| Assay ID | Title | Year | Journal | Article |
|---|
| AID31892 | Thermal denaturation in alternating poly(dA-dT)poly(dA-dT) homopolymer (AT) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID266450 | Inhibition of elastase | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID233022 | Thermal melting temperature for (dCGCGAATTCGCG)2 at a concentration of 3*10e-6 M base pairs at a ratio of 0.6 compound per base pair | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. |
| AID215197 | Inhibition constant against bovine trypsin | 1983 | Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
| Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. |
| AID233938 | Ratio between poly-dAdT and poly-dGdC binding | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID1132857 | Anticoagulant activity in human plasma assessed as prolongation of partial thromboplastin time at 10'-5 M incubated for 30 secs (Rvb = 59 +/- 5.4 secs) | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID1132853 | Competitive reversible inhibition of porcine pancreatic kallikrein using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 180 mins by Michaelis-Menten plot analysis | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID643992 | Inhibition of human trypsin in presence of Zn2+ | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
| Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2). |
| AID81733 | Minimum concentration required for the complete blockage of virus induced cell division. | 1983 | Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
| Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. |
| AID233025 | Thermal melting temperature determined for poly(dA).poly(dT) at a concentration of 5*10e-5) M base pairs at a ratio of 0.6 compound per base pair | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. |
| AID266445 | Inhibition of human beta tryptase | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID266449 | Inhibition of thrombin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID227749 | Binding constant obtained in an ethidium displacement assay for the sequence d(CGGAATTCGCG)2 | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. |
| AID1132851 | Competitive reversible inhibition of bovine thrombin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 40 mins by Michaelis-Menten plot analysis | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID238535 | In vitro inhibitory activity against tryptase | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase. |
| AID233024 | Thermal melting temperature for poly(A).poly(U) at a concentration of 5*10e-5) M base pairs at a ratio of 0.6 compound per base pair | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. |
| AID266451 | Selectivity for human beta tryptase over trypsin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID266452 | Selectivity for human beta tryptase over F10a | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID213272 | Inhibition constant against bovine thrombin | 1983 | Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
| Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. |
| AID1132852 | Competitive reversible inhibition of bovine trypsin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 30 mins by Michaelis-Menten plot analysis | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID266448 | Inhibition of plasmin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID72882 | Thermal denaturation in alternating poly(dG-dC)-poly(dG-dC) homopolymer (GC) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID266454 | Selectivity for human beta tryptase over thrombin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID157985 | Inhibition constant against human plasminogen | 1983 | Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
| Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. |
| AID266447 | Inhibition of F10a | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID644011 | Inhibition of human trypsin in presence of EDTA | 2012 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 22, Issue:2
| Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2). |
| AID42661 | In vitro inhibitory potency was tested against botulinum neurotoxin/B (BoNT/B) expressed as Ki | 2003 | Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
| Development of potent inhibitors of botulinum neurotoxin type B. |
| AID266453 | Selectivity for human beta tryptase over plasmin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID266446 | Inhibition of trypsin | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID233023 | Thermal melting temperature determined for (dG-C)4 at a concentration of 3*10e-6 M base pairs at a ratio of 0.6 compound per base pair | 1996 | Journal of medicinal chemistry, Mar-29, Volume: 39, Issue:7
| Synthesis and DNA interactions of benzimidazole dications which have activity against opportunistic infections. |
| AID215664 | Inhibition constant against Urokinase | 1983 | Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
| Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin. |
| AID1132855 | Competitive reversible inhibition of bovine trypsin using N-benzoyl-L-phenylalanyl-L-valyl-L-arginine-p-nitroanilide hydrochloride as substrate after 15 to 30 mins by Michaelis-Menten plot analysis | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID31893 | Thermal denaturation in sonicated poly(dA)-poly(dT) homopolymer (AT) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID308545 | Antiviral activity against RSV long A with F1 protein K394R mutation in HEp2 cells | 2007 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16
| Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity. |
| AID266455 | Selectivity for human beta tryptase over elastase | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. |
| AID1132858 | Anticoagulant activity in human plasma assessed as prolongation of partial thromboplastin time at 5 x 10'-6 M incubated for 30 secs (Rvb = 59 +/- 5.4 secs) | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID54984 | Thermal denaturation in sonicated calf thymus DNA (CT DNA) | 1993 | Journal of medicinal chemistry, Jun-11, Volume: 36, Issue:12
| Structure, DNA minor groove binding, and base pair specificity of alkyl- and aryl-linked bis(amidinobenzimidazoles) and bis(amidinoindoles). |
| AID1132856 | Anticoagulant activity in human plasma assessed as prolongation of partial thromboplastin time at 10'-4 M incubated for 30 secs (Rvb = 59 +/- 5.4 secs) | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7
| Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases. |
| AID239009 | Inhibitory activity against human Tryptase beta 2 expressed in yeast cells | 2004 | Bioorganic & medicinal chemistry letters, Oct-04, Volume: 14, Issue:19
| Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation. |
| AID977610 | Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB | 1998 | Nature, Feb-05, Volume: 391, Issue:6667
| Design of potent selective zinc-mediated serine protease inhibitors. |
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1998 | Nature, Feb-05, Volume: 391, Issue:6667
| Design of potent selective zinc-mediated serine protease inhibitors. |
| AID1797494 | Enzyme Inhibition Assay from Article 10.1038/35422: \\Design of potent selective zinc-mediated serine protease inhibitors.\\ | 1998 | Nature, Feb-05, Volume: 391, Issue:6667
| Design of potent selective zinc-mediated serine protease inhibitors. |
| AID1797470 | Determination of Inhibitor Potency and Selectivity from Article 10.1021/jm061066t: \\Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines.\\ | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. |
| AID493017 | Wombat Data for BeliefDocking | 2007 | Journal of medicinal chemistry, May-17, Volume: 50, Issue:10
| Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |