Compounds > acetylcysteine

acetylcysteine and Fibrosis

acetylcysteine has been researched along with Fibrosis in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (31.48)29.6817
2010's26 (48.15)24.3611
2020's11 (20.37)2.80

Authors

AuthorsStudies
Khaleel, EF1
Anderegg, U; Bauer, M; Fink, B; Röder, S; Zenclussen, AC1
Chen, J; Chen, L; Chen, M; Li, W; Liao, Y; Liu, L; Qin, J; Shen, Y; Wang, T; Wen, F; Wu, Y; Xiong, S; Zhou, H; Zi, K1
Kandel, R; Singh, KP1
Dong, W; Gong, Z; Li, J; Liu, G; Liu, Z; Luo, T; Ma, Y; Song, R; Wang, X; Zhang, K; Zhu, J; Zou, H1
Biederman, L; Brodsky, SV; Dasgupta, A; Ivanov, I; Medipally, A; Mikhalina, G; Rovin, B; Satoskar, AA; Xiao, M1
Kim, KJ; Moon, SJ; Park, KS; Tagkopoulos, I1
Aguado, T; Botella, LM; Del Río, M; Ferrer-Mayorga, G; García, A; García, M; Martínez-Santamaría, L; Sánchez-Puelles, JM1
Honma, S; Sakai, M; Soma, I; Tani, I; Toriyabe, K; Yoshida, M1
Cao, L; Gui, Y; Tan, Y; Zhang, J; Zheng, Y1
Abd El-Aziz, EA; Abdelhaffez, AS; Ahmed, AM; Tohamy, MB1
Li, H; Li, W; Liu, W; Peng, W; Tang, K; Xu, D; Xu, YW; Zhao, Y; Zhu, G; Zhu, M1
Adamcova, M; Aziriova, S; Balazova, L; Celec, P; Krajcirovicova, K; Pechanova, O; Repova, K; Simko, F; Tothova, L; Vrankova, S; Zorad, S1
Acer, T; Aslan, GI; Hicsonmez, A; Otgun, I; Tepeoglu, M1
Chu, PY; Du, XJ; Fiedler, A; Giam, B; Horlock, D; Kaye, DM; Kiriazis, H; Kuruppu, S; Marques, FZ; Rajapakse, NW; Smith, AI1
Bluemke, DA; Chang, J; Cheong, BY; Hessabi, M; Kleiman, NS; Li, L; Liu, CY; Marian, AJ; Nagueh, SF; Rahbar, MH; Syrris, P; Tan, Y; Willerson, JT1
Chi, RF; Fan, B; Li, B; Qin, FZ; Sun, Y; Wang, JP; Wang, K; Yang, ZJ1
Hou, FF; Li, C; Li, Y; Liu, C; Wang, J; Xie, N1
Choo, MS; Heo, J; Ju, H; Kim, S; Lee, S; Lim, J; Ryu, CM; Shin, DM; Shin, JH; Yu, HY1
Jiang, T; Xu, SH; Yu, JF; Yu, QY; Zhang, JX; Zhou, CF; Zhu, QX1
Bucala, R; Furuichi, K; Hara, A; Kaneko, S; Matsushima, K; Mukaida, N; Sakai, N; Sakai, Y; Takeya, M; Takuwa, Y; Wada, T1
Broumand, MA; Darabi, F; Jenab, Y; Khalili, H; Salarifar, M; Talasaz, AH1
Darcha, C; Matsuzaki, S1
Duan, YY; Liu, C; Lu, XZ; Ma, J; Shen, MZ; Xing, CY; Yuan, LJ1
Gan, XX; Lu, LM; Miao, NJ; Shen, Y; Xu, D; Xu, JL; Xue, H; Zhang, W; Zhou, L1
Chu, PY; Du, XJ; Giam, B; Horlock, D; Kaye, DM; Kiriazis, H; Kuruppu, S; Rajapakse, NW; Smith, AI1
