, X; Zhang, Y, 2018) |
| " Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions." | 4.98 | Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention. ( Allawadhi, P; Godugu, C; Khurana, A; Kumari, P; Sayed, N, 2018) |
| "This study aims to shed light on aconite's potential as an anti-fibrotic agent and elucidate its mechanisms in a rat model of isoproterenol (ISO)-induced cardiac fibrosis." | 4.84 | Understanding aconite's anti-fibrotic effects in cardiac fibrosis. ( Feng, Y; He, J; Li, D; Peng, C; Xing, Z; Yang, C, 2024) |
| " Hemodynamics, lipid profile, liver enzymes, urea, and creatinine were assessed in conjunction with heart failure markers (serum NT-proANP and cTnI)." | 4.31 | Inhibition of transglutaminase 2 (TG2) ameliorates ventricular fibrosis in isoproterenol-induced heart failure in rats. ( Abusara, S; Al-Dwairi, A; Al-Shboul, O; Al-U'datt, DGF; AlQudah, M; Altuntas, Y; Alu'datt, M; Alzoubi, KH; Hiram, R; Jaradat, S; Tranchant, CC, 2023) |
| "We investigated the effects of pravastatin (PRAVA) on isoprenaline (ISP) induced cardiac fibrosis using four groups of mice: untreated control, PRAVA, ISP, ISP + PRAVA groups." | 4.31 | Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model. ( Gari, M; Kumar Mariappan, A; Kumar, A; Kumar, D; Kumar, T; Lingaraju, MC; Parida, S; Rana, A; Sharma, M; Singh, TU, 2023) |
| "To evaluate the cardioprotective effects and the potential mechanisms of the ethanol extracts of SD-3 against isoproterenol (ISO)-induced heart failure (HF) in rats." | 4.12 | Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics. ( Bai, X; Fu, DN; Liu, MJ; Na, RS; Wang, Y; Wei, CX; Yu, LJ; Zhen, D, 2022) |
| " However, its effects on isoproterenol-induced myocardial fibrosis in mice remain unknown." | 4.12 | Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions. ( Li, C; Niu, G; Sun, K; Wang, F; Weng, J; Xie, M; Zhang, J; Zhang, Q, 2022) |
| "Gallic acid has been reported to mitigate cardiac hypertrophy, fibrosis and arterial hypertension." | 4.12 | Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg. ( Bai, L; Han, X; Jeong, MH; Kee, HJ, 2022) |
| "Inflammation can contribute to the initiation and progression of atrial fibrillation (AF), and pinocembrin can suppress downstream inflammatory cytokine production by inhibiting the inflammation pathway." | 4.12 | Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats. ( Chen, X; Liu, Z; Wan, W; Yang, B; Ye, T; Yu, Y; Zhang, C, 2022) |
| "To study the effect of sinomenine (Sin) on isoproterenol (Iso, β-agonist)-induced cardiac hypertrophy (CH), we set up four mouse groups: control, Iso model, Iso+metoprolol (Met, β blocker) 60 mg/kg and Iso+Sin 120 mg/kg." | 4.02 | Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice. ( Chen, J; Fang, P; Li, L; Tao, H; Zhang, C, 2021) |
| " In this study, we observed the high expression of MBNL1 in cardiac tissue and peripheral blood of an isoproterenol (ISO)-induced cardiac hypertrophy mouse model." | 4.02 | MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo. ( Liang, C; Luo, Y; Xu, Y; Zhang, T, 2021) |
| "To evaluate the effects of Huoxin Pill (, HXP) on cardiac fibrosis and heart failure (HF) in isoproterenol (ISO)-induced HF rats." | 4.02 | Huoxin Pill () Attenuates Cardiac Fibrosis by Suppressing TGF-β1/Smad2/3 Pathway in Isoproterenol-Induced Heart Failure Rats. ( Chu, JF; Huang, B; Li, Q; Lu, Y; Peng, J; Peng, MZ; Shen, AL; Shen, ZQ; Yang, ML; Zhou, XL, 2021) |
| "8%) alleviated myocardial fibrosis when compared with the isoproterenol group (10." | 4.02 | Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway. ( Fu, W; Sui, D; Wang, Q; Wang, Y; Xu, H; Yu, X, 2021) |
| "As rats develop myocardial infarction (MI) like lesions when injected with large doses of isoproterenol (ISO), this investigation was designed to evaluate the dose-dependent effects of thymoquinone (TQ) on ISO-induced myocardial injury in rats." | 4.02 | Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis, autophagy, and fibrosis. ( Elhadidy, WF; Farag, MM; Khalifa, AA; Rashad, RM, 2021) |
| " From day 6, the mice were injected with the nonselective β-agonist isoproterenol for 4 consecutive days to induce diastolic dysfunction and subendocardial fibrosis while maintaining systolic function." | 4.02 | Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage. ( Beyhoff, N; Blumrich, A; Foryst-Ludwig, A; Goeritzer, M; Grune, J; Jaeger, C; Kasch, J; Kintscher, U; Klopfleisch, R; Luettges, K; Müller, OJ; Ritter, D; Smeir, E; Thiele, A, 2021) |
| " In a mouse model of isoproterenol-induced cardiac injury, TPGS is not able to affect cardiac remodeling, however combination of vitamin E TPGS and Apelin counteracts myocardial apoptosis, oxidative stress, hypertrophy and fibrosis." | 3.96 | In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin. ( Blanzat, M; Boal, F; Cassel, S; Cinato, M; Dejugnat, C; Jimenez, T; Kunduzova, O; Leme Goto, P; Loi, H; Marsal, D; Merachli, F; Santin, Y; Todua, N; Tronchere, H; Vons, B, 2020) |
| "This study aimed to investigate the anti-fibrotic effects of ghrelin in isoproterenol (ISO)-induced myocardial fibrosis and the underlying mechanism." | 3.96 | Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol. ( Feng, L; Lin, P; Ren, Q; Wang, Q; Zhang, B, 2020) |
| " acuta ameliorated cardiac function and inhibited isoproterenol (ISO)‑induced myocardial fibrosis in rats." | 3.96 | The aqueous extract of Gentianella acuta improves isoproterenol‑induced myocardial fibrosis via inhibition of the TGF‑β1/Smads signaling pathway. ( Li, AY; Li, YF; Liu, Y; Song, JN; Sun, JH; Xu, GR; Yang, HX; Zhang, C; Zhang, Y, 2020) |
| " We determined that the knockout of WWP2 specifically in myocardium decreased the level of PARP1 ubiquitination and increased the effects of isoproterenol (ISO)-induced PARP1 and PARylation, in turn aggravating ISO-induced myocardial hypertrophy, heart failure, and myocardial fibrosis." | 3.96 | Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. ( Cao, L; Qian, H; Sun, Y; Wu, S; Zhang, N; Zhang, Y, 2020) |
| " This study evaluated whether LCZ696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (ISO)-treated rats compared with valsartan alone." | 3.91 | Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. ( Akagi, S; Ito, H; Kondo, M; Miura, D; Miyoshi, T; Nakamura, K; Ohno, Y; Saito, Y; Yoshida, M, 2019) |
| "Stevioside, a natural glycoside compound, has many beneficial biological activities, but its protective effect on myocardial fibrosis has not been reported yet." | 3.91 | Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway. ( Jia, CH; Shen, W; Wang, J; Xie, ML; Zhang, JY, 2019) |
| " Furthermore, the effects of 2-ME on blood pressure and cardiovascular remodeling in the constricted aorta (CA) rat model and on isoproterenol-induced (ISO) cardiac hypertrophy and fibrosis were examined." | 3.91 | 2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury. ( Bastacky, SI; Jackson, EK; Salah, E; Tofovic, SP, 2019) |
| " To assess the effects of phosphodiesterase type 3 and phosphodiesterase type 5 inhibitors on cardiac function and left ventricular myocardial fibrosis in catecholamine-induced myocardial injury, sildenafil and pimobendan were administered to male Wistar rats 24 hours after isoproterenol injection." | 3.91 | Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction. ( Nakata, TM; Shimada, K; Suzuki, K; Tanaka, R; Uemura, A, 2019) |
| "We hypothesized that Chikusetsusaponin IVa (CS), a major component of Saponins from Panaxjaponicus, may improve isoprenaline induced myocardial fibrosis via AMPK/mTOR/ULK1 mediated autophagy METHODS: Continuous subcutaneous injection of isoproterenol for 21 days was used to induce myocardial fibrosis in mice and high and low doses (15 mg/kg and 5 mg/kg) of CS was administered by oral gavage to observe the efficacy." | 3.91 | Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling. ( He, Y; Liu, C; Liu, X; Wang, J; Wang, L; Wang, T; Wu, X; Yuan, D; Zhang, C; Zheng, J; Zhou, Z, 2019) |
| "The present study aimed at investigating the effect and mechanism of lncRNA Growth Arrest-Specific 5 (GAS5) in cardiac fibrosis induced by isoproterenol (ISO) in vivo." | 3.91 | Overexpression of lncRNA GAS5 attenuates cardiac fibrosis through regulating PTEN/MMP-2 signal pathway in mice. ( Chen, CH; Liu, HL; Sun, YJ, 2019) |
| " The aim of the present study was to investigate the role of curcumin in regulating autophagy and mammalian target of rapamycin (mTOR) signaling in isoproterenol-induced cardiac hypertrophy and fibrosis in the rat." | 3.88 | Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR. ( Li, CL; Liu, JX; Liu, R; Wang, JR; Yang, J; Zhang, HB, 2018) |
| "To evaluate the effect of oltipraz (OPZ) on isoproterenol-induced heart failure (HF) and heart function." | 3.88 | Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response. ( Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY, 2018) |
| "There may be cardio-renal interactions in rats of isoproterenol-induced heart failure, which may be associated with renal fibrosis and endothelial-to-mesenchymal transition (EndMT)." | 3.85 | Relaxin Ameliorates Renal Fibrosis and Expression of Endothelial Cell Transition Markers in Rats of Isoproterenol-Induced Heart Failure. ( Cai, J; Chen, L; Chen, X; Ge, W; Zheng, G; Zhou, H; Zhou, X, 2017) |
| "Male Sprague Dawley rats were treated with isoproterenol (ISO) to induce cardiac remodeling and fibrosis and treated with either miR-30e agomir (AG) or antagomir and respective controls." | 3.85 | MiR-30e Attenuates Isoproterenol-induced Cardiac Fibrosis Through Suppressing Snai1/TGF-β Signaling. ( Chang, H; Zhang, H; Zhang, L; Zhang, W, 2017) |
| "To study the effect of curcumin on fibroblasts in rats with cardiac fibrosis." | 3.85 | Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1. ( Ding, CH; Ma, J; Ma, SY, 2017) |
| "Male Sprague Dawley rats were given isoproterenol 5 mg/kg once a day for 7 days to establish heart failure model by subcutaneous injection." | 3.85 | Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway. ( Ma, P; Wang, Y; Xiong, A; Xu, Q; Xu, Y; Zhou, R, 2017) |
| "Isoproterenol infusions generated significant cardiac fibrosis (p < 0." | 3.83 | Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats. ( Cheng, PW; Hsiao, M; Lai, CC; Liou, JC; Liu, CP; Lu, PJ; Lu, WH; Sun, GC; Tseng, CJ, 2016) |
| " In a cardiac specific transgenic mouse model, it was observed that overexpression of hHole specifically in heart attenuated cardiac hypertrophy and fibrosis induced by isoproterenol (ISO), with blunted transcriptions of ERK1/2, total ERK1/2 proteins and phosphorylated ERK1/2 (p-ERK1/2) levels." | 3.83 | Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling. ( Cao, L; Chen, F; Dai, G; Deng, Y; Fan, X; Jiang, Z; Li, Y; Liu, X; Luo, S; Mo, X; Peng, X; Shi, Y; Wan, Y; Wang, X; Wang, Y; Wu, X; Xu, W; Ye, X; Yuan, W; Zeng, Q; Zhang, S; Zhou, J; Zhu, X, 2016) |
