Page last updated: 2024-08-26

bosentan anhydrous and Fibrosis

bosentan anhydrous has been researched along with Fibrosis in 23 studies

Research

Studies (23)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (8.70)	18.2507
2000's	10 (43.48)	29.6817
2010's	10 (43.48)	24.3611
2020's	1 (4.35)	2.80

Authors

Authors	Studies
Aubert, JD; Juillerat-Jeanneret, L	1
Akita, K; Isobe, S; Isoda, K; Iwakura, Y; Minamino, T; Niida, T; Ohtomo, F; Sano, M; Sato-Okabayashi, Y; Shimada, K	1
Akamata, K; Aozasa, N; Asano, Y; Ichimura, Y; Noda, S; Sato, S; Takahashi, T; Taniguchi, T; Toyama, T	1
Alessandro, B; Andrea, O; Antonio, P; Claudio, L; Daniela, R; Elisa, T; Federico, C; Giacomo, M; Giuseppe, A; Giuseppe, P; Mariaelisa, R; Marzia, D; Ruggero, B	1
Belloni, AS; Buccella, V; Calò, LA; Caroccia, B; Gioco, F; Guerzoni, E; Guidolin, D; Montini, B; Pagnin, E; Petrelli, L; Piazza, M; Ravarotto, V; Rossi, GP; Seccia, TM	1
Brock, P; Emmrich, J; Fitzner, B; Holzhüter, SA; Jaster, R; Liebe, S; Nizze, H; Sparmann, G	1
Abraham, DJ; Denton, CP; Huh, K; Kapoor, M; Leask, A; Liu, S; McCann, M; Shi-wen, X; Woodgett, JR	1
Hadi, AM; Mouchaers, KT; Postmus, PE; Schalij, I; van der Laarse, WJ; van Hinsbergh, VW; van Nieuw Amerongen, GP; Versteilen, AM; Vonk-Noordegraaf, A	1
Busnadiego, O; García-Fernández, RA; Jiménez, CL; Lagares, D; Lamas, S; Magán-Marchal, N; Rodríguez-Pascual, F	1
Felder, G; Gensch, K; Haust, M; Kuhn, A; Ohmann, C; Ruland, V; Ruzicka, T; Verde, P; Weber, R	1
Derk, CT; Shetty, N	1
Choudhary, G; Harrington, EO; Klinger, JR; Martin, D; Troncales, F	1
Feng, QZ; Li, M; Shi, ZG; Yang, B	1
Brizzolara, R; Cutolo, M; Ferrone, C; Montagna, P; Parodio, A; Seriolo, B; Soldano, S; Sulli, A; Villaggio, B	1
Belloni, AS; Kreutz, R; Nussdorfer, GG; Paul, M; Pessina, AC; Rossi, GP; Seccia, TM	1
Chen, YP; Tang, GY; Tian, XF	1
Bröijersén, A; Bulhak, A; Gonon, AT; Pernow, J	1
Clozel, M; Salloukh, H	1
Chen, YP; Dong, HR; Qiu, CB; Zhang, C	1
Abraham, DJ; Black, CM; Bou-Gharios, G; Chen, Y; Dashwood, MR; Denton, CP; du Bois, RM; Howat, S; Kennedy, L; Leask, A; Pearson, JD; Renzoni, EA; Shi-Wen, X	1
Clozel, JP; Clozel, M; Gonzales, MF; Hess, P; Heudes, D; Karam, H; Löffler, BM	1
Bruneval, P; Clozel, JP; Clozel, M; Gonzales, MF; Heudes, D; Karam, H; Löffler, BM	1
Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Tharaux, PL	1

Reviews

3 review(s) available for bosentan anhydrous and Fibrosis

Article	Year
Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis. Journal of medicinal chemistry, 2016, 09-22, Volume: 59, Issue:18 Topics: Animals; Cardiovascular Diseases; Clinical Trials as Topic; Endothelin Receptor Antagonists; Fibrosis; Humans; Hypertension, Pulmonary; Neoplasms; Receptors, Endothelin	2016
Endothelin receptor antagonists as disease modifiers in systemic sclerosis. Inflammation & allergy drug targets, 2011, Volume: 10, Issue:1 Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Familial Primary Pulmonary Hypertension; Fibrosis; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome	2011
Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Annals of medicine, 2005, Volume: 37, Issue:1 Topics: Administration, Oral; Animals; Bosentan; Cell Division; Connective Tissue Diseases; Endothelin Receptor Antagonists; Endothelins; Fibroblasts; Fibrosis; Humans; Sulfonamides	2005