Ali, SA; Batra, SK; Chakraborty, S; Das, B; Dash, P; Jain, S; Mohanty, AK; Panda, SK; Senapati, S; Suklabaidya, S; Swaminathan, S1
Bilal, M; Haseeb, A; Khan, MA1
Ayyavoo, A; Dandapani, R; Nagasubramanian, V; Raghupathy, P; Rajamani, M1
Akita, Y; Iwasaka, T; Matsuhisa, S; Moriguchi, A; Okazaki, T; Otani, H; Sato, D; Yamashita, K1
Aleksandrowicz, E; Larczyński, W; Lysiak-Szydłowska, W; Renke, M; Rutkowski, B; Rutkowski, P; Tylicki, L1
Betocchi, S; Chen, J; Chen, SN; Efimov, IR; Li, W; Lombardi, R; Marian, AJ; Ripplinger, CM; Rodriguez, G; Wickline, SA; Willerson, JT1
Ann, Y; Ichikawa, T; Ichinose, M; Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Mao, L; Rennard, SI; Sugiura, H; Togo, S; Wang, XQ1
Ha, H; Kim, YO; Lee, HB; Noh, H; Oh, EY; Seo, JY; Yu, MR1
Cardounel, AJ; Carnes, CA; Gyorke, S; Hamlin, RL; Khan, M; Nakayama, T; Nishijima, Y; Sridhar, A; Terentyev, D; Terentyeva, R1
Knobloch, K; Redeker, J; Vogt, PM1
Chen, F; Chen, PS; Fishbein, MC; Garfinkel, A; Karagueuzian, HS; Lin, SF; Mandel, WJ; Morita, N; Qu, Z; Sovari, AA; Weiss, JN; Xie, LH; Xie, Y1
Crespo, I; Cuevas, MJ; de Oliveira, MG; de Souza, GF; González-Gallego, J; Marroni, NP; Tuñón, MJ; Vercelino, R1
McCarty, MF1
Moreno-Otero, R; Trapero-Marugán, M1
Adijiang, A; Bolati, D; Dateki, M; Enomoto, A; Nishijima, F; Niwa, T; Shimizu, H1
Hamatani, H; Hiromura, K; Kuroiwa, T; Maeshima, A; Nojima, Y; Sakairi, T; Takahashi, S; Takeuchi, S; Tomioka, M1
Abdolrasulnia, R; Blackwell, TS; Cheng, DS; Degryse, AL; Lawson, WE; Tanjore, H; Zoz, DF1
Favari, L; Galicia-Moreno, M; Muriel, P1
Ardehali, H; Chawla, K; Epting, CL; Ghanefar, M; Laakso, M; Tran, M; Wu, R; Wyatt, E1
Fujimiya, T; Naito, K; Shiraishi, K; Yoshida, K1
Boor, PJ; Conklin, D; Dugas, TR; Hebert, VY; Hennard, KL; Kanz, MF; Liu, H; Santa Cruz, V1
Aban, M; Apa, DD; Dilek, S; Kaplanoğlu, M; Oz, U; Pata, O; Tok, E; Yazici, G1
Chen, Y; Fürst, D; Jesnowski, R; Kleeff, J; Kolb, A; Löhr, M; Ringel, J; Schareck, WD; Schrödel, A1
Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W1
Byrne, JA; Cave, AC; Grieve, DJ; Johar, S; Layland, J; Shah, AM; Siva, A1
Chen, SN; Lombardi, R; Marian, AJ; Senthil, V1
Allen, DG; Williams, IA1
Dal Pizzol, F; Pinho, RA; Rocha, LG; Silva, LA; Silveira, PC; Soares, FS; Streck, EL; Teixeira, KC; Valença, SS1