| "Cardiac fibrosis was induced by subcutaneous isoproterenol (ISO) injection, and rapamycin was simultaneously administered orally for 14 days." | 3.81 | Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: the role of autophagy. ( Dong, RQ; Gu, HR; Hu, ZW; Wang, ZF; Wu, YQ; Xie, J; Zhao, C, 2015) |
| "Using the β-adrenergic agonist isoproterenol as a specific pathological stressor to circumvent the problem of etiologic heterogeneity, we performed a genome-wide association study for genes influencing cardiac hypertrophy and fibrosis in a large panel of inbred mice." | 3.81 | Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice. ( Avetisyan, R; Lusis, AJ; Martin, L; Rau, CD; Ren, S; Romay, MC; Wang, J; Wang, Y, 2015) |
| "In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice." | 3.81 | Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice. ( Li, J; Liu, J; Lu, P; Qi, Z; Ren, J; Tian, W; Yang, L; Zhu, M, 2015) |
| " The present study was designed to investigate the effect of pretreatment with SIM on isoproterenol (ISO)-induced cardiac hypertrophy in rats." | 3.81 | Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. ( Al-Manee, RZ; Al-Oteibi, MM; Al-Rasheed, NM; Al-Shareef, SA; Hasan, IH; Mahmoud, AM; Mohamad, RA, 2015) |
| "Although it is well known that isoproterenol (ISO) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (HSF1) has a role in this process." | 3.81 | Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice. ( Fang, L; Xie, Y; Zhang, B; Zhang, L, 2015) |
| "Isoproterenol (5 mg·kg(-1)·d(-1)) was used to establish the cardiac fibrosis model in rats, which were administered RLX." | 3.81 | Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway. ( Cai, JJ; Chen, LZ; Chen, X; Gao, Z; Gong, YS; Huang, WJ; Wang, LX; Zhang, HQ; Zhou, H; Zhou, X, 2015) |
| "RDN can effectively attenuate the left atrial fibrosis in rats with isoproterenol induced chronic heart failure." | 3.81 | [Effects of renal denervation on left atrial fibrosis in rats with isoproterenol induced chronic heart failure]. ( Li, Z; Liu, Q; Lu, D; Shan, Q; Wang, K; Wang, S; Zhang, Q, 2015) |
| "The physiological mechanisms involved in isoproterenol (ISO)-induced chronic heart failure (CHF) are not fully understood." | 3.80 | Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide. ( Chen, LL; Hong, HS; Li, YH; Lin, XH; Zhu, XQ, 2014) |
| "Scutellarin (SCU) is the major active component of breviscapine and has been reported to be capable of decreasing myocardial fibrosis." | 3.80 | Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats. ( Cai, J; Chen, L; Chen, X; Huang, W; Zhang, H; Zheng, G; Zhou, H; Zhou, X, 2014) |
| "To establish a model of cardiac fibrosis induced by isoproterenol (ISO), the non-selective β adrenoceptor agonist, injected subcutaneously for 7 days in rats, and to observe changes of transcription factor NF-κB in the model." | 3.80 | [Activation of transcription factor NF-κB in a rat model of cardiac fibrosis induced by β-adrenoceptor stimulation]. ( Li, ZJ; Lu, HY; Tian, AJ; Yang, CZ; Yang, QX; Yin, Q; Zhang, YY; Zheng, XH; Zheng, XP, 2014) |
| "To explore the effects of glutamine (Gln) induced heat shock protein 70(Hsp70) overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline(ISO)treated rats and related mechanisms." | 3.79 | [Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline-treated rats]. ( Bao, HG; Chen, YQ; Li, T; Ma, L; Wang, F; Zhang, WZ, 2013) |
| "In PKA inhibitor peptide transgenic mice, chronic isoproterenol failed to induce cardiac hypertrophy, fibrosis, and myocyte apoptosis, and decreased cardiac function." | 3.79 | Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. ( Ai, X; Chen, X; Fu, Q; Gao, E; Gao, H; Ge, XJ; Jin, J; Kunapuli, SP; Li, Y; Makarewich, C; Szeto, C; Tang, A; Tang, M; Wang, F; Wang, J; Xiang, KY; Zeng, C; Zhang, X; Zhou, L, 2013) |
| "Persistent β-adrenergic receptor stimulation with isoproterenol is associated with cardiac hypertrophy as well as cardiac synthesis of angiotensin II." | 3.78 | Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. ( Ballesteros, S; Cachofeiro, V; Davel, AP; de las Heras, N; Lahera, V; Martín-Fernández, B; Miana, M; Rossoni, LV; Valero-Muñoz, M; Vassallo, D, 2012) |
| "Castration significantly increased cardiomyocyte apoptosis and fibrosis that was normally induced by isoproterenol (P<0." | 3.78 | Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure. ( Cao, JX; Fu, L; Han, Y; Kang, NN; Sun, JF; Xu, J; Zheng, M, 2012) |
| "Cardiac hypertrophy was induced in wild-type and IL-10 knockout mice by isoproterenol (ISO) infusion." | 3.78 | Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB. ( Barefield, D; Ghosh, AK; Gupta, R; Hoxha, E; Kishore, R; Krishnamurthy, P; Lambers, E; Mackie, A; Qin, G; Ramirez, V; Sadayappan, S; Singh, N; Thal, M; Verma, SK, 2012) |
| "To explore the effects of Sini Decoction (SD) on the expressions of Samd2 and Smad7 isoproterenol (Iso) induced myocardial fibrosis rats." | 3.78 | [Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats]. ( Liao, HC; Liu, Y; Zhou, B, 2012) |
| "To investigate the therapeutic effect of PI3Kgamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by Isoproterenol in rats." | 3.77 | [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. ( Hu, XH; Jiang, W; Li, Y; Qing, Y; Song, LF; Tong, QY; Wu, XH, 2011) |
| " Isoproterenol (ISO) infusion can accelerate cardiomyopathy in young SHHFs, while dietary salt loading in hypertensive rats induces cardiac fibrosis, hypertrophy, and--in a minority-congestive HF." | 3.77 | Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. ( Carll, AP; Costa, DL; Farraj, AK; Haykal-Coates, N; Hazari, MS; Nyska, A; Richards, JH; Willis, MS; Winsett, DW, 2011) |
| " Moreover, the PDE1 inhibitor attenuated isoproterenol-induced interstitial fibrosis in mice." | 3.77 | Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. ( Cai, Y; Dostmann, WR; Fujiwara, K; Miller, CL; Oikawa, M; Thomas, T; Yan, C; Zaccolo, M, 2011) |
| "The aim of this study was to clarify the effects of renin-angiotensin system (RAS) blockade by captopril, an angiotensin converting enzyme inhibitor, and telmisartan, an angiotensin II type 1 receptor antagonist, on matrix metalloproteinase (MMP)-2 and MMP-9 expressions and development of left ventricular (LV) fibrosis induced by isoprenaline in rats." | 3.76 | Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats. ( Hara, Y; Hoshino, Y; Kosaka, N; Okada, M; Yamawaki, H, 2010) |
| " We found that, in the left ventricle, Gal-3 1) enhanced macrophage and mast cell infiltration, increased cardiac interstitial and perivascular fibrosis, and causes cardiac hypertrophy; 2) increased TGF-beta expression and Smad3 phosphorylation; and 3) decreased negative change in pressure over time response to isoproterenol challenge, ratio of early left ventricular filling phase to atrial contraction phase, and left ventricular ejection fraction." | 3.75 | N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin. ( André, S; Carretero, OA; D'Ambrosio, M; Gabius, HJ; Liao, TD; Liu, YH; Peng, H; Rhaleb, NE; Sharma, U, 2009) |
| "Our study demonstrates the contribution of IL-17 to myocardial fibrosis in isoproterenol-induced HF." | 3.75 | IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure. ( Feng, W; Li, W; Li, Y; Liu, W; Wang, F; Yan, W, 2009) |
| "Isoproterenol treatment of Brown Norway and Lewis rats (high and low plasma angiotensin-I-converting enzyme activity, respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown Norway rats." | 3.74 | Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism. ( Copaja Soto, M; Díaz-Araya, G; Jalil, JE; Lavandero, S; Lijnen, P; Ordenes, GE; Paz Ocaranza, M; Saldaña, A; Valenzuela, R; Vio, C; Vivar Sanchez, R, 2008) |
| "To study whether urotensin II (UII), a potent vasoconstrictive peptide, is involved in the development of cardiac hypertrophy and fibrogenesis of rats induced by isoproterenol (ISO)." | 3.74 | Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol. ( Bu, DF; Li, YG; Liu, BG; Pang, YZ; Tan, XR; Tang, CS; Wang, DM; Wei, RH; Zhang, YG, 2007) |
| " Similarly, adult beta1KOmdx males were more prone to isoproterenol-induced heart failure and death compared with control groups." | 3.74 | Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification. ( Chu, AL; Chun, J; Elsherif, L; Huang, MS; Kaufman, SJ; Li, RY; Mekany, MA; Ross, RS; Shai, SY; Yang, Y, 2008) |
| " The aim of the present study was to evaluate the role of aldosterone and angiotensin II on formation of left ventricular fibrosis induced by chronic beta-adrenergic stimulation with isoproterenol (iso) in the rat heart failure model induced by myocardial infarction (MI)." | 3.73 | Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist. ( Bos, R; Findji, L; Lechat, P; Médiani, O; Mougenot, N; Vanhoutte, PM, 2005) |
| " We tested the hypothesis that this ACE gene polymorphism determines the extent of cardiac fibrosis induced by isoproterenol (Iso) in the rat." | 3.72 | Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats. ( Carreño, JE; Díaz-Araya, G; Jalil, JE; Lavandero, S; Muñoz, D; Ocaranza, MP; Riveros, JP, 2004) |
| "These findings indicated that celiprolol attenuates cardiac myocyte hypertrophy both in vitro and in vivo and halts the process leading from hypertrophy to heart failure." | 3.72 | Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice. ( Asakura, M; Asano, Y; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Kitamura, S; Liao, Y; Minamino, T; Ogai, A; Sanada, S; Shintani, Y; Takashima, S; Tomoike, H, 2004) |
| "This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ventricular hypertrophy (LVH) and myocardial fibrosis." | 3.71 | Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis. ( Chiong, M; Díaz-Araya, G; Ebensperger, R; Irarrázaval, P; Jalil, JE; Lavandero, S; Muñoz, D; Ocaranza, MP; Riveros, JP; Sabat, S, 2002) |
| "By preventing isoprenaline induced myocardial injury and fibrosis, amiodarone may have a cardioprotective role." | 3.69 | Amiodarone protection against myocardial injury and fibrosis induced by isoprenaline is abolished by thyroid hormone. ( Cespedes, C; Dussaillant, G; Jalil, JE, 1994) |
| "A study was designed to determine whether phenytoin (PHE) prevents the myocardial necrosis and subsequent fibrosis produced by isoproterenol (ISO)." | 3.68 | Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats. ( Besbasi, FS; Hamlin, RL, 1990) |
| "Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis." | 3.67 | Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis. ( Benjamin, IJ; Cho, K; Clark, WA; Jalil, JE; Tan, LB; Weber, KT, 1989) |
