Page last updated: 2024-08-07 23:21:54
Kit ligand
A kit ligand that is encoded in the genome of human. [PRO:DNx, UniProtKB:P21583]
Synonyms
Mast cell growth factor;
MGF;
Stem cell factor;
SCF;
c-Kit ligand
Research
Bioassay Publications (1)
Timeframe | Studies on this Protein(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
---|---|---|---|---|---|
indirubin-5-sulfonate | Homo sapiens (human) | IC50 | 6.8000 | 1 | 6 |
indirubin | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
Enables
This protein enables 4 target(s):
Target | Category | Definition |
---|---|---|
protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
growth factor activity | molecular function | The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194] |
stem cell factor receptor binding | molecular function | Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. [GOC:jl, PMID:10698217] |
cytokine activity | molecular function | The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802] |
Located In
This protein is located in 7 target(s):
Target | Category | Definition |
---|---|---|
extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
cytoskeleton | cellular component | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875] |
plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
lamellipodium | cellular component | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. [ISBN:0815316194] |
filopodium | cellular component | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. [GOC:mah, GOC:pr, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
Target | Category | Definition |
---|---|---|
plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 27 target(s):
Target | Category | Definition |
---|---|---|
ovarian follicle development | biological process | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. [https://www.ncbi.nlm.nih.gov/books/NBK279054/] |
neural crest cell migration | biological process | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] |
hematopoietic progenitor cell differentiation | biological process | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] |
myeloid leukocyte differentiation | biological process | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. [GOC:add, PMID:16551251] |
positive regulation of leukocyte migration | biological process | Any process that activates or increases the frequency, rate, or extent of leukocyte migration. [GOC:add] |
positive regulation of myeloid leukocyte differentiation | biological process | Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. [GOC:add] |
cell adhesion | biological process | The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf] |
Ras protein signal transduction | biological process | An intracellular signaling cassette in which a small monomeric GTPase of the Ras subfamily relays a signal. [GOC:bf] |
positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
male gonad development | biological process | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid] |
response to organic cyclic compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef] |
mast cell apoptotic process | biological process | Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130] |
negative regulation of mast cell apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. [GOC:add, GOC:mtg_apoptosis] |
embryonic hemopoiesis | biological process | The stages of blood cell formation that take place within the embryo. [GOC:bf] |
ectopic germ cell programmed cell death | biological process | Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. [PMID:12814944] |
T cell proliferation | biological process | The expansion of a T cell population by cell division. Follows T cell activation. [GOC:jl] |
positive regulation of T cell proliferation | biological process | Any process that activates or increases the rate or extent of T cell proliferation. [GOC:ai] |
positive regulation of melanocyte differentiation | biological process | Any process that activates or increases the frequency, rate or extent of melanocyte differentiation. [GOC:go_curators] |
positive regulation of Ras protein signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction. [GOC:bf] |
positive regulation of peptidyl-tyrosine phosphorylation | biological process | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. [GOC:ai] |
mast cell proliferation | biological process | The expansion of a mast cell population by cell division. [GOC:add] |
positive regulation of mast cell proliferation | biological process | Any process that activates or increases the rate or extent of mast cell proliferation. [GOC:add, GOC:mah] |
extrinsic apoptotic signaling pathway in absence of ligand | biological process | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] |
melanocyte migration | biological process | The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. [CL:0000148, GOC:uh, PMID:22637532] |
mast cell migration | biological process | The movement of a mast cell within or between different tissues and organs of the body. [GOC:cvs, PMID:24152847] |
positive regulation of hematopoietic progenitor cell differentiation | biological process | Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. [GOC:BHF, GOC:rl, GOC:TermGenie] |
positive regulation of hematopoietic stem cell proliferation | biological process | Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation. [GOC:TermGenie, PMID:23403623] |