Reviews

1 review(s) available for acetylcysteine and Fibrosis

ArticleYear
Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies.
    Medical hypotheses, 2010, Volume: 75, Issue:2

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Atrial Fibrillation; Fibrosis; Heart Failure; Humans; Mitochondria; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxynitrous Acid; Superoxides

2010

Trials

4 trial(s) available for acetylcysteine and Fibrosis

ArticleYear
The effect of N-acetylcysteine in patients with non-cystic fibrosis bronchiectasis (NINCFB): study protocol for a multicentre, double-blind, randomised, placebo-controlled trial.
    BMC pulmonary medicine, 2022, Nov-07, Volume: 22, Issue:1

    Topics: Acetylcysteine; Anti-Bacterial Agents; Bronchiectasis; Cystic Fibrosis; Double-Blind Method; Fibrosis; Humans; Multicenter Studies as Topic; Prospective Studies; Quality of Life; Randomized Controlled Trials as Topic; RNA, Ribosomal, 16S

2022
Hypertrophy Regression With N-Acetylcysteine in Hypertrophic Cardiomyopathy (HALT-HCM): A Randomized, Placebo-Controlled, Double-Blind Pilot Study.
    Circulation research, 2018, 04-13, Volume: 122, Issue:8

    Topics: Acetylcysteine; Adult; Aged; Antioxidants; Cardiomyopathy, Hypertrophic; Connectin; Double-Blind Method; Echocardiography, Doppler; Exome; Female; Fibrosis; Heart; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardium; Pilot Projects; Polymorphism, Single Nucleotide

2018
N-Acetylcysteine effects on transforming growth factor-β and tumor necrosis factor-α serum levels as pro-fibrotic and inflammatory biomarkers in patients following ST-segment elevation myocardial infarction.
    Drugs in R&D, 2013, Volume: 13, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Biomarkers; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Fibrosis; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Transforming Growth Factor beta; Treatment Outcome; Tumor Necrosis Factor-alpha

2013
The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebo-controlled, randomized, open, cross-over study.
    Kidney & blood pressure research, 2008, Volume: 31, Issue:6

    Topics: Acetylcysteine; Adult; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Biomarkers; Chronic Disease; Cross-Over Studies; Drug Therapy, Combination; Female; Fibrosis; Humans; Kidney Diseases; Kidney Tubules; Male; Proteinuria; Treatment Outcome

2008

Other Studies

49 other study(ies) available for acetylcysteine and Fibrosis

ArticleYear
l-Thyroxine induces left ventricular remodeling and fibrosis in rats by upregulating miR-21 in a reactive oxygen-dependent mechanism: a protective role of
    Drug and chemical toxicology, 2022, Volume: 45, Issue:6

    Topics: Acetylcysteine; Actins; Animals; Antagomirs; Collagen; Fibrosis; Glutathione; Inflammasomes; Interleukin-6; Male; Mammals; MicroRNAs; NF-kappa B; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Thyroxine; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Ventricular Remodeling

2022
    Genes, 2022, Sep-27, Volume: 13, Issue:10

    Topics: Acetylcysteine; Apoptosis; Brefeldin A; Cadmium; Fibrosis; Humans; Interleukin-17; Leukocytes, Mononuclear; Mercury; Nicotiana; Oxidative Stress

2022
Higher Concentrations of Folic Acid Cause Oxidative Stress, Acute Cytotoxicity, and Long-Term Fibrogenic Changes in Kidney Epithelial Cells.
    Chemical research in toxicology, 2022, 11-21, Volume: 35, Issue:11

    Topics: Acetylcysteine; Animals; Antioxidants; Epithelial Cells; Fibrosis; Folic Acid; Humans; Kidney; Mice; Oxidative Stress; Reactive Oxygen Species

2022
N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1-P53 signaling pathway.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Acetylcysteine; Animals; Cadmium; Cellular Senescence; Fibrosis; Kidney; Rats; Renal Insufficiency, Chronic; Signal Transduction; Sirtuin 1; Tumor Suppressor Protein p53

2023
N-acetylcysteine ameliorates hematuria-associated tubulointerstitial injury in 5/6 nephrectomy mice.
    Physiological reports, 2023, Volume: 11, Issue:13

    Topics: Acetylcysteine; Animals; Fibrosis; Hematuria; Humans; Kidney; Mice; Mice, Inbred C57BL; Nephrectomy; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Warfarin

2023
Network-based modeling of drug effects on disease module in systemic sclerosis.
    Scientific reports, 2020, 08-07, Volume: 10, Issue:1

    Topics: Acetylcysteine; Dasatinib; Drug Repositioning; Female; Fibrosis; Genome-Wide Association Study; Humans; Imatinib Mesylate; Indoles; Male; Molecular Targeted Therapy; Protein Kinase Inhibitors; Scleroderma, Systemic; Signal Transduction

2020
Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa.
    Cells, 2020, 09-16, Volume: 9, Issue:9

    Topics: Acetylcysteine; Activin Receptors, Type II; Antioxidants; Case-Control Studies; Collagen Type VII; Drug Repositioning; Endoglin; Epidermolysis Bullosa; Estrogen Antagonists; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Inheritance Patterns; Primary Cell Culture; Raloxifene Hydrochloride; Receptor, Transforming Growth Factor-beta Type I; Severity of Illness Index; Signal Transduction; Skin; Smad Proteins; Transforming Growth Factor beta1