| "A study of isoproterenol-induced (1 mg/kg) myocardial fibrosis in the rat was undertaken, taking advantage of the differential colorization provided by thick and thin collagen fibers to picrosirius red and polarization microscopy." | 3.67 | The fibrillar nature and structure of isoproterenol-induced myocardial fibrosis in the rat. ( Jalil, JE; Janicki, JS; Pick, R; Weber, KT, 1989) |
| "Cardiac fibrosis is an essential structural remodeling associated with HF; therefore, preventing cardiac fibrosis is crucial to decelerating the progression of HF." | 1.91 | Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38. ( Adu-Amankwaah, J; An, K; Cui, J; Lin, L; Song, N; Sun, H; Tan, R; Wang, M; You, Q; Yuan, J, 2023) |
| "Myocardial fibrosis is a pathological hallmark of cardiac dysfunction." | 1.91 | Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis. ( Buigues, M; Dekker, N; García, NA; González-King, H; Sepúlveda, P; Silva, AM; Tejedor, S, 2023) |
| "Pathological cardiac hypertrophy is a characteristic feature in many cardiovascular diseases (CVDs)." | 1.72 | Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response. ( Kulhari, U; Kumar, A; Kundu, S; Mugale, MN; Murty, US; Ram, C; Sahu, BD; Syed, AM, 2022) |
| "Cardiac fibrosis is a common cause of most cardiovascular diseases." | 1.72 | Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway. ( Chen, K; Li, Z; Zhu, YZ, 2022) |
| "Lycorine is an alkaloid with several beneficial biological properties." | 1.62 | Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis. ( Fu, Y; Li, P; Wang, ZH; Wu, J; Wu, YX; Wu, ZX, 2021) |
| " The ß-adrenergic agonist isoproterenol hydrochloride is used for its cardiac effects in a variety of different dosing regimens with high doses causing acute cardiomyocyte necrosis." | 1.62 | Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart. ( Baxan, N; Bedard, O; Benson, L; Boyle, JJ; Branca, J; Forte, E; Harding, SE; Hasham, MG; Ng, FS; Panahi, M; Rosenthal, N; Sattler, S, 2021) |
| "Cardiac fibrosis is a pathological hallmark of progressive heart diseases currently lacking effective treatment." | 1.62 | Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation. ( Li, B; Li, J; Lin, Q; Liu, N; Liu, Q; Tu, T; Wu, K; Xiao, Y; Xu, W; Zhang, B; Zuo, W, 2021) |
| "Cardiac fibrosis is the final event of heart failure and is associated with almost all forms of cardiovascular disease." | 1.62 | C188-9 reduces TGF-β1-induced fibroblast activation and alleviates ISO-induced cardiac fibrosis in mice. ( Jin, Y; Liu, J; Wang, B; Zhang, J; Zuo, S, 2021) |
| "Crocin treatment suppressed these inflammatory cytokine expressions." | 1.56 | Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis. ( Cheng, J; Chu, L; Chu, X; Guan, S; Han, X; Jin, W; Li, Z; Ma, Z; Sun, S; Xue, Y; Zhang, X; Zhang, Y, 2020) |
| "Cardiac fibrosis is a common characteristic of many cardiac diseases." | 1.56 | Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway. ( Feng, K; Tang, Y; Tao, R; Wei, Y; Wu, Y; Xu, H; Zhao, Y, 2020) |
| "A rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg·kg-1·day-1) for 4 weeks, with or without ALS treatment at 20 mg·kg-1·day-1." | 1.56 | Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways. ( Guo, D; Liu, H; Zhao, Z, 2020) |
| "Cardiac hypertrophy is an independent risk factor of many cardiovascular diseases." | 1.56 | Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis. ( Abdel-Kader, MS; Albaqami, FF; Alharthy, KM; Althurwi, HN; Salkini, MA, 2020) |
| "Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death." | 1.56 | Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways. ( Chen, Y; Meng, Q; Sun, D; Yao, X; Zhan, K; Zhang, X; Zhao, Y; Zhu, L, 2020) |
| "Piperine pretreatment significantly prevented these changes in ISO treated group." | 1.56 | The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity. ( Aliev, G; Beeraka, NM; Chubarev, VN; Dhivya, V; Gavryushova, LV; Huang, CY; Mikhaleva, LM; Minyaeva, NN; Tarasov, VV; Viswanadha, VP, 2020) |
| " We hypothesized that experimental diabetes in rats combined with a cardiac or renal stressor, would mimic diabetic cardiomyopathy and nephropathy, respectively." | 1.56 | Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy. ( Fink, LN; Jelsing, J; Johansen, TT; Lindsay, RT; Murray, AJ; Pedersen, AA; Pedersen, PJ; Pedersen, TX; Secher, T; Skarsfeldt, T; Thisted, L; Thomsen, MB; Thrane, ST; Zois, NE; Østergaard, MV, 2020) |
| "It was found that SMYAD could regulate cardiac hypertrophy and fibrosis makers' mRNA levels in vitro and vivo." | 1.56 | Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure. ( Chen, Y; Jiang, Y; Yao, X; Zhang, F; Zhang, X; Zhao, Y; Zhu, L, 2020) |
| "Cardiac fibrosis is a crucial aspect of cardiac remodeling that can severely affect cardiac function." | 1.51 | Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. ( Che, Y; Jin, YG; Shen, DF; Wang, SS; Wang, ZP; Wu, QQ; Yuan, Y, 2019) |
| "Cardiac fibrosis was induced in C57BL/6 mice by subcutaneously injecting isoproterenol." | 1.51 | SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition. ( Fan, XF; Gong, YS; Han, LP; Li, X; Liu, ZH; Wang, X; Zhang, Y, 2019) |
| "Cardiac fibrosis is a crucial factor of heart failure." | 1.48 | MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel. ( Feng, K; Liu, T; Liu, Y; Lu, C; Pan, Y; Tang, Y; Wang, X; Wu, Y; Xu, H, 2018) |
| "Cardiac fibrosis is a common feature of many cardiac pathophysiologic conditions." | 1.48 | Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome. ( Qi, R; Tuerdi, N; Wan, Y; Wang, Y; Xu, L; Ye, M, 2018) |
| "Pretreatment with GW9662, a specific inhibitor of peroxisome proliferator activated receptor-γ (PPAR-γ), reversed the effect elicited by piperine in vitro." | 1.46 | Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways. ( Ma, ZG; Tang, QZ; Wang, SS; Xu, SC; Yuan, YP; Zhang, X, 2017) |
| "Cardiac fibrosis is a significant global health problem with limited treatment choices." | 1.46 | Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model. ( Chen, GX; Fan, T; Hou, J; Liang, MY; Wang, LX; Wu, ZK; Yang, X; Yue, Y, 2017) |
| "Fusaric acid (FA) is a novel compound derived from a class of nicotinic acid derivatives, exhibiting activity against cancers." | 1.46 | Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. ( Li, X; Wang, HF; Zhang, ZL, 2017) |
| "Isoproterenol (ISO) has been widely used to establish cardiac injury in vivo and in vitro." | 1.46 | Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress. ( Chen, DL; Wang, Z; Yang, J, 2017) |
| "Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure." | 1.46 | Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis. ( Dai, H; Jia, G; Liang, C; Lu, M; Wang, H; Wang, Y, 2017) |
| "Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions." | 1.43 | HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression. ( Hu, W; Li, J; Shi, KH; Tao, H; Yang, JJ, 2016) |
| "While Huntington's disease (HD) is classified as a neurological disorder, HD patients exhibit a high incidence of cardiovascular events leading to heart failure and death." | 1.43 | Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease. ( Colwell, CS; Coppola, G; Fishbein, MC; Gao, F; Ghiani, CA; Jordan, MC; Park, S; Roos, KP; Schroeder, AM; Wang, HB, 2016) |
| "Cardiac fibrosis is an important pathological feature of cardiac remodeling in heart diseases." | 1.43 | Epigenetic factors MeCP2 and HDAC6 control α-tubulin acetylation in cardiac fibroblast proliferation and fibrosis. ( Li, J; Shi, KH; Tao, H; Yang, JJ, 2016) |
| "Gallic acid pretreatment attenuated concentric cardiac hypertrophy." | 1.43 | Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. ( Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y, 2016) |
| "Cardiac fibrosis is a common feature of advanced coronary heart disease and is characteristic of heart disease." | 1.42 | A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway. ( Bai, Y; Fan, TP; Li, Z; Lu, H; Tian, A; Wu, J; Yang, C; Yang, Q; Yin, Q; Zhang, Y; Zheng, X, 2015) |
| "Fibrosis was markedly increased by ISO." | 1.42 | l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy. ( Babal, P; Doka, G; Janega, P; Klimas, J; Kralova, E; Krenek, P; Kuracinova, K; Pivackova, L; Srankova, J, 2015) |
| "Triptolide (TPL) is a diterpene triepoxide with potent immunosuppressive and anti-inflammatory properties." | 1.42 | Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway. ( Chen, J; Huang, D; Huang, Y; Ke, J; Li, L; Liu, M; Wu, W, 2015) |
| "Treatment with allopurinol to ISO induced rats prevented the elevated activities of AST, ALT, and ALP enzymes, and the levels of lipid peroxidation products and increased reduced glutathione concentration." | 1.42 | Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats. ( Alam, MA; Potol, MA; Sagor, MA; Tabassum, N, 2015) |
| "All mice were 10 weeks of age." | 1.40 | Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction. ( Armstrong, DW; Johri, AM; Matangi, MF; Meens, JA; Pang, SC; Tse, MY; Ventura, NM; Wong, PG, 2014) |
| "Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure." | 1.40 | Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis. ( Jia, P; Li, Z; Lu, H; Tian, A; Wu, J; Xing, R; Yang, C; Yang, L; Zhang, Y; Zheng, X, 2014) |
| "Also HRC-null mice exhibited severe cardiac hypertrophy, fibrosis, pulmonary edema and decreased survival after TAC." | 1.39 | Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress. ( Bers, DM; Cha, H; Chen, S; Cho, C; Franzini-Armstrong, C; Ginsburg, KS; Han, P; Hong, S; Jin, S; Kim, DH; Kranias, EG; Lee, H; Oh, JG; Park, CS; Park, I; Park, WJ; Singh, VP; Wang, HS, 2013) |
| "Cryptotanshinone is an active ingredient of Salvia miltiorrhiza that has been used in traditional Chinese medicine for treating cardiovascular disorders." | 1.38 | Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2. ( Li, D; Ma, S; Tang, B; Wang, K; Yang, D; Yang, Y, 2012) |
| "Cardiomyopathy in Duchenne muscular dystrophy (DMD) is an increasing cause of death in patients." | 1.37 | Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice. ( Guerron, AD; Hoffman, EP; Nagaraju, K; Sali, A; Spurney, CF; van der Meulen, JH; Yu, Q, 2011) |
| " Experimentally, chronic administration of the β-AR agonist isoproterenol (ISO) has been most commonly used to model β-AR-induced cardiac remodeling." | 1.37 | Distinct actions of intermittent and sustained β-adrenoceptor stimulation on cardiac remodeling. ( Chen, C; Fu, Y; Li, Z; Ma, X; Shen, Q; Song, Y; Zhang, Y, 2011) |
| "In vivo, cardiac hypertrophy was induced by injection of ISO (5 mg." | 1.36 | KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways. ( Chen, IJ; Dai, ZK; Hsu, JH; Liou, SF; Liu, CP; Wu, BN; Wu, JR; Wu, PJ; Yeh, JL, 2010) |
