Kit ligand

A kit ligand that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21583]

Synonyms

Mast cell growth factor;
MGF;
Stem cell factor;
SCF;
c-Kit ligand

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
indirubin-5-sulfonate	Homo sapiens (human)	IC50	6.8000	1	6
indirubin	Homo sapiens (human)	IC50	2.0000	1	1

Enables

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
growth factor activity	molecular function	The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]
stem cell factor receptor binding	molecular function	Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. [GOC:jl, PMID:10698217]
cytokine activity	molecular function	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]

Located In

This protein is located in 7 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytoskeleton	cellular component	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
lamellipodium	cellular component	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194]
filopodium	cellular component	Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 27 target(s):

Target	Category	Definition
ovarian follicle development	biological process	The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/]
neural crest cell migration	biological process	The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
hematopoietic progenitor cell differentiation	biological process	The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]
myeloid leukocyte differentiation	biological process	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. [GOC:add, PMID:16551251]
positive regulation of leukocyte migration	biological process	Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add]
positive regulation of myeloid leukocyte differentiation	biological process	Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
Ras protein signal transduction	biological process	An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf]
positive regulation of cell population proliferation	biological process	Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
male gonad development	biological process	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
response to organic cyclic compound	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
mast cell apoptotic process	biological process	Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130]
negative regulation of mast cell apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]
embryonic hemopoiesis	biological process	The stages of blood cell formation that take place within the embryo. [GOC:bf]
ectopic germ cell programmed cell death	biological process	Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. [PMID:12814944]
T cell proliferation	biological process	The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl]
positive regulation of T cell proliferation	biological process	Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai]
positive regulation of melanocyte differentiation	biological process	Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators]
positive regulation of Ras protein signal transduction	biological process	Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. [GOC:bf]
positive regulation of peptidyl-tyrosine phosphorylation	biological process	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai]
mast cell proliferation	biological process	The expansion of a mast cell population by cell division. [GOC:add]
positive regulation of mast cell proliferation	biological process	Any process that activates or increases the rate or extent of mast cell proliferation. [GOC:add, GOC:mah]
extrinsic apoptotic signaling pathway in absence of ligand	biological process	The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705]
melanocyte migration	biological process	The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532]
mast cell migration	biological process	The movement of a mast cell within or between different tissues and organs of the body. [GOC:cvs, PMID:24152847]
positive regulation of hematopoietic progenitor cell differentiation	biological process	Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie]
positive regulation of hematopoietic stem cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623]

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