Trials

1 trial(s) available for bosentan anhydrous and Fibrosis

Article	Year
Effect of bosentan on skin fibrosis in patients with systemic sclerosis: a prospective, open-label, non-comparative trial. Rheumatology (Oxford, England), 2010, Volume: 49, Issue:7 Topics: Aged; Bosentan; Endothelin Receptor Antagonists; Female; Fibrosis; Humans; Male; Middle Aged; Receptors, Endothelin; Scleroderma, Systemic; Skin Ulcer; Statistics as Topic; Sulfonamides; Treatment Outcome	2010

Other Studies

19 other study(ies) available for bosentan anhydrous and Fibrosis

Article	Year
Blocking of interleukin-1 suppresses angiotensin II-induced renal injury. Clinical science (London, England : 1979), 2021, 09-17, Volume: 135, Issue:17 Topics: Angiotensin II; Animals; Antibodies; Blood Pressure; Bosentan; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Humans; Hypertension; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Kidney; Kidney Diseases; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction	2021
Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis research & therapy, 2014, Apr-03, Volume: 16, Issue:2 Topics: Animals; Bosentan; Chromatin Immunoprecipitation; Collagen Type I; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Fibroblasts; Fibrosis; Humans; Immunoblotting; Mice; Phenotype; Proto-Oncogene Protein c-fli-1; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Scleroderma, Systemic; Signal Transduction; Skin; Sulfonamides	2014
Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis. Journal of immunology research, 2015, Volume: 2015 Topics: Anti-Inflammatory Agents; Bosentan; CD4-Positive T-Lymphocytes; Endothelin Receptor Antagonists; Endothelin-1; Female; Fibroblasts; Fibrosis; Humans; Inflammation; Interferon-gamma; Male; Middle Aged; Monocytes; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides	2015
Endothelin-1 Drives Epithelial-Mesenchymal Transition in Hypertensive Nephroangiosclerosis. Journal of the American Heart Association, 2016, 07-21, Volume: 5, Issue:7 Topics: Actins; Angiotensin Receptor Antagonists; Animals; Animals, Genetically Modified; Biphenyl Compounds; Bosentan; Cadherins; Endothelin B Receptor Antagonists; Endothelin-1; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Hypertension; Irbesartan; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Oligopeptides; Piperidines; Rats; Receptor, Endothelin B; rho-Associated Kinases; Signal Transduction; Sulfonamides; Tetrazoles	2016
Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cells. Digestive diseases and sciences, 2009, Volume: 54, Issue:2 Topics: Animals; Bosentan; Carcinoma; Cell Line, Tumor; Coculture Techniques; Collagen; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Organotin Compounds; Pancreas; Pancreatic Neoplasms; Pancreatitis, Chronic; Rats; Receptors, Endothelin; Sulfonamides	2009
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism. The Journal of clinical investigation, 2008, Volume: 118, Issue:10 Topics: Animals; Apoptosis; beta Catenin; Bosentan; Cell Line; Cicatrix; Collagen; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptor, Endothelin A; Receptor, Endothelin B; Sequence Deletion; Signal Transduction; Sulfonamides; Time Factors; Wound Healing	2008
Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:1 Topics: Animals; Body Weight; Bosentan; Capillaries; Cyclic GMP-Dependent Protein Kinases; Diffusion; Endothelin Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Myoglobin; Organ Size; Oxygen Consumption; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Pulmonary Artery; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones; Ultrasonography	2009
Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. Arthritis and rheumatism, 2010, Volume: 62, Issue:3 Topics: Actins; Animals; Benzamides; Bleomycin; Blotting, Western; Bosentan; Cells, Cultured; Collagen Type I; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis; Mice; Mice, Inbred C3H; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skin; Sulfonamides; Transfection; Transforming Growth Factor beta1; Wound Healing	2010
Bosentan attenuates right ventricular hypertrophy and fibrosis in normobaric hypoxia model of pulmonary hypertension. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2011, Volume: 30, Issue:7 Topics: Animals; Antihypertensive Agents; Bosentan; Collagen; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Fibrosis; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Myocardium; Protein Isoforms; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Ventricular Dysfunction, Right	2011