| "Isoprenaline-induced cardiac hypertrophy was associated with increased expression of beta myosin heavy chain, which was also prevented by Ro5-4864." | 1.36 | Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats. ( Dinda, AK; Enjamoori, R; Jaiswal, A; Kumar, S; Maulik, SK; Seth, S, 2010) |
| "Treatment with isoproterenol (iso) for 7 days caused myocardial damage and left ventricular (LV) dysfunction in the cardiomyopathic mice." | 1.35 | Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation. ( Adachi, Y; Enoki, C; Ikehara, S; Imamura, H; Iwasaka, T; Kaneko, K; Otani, H; Sato, D; Taniuchi, S; Tatsumi, K, 2008) |
| "However, the role of RALT in cardiac hypertrophy remains unclear." | 1.35 | Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling. ( Bian, ZY; Cai, J; Ghosh, AK; Li, A; Li, H; Shen, DF; Tang, QZ; Yan, L; Yang, L; Yang, Q; Yang, XC; Yi, FF, 2009) |
| "Cardiac fibrosis was evaluated via histopathological analysis." | 1.35 | Doxycycline attenuates isoproterenol-induced myocardial fibrosis and matrix metalloproteinase activity in rats. ( Hara, Y; Higuchi, S; Hori, Y; Hoshi, F; Itoh, N; Kanai, K; Kunihiro, S; Sato, S; Yoshioka, K, 2009) |
| "Quantification of fibrosis is a key parameter in the assessment of the severity of cardiovascular disease and efficacy of future candidate therapies." | 1.35 | Quantification of cardiac fibrosis by colour-subtractive computer-assisted image analysis. ( Gaspard, GJ; Pasumarthi, KB, 2008) |
| "Isoproterenol (ISO) was given to C57BL mice with or without ARB (olmesartan) treatment and to AT1aR(-/-) mice by a subcutaneously implanted osmotic mini-pump for 11 days at a rate of 15 mg/kg/day." | 1.34 | Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. ( Abe, Y; Fujisawa, Y; Kimura, S; Nagai, Y; Nishiyama, A; Ohmori, K; Zhang, GX, 2007) |
| "Sudden cardiac death is related to adrenergic stress and is independent of the development of fibrosis but occurred only in male mice." | 1.32 | Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T. ( Ikeda, K; Leinwand, LA; Maass, AH; Maier, SK; Oberdorf-Maass, S, 2004) |
| "Cardiac fibrosis was less marked in RV." | 1.30 | Remodelling of cardiac extracellular matrix during beta-adrenergic stimulation: upregulation of SPARC in the myocardium of adult rats. ( Annoni, G; Arosio, B; Fiordaliso, F; Gagliano, N; Latini, R; Luvarà, G; Masson, S; Santambrogio, D; Vergani, C, 1998) |
| "Fibrosis was identified by collagen-specific staining with picrosirius red." | 1.29 | Angiotensin-converting enzyme and wound healing in diverse tissues of the rat. ( Sun, Y; Weber, KT, 1996) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 1.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| "The effects of cardiac hypertrophy on the structure, function and tolerance to ischemia of rat hearts have been investigated." | 1.27 | Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats. ( Brinkman, CJ; Huysmans, HA; Kappetein, AP; Los, GJ; van der Laarse, A; Weening, JJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (1.61) | 18.7374 |
| 1990's | 8 (3.21) | 18.2507 |
| 2000's | 30 (12.05) | 29.6817 |
| 2010's | 132 (53.01) | 24.3611 |
| 2020's | 75 (30.12) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 24 |
| Shang, Z | 1 |
| Liu, A | 1 |
| Emran, T | 1 |
| Chowdhury, NI | 1 |
| Sarker, M | 1 |
| Bepari, AK | 1 |
| Hossain, M | 2 |
| Rahman, GMS | 2 |
| Reza, HM | 2 |
| Wu, J | 8 |
| Fu, Y | 5 |
| Wu, YX | 1 |
| Wu, ZX | 1 |
| Wang, ZH | 1 |
| Li, P | 1 |
| Lim, Y | 1 |
| Jeong, A | 1 |
| Kwon, DH | 1 |
| Lee, YU | 1 |
| Kim, YK | 1 |
| Ahn, Y | 1 |
| Kook, T | 1 |
| Park, WJ | 2 |
| Kook, H | 1 |
| Zhen, D | 1 |
| Na, RS | 1 |
| Wang, Y | 12 |
| Bai, X | 1 |
| Fu, DN | 1 |
| Wei, CX | 1 |
| Liu, MJ | 1 |
| Yu, LJ | 1 |
| Hong, MH | 1 |
| Na, SW | 1 |
| Jang, YJ | 1 |
| Yoon, JJ | 1 |
| Lee, YJ | 2 |
| Lee, HS | 1 |
| Kim, HY | 1 |
| Kang, DG | 1 |
| Syed, AM | 1 |
| Kundu, S | 1 |
| Ram, C | 1 |
| Kulhari, U | 1 |
| Kumar, A | 2 |
| Mugale, MN | 1 |
| Murty, US | 1 |
| Sahu, BD | 1 |
| Li, L | 7 |
| Fang, P | 2 |
| Chen, J | 3 |
| Zhang, C | 4 |
| Tao, H | 4 |
| Yáñez-Bisbe, L | 1 |
| Garcia-Elias, A | 1 |
| Tajes, M | 1 |
| Almendros, I | 1 |
| Rodríguez-Sinovas, A | 1 |
| Inserte, J | 1 |
| Ruiz-Meana, M | 1 |
| Farré, R | 1 |
| Farré, N | 1 |
| Benito, B | 1 |
| Wang, F | 5 |
| Zhang, J | 7 |
| Niu, G | 1 |
| Weng, J | 1 |
| Zhang, Q | 4 |
| Xie, M | 2 |
| Li, C | 1 |
| Sun, K | 1 |
| Fatima, M | 1 |
| Gao, J | 1 |
| Han, T | 1 |
| Ding, Y | 1 |
| Wen, E | 1 |
| Jia, L | 1 |
| Wang, R | 1 |
| Wang, W | 5 |
| Zhao, S | 1 |
| Bai, L | 3 |
| Liu, E | 1 |
| Zhao, M | 1 |
| Han, M | 1 |
| Liang, L | 2 |
| Song, Q | 1 |
| Li, X | 5 |
| Du, Y | 1 |
| Hu, D | 1 |
| Cheng, Y | 1 |
| Wang, QK | 1 |
| Ke, T | 1 |
| Du, XQ | 1 |
| Shi, LP | 1 |
| Chen, ZW | 2 |
| Hu, JY | 1 |
| Zuo, B | 1 |
| Xiong, Y | 1 |
| Cao, WF | 1 |
| Han, X | 3 |
| Kee, HJ | 2 |
| Jeong, MH | 2 |
| Fu, J | 1 |
| Chen, L | 5 |
| Su, C | 1 |
| Feng, X | 1 |
| Huang, K | 1 |
| Zhang, L | 5 |
| Yang, X | 2 |
| Fu, Q | 2 |
| Li, M | 2 |
| Tan, H | 1 |
| Gao, T | 1 |
| Han, L | 1 |
| Teng, X | 1 |
| Zhang, X | 9 |
| Tang, K | 1 |
| Jiao, LM | 1 |
| Qi, YR | 1 |
| Wang, TC | 1 |
| Li, YL | 1 |
| Xu, JL | 1 |
| Wang, ZW | 1 |
| Yu, B | 1 |
| Liu, HM | 1 |
| Zhao, W | 1 |
| Lunardon, G | 1 |
| de Oliveira Silva, T | 1 |
| Lino, CA | 1 |
| Lu, YW | 1 |
| Miranda, JB | 1 |
| Asprino, PF | 1 |
| de Almeida Silva, A | 1 |
| Nepomuceno, GT | 1 |
| Irigoyen, MCC | 1 |
| Carneiro-Ramos, MS | 1 |
| Takano, APC | 1 |
| Martinho, HDS | 1 |
| Barreto-Chaves, MLM | 1 |
| Wang, DZ | 1 |
| Diniz, GP | 1 |
| Li, Z | 14 |
| Chen, K | 1 |
| Zhu, YZ | 1 |
| Liu, Z | 1 |
| Chen, X | 7 |
| Ye, T | 1 |
| Wan, W | 1 |
| Yu, Y | 1 |
| Yang, B | 1 |
| Zhou, W | 3 |
| Xu, JS | 3 |
| Tan, R | 1 |
| You, Q | 1 |
| Cui, J | 3 |
| Wang, M | 2 |
| Song, N | 1 |
| An, K | 1 |
| Lin, L | 1 |
| Adu-Amankwaah, J | 1 |
| Yuan, J | 1 |
| Sun, H | 2 |
| Baka, T | 1 |
| Stanko, P | 1 |
| Repova, K | 1 |
| Aziriova, S | 1 |
| Krajcirovicova, K | 1 |
| Barta, A | 1 |
| Zorad, S | 1 |
| Simko, F | 1 |
| Al-U'datt, DGF | 1 |
| Tranchant, CC | 1 |
| Alu'datt, M | 1 |
| Abusara, S | 1 |
| Al-Dwairi, A | 1 |
| AlQudah, M | 1 |
| Al-Shboul, O | 1 |
| Hiram, R | 1 |
| Altuntas, Y | 1 |
| Jaradat, S | 1 |
| Alzoubi, KH | 1 |
| Sharma, M | 2 |
| Singh, TU | 2 |
| Rana, A | 2 |
| Kumar, T | 2 |
| Gari, M | 2 |
| Mani, P | 1 |
| Lingaraju, MC | 2 |
| Parida, S | 2 |
| Singh, V | 1 |
| Sahoo, M | 1 |
| Kumar, D | 2 |
| Tejedor, S | 1 |
| Buigues, M | 1 |
| González-King, H | 1 |
| Silva, AM | 1 |
| García, NA | 1 |
| Dekker, N | 1 |
| Sepúlveda, P | 1 |
| Yusifov, A | 1 |
| Borders, MO | 1 |
| DeHoff, MA | 1 |
| Polson, SM | 1 |
| Schmitt, EE | 1 |
| Bruns, DR | 1 |
| Kumar Mariappan, A | 1 |
| Xing, Z | 1 |
| Yang, C | 7 |
| Feng, Y | 2 |
| He, J | 1 |
| Peng, C | 1 |
| Li, D | 4 |
| Jin, W | 1 |
| Xue, Y | 1 |
| Ma, Z | 2 |
| Sun, S | 1 |
| Chu, X | 1 |
| Cheng, J | 2 |
| Guan, S | 1 |
| Chu, L | 2 |
| Che, Y | 1 |
| Shen, DF | 2 |
| Wang, ZP | 1 |
| Jin, YG | 1 |
| Wu, QQ | 1 |
| Wang, SS | 2 |
| Yuan, Y | 1 |
| Wei, Y | 1 |
| Wu, Y | 3 |
| Feng, K | 3 |
| Zhao, Y | 3 |
| Tao, R | 1 |
| Xu, H | 4 |
| Tang, Y | 3 |
| Qian, L | 2 |
| Li, J | 9 |
| Ming, H | 1 |
| Fang, L | 2 |
| Li, Y | 6 |
| Zhang, M | 1 |
| Xu, Y | 3 |
| Ban, Y | 1 |
| Zhang, W | 2 |
| Liu, Y | 7 |
| Wang, N | 2 |
| Zhou, X | 6 |
| Park, KH | 1 |
| Yamazaki, D | 1 |
| Lin, PH | 1 |
| Nishi, M | 1 |
| Qiu, L | 1 |
| Murayama, T | 1 |
| Zou, X | 1 |
| Takeshima, H | 1 |
| Zhou, J | 2 |
| Ma, J | 2 |
| Sun, J | 2 |
| Hao, W | 1 |
| Fillmore, N | 1 |
| Ma, H | 1 |
| Springer, D | 1 |
| Yu, ZX | 1 |
| Sadowska, A | 1 |
| Garcia, A | 1 |
| Chen, R | 3 |
| Muniz-Medina, V | 1 |
| Rosenthal, K | 1 |
| Lin, J | 1 |
| Kuruvilla, D | 1 |
| Osbourn, J | 1 |
| Karathanasis, SK | 1 |
| Walker, J | 1 |
| Murphy, E | 1 |
| Leme Goto, P | 1 |
| Cinato, M | 1 |
| Merachli, F | 1 |
| Vons, B | 1 |
| Jimenez, T | 1 |
| Marsal, D | 1 |
| Todua, N | 1 |
| Loi, H | 1 |
| Santin, Y | 1 |
| Cassel, S | 1 |
| Blanzat, M | 1 |
| Tronchere, H | 1 |
| Dejugnat, C | 1 |
| Kunduzova, O | 1 |
| Boal, F | 1 |
| Ren, Q | 1 |
| Lin, P | 1 |
| Wang, Q | 3 |
| Zhang, B | 3 |
| Feng, L | 1 |
| Zhang, N | 3 |
| Sun, Y | 4 |
| Ouyang, F | 1 |
| Liu, X | 4 |
| Liu, G | 1 |
| Qiu, H | 1 |
| He, Y | 2 |
| Hu, H | 2 |
| Jiang, P | 1 |
| Yang, HX | 1 |
| Xu, GR | 1 |
| Sun, JH | 1 |
| Song, JN | 1 |
| Li, YF | 1 |
| Li, AY | 1 |
| Zhao, Z | 1 |
| Liu, H | 1 |
| Guo, D | 1 |
| Zhou, T | 1 |
| Wang, J | 8 |
| Xu, J | 3 |
| Zheng, C | 1 |
| Niu, Y | 1 |
| Wang, C | 1 |
| Xu, F | 1 |
| Yuan, L | 1 |
| Zhao, X | 1 |
| Xu, P | 1 |
| Qian, H | 1 |
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| Cao, L | 2 |
| Althurwi, HN | 1 |
| Abdel-Kader, MS | 1 |
| Alharthy, KM | 1 |
| Salkini, MA | 1 |
| Albaqami, FF | 1 |
| Liu, M | 2 |
| Feng, J | 2 |
| Du, Q | 1 |
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| Ren, S | 2 |
| Li, S | 2 |
| Kim, TH | 1 |
| Kurmangaliyev, YZ | 1 |
| Nasiri, R | 1 |
| Ahadian, S | 1 |
| Nguyen, T | 1 |
| Tan, XHM | 1 |
| Zhou, Y | 1 |
| Wu, R | 1 |
| Rodriguez, A | 1 |
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| Whitelegge, J | 1 |
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| Birk, DE | 1 |
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| Deb, A | 1 |
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| Wei, WY | 1 |
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| Wu, HM | 1 |
| Ma, ZG | 2 |
| Tang, QZ | 4 |
| Sun, D | 1 |
| Chen, Y | 7 |
| Zhan, K | 1 |
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| Yao, X | 2 |
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| Yang, J | 4 |
| Shuai, W | 1 |
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| Viswanadha, VP | 1 |
| Dhivya, V | 1 |
| Beeraka, NM | 1 |
| Huang, CY | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| BAT as a Therapeutic for the Metabolic and Cardiac Dysfunction With Senescence Pilot[NCT03793127] | 24 participants (Actual) | Interventional | 2019-01-23 | Active, not recruiting | |||
| The Effect of Allopurinol on Malondialdehyde, Nitric Oxide, Kidney Injury Molecule-1 Urine Levels, Resistive Index and Renal Elastography in Kidney Stone Patients After Extra Corporeal Shockwave Lithotripsy[NCT05414669] | Phase 4 | 35 participants (Actual) | Interventional | 2020-08-06 | Completed | ||
| A Prospective Randomized Placebo-controlled Study of the Effect of Eplerenone on Left Ventricular Diastolic Function in Women Receiving Anthracycline Therapy for Breast Cancer[NCT01708798] | Phase 2/Phase 3 | 44 participants (Actual) | Interventional | 2014-05-31 | Terminated (stopped due to Futility) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for isoproterenol and Fibrosis
| Article | Year |
|---|---|
Inhibition of myocardial hypertrophy by magnesium isoglycyrrhizinate through the TLR4/NF-κB signaling pathway in mice.