2020
Effect of N-Acetyl Cysteine on Renal Interstitial Fibrosis in Mice.
    Biological & pharmaceutical bulletin, 2020, Volume: 43, Issue:12

    Topics: Acetylcysteine; Animals; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Kidney Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Reactive Oxygen Species; Ureteral Obstruction

2020
N-acetylcysteine protects neonatal mice from ventricular hypertrophy induced by maternal obesity in a sex-specific manner.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 133

    Topics: Acetylcysteine; Animal Nutritional Physiological Phenomena; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; Female; Fibrosis; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Maternal Nutritional Physiological Phenomena; Mice, Inbred C57BL; Obesity, Maternal; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors; Ventricular Function, Left; Ventricular Remodeling

2021
N-acetyl cysteine can blunt metabolic and cardiovascular effects via down-regulation of cardiotrophin-1 in rat model of fructose-induced metabolic syndrome.
    Archives of physiology and biochemistry, 2023, Volume: 129, Issue:4

    Topics: Acetylcysteine; Animals; Aorta; Down-Regulation; Fibrosis; Fructose; Insulin Resistance; Male; Metabolic Syndrome; Oxidative Stress; Rats; Rats, Wistar

2023
Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy.
    Journal of the American Heart Association, 2017, Apr-21, Volume: 6, Issue:4

    Topics: Acetylcysteine; Animals; Cardiomegaly; Cardiomyopathy, Dilated; Case-Control Studies; Catalase; Down-Regulation; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex IV; Fibrosis; Humans; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Membrane Transport Proteins; Mice; Mice, Knockout; Mice, Transgenic; Mitochondrial Precursor Protein Import Complex Proteins; Myocardium; Myocytes, Cardiac; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase

2017
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
    International journal of molecular sciences, 2017, Jul-25, Volume: 18, Issue:8

    Topics: Acetylcysteine; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension; Light; Male; Melatonin; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Ventricular Remodeling

2017
The effect of intraperitoneal n-acetylcysteine on postoperative adhesions in rat models.
    Annali italiani di chirurgia, 2017, Volume: 88

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cecum; Drug Evaluation, Preclinical; Female; Fibrosis; Instillation, Drug; Peritoneal Cavity; Peritoneal Diseases; Rats; Rats, Wistar; Single-Blind Method; Tissue Adhesions

2017
N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.
    Scientific reports, 2017, 12-18, Volume: 7, Issue:1

    Topics: Acetylcysteine; Animals; Cardio-Renal Syndrome; Cardiomyopathy, Dilated; Disease Models, Animal; Fibrosis; Glomerular Filtration Rate; Glutathione; Kidney; Kidney Diseases; Kidney Glomerulus; Male; Mice; Mice, Transgenic; Myocardium; Nephritis; Oxidative Stress; Urinary Tract

2017
Antioxidant N-acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats.
    European journal of pharmacology, 2018, Nov-15, Volume: 839

    Topics: Acetylcysteine; Adaptation, Physiological; Adenine; Animals; Antioxidants; Autophagy; Blood Pressure; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Male; Myocytes, Cardiac; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Ventricular Remodeling

2018
N-acetylcysteine ameliorates cisplatin-induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation.
    Free radical biology & medicine, 2019, Volume: 130

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Cellular Senescence; Cisplatin; Fibrosis; Humans; Kidney; Mice; Oxidative Stress; Rats; Renal Insufficiency, Chronic; Sirtuin 1; Tumor Suppressor Protein p53

2019
N-acetylcysteine prevents bladder tissue fibrosis in a lipopolysaccharide-induced cystitis rat model.
    Scientific reports, 2019, 05-31, Volume: 9, Issue:1

    Topics: Acetylcysteine; Animals; CARD Signaling Adaptor Proteins; Chemokine CXCL10; Cystitis; Disease Models, Animal; Female; Fibrosis; Gene Expression Profiling; Inflammation; Lipopolysaccharides; Protamines; Rats; Rats, Sprague-Dawley; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Urinary Bladder