Bosentan ameliorates the expression of fibrotic related growth factors and collagen-1 in diabetic mice. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2012, Volume: 12, Issue:8 Topics: Animals; Bosentan; Collagen; Diabetes Mellitus, Experimental; Endothelin Receptor Antagonists; Fibrosis; Male; Mice; Mice, Inbred C57BL; Myocardium; RNA, Messenger; Streptozocin; Sulfonamides; Vascular Endothelial Growth Factor A	2012
Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients. Reumatismo, 2012, Dec-11, Volume: 64, Issue:5 Topics: Aged; Bosentan; Cells, Cultured; Collagen Type I; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Extracellular Matrix Proteins; Female; Fibrillin-1; Fibrillins; Fibroblasts; Fibronectins; Fibrosis; Humans; Isoxazoles; Microfilament Proteins; Middle Aged; Primary Cell Culture; Scleroderma, Systemic; Sulfonamides; Thiophenes	2012
Cardiac fibrosis occurs early and involves endothelin and AT-1 receptors in hypertension due to endogenous angiotensin II. Journal of the American College of Cardiology, 2003, Feb-19, Volume: 41, Issue:4 Topics: Angiotensin II; Animals; Animals, Genetically Modified; Antihypertensive Agents; Biphenyl Compounds; Bosentan; Cardiomyopathies; Dansyl Compounds; Disease Models, Animal; Endothelin-1; Fibrosis; Hypertension; Irbesartan; Male; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Cell Surface; Sulfonamides; Tetrazoles; Time Factors; Vasoconstrictor Agents	2003
[Renoprotective effects of nonselective endothelin receptor antagonist bosentan on rats with interstitial fibrosis following unilateral ureteral obstruction]. Zhonghua yi xue za zhi, 2003, Mar-25, Volume: 83, Issue:6 Topics: Animals; Bosentan; Collagen Type I; Endothelin-1; Female; Fibrosis; Kidney; Protective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Tissue Inhibitor of Metalloproteinase-1; Ureteral Obstruction	2003
Cardioprotective effect of an endothelin receptor antagonist during ischaemia/reperfusion in the severely atherosclerotic mouse heart. British journal of pharmacology, 2005, Volume: 144, Issue:6 Topics: Animals; Arteriosclerosis; Bosentan; Cardiotonic Agents; Coronary Circulation; Endothelin Receptor Antagonists; Fibrosis; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Reperfusion; Sulfonamides	2005
[The therapeutic effects of bosentan and valsartan on renal interstitial fibrosis of chronic aristolochic acid nephropathy]. Zhonghua yi xue za zhi, 2005, Sep-28, Volume: 85, Issue:37 Topics: Animals; Aristolochic Acids; Bosentan; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Fibrosis; Kidney; Kidney Diseases; Male; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Sulfonamides; Tetrazoles; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1; Valine; Valsartan	2005
Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix biology : journal of the International Society for Matrix Biology, 2007, Volume: 26, Issue:8 Topics: Biopsy; Bosentan; Cell Adhesion; Cells, Cultured; Collagen Type I; Connective Tissue Growth Factor; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Fibroblasts; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Lung; Receptor, Endothelin A; Receptor, Endothelin B; RNA, Messenger; Scleroderma, Systemic; Signal Transduction; Sulfonamides	2007
Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats. Cardiovascular research, 1996, Volume: 31, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Benzimidazoles; Bosentan; Calcium Channel Blockers; Cardiomegaly; Collagen; Coronary Circulation; Desoxycorticosterone; Enalapril; Endothelin Receptor Antagonists; Fibrosis; Hypertension; Male; Mibefradil; Myocardium; Perfusion; Rats; Rats, Wistar; Sulfonamides; Tetrahydronaphthalenes	1996
Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Benzimidazoles; Body Weight; Bosentan; Calcium Channel Blockers; Cardiomegaly; Coronary Circulation; Enalapril; Endothelins; Fibrosis; Heart Ventricles; Hemodynamics; Hormones; Hypertension; Kidney; Mibefradil; Myocardium; Rats; Rats, Inbred SHR; Sulfonamides; Tetrahydronaphthalenes	1996
Regression of renal vascular fibrosis by endothelin receptor antagonism. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Collagen; Collagen Type I; Endothelin Receptor Antagonists; Endothelins; Fibrosis; Gene Expression Regulation; Hypertension, Renovascular; Kidney Glomerulus; Luciferases; Male; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Perfusion; Renal Artery; Staining and Labeling; Sulfonamides; Time Factors	2001