Topics: Animals; Anti-Inflammatory Agents; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Creatine K | 2018 |
Isoproterenol-induced cardiac ischemia and fibrosis: Plant-based approaches for intervention.
Topics: Alkaloids; Animals; Fibrosis; Flavonoids; Glycosides; Heart; Humans; Isoproterenol; Myocardial Infar | 2018 |
247 other studies available for isoproterenol and Fibrosis
| Article | Year |
|---|---|
Angiotensin-(3-7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiovascular Agents; Cells, Cultured; Cyclic AMP; Cyclic AM | 2021 |
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carnitine; Disease Models, Animal; Fibrosis; Inflam | 2021 |
Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis.
Topics: Amaryllidaceae Alkaloids; Animals; Apoptosis; Cytokines; Fibrosis; Heart; Heart Diseases; Inflammati | 2021 |
P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation.
Topics: Acetylation; Actins; Animals; Cell Movement; Cell Nucleus; Collagen Type I; Collagen Type I, alpha 1 | 2021 |
Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics.
Topics: Animals; Ethanol; Fibrosis; Heart Failure; Isoproterenol; Male; Mitochondrial Dynamics; Myocardium; | 2022 |
Betulinic Acid Improves Cardiac-Renal Dysfunction Caused by Hypertrophy through Calcineurin-NFATc3 Signaling.
Topics: Animals; Betulinic Acid; Biomarkers; Calcineurin; Cardiomegaly; Fibrosis; Heart; Heart Ventricles; I | 2021 |
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response.
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Cardiomegaly; Cathartics; Emodin; Fibrosis; Isoprot | 2022 |
Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice.
Topics: Animals; Cardiomegaly; Fibrosis; Isoproterenol; Mice; Morphinans; NF-kappa B; Stroke Volume; Superox | 2021 |
Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy.
Topics: Aging; Animals; Cardiomyopathies; Collagen; Disease Models, Animal; Female; Fibrosis; Gene Expressio | 2021 |
Apigenin inhibits isoproterenol-induced myocardial fibrosis and Smad pathway in mice by regulating oxidative stress and miR-122-5p/155-5p expressions.
Topics: Animals; Apigenin; Cardiomyopathies; Collagen; Fibrosis; Isoproterenol; Mice; MicroRNAs; NF-kappa B; | 2022 |
MED1 Deficiency in Macrophages Aggravates Isoproterenol-Induced Cardiac Fibrosis in Mice.
Topics: Animals; Fibrosis; Isoproterenol; Macrophages; Mediator Complex Subunit 1; Mice; Mice, Inbred C57BL; | 2022 |
Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling.
Topics: Animals; Arrhythmias, Cardiac; Connexin 43; Fibrosis; Isoproterenol; Mice; Mice, Knockout; NAV1.5 Vo | 2022 |
Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice
Topics: Akkermansia; Amino Acids; Animals; Bacteroidetes; Feces; Fibrosis; Gastrointestinal Microbiome; Isop | 2022 |
Syringic acid mitigates isoproterenol-induced cardiac hypertrophy and fibrosis by downregulating Ereg.
Topics: Animals; Cardiomegaly; Fibrosis; Gallic Acid; Isoproterenol; Mice; Myocardium | 2022 |
PGE2 protects against heart failure through inhibiting TGF-β1 synthesis in cardiomyocytes and crosstalk between TGF-β1 and GRK2.
Topics: Animals; Dinoprostone; Fibrosis; Heart Diseases; Heart Failure; Isoproterenol; Male; Mice; Mice, Inb | 2022 |
Gypensapogenin I Ameliorates Isoproterenol (ISO)-Induced Myocardial Damage through Regulating the TLR4/NF-κB/NLRP3 Pathway.
Topics: Animals; Cardiomyopathies; Fibrosis; Isoproterenol; Mice; Mice, Inbred C57BL; Molecular Docking Simu | 2022 |
Discovery of Novel Pyrazole-Based KDM5B Inhibitor
Topics: Animals; DNA-Binding Proteins; Fibrosis; Isoproterenol; Jumonji Domain-Containing Histone Demethylas | 2022 |
Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Fibrosis; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Mi | 2022 |
Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway.
Topics: Animals; Cardiovascular Diseases; Fibrosis; Isoproterenol; Myocytes, Cardiac; Pyroptosis; Rats; Sign | 2022 |
Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Caspase 1; Collagen Type I; Connexins; Disease Mode | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sophocarpine Alleviates Isoproterenol-Induced Kidney Injury by Suppressing Inflammation, Apoptosis, Oxidative Stress and Fibrosis.
Topics: Alkaloids; Animals; Apoptosis; Fibrosis; Inflammation; Isoproterenol; Kidney; Mice; NF-E2-Related Fa | 2022 |
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
Topics: Animals; Cardiomyopathies; Fibrosis; Heart Failure; Isoproterenol; Matrix Metalloproteinase 2; Mice; | 2023 |
Ivabradine curbs isoproterenol-induced kidney fibrosis.
Topics: Animals; Collagen Type I; Fibrosis; Heart Rate; Isoproterenol; Ivabradine; Kidney; Kidney Diseases; | 2023 |
Inhibition of transglutaminase 2 (TG2) ameliorates ventricular fibrosis in isoproterenol-induced heart failure in rats.
Topics: Animals; Chromatography, Liquid; Collagen; Creatinine; Cystamine; Fibrosis; Heart Failure; Isoproter | 2023 |
Biochanin-A alleviates fibrosis and inflammation in cardiac injury in mice.
Topics: Animals; Collagen; Collagen Type I; Fibrosis; Heart Injuries; Inflammation; Isoproterenol; Lipids; M | 2023 |
Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis.
Topics: Animals; Extracellular Vesicles; Fibrosis; Humans; Isoproterenol; Mesenchymal Stem Cells; Mice; Onco | 2023 |
Juvenile physical activity protects against isoproterenol-induced cardiac dysfunction later in life.
Topics: Animals; Exercise; Female; Fibrosis; Heart Diseases; Isoproterenol; Male; Mice; Motor Activity; Myoc | 2023 |
Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model.
Topics: Animals; Body Weight; Collagen; Fibrosis; Isoproterenol; Mice; Pravastatin; Transforming Growth Fact | 2023 |
Understanding aconite's anti-fibrotic effects in cardiac fibrosis.
Topics: Aconitum; Animals; Cardiomyopathies; Collagen; Fibrosis; Galactose; Isoproterenol; Myocardium; Rats; | 2024 |
Crocin attenuates isoprenaline-induced myocardial fibrosis by targeting TLR4/NF-κB signaling: connecting oxidative stress, inflammation, and apoptosis.
Topics: Animals; Anti-Inflammatory Agents; Cardiomyopathies; Cardiotonic Agents; Carotenoids; Fibrosis; Isop | 2020 |
Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats.
Topics: Animals; Berberine; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Coculture Techniqu | 2019 |
Astragaloside IV inhibits cardiac fibrosis via miR-135a-TRPM7-TGF-β/Smads pathway.
Topics: Animals; Animals, Newborn; Astragalus Plant; Cardiomyopathy, Hypertrophic; Cells, Cultured; Disease | 2020 |
GHSR deficiency exacerbates cardiac fibrosis: role in macrophage inflammasome activation and myofibroblast differentiation.
Topics: Animals; Cardiomyopathies; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Extra | 2020 |
TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle.
Topics: Animals; Calcium; Calcium Signaling; Cardiotonic Agents; Electrocardiography; Endoplasmic Reticulum; | 2020 |
Human Relaxin-2 Fusion Protein Treatment Prevents and Reverses Isoproterenol-Induced Hypertrophy and Fibrosis in Mouse Heart.
Topics: Animals; Cardiomegaly; Fibrosis; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Myocardium | 2019 |
In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin.
Topics: Animals; Apelin; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cell Hypoxia; Cell Line; Diabetic Card | 2020 |
Chronic peripheral ghrelin injection exerts antifibrotic effects by increasing growth differentiation factor 15 in rat hearts with myocardial fibrosis induced by isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Disease Models, Animal; Fibrosis; Ghrelin; Grow | 2020 |
LncRNA ROR facilitates myocardial fibrosis in rats with viral myocarditis through regulating C-Myc expression.
Topics: Animals; Fibrosis; Isoproterenol; Male; Myocarditis; Myocardium; Proto-Oncogene Proteins c-myc; Rats | 2019 |
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Topics: Animals; Biomarkers; Biopsy; Cardiomyopathies; Disease Models, Animal; Disease Susceptibility; Extra | 2020 |
The aqueous extract of Gentianella acuta improves isoproterenol‑induced myocardial fibrosis via inhibition of the TGF‑β1/Smads signaling pathway.
Topics: Actins; Animals; Collagen; Fibrosis; Gentianella; Isoproterenol; Male; Models, Biological; Myocardiu | 2020 |
Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways.
Topics: Amides; Angiotensin II; Animals; Apoptosis; Blotting, Western; Cardiomegaly; Disease Models, Animal; | 2020 |
A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging.
Topics: Animals; Cardiomyopathies; Cells, Cultured; Electron Transport; Fibrosis; Fluorescent Dyes; Humans; | 2020 |
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Topics: Animals; Cardiomegaly; Fibrosis; Heart Failure; Humans; Isoproterenol; Leupeptins; Lysine; Male; Mic | 2020 |
Cymbopogon Proximus Essential Oil Protects Rats against Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis.
Topics: Animals; Atrial Natriuretic Factor; Cardiomegaly; Collagen Type I; Collagen Type III; Cymbopogon; Fi | 2020 |
Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Down-Regulation; Fibrosis; Gene Expression Regula | 2020 |
Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.
Topics: Animals; Cicatrix; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Collagen Type | 2020 |
Matrine attenuates pathological cardiac fibrosis via RPS5/p38 in mice.
Topics: Alkaloids; Animals; Cardiomyopathies; Cardiotonic Agents; Cell Movement; Cell Proliferation; Cell Tr | 2021 |
Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Collagen; Drugs, Chinese Herbal; Echocardiograp | 2020 |
Deletion of Microfibrillar-Associated Protein 4 Attenuates Left Ventricular Remodeling and Dysfunction in Heart Failure.
Topics: Adrenergic beta-Agonists; Animals; Aorta; Biomechanical Phenomena; Cardiomegaly; Carrier Proteins; C | 2020 |
The protective effect of piperine against isoproterenol-induced inflammation in experimental models of myocardial toxicity.
Topics: Adrenergic beta-Agonists; Alkaloids; Animals; Benzodioxoles; Cardiomegaly; Cytokines; Endothelium; F | 2020 |
α-Galactosylceramide and its analog OCH differentially affect the pathogenesis of ISO-induced cardiac injury in mice.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Cytokines; Fibrosis; Galactosylceramides; Glycolipids; In | 2020 |
Rat pancreatectomy combined with isoprenaline or uninephrectomy as models of diabetic cardiomyopathy or nephropathy.
Topics: Albuminuria; Animals; C-Peptide; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Diabeti | 2020 |
Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway.
Topics: Animals; Disease Models, Animal; Fibrosis; Flavonoids; Hypertrophy, Left Ventricular; Isoproterenol; | 2021 |
Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.
Topics: Adaptive Immunity; Adoptive Transfer; Animals; Dendritic Cells; Disease Models, Animal; Female; Fibr | 2021 |
MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo.
Topics: 3' Untranslated Regions; Animals; Animals, Newborn; Apoptosis; Base Sequence; Cardiomegaly; Disease | 2021 |
Huoxin Pill () Attenuates Cardiac Fibrosis by Suppressing TGF-β1/Smad2/3 Pathway in Isoproterenol-Induced Heart Failure Rats.
Topics: Animals; Drugs, Chinese Herbal; Fibrosis; Heart Failure; Isoproterenol; Rats; Rats, Wistar; Signal T | 2021 |
Appearance of Heterogeneous Macrophages During Development of Isoproterenol-Induced Rat Myocardial Fibrosis.
Topics: Animals; Fibrosis; Inflammation; Isoproterenol; Macrophages; Rats; Rats, Inbred F344 | 2021 |
MicroRNA‑331 inhibits isoproterenol‑induced expression of profibrotic genes in cardiac myofibroblasts via the TGFβ/smad3 signaling pathway.
Topics: 3' Untranslated Regions; Animals; Biomarkers; Cardiotonic Agents; Cells, Cultured; Fibrosis; Gene Ex | 2021 |
CTRP12 Alleviates Isoproterenol Induced Cardiac Fibrosis via Inhibiting the Activation of P38 Pathway.
Topics: Adipokines; Animals; Fibroblasts; Fibrosis; Heart Diseases; Humans; Isoproterenol; Male; Mice; Mice, | 2021 |
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.
Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Fibrosis; Ginsenosides; Isoproterenol | 2021 |
Pinoresinol diglucoside (PDG) attenuates cardiac hypertrophy via AKT/mTOR/NF-κB signaling in pressure overload-induced rats.
Topics: Animals; Animals, Newborn; Aorta, Abdominal; Cardiomegaly; Constriction, Pathologic; Disease Models, | 2021 |
Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation.
Topics: Acetylation; Animals; Cardiotonic Agents; Fibrosis; Heart Diseases; Isoproterenol; Male; Mice; Mice, | 2021 |
Higenamine attenuates cardiac fibroblast abstract and fibrosis via inhibition of TGF-β1/Smad signaling.
Topics: Actins; Adrenergic beta-Agonists; Alkaloids; Animals; Aorta; Apoptosis; Cardiomegaly; Fibrinolytic A | 2021 |
Origanum majorana L. Extract Protects Against Isoproterenol-Induced Cardiotoxicity in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cardiotoxicity; Disease Models, Animal; | 2021 |
Periplocymarin protects against myocardial fibrosis induced by β-adrenergic activation in mice.
Topics: Adrenergic beta-Agonists; Animals; Cardiac Glycosides; Cardiomyopathies; Cyclooxygenase 2; Echocardi | 2021 |
Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-β/Smads pathway.
Topics: Animals; Cardiotonic Agents; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; | 2021 |
Cardiac Fibroblasts Mediate a Sexually Dimorphic Fibrotic Response to β-Adrenergic Stimulation.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Disease Progression; Female; Fibroblasts; | 2021 |
C188-9 reduces TGF-β1-induced fibroblast activation and alleviates ISO-induced cardiac fibrosis in mice.
Topics: Animals; Fibroblasts; Fibrosis; Isoproterenol; Mice; Myocardium; Transforming Growth Factor beta1 | 2021 |
Inhibition of double stranded RNA dependent protein kinase (PKR) abrogates isoproterenol induced myocardial ischemia in vitro in cultured cardiomyocytes and in vivo in wistar rats.
Topics: Animals; Cell Line; Disease Models, Animal; eIF-2 Kinase; Fibrosis; Heart; Humans; Isoproterenol; Ma | 2021 |
Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Autophagy; Autophagy-Related Proteins; Case-Control | 2021 |
Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.
Topics: Animals; Cardiomyopathies; Disease Models, Animal; Female; Fibrosis; Isoproterenol; Mice, Inbred mdx | 2021 |
Thymoquinone dose-dependently attenuates myocardial injury induced by isoproterenol in rats via integrated modulations of oxidative stress, inflammation, apoptosis, autophagy, and fibrosis.
Topics: Animals; Antioxidants; Apoptosis; Autophagy; Benzoquinones; Cardiotonic Agents; Disease Progression; | 2021 |
Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage.
Topics: Aniline Compounds; Animals; Cellular Reprogramming; Disease Models, Animal; Fatty Acids; Fibrosis; H | 2021 |
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Camphanes; Cardiotoxicity; Cell Line; Di | 2021 |
Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways.
Topics: Angiotensin II; Animals; Apoptosis; Cell Line; Extracellular Signal-Regulated MAP Kinases; Fibrosis; | 2021 |
Immune cell β
Topics: Adoptive Transfer; Animals; Bone Marrow Transplantation; Cell Death; Cell Proliferation; Cells, Cult | 2021 |
Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways.
Topics: Alkaloids; Angiotensin II; Anilides; Animals; Benzodioxoles; Cell Differentiation; Cells, Cultured; | 2017 |
Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats.
Topics: Aging; Animals; Fibrosis; Isoproterenol; Male; Oxidative Stress; Rats; Rats, Long-Evans; Ubiquinone; | 2017 |
IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult.
Topics: Adrenergic beta-Agonists; Animals; Cytokines; Fibrosis; Heart; Humans; Inflammasomes; Inflammation; | 2018 |
Imatinib attenuates cardiac fibrosis by inhibiting platelet-derived growth factor receptors activation in isoproterenol induced model.
Topics: Animals; Cell Survival; Cells, Cultured; Echocardiography; Fibrosis; Gene Expression; Heart Diseases | 2017 |
Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways.
Topics: Animals; Collagen Type I; Collagen Type III; Fibrosis; Fusaric Acid; Heart Failure; Isoproterenol; J | 2017 |
Relaxin Ameliorates Renal Fibrosis and Expression of Endothelial Cell Transition Markers in Rats of Isoproterenol-Induced Heart Failure.
Topics: Animals; Biomarkers; Blotting, Western; Collagen; Dose-Response Relationship, Drug; Endothelial Cell | 2017 |
PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Fibrosis; Gold; Heart; Interleukin-6; Isoproterenol | 2017 |
Shikonin ameliorates isoproterenol (ISO)-induced myocardial damage through suppressing fibrosis, inflammation, apoptosis and ER stress.
Topics: Animals; Apoptosis; Cardiomyopathies; Caspase 3; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2017 |
MiR-30e Attenuates Isoproterenol-induced Cardiac Fibrosis Through Suppressing Snai1/TGF-β Signaling.
Topics: Animals; Fibrosis; Isoproterenol; Male; MicroRNAs; Myocardium; Rats; Rats, Sprague-Dawley; Signal Tr | 2017 |
Renal sympathetic denervation alleviates myocardial fibrosis following isoproterenol-induced heart failure.
Topics: Animals; Biomarkers; Connective Tissue Growth Factor; Disease Models, Animal; Echocardiography; Fibr | 2017 |
The Effects of Periostin in a Rat Model of Isoproterenol: Mediated Cardiotoxicity.
Topics: Animals; Apoptosis; Cardiotoxicity; Cell Adhesion Molecules; Cell Proliferation; Cytoprotection; Dis | 2018 |
The Aldosterone Receptor Antagonist Eplerenone Inhibits Isoproterenol-Induced Collagen-I and 11β-HSD1 Expression in Rat Cardiac Fibroblasts and the Left Ventricle.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenergic beta-Agonists; Animals; Cells, Cultured; Col | 2017 |
Oligomeric proanthocyanidins protect myocardium by mitigating left ventricular remodeling in isoproterenol-induced postmyocardial infarction.
Topics: Animals; Antioxidants; Bone Morphogenetic Protein 4; Cardiovascular Agents; Collagen; Disease Models | 2018 |
Pin1 facilitates isoproterenol‑induced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2‑ERK1/2 signal transduction pathway in rats.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antioxidants; Collagen; Extracellular Signal-Regulate | 2018 |
Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Topics: Activating Transcription Factor 6; Animals; Cardiomyopathy, Hypertrophic; Cells, Cultured; Extracell | 2018 |
Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.
Topics: Acetamides; Animals; Azepines; Cardiotonic Agents; Dogs; Fibrosis; Heart Diseases; Humans; Hydrophob | 2018 |
Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats.
Topics: Aminobutyrates; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Disease Models, Anima | 2019 |
MicroRNA-135a inhibits cardiac fibrosis induced by isoproterenol via TRPM7 channel.
Topics: Animals; Cell Differentiation; Cell Proliferation; Collagen Type I; Down-Regulation; Fibroblasts; Fi | 2018 |
Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.
Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Disease Models, Animal; Drugs, Chinese Herbal; Fi | 2018 |
Age-related changes in cardiac electrophysiology and calcium handling in response to sympathetic nerve stimulation.
Topics: Action Potentials; Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Calcium; Electric Stimul | 2018 |
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
Topics: Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Fibr | 2018 |
Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction.
Topics: Animals; Atrial Natriuretic Factor; Cardiovascular Agents; Collagen Type I; Collagen Type III; Disea | 2019 |
Mechanistic insights to the cardioprotective effect of blueberry nutraceutical extract in isoprenaline-induced cardiac hypertrophy.
Topics: Animals; Blueberry Plants; Cardiomegaly; Cardiotonic Agents; Catalase; Dietary Supplements; Fibrosis | 2018 |
Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mTOR.
Topics: Animals; Autophagy; Beclin-1; Cardiomegaly; Curcumin; Fibrosis; Isoproterenol; Male; Myocardium; Rat | 2018 |
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibr | 2018 |
Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis.
Topics: Angiotensin II; Animals; Collagen; Diterpenes; Down-Regulation; Enzyme Activation; Epoxy Compounds; | 2019 |
Phosphocreatine Attenuates Isoproterenol-Induced Cardiac Fibrosis and Cardiomyocyte Apoptosis.
Topics: Animals; Apoptosis; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Heart Diseases; Hu | 2019 |
Syringic acid protects from isoproterenol induced cardiotoxicity in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers; Biphenyl Compounds; Body Weight; Cardiotoxicity; Cyt | 2019 |
Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cardiomyopathies; Cell Line; Diterpene | 2019 |
2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.
Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Blood Pressure; Fibrosis; Glomerular Filtration Rate; H | 2019 |
Contrasting Effects of Inhibition of Phosphodiesterase 3 and 5 on Cardiac Function and Interstitial Fibrosis in Rats With Isoproterenol-Induced Cardiac Dysfunction.
Topics: Animals; Arrhythmias, Cardiac; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; | 2019 |
MiR-1a-3p mitigates isoproterenol-induced heart failure by enhancing the expression of mitochondrial ND1 and COX1.
Topics: Animals; Antagomirs; Apoptosis; Electron Transport Complex IV; Fibrosis; Heart Failure; Intracellula | 2019 |
Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cardiomyopat | 2019 |
Exercise Attenuates Acute β-Adrenergic Overactivation-Induced Cardiac Fibrosis by Modulating Cytokines.
Topics: Animals; Cytokines; Disease Models, Animal; Exercise Therapy; Fibrosis; Gene Expression Regulation; | 2019 |
Overexpression of lncRNA GAS5 attenuates cardiac fibrosis through regulating PTEN/MMP-2 signal pathway in mice.
Topics: Actins; Adrenergic beta-Antagonists; Animals; Collagen Type I; Echocardiography; Fibrosis; Heart Dis | 2019 |
Gold Nanoparticles for Targeting the Fibrotic Heart: A Probe Indicating Vascular Permeability.
Topics: Animals; Capillary Permeability; Fibrosis; Gold; Heart; Isoproterenol; Metal Nanoparticles; Mice | 2019 |
Dissection of mechanisms of Chinese medicinal formula Si-Miao-Yong-an decoction protects against cardiac hypertrophy and fibrosis in isoprenaline-induced heart failure.
Topics: Animals; Cardiomegaly; Cell Line; Doxorubicin; Drugs, Chinese Herbal; Fibrosis; Heart Failure; Isopr | 2020 |
The cardioprotective effects of icariin on the isoprenaline-induced takotsubo-like rat model: Involvement of reactive oxygen species and the TLR4/NF-κB signaling pathway.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Echocardiography; Fibrosis; Flavonoids; Humans; | 2019 |
Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.
Topics: Animals; Biopsy, Needle; Disease Models, Animal; Echocardiography; Endocardium; Fibrosis; Germany; H | 2019 |
SIRT1 activation attenuates cardiac fibrosis by endothelial-to-mesenchymal transition.
Topics: Animals; Cardiomegaly; Cell Line; Cell Nucleus; Collagen; Down-Regulation; Endothelium; Fibrosis; Is | 2019 |
HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Cell Line; Disease Models, Animal; ELAV-Like P | 2020 |
Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.
