N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

An N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UK23]

EC 3.1.4.45;
Mannose 6-phosphate-uncovering enzyme;
Phosphodiester alpha-GlcNAcase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
n-acetylglucosaminono-1,5-lactone o-(phenylcarbamoyl)oxime	Homo sapiens (human)	Kinact	0.0460	1	1

This protein enables 2 target(s):

Target	Category	Definition
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity	molecular function	Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. [EC:3.1.4.45]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

This protein is located in 2 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
Golgi cisterna membrane	cellular component	The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. [GOC:ecd, GOC:mah]

This protein is involved in 6 target(s):

Target	Category	Definition
carbohydrate metabolic process	biological process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732]
protein glycosylation	biological process	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr]
protein targeting to lysosome	biological process	The process of directing proteins towards the lysosome using signals contained within the protein. [GOC:curators]
lysosome organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. [GOC:mah]
protein modification process	biological process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl]
secretion of lysosomal enzymes	biological process	The controlled release of lysosomal enzymes by a cell. [GOC:mah]