2019
N-acetylcysteine attenuates subcutaneous administration of bleomycin-induced skin fibrosis and oxidative stress in a mouse model of scleroderma.
    Clinical and experimental dermatology, 2013, Volume: 38, Issue:4

    Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Bleomycin; Catalase; Disease Models, Animal; Female; Fibrosis; Free Radical Scavengers; Injections, Subcutaneous; Malondialdehyde; Mice; Mice, Inbred BALB C; Oxidative Stress; Reactive Oxygen Species; Scleroderma, Localized; Skin; Superoxide Dismutase; Thiobarbiturates

2013
CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations.
    Clinical and experimental nephrology, 2013, Volume: 17, Issue:6

    Topics: Acetylcysteine; Cell Movement; Chemokine CCL2; Collagen Type I; Cytochalasin B; Fibrosis; Glucose; Glucose Transport Proteins, Facilitative; Humans; Kidney; Leukocyte Common Antigens; Monocytes; Receptors, CCR2; Transforming Growth Factor beta1

2013
Antifibrotic properties of epigallocatechin-3-gallate in endometriosis.
    Human reproduction (Oxford, England), 2014, Volume: 29, Issue:8

    Topics: Acetylcysteine; Actins; Adult; Animals; Catechin; Cell Movement; Cell Proliferation; Cells, Cultured; Connective Tissue Growth Factor; Endometriosis; Female; Fibronectins; Fibrosis; Humans; Matrix Metalloproteinase 2; Mice; Mice, Nude; Peptide Fragments; Signal Transduction

2014
N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition.
    BMC cardiovascular disorders, 2015, Aug-06, Volume: 15

    Topics: Acetylcysteine; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Male; Mice; Mice, Inbred C57BL; Oxidative Stress

2015
N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:5

    Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Cell Line; Fibroblasts; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Renin-Angiotensin System; Ureteral Obstruction

2016
N-acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure.
    Physiological reports, 2016, Volume: 4, Issue:7

    Topics: Acetylcysteine; Animals; Antioxidants; Collagen Type I; Collagen Type III; Disease Models, Animal; Fibrosis; Genetic Predisposition to Disease; Heart Failure; Male; Mice, Inbred C57BL; Mice, Transgenic; Myocytes, Cardiac; Oxidative Stress; Phenotype; Protein Serine-Threonine Kinases; Time Factors; Ultrasonography; Ventricular Function, Left; Ventricular Remodeling

2016
Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia.
    Oncotarget, 2016, Jul-05, Volume: 7, Issue:27

    Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Disulfiram; Fibrosis; Guinea Pigs; Humans; Pancreas; Pancreatic Neoplasms; Pancreatic Stellate Cells; Pyridones; Rats; Xenograft Model Antitumor Assays

2016
N-Acetyl Cysteine: A Possible Treatment for Diabetic Cardiomyopathy.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016, Volume: 26, Issue:8

    Topics: Acetylcysteine; Animals; Antiviral Agents; Diabetic Cardiomyopathies; Fibrosis; Mice; Oxidative Stress

2016
Surgically Induced Necrotizing Scleritis Following Strabismus Surgery Treated Successfully with Topical N-acetylcysteine in a Child with Congenital Fibrosis of Extraocular Muscles and Varadi Papp Syndrome.
    Strabismus, 2017, Volume: 25, Issue:1

    Topics: Acetylcysteine; Administration, Topical; Ascorbic Acid; Child; Fibrosis; Free Radical Scavengers; Humans; Male; Oculomotor Muscles; Ophthalmic Solutions; Ophthalmologic Surgical Procedures; Ophthalmoplegia; Orofaciodigital Syndromes; Postoperative Complications; Scleritis; Strabismus

2017
N-acetylcysteine abolishes the protective effect of losartan against left ventricular remodeling in cardiomyopathy hamster.
    Antioxidants & redox signaling, 2008, Volume: 10, Issue:12

    Topics: Acetylcysteine; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Benzylamines; Cardiomyopathies; Cricetinae; Drug Interactions; Enzyme Inhibitors; Fibrosis; Free Radical Scavengers; Heart; Heart Ventricles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Ventricular Function, Left; Ventricular Remodeling

2008
Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms.
    Circulation, 2009, Mar-17, Volume: 119, Issue:10