Topics: Animals; Calcium Signaling; Calcium-Binding Proteins; Cardiac Pacing, Artificial; Cardiomegaly; Dise | 2013 |
[Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline-treated rats].
Topics: Animals; Connexin 43; Fibrosis; Gene Expression Regulation; Glutamine; Heart Atria; HSP70 Heat-Shock | 2013 |
No overt structural or functional changes associated with PEG-coated gold nanoparticles accumulation with acute exposure in the mouse heart.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cardiotoxins; Disease Models, Animal; Drug Delivery | 2013 |
Adenosine prevents isoprenaline-induced cardiac contractile and electrophysiological dysfunction.
Topics: Adenosine; Animals; Biomarkers; Electrophysiological Phenomena; Fibrosis; Heart; Isoproterenol; Lipi | 2013 |
Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo.
Topics: Aged; Animals; Antigens, Neoplasm; Apoptosis; Biomarkers, Tumor; Chemokine CCL7; Female; Fibrosis; H | 2014 |
A novel β-adrenergic response element regulates both basal and agonist-induced expression of cyclin-dependent kinase 1 gene in cardiac fibroblasts.
Topics: Adrenergic beta-Agonists; Animals; CCAAT-Binding Factor; CDC2 Protein Kinase; Cell Proliferation; Ce | 2014 |
Deletion of CXCR4 in cardiomyocytes exacerbates cardiac dysfunction following isoproterenol administration.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Chemokine CXCL12; De | 2014 |
Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction.
Topics: Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Female; Fibrosis; GATA T | 2014 |
HIP-55/DBNL-dependent regulation of adrenergic receptor mediates the ERK1/2 proliferative pathway.
Topics: Animals; Animals, Newborn; Cell Proliferation; Cells, Cultured; Fibroblasts; Fibrosis; Gene Expressi | 2014 |
Exercise protects against chronic β-adrenergic remodeling of the heart by activation of endothelial nitric oxide synthase.
Topics: Animals; Cardiomegaly; Fibrosis; Heart; Hemodynamics; Isoproterenol; Mice; Mice, Inbred C57BL; Myoca | 2014 |
Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy.
Topics: Adrenergic beta-Agonists; Age Factors; Animals; Calcium; Calcium Channels, L-Type; Calcium-Binding P | 2014 |
Apocynin attenuates isoproterenol-induced myocardial injury and fibrogenesis.
Topics: Acetophenones; Animals; Antioxidants; Cardiomyopathies; Female; Fibrosis; Humans; Isoproterenol; Mal | 2014 |
Danshensu inhibits β-adrenergic receptors-mediated cardiac fibrosis by ROS/p38 MAPK axis.
Topics: Adrenergic beta-Agonists; Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Collagen T | 2014 |
DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.
Topics: Actins; Animals; Animals, Newborn; Azacitidine; Cells, Cultured; Collagen Type I; Collagen Type I, a | 2014 |
Toll-like receptor 4 knockout protects against isoproterenol-induced cardiac fibrosis: the role of autophagy.
Topics: Animals; Autophagy; Cardiotonic Agents; Fibrosis; Heart Diseases; Isoproterenol; Male; Mice; Mice, I | 2015 |
Changes in cardiac aldosterone and its synthase in rats with chronic heart failure: an intervention study of long-term treatment with recombinant human brain natriuretic peptide.
Topics: Aldosterone; Animals; Cardiotonic Agents; Chronic Disease; Collagen; Cytochrome P-450 CYP11B2; Disea | 2014 |
Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathies; Cell Size; Diseas | 2014 |
Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats.
Topics: Actins; Animals; Apigenin; Basic Helix-Loop-Helix Transcription Factors; Calcium-Binding Proteins; D | 2014 |
Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs.
Topics: Animals; Antioxidants; Cardiomegaly; Fibrosis; Guanidines; Heart Ventricles; Isoproterenol; Male; Ma | 2014 |
Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Chromosome Mapping; Female; Fibrosis; Genetic Loci; | 2015 |
Temporal and gefitinib-sensitive regulation of cardiac cytokine expression via chronic β-adrenergic receptor stimulation.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomegaly; Cells, Cultured; Chemokine CCL2; ErbB Re | 2015 |
[Activation of transcription factor NF-κB in a rat model of cardiac fibrosis induced by β-adrenoceptor stimulation].
Topics: Animals; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; Interleukin-6; Isopro | 2014 |
[Establishment of a FVB/N mouse model of cardiac hypertrophy by isoprenaline].
Topics: Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Isoproterenol; Mice; Mice, Inbred Strains | 2014 |
Mst1 inhibition rescues β1-adrenergic cardiomyopathy by reducing myocyte necrosis and non-myocyte apoptosis rather than myocyte apoptosis.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Blotting, Western; Cardiomyopathies; Disease Models, A | 2015 |
Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy.
Topics: Animals; Biomarkers; Cardiomyopathies; Cats; Cell Proliferation; Cells, Cultured; Disease Models, An | 2015 |
Nitric oxide synthase inhibition abolishes exercise-mediated protection against isoproterenol-induced cardiac hypertrophy in female mice.
Topics: Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Echocardiography; Enzyme Inhibitors; | 2015 |
A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway.
Topics: Animals; Animals, Newborn; Cell Proliferation; Dose-Response Relationship, Drug; Drugs, Chinese Herb | 2015 |
l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
Topics: Amidohydrolases; Animals; Arginine; Cardiomyopathies; Cardiotonic Agents; Disease Models, Animal; Do | 2015 |
Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy.
Topics: Adipose Tissue, Brown; Animals; Biomarkers; Blood Pressure; Body Weight; Cardiomyopathies; Cardioton | 2015 |
Triptolide alleviates isoprenaline-induced cardiac remodeling in rats via TGF-β1/Smad3 and p38 MAPK signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiotonic Agents; Diterpenes; Ep | 2015 |
CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calcium-Cal | 2015 |
Xanthine Oxidase Inhibitor, Allopurinol, Prevented Oxidative Stress, Fibrosis, and Myocardial Damage in Isoproterenol Induced Aged Rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Allopurinol; Animals; Aspartate Aminotransferases; Body | 2015 |
Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway.
Topics: Animals; Biomarkers; Cardiomegaly; Creatine Kinase, MB Form; Cytoprotection; Disease Models, Animal; | 2015 |
Roles of heat shock factor 1 in isoproterenol‑induced myocardial fibrosis in mice.
Topics: Animals; Cardiomyopathies; Collagen; Disease Models, Animal; DNA-Binding Proteins; Fibrosis; Gene Ex | 2015 |
Relaxin inhibits cardiac fibrosis and endothelial-mesenchymal transition via the Notch pathway.
Topics: Animals; Cardiomyopathies; Cell Movement; Cells, Cultured; Collagen; Dipeptides; Disease Models, Ani | 2015 |
HDAC6 Promotes Cardiac Fibrosis Progression through Suppressing RASSF1A Expression.
Topics: Actins; Anilides; Animals; Cell Proliferation; Cells, Cultured; Collagen Type I; Collagen Type I, al | 2016 |
Heterozygous deletion of sarcolipin maintains normal cardiac function.
Topics: Adrenergic beta-Agonists; Animals; Calcium Signaling; Female; Fibrosis; Gene Deletion; Genotype; Het | 2016 |
Bone marrow mesenchymal stromal cells with CD47 high expression via the signal transducer and activators of transcription signaling pathway preventing myocardial fibrosis.
Topics: Animals; Antibodies, Bispecific; Cardiomyopathies; CD47 Antigen; Cells, Cultured; Collagen; Disease | 2015 |
Renal Denervation Findings on Cardiac and Renal Fibrosis in Rats with Isoproterenol Induced Cardiomyopathy.
Topics: Angiotensin II; Animals; Biomarkers; Cardiomyopathies; Cytokines; Denervation; Fibrosis; Heart Atria | 2015 |
MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Binding Sites; Cell Proliferation; Collagen; Conser | 2015 |
Inhibition of Galectin-3 Pathway Prevents Isoproterenol-Induced Left Ventricular Dysfunction and Fibrosis in Mice.
Topics: Animals; Disease Models, Animal; Echocardiography; Fibrosis; Galectin 3; Gene Expression Regulation; | 2016 |
Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease.
Topics: Adrenergic beta-Agonists; Aging; Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Fibrosis; | 2016 |
[Effects of renal denervation on left atrial fibrosis in rats with isoproterenol induced chronic heart failure].
Topics: Animals; Denervation; Fibrosis; Heart Atria; Heart Failure; Isoproterenol; Kidney; Male; Rats; Rats, | 2015 |
Curcumin reduces cardiac fibrosis by inhibiting myofibroblast differentiation and decreasing transforming growth factor β1 and matrix metalloproteinase 9 / tissue inhibitor of metalloproteinase 1.
Topics: Angiotensin II; Animals; Cell Differentiation; Cell Proliferation; Collagen Type I; Collagen Type II | 2017 |
Epigenetic factors MeCP2 and HDAC6 control α-tubulin acetylation in cardiac fibroblast proliferation and fibrosis.
Topics: Acetylation; Actins; Animals; Becaplermin; Cell Cycle; Cell Proliferation; Cell Survival; Collagen T | 2016 |
Downregulation of β-Adrenoceptors in Isoproterenol-Induced Cardiac Remodeling through HuR.
Topics: 3' Untranslated Regions; Animals; Cardiomegaly; Cells, Cultured; Down-Regulation; ELAV-Like Protein | 2016 |
Paricalcitol Attenuates Cardiac Fibrosis and Expression of Endothelial Cell Transition Markers in Isoproterenol-Induced Cardiomyopathic Rats.
Topics: Actins; Animals; Cardiomyopathies; Disease Models, Animal; Endothelial Cells; Epithelial-Mesenchymal | 2016 |
Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice.
Topics: Animals; Atrial Remodeling; Fibrosis; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoprot | 2016 |
Cardiac Specific Overexpression of hHole Attenuates Isoproterenol-Induced Hypertrophic Remodeling through Inhibition of Extracellular Signal-Regulated Kinases (ERKs) Signalling.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Humans; Intracellular Signaling Peptides an | 2016 |
Increased 4-hydroxy-2-nonenal-induced proteasome dysfunction is correlated with cardiac damage in streptozotocin-injected rats with isoproterenol infusion.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Animals; Cell Line; Diabetes Mellitus, Experimenta | 2016 |
Transgenic overexpression of transient receptor potential vanilloid subtype 1 attenuates isoproterenol-induced myocardial fibrosis in mice.
Topics: Animals; Cyclic GMP; Fibroblasts; Fibrosis; Hemodynamics; Isoproterenol; Male; Mice, Inbred C57BL; M | 2016 |
Exacerbated cardiac fibrosis induced by β-adrenergic activation in old mice due to decreased AMPK activity.
Topics: Adrenergic beta-Agonists; Aging; AMP-Activated Protein Kinases; Animals; Fibrosis; Heart; Isoprotere | 2016 |
Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Gallic Acid; Gene Expressi | 2016 |
Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.
Topics: A Kinase Anchor Proteins; Animals; Calcineurin; Calcium Signaling; Calcium-Binding Proteins; Cardiom | 2017 |
Lumican-null mice are susceptible to aging and isoproterenol-induced myocardial fibrosis.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Caspase 3; Chondroitin Sulfate Proteoglycans; Collage | 2017 |
Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway.
Topics: Amidohydrolases; Animals; Biomarkers; Cardiotonic Agents; Disease Models, Animal; Fibrosis; Heart Fa | 2017 |
miR-29c is implicated in the cardioprotective activity of Panax notoginseng saponins against isoproterenol-induced myocardial fibrogenesis.
Topics: Animals; Cardiotonic Agents; Drugs, Chinese Herbal; Fibrosis; Isoproterenol; Male; Mice; Mice, Inbre | 2017 |
Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.
Topics: Animals; Antioxidants; Cardiomyopathies; Cardiotonic Agents; Extracellular Matrix Proteins; Fibrosis | 2017 |
Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis.
Topics: Animals; Astragalus Plant; Cell Proliferation; Collagen Type I; Female; Fibroblasts; Fibrosis; Heart | 2017 |
Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantation.
Topics: Adrenergic beta-Agonists; Animals; Bone Marrow Transplantation; Cardiomyopathies; Cell Differentiati | 2008 |
The influence of gender on cardiac fibrosis induced by sympathetic stimulation.