    Topics: Acetylcysteine; Actins; Animals; Animals, Genetically Modified; Antioxidants; Cardiomyopathy, Hypertrophic; Cell Size; Disease Models, Animal; Female; Fibrosis; Glutathione; Heart Failure, Systolic; Humans; Male; MAP Kinase Signaling System; Myocytes, Cardiac; Myosin Heavy Chains; NFATC Transcription Factors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Rabbits; Sulfhydryl Compounds; Ventricular Fibrillation

2009
N-acetyl-L-cysteine inhibits TGF-beta1-induced profibrotic responses in fibroblasts.
    Pulmonary pharmacology & therapeutics, 2009, Volume: 22, Issue:6

    Topics: Acetylcysteine; Actins; Animals; Blotting, Western; Cells, Cultured; Collagen Type I; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibronectins; Fibrosis; Humans; Rats; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

2009
Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:3

    Topics: Acetylcysteine; Amides; Animals; Antioxidants; Biphenyl Compounds; Cell Line; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Male; Mice; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Recombinant Proteins; Repressor Proteins; RNA Interference; RNA, Messenger; Transforming Growth Factor beta1; Valproic Acid

2009
Chronic heart failure and the substrate for atrial fibrillation.
    Cardiovascular research, 2009, Nov-01, Volume: 84, Issue:2

    Topics: Acetylcysteine; Action Potentials; Animals; Atrial Fibrillation; Atrial Function, Left; Calcium Channels, L-Type; Calcium Signaling; Cardiac Pacing, Artificial; Chronic Disease; Disease Models, Animal; Dogs; Female; Fibrosis; Heart Conduction System; Heart Failure; Male; Myocardial Contraction; Myocardium; Oxidation-Reduction; Oxidative Stress; Pilot Projects; Potassium Channels; Receptor, Angiotensin, Type 1; Refractory Period, Electrophysiological; Time Factors; Ventricular Function, Left

2009
Antifibrotic medication using a combination of N-acetyl-L-cystein (NAC) and ACE inhibitors can prevent the recurrence of Dupuytren's disease.
    Medical hypotheses, 2009, Volume: 73, Issue:5

    Topics: Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Dupuytren Contracture; Fibrosis; Humans; Models, Theoretical; Secondary Prevention; Transforming Growth Factor beta1

2009
Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Acetylcysteine; Action Potentials; Age Factors; Aging; Animals; Antioxidants; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Communication; Computer Simulation; Disease Models, Animal; Electrocardiography; Enzyme Activation; Fibrosis; Heart Ventricles; Hydrogen Peroxide; Male; Models, Cardiovascular; Myocytes, Cardiac; Oxidants; Oxidative Stress; Perfusion; Protein Kinase Inhibitors; Rabbits; Rats; Rats, Inbred F344; Sulfonamides; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation

2009
S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats.
    Journal of molecular medicine (Berlin, Germany), 2010, Volume: 88, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Fibrosis; Immunohistochemistry; Lipid Peroxidation; Liver; Liver Cirrhosis; Male; MAP Kinase Signaling System; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase

2010
Hepatoprotective effects of antioxidants in chronic hepatitis C.
    World journal of gastroenterology, 2010, Apr-21, Volume: 16, Issue:15

    Topics: Acetylcysteine; Antioxidants; Disease Progression; Fatty Liver; Fibrosis; Hepacivirus; Hepatitis C, Chronic; Humans; Liver; Nitric Oxide; Oxidative Stress; S-Adenosylmethionine; Virus Replication

2010
Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.
    American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:5

    Topics: Acetylcysteine; Animals; Benzothiazoles; Cell Line; Cell Proliferation; Cellular Senescence; Fibrosis; Humans; Indican; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Toluene; Tumor Suppressor Protein p53

2010
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
    Nephrology (Carlton, Vic.), 2011, Volume: 16, Issue:1

    Topics: Acetylcysteine; Actins; Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Kidney Diseases; Leupeptins; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Ureteral Obstruction

2011
Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress.
    The Journal of biological chemistry, 2011, Sep-02, Volume: 286, Issue:35

    Topics: Acetylcysteine; Animals; Cadherins; Endoplasmic Reticulum; Epithelium; Fibrosis; Humans; Membrane Proteins; Mesoderm; Mice; Microscopy, Phase-Contrast; Models, Biological; Mutation; Phosphoproteins; Pulmonary Alveoli; Pulmonary Surfactant-Associated Protein C; Rats; Tunicamycin; Zonula Occludens-1 Protein

2011
Antifibrotic and antioxidant effects of N-acetylcysteine in an experimental cholestatic model.
    European journal of gastroenterology & hepatology, 2012, Volume: 24, Issue:2

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Catalase; Cholestasis; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Fibrosis; Glutathione; Inflammation Mediators; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar

2012
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production.
    EMBO molecular medicine, 2012, Volume: 4, Issue:7

    Topics: Acetylcysteine; Animals; Antioxidants; Cardiomegaly; Cells, Cultured; Fibrosis; Heterozygote; Hexokinase; Male; Mice; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Pressure; Protein Binding; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering

2012
Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat.
    The Journal of urology, 2003, Volume: 170, Issue:5

    Topics: Acetylcysteine; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Enalapril; Fibrosis; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Leydig Cells; Losartan; Male; Rats; Rats, Wistar; Spermatogenesis; Testis; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasectomy

2003
Vascular medial hyperplasia following chronic, intermittent exposure to 4,4'-methylenedianiline.
    Cardiovascular toxicology, 2004, Volume: 4, Issue:1

    Topics: Acetylcysteine; Aniline Compounds; Animals; Bile Ducts; Biotransformation; Blood Vessels; Carcinogens; Cell Division; Cells, Cultured; Epithelial Cells; Female; Fibrosis; Free Radical Scavengers; Glutathione Transferase; Hepatic Artery; Hyperplasia; Liver Cirrhosis, Biliary; Male; Muscle, Smooth, Vascular; Oxidation-Reduction; Portal Vein; Rats; Rats, Sprague-Dawley; Sex Characteristics

2004
The effect of inducible nitric oxide synthase on postoperative adhesion formation in rats.
    European journal of obstetrics, gynecology, and reproductive biology, 2004, Nov-10, Volume: 117, Issue:1

    Topics: Acetylcysteine; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Fibrosis; Inflammation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneal Diseases; Peritoneum; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesions

2004
Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine.
    Laboratory investigation; a journal of technical methods and pathology, 2005, Volume: 85, Issue:10

    Topics: Acetylcysteine; Antigens, Polyomavirus Transforming; Biomarkers; Cell Cycle; Cell Line; Cell Proliferation; Collagen; Drug Combinations; Fibrosis; Gene Expression; Humans; Karyotyping; Laminin; Pancreas; Platelet-Derived Growth Factor; Proteoglycans; Telomerase; Transforming Growth Factor beta; Vitamin A

2005
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation

2006
Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload.
    Journal of the American College of Cardiology, 2006, Feb-21, Volume: 47, Issue:4

    Topics: Acetylcysteine; Animals; Aorta; Echocardiography; Fibrosis; Hypertrophy, Left Ventricular; Isoenzymes; Ligation; Male; Mice; Mice, Knockout; Myocardial Contraction; Myocardium; NADPH Oxidases; Ventricular Function, Left

2006
Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation.
    Journal of the American College of Cardiology, 2006, Feb-21, Volume: 47, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Cardiomyopathy, Hypertrophic; Collagen; DNA; DNA, Mitochondrial; Echocardiography; Fibrosis; Gene Expression; Heart; Lipid Peroxidation; Malondialdehyde; Matrix Metalloproteinase 1; Mice; Mice, Transgenic; Myocardium; Procollagen; Reverse Transcriptase Polymerase Chain Reaction

2006
The role of reactive oxygen species in the hearts of dystrophin-deficient mdx mice.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Acetylcysteine; Actin Cytoskeleton; Animals; Antioxidants; Calcium; Disease Models, Animal; Dystrophin; Fibrosis; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular Dystrophy, Duchenne; Myocardium; Myocytes, Cardiac; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species

2007
Attenuation of bleomycin-induced lung injury and oxidative stress by N-acetylcysteine plus deferoxamine.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:2

    Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Bleomycin; Catalase; Deferoxamine; Drug Therapy, Combination; Fibrosis; Iron Chelating Agents; L-Lactate Dehydrogenase; Lipid Peroxidation; Lung; Lung Diseases; Male; Mice; Mice, Inbred Strains; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2008