Topics: Animals; Dobutamine; Dose-Response Relationship, Drug; Female; Fibrosis; Heart; Isoproterenol; Male; | 2008 |
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism.
Topics: Animals; Cardiomegaly; Cell Proliferation; Chemokine CCL2; Collagen; Endothelin-1; Fibroblasts; Fibr | 2008 |
[Expression and implication of angiotensin II type 1 receptor in myocardial fibrosis of rats].
Topics: Animals; Aspartate Aminotransferases; Cardiomyopathies; Cell Differentiation; Creatine Kinase; Fibro | 2008 |
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin.
Topics: Animals; Anti-Inflammatory Agents; Blood Pressure; Body Weight; Cardiac Output; Cardiomegaly; Cardio | 2009 |
Targeted expression of receptor-associated late transducer inhibits maladaptive hypertrophy via blocking epidermal growth factor receptor signaling.
Topics: Adenoviridae; Angiotensin II; Animals; Cardiomegaly; Cells, Cultured; Collagen; Disease Models, Anim | 2009 |
Stimulation of kappa-opioid receptor reduces isoprenaline-induced cardiac hypertrophy and fibrosis.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; A | 2009 |
IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.
Topics: Animals; Disease Models, Animal; Fibrosis; Heart Failure; Interleukin-17; Isoproterenol; Male; Matri | 2009 |
Doxycycline attenuates isoproterenol-induced myocardial fibrosis and matrix metalloproteinase activity in rats.
Topics: Adrenergic beta-Agonists; Animals; Anti-Bacterial Agents; Doxycycline; Fibrosis; Heart; Isoprotereno | 2009 |
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Diastole; Electrocardiography; Fibrosis; Gene Expression | 2010 |
Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.).
Topics: Adrenergic beta-Agonists; Animals; Antioxidants; Captopril; Cardiomegaly; Fibrosis; Heart; Isoproter | 2009 |
Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.
Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; DNA-Binding Proteins; Dystrophin; Echocardiogr | 2010 |
Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart.
Topics: Angiotensin I; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium; Disease Models, Animal; Fibro | 2010 |
The role of microRNA-133 in cardiac hypertrophy uncovered.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Diastole; Electrocardiography; Fibrosis; Gene Expression | 2010 |
KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
Topics: Animals; Calcineurin; Cardiomegaly; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models | 2010 |
Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.
Topics: Adrenergic beta-Agonists; Age Factors; Animals; Apoptosis; Cardiomegaly; Disease Models, Animal; Enz | 2010 |
Prolonged mechanical unloading preserves myocardial contractility but impairs relaxation in rat heart of dilated cardiomyopathy accompanied by myocardial stiffness and apoptosis.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomyopathy, Dilated; Collagen Type I; Diastole; Di | 2010 |
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Topics: Aging; Animals; Calcium; Cardiomyopathies; Cyclic AMP-Dependent Protein Kinases; Death, Sudden; Fibr | 2010 |
Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats.
Topics: Animals; Antioxidants; Benzodiazepinones; Cardiomegaly; Disease Models, Animal; Dose-Response Relati | 2010 |
Effects of captopril and telmisartan on matrix metalloproteinase-2 and -9 expressions and development of left ventricular fibrosis induced by isoprenaline in rats.
Topics: Animals; Benzimidazoles; Benzoates; Captopril; Drug Therapy, Combination; Fibrosis; Gene Expression | 2010 |
Acid-sensing ion channel 3, but not capsaicin receptor TRPV1, plays a protective role in isoproterenol-induced myocardial ischemia in mice.
Topics: Acid Sensing Ion Channels; Animals; Disease Models, Animal; Electrocardiography, Ambulatory; Fibrosi | 2011 |
Spironolactone decreases isoproterenol-induced ventricular fibrosis and matrix metalloproteinase-2 in rats.
Topics: Animals; Fibrosis; Gene Expression Regulation, Enzymologic; Heart Diseases; Isoproterenol; Male; Mat | 2011 |
Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice.
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Aortic Valve; Blood Pressure; Body Weight; | 2011 |
Distinct actions of intermittent and sustained β-adrenoceptor stimulation on cardiac remodeling.
Topics: Adrenergic beta-Agonists; Animals; Echocardiography; Fibrosis; Heart Rate; Hypertrophy; Infusion Pum | 2011 |
Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.
Topics: Animals; Cardiotonic Agents; Collagen; Coumarins; Fibrosis; Gene Expression Regulation; Glyceraldehy | 2011 |
[The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats].
Topics: Animals; Cardiomegaly; Fibrosis; Isoproterenol; Male; Myocardium; Proteasome Endopeptidase Complex; | 2011 |
Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats.
Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Bronchoalveolar Lavage Fluid; Cardiomyopathies; Fibr | 2011 |
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
Topics: Adrenergic beta-Agonists; Animals; Blotting, Western; Cyclic Nucleotide Phosphodiesterases, Type 1; | 2011 |
Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression.
Topics: Animals; Biological Products; Cardiomyopathies; Cardiotonic Agents; Collagen; Disease Models, Animal | 2012 |
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol.
Topics: Adrenergic beta-Agonists; Animals; Endoplasmic Reticulum Stress; Fibrosis; Humans; Isoproterenol; Ma | 2012 |
Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1.
Topics: Aldosterone; Animals; Blood Pressure; Cardiomegaly; Fibrosis; Heart; Immediate-Early Proteins; Infla | 2012 |
Testosterone improves cardiac function and alters angiotensin II receptors in isoproterenol-induced heart failure.
Topics: Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Fibrosis; Heart Failure; Hemodynamics | 2012 |
Genetic suppression of Gαs protein provides rate control in atrial fibrillation.
Topics: Adrenergic beta-Agonists; Animals; Atrial Fibrillation; Atrioventricular Node; Cardiac Pacing, Artif | 2012 |
Cryptotanshinone attenuates isoprenaline-induced cardiac fibrosis in mice associated with upregulation and activation of matrix metalloproteinase-2.
Topics: Animals; Drugs, Chinese Herbal; Enzyme Activation; Fibrosis; Heart Ventricles; Hemodynamics; Isoprot | 2012 |
Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Disease Susceptibility; Fibrosis; Interleukin-10; Iso | 2012 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
Granulocyte colony-stimulating factor improves early remodeling in isoproterenol-induced cardiac injury in rats.
Topics: Animals; Collagen; Dilatation, Pathologic; Disease Models, Animal; Echocardiography; Fibrosis; Granu | 2012 |
[Effects of Sini decoction on the expressions of Smad2 and Smad7 in isoproterenol induced myocardial fibrosis rats].
Topics: Animals; Cardiomyopathies; Drugs, Chinese Herbal; Fibrosis; Isoproterenol; Male; Myocardium; Rats; R | 2012 |
Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Calcium; Calcium-Calmodulin-Dependent Protein Kinas | 2013 |
Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis.
Topics: Animals; Cardiotonic Agents; Fibrosis; Hemodynamics; Hypertrophy, Left Ventricular; Isoproterenol; L | 2002 |
Toxic cardiac effects of catecholamines: role of beta-adrenoceptor downregulation.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Blood Pressure | 2002 |
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Catalytic Domain; Disease Models, Animal; Fibrosis; | 2003 |
Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats.
Topics: Animals; Cardiomegaly; Cell Division; Female; Fibrosis; Genotype; Heart; Isoproterenol; Male; Matrix | 2004 |
Blockade of beta 1- and desensitization of beta 2-adrenoceptors reduce isoprenaline-induced cardiac fibrosis.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Recep | 2004 |
Potassium canrenoate, an aldosterone receptor antagonist, reduces isoprenaline-induced cardiac fibrosis in the rat.
Topics: Animals; Blood Pressure; Canrenoic Acid; Cardiomyopathies; Disease Models, Animal; Dose-Response Rel | 2004 |
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction.
Topics: Adrenergic beta-Agonists; Animals; Enzyme Induction; Fibrosis; Humans; Hypertrophy; Hypertrophy, Lef | 2004 |
Celiprolol, a vasodilatory beta-blocker, inhibits pressure overload-induced cardiac hypertrophy and prevents the transition to heart failure via nitric oxide-dependent mechanisms in mice.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; Celiprol | 2004 |
Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Fibrosis; Gene Expression Regulation; Heart Failure | 2004 |
Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Amino Acid Substitution; Angiotensin II; Animal | 2004 |
Inhibition of catecholamine-induced cardiac fibrosis by an aldosterone antagonist.
Topics: Adrenergic beta-Agonists; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Anim | 2005 |
Animal models of cardiac fibrosis.
Topics: Aldosterone; Angiotensin II; Animals; Disease Models, Animal; Fibroblasts; Fibrosis; Heart Diseases; | 2005 |
Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.
Topics: Animals; Apoptosis; Capillaries; Cardiomegaly; Cardiotonic Agents; Coronary Circulation; Diabetes Co | 2005 |
Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Fibrosis; Ghrelin; Growth Hormone; Isoproterenol; Male; M | 2006 |
Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiomegaly; Cardiotonic Agents; Cells, Cultured; Dow | 2006 |
Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol.
Topics: Angiotensin II; Animals; Cardiomegaly; Cell Proliferation; Collagen; Fibroblasts; Fibrosis; Hydroxyp | 2007 |
Beta1 integrins modulate beta-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling.
Topics: Adrenergic beta-Agonists; Animals; Apoptosis; Cardiac Output, Low; Echocardiography; Extracellular S | 2007 |
Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice.
Topics: Adrenergic beta-Agonists; Angiotensins; Animals; Antioxidants; Blotting, Western; Cardiomegaly; Coll | 2007 |
Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.
Topics: Adrenergic beta-Agonists; Animals; Calcinosis; Calcium-Binding Proteins; Cardiomyopathies; Cell Adhe | 2008 |
Quantification of cardiac fibrosis by colour-subtractive computer-assisted image analysis.
Topics: Animals; Color; Fibrosis; Heart Diseases; Image Processing, Computer-Assisted; Isoproterenol; Male; | 2008 |
Amiodarone protection against myocardial injury and fibrosis induced by isoprenaline is abolished by thyroid hormone.
Topics: Amiodarone; Animals; Fibrosis; Fluorescent Antibody Technique; Heart; Isoproterenol; Male; Myocardiu | 1994 |
Angiotensin-converting enzyme and wound healing in diverse tissues of the rat.
Topics: Animals; Autoradiography; Endocardium; Fibrosis; Foreign-Body Reaction; Infarction; Isoproterenol; M | 1996 |
Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression.
Topics: Animals; Female; Fibrosis; GTP-Binding Proteins; Heart; Hemodynamics; Isoproterenol; Male; Mice; Mic | 1996 |
Remodelling of cardiac extracellular matrix during beta-adrenergic stimulation: upregulation of SPARC in the myocardium of adult rats.
Topics: Adrenergic beta-Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; Collagen; Extracellular | 1998 |
C-myc protooncogene modulates cardiac hypertrophic growth in transgenic mice.
Topics: Actins; Adenylyl Cyclases; Animals; Cardiomegaly; Fibrosis; Heart; Isomerism; Isoproterenol; Mice; M | 1992 |
Modification of atrioventricular node transmission properties by intraoperative neodymium-YAG laser photocoagulation in dogs.
Topics: Animals; Atrioventricular Node; Dogs; Feasibility Studies; Female; Fibrosis; Follow-Up Studies; Hear | 1991 |
Reactive and reparative fibrillar collagen remodelling in the hypertrophied rat left ventricle: two experimental models of myocardial fibrosis.
Topics: Animals; Cardiomegaly; Collagen; Disease Models, Animal; Fibrosis; Heart; Ischemia; Isoproterenol; K | 1990 |
Influence of phenytoin on isoproterenol-induced myocardial fibrosis in rats.
Topics: Animals; Cardiomyopathies; Female; Fibrosis; Isoproterenol; Myocardium; Phenytoin; Rats; Rats, Inbre | 1990 |
Effect of verapamil on the development of chronic experimental Chagas' disease.
Topics: Adenylyl Cyclases; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, | 1989 |
Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Cardiomegaly; DNA; DNA Replication; Fibrosis; Hear | 1989 |
The fibrillar nature and structure of isoproterenol-induced myocardial fibrosis in the rat.
Topics: Animals; Collagen; Fibrosis; Heart; Isoproterenol; Male; Microscopy, Polarization; Myocardium; Rats; | 1989 |
Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats.
Topics: Animals; Cardiomegaly; Cardioplegic Solutions; Creatine Kinase; Diltiazem; Fibrosis; Heart Arrest, I | 1988 |