Page last updated: 2024-10-19

melatonin and Fibrosis

melatonin has been researched along with Fibrosis in 41 studies

Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

Research Excerpts

ExcerptRelevanceReference
"The PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database (VIP), and SinoMed databases were searched from inception to March 1st, 2022 to retrieve eligible studies that evaluated the effect of melatonin supplementation on the levels of malondialdehyde (MDA), lipid peroxidation (LPO), nitric oxide (NO), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) in animal models of fibrosis."9.41Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis. ( Huang, XF; Li, D; Liao, YQ; Ling, YJ; Luo, JY; Pan, JH, 2023)
" To address this, we investigated the effect of melatonin on ischemia-induced fibrosis."7.96Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020)
"Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy."7.96Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020)
"Melatonin is a hormone produced by the pineal gland, and it has extensive beneficial effects on various tissue and organs; however, whether melatonin has any effect on cardiac fibrosis in the pathogenesis of diabetic cardiomyopathy (DCM) is still unknown."7.96Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. ( Che, H; Dong, R; Li, H; Li, Y; Liu, Y; Lv, J; Sahil, A; Wang, L; Wang, Y; Xue, H; Yang, Z, 2020)
"To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis."7.88Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018)
"Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol."7.85Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. ( Chen, X; Duan, W; Jin, Z; Jing, L; Li, B; Li, K; Liang, H; Liu, J; Liu, Z; Reiter, RJ; Ren, K; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, B; Yu, S; Zhai, M; Zhang, B; Zhang, M, 2017)
"To investigate the effects of melatonin and octreotide in the prevention of peridural fibrosis in an experimental rat model."7.76Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy. ( Erol, FS; Ilhan, N; Kavakli, A; Ozercan, IH; Sarsilmaz, M, 2010)
"To investigate whether melatonin (MLT) treatment has any protective effect on unilateral ureteral obstruction (UUO)-induced kidney injury in rats."7.75Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. ( Cekmen, M; Ilbey, YO; Ozbek, E; Ozbek, M; Simsek, A; Somay, A, 2009)
"The administration of L-NAME inhibited NOS activity, increased conjugated dienes concentration, elevated blood pressure and induced LVH and fibrosis (indicated by increased collagenous proteins and hydroxyproline levels)."7.75Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. ( Adamcova, M; Barta, A; Krajcirovicova, K; Paulis, L; Pechanova, O; Pelouch, V; Simko, F; Zicha, J, 2009)
"We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency."7.71The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002)
"Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body."6.58Melatonin in Heart Failure: A Promising Therapeutic Strategy? ( Maarman, GJ; Nduhirabandi, F, 2018)
"Fibrosis is a common occurrence following organ injury and failure."6.53Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016)
"Melatonin has received attention as a potential antifibrotic agent due to its anti-proliferative actions on PSCs."5.72Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia. ( Estaras, M; Garcia, A; Gonzalez, A; Iovanna, JL; Martinez, R; Ortiz-Placin, C; Santofimia-Castaño, P, 2022)
"The hypoxic microenvironment of cryptorchidism is an important factor in the impairment and fibrosis of Sertoli cells which result in blood-testis barrier (BTB) destruction and spermatogenesis loss."5.72Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells. ( Lee, Y; Li, D; Li, X; Wang, W; Wei, H; Wei, J; Xiao, L; Yao, H, 2022)
"Melatonin has been demonstrated to ameliorate cardiac hypertrophy and its accompanied fibrosis in previous studies."5.56A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy. ( Cao, F; Lei, C; Liu, L; Wang, B; Wang, J; Wang, X; Yang, Q; Yuan, J; Zhang, J; Zhao, X; Zhu, X, 2020)
"Melatonin treatment for 8 weeks markedly attenuated cardiac hypertrophy and restored impaired cardiac function, as indicated by a decreased HW/BW ratio, reduced cell cross-sectional area and fibrosis, downregulated the mRNA levels of ANP, BNP, and β-MHC and ameliorated adverse effects on the LVEF and LVFS."5.56Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. ( Ding, P; Fan, ZG; Gao, EH; Kong, LH; Liu, Y; Xu, CN; Yang, J; Yang, LF, 2020)
"The PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang database, China Science and Technology Journal Database (VIP), and SinoMed databases were searched from inception to March 1st, 2022 to retrieve eligible studies that evaluated the effect of melatonin supplementation on the levels of malondialdehyde (MDA), lipid peroxidation (LPO), nitric oxide (NO), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT) in animal models of fibrosis."5.41Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis. ( Huang, XF; Li, D; Liao, YQ; Ling, YJ; Luo, JY; Pan, JH, 2023)
" Melatonin, an endogenous hormone, can alleviate fibrosis in multiple models of diseases."4.84Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling. ( Cao, X; Chen, C; Chen, M; Deng, W; Dong, Y; Hu, Z; Huang, J; Long, Q; Luo, S; Lv, D; Rong, Y; Tang, B; Wang, H; Xu, Z, 2024)
"Melatonin is a hormone produced by the pineal gland, and it has extensive beneficial effects on various tissue and organs; however, whether melatonin has any effect on cardiac fibrosis in the pathogenesis of diabetic cardiomyopathy (DCM) is still unknown."3.96Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy. ( Che, H; Dong, R; Li, H; Li, Y; Liu, Y; Lv, J; Sahil, A; Wang, L; Wang, Y; Xue, H; Yang, Z, 2020)
" To address this, we investigated the effect of melatonin on ischemia-induced fibrosis."3.96Melatonin suppresses ischemia-induced fibrosis by regulating miR-149. ( Han, YS; Lee, JH; Lee, SH, 2020)
"Melatonin can inhibit renal inflammation and fibrosis by inhibiting the NF-κB and TGF-β1/Smad3 signaling pathways, and melatonin may be a promising therapeutic target in diabetic nephropathy."3.96Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice. ( Fan, Z; Qi, X; Wu, Y; Xia, L; Yang, W, 2020)
"To evaluate the melatonin effects in these animals, we studied the renal cytoarchitecture by means of morphological analyses, immunofluorescence expression of specific markers related to fibrosis, oxidative stress, inflammation and apoptosis."3.88Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model. ( Bonomini, F; Dos Santos, M; Favero, G; Rezzani, R; Rodella, LF; Stacchiotti, A; Veronese, FV, 2018)
"Melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol."3.85Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. ( Chen, X; Duan, W; Jin, Z; Jing, L; Li, B; Li, K; Liang, H; Liu, J; Liu, Z; Reiter, RJ; Ren, K; Yang, J; Yang, Y; Yi, D; Yi, W; Yu, B; Yu, S; Zhai, M; Zhang, B; Zhang, M, 2017)
" Myocyte necrosis and fibrosis were diminished with melatonin while vasculitis was prevented."3.80Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model. ( Erkal, HŞ; Gürses, I; Özeren, M; Serin, M; Yücel, N, 2014)
"To investigate the effects of melatonin and octreotide in the prevention of peridural fibrosis in an experimental rat model."3.76Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy. ( Erol, FS; Ilhan, N; Kavakli, A; Ozercan, IH; Sarsilmaz, M, 2010)
"To investigate whether melatonin (MLT) treatment has any protective effect on unilateral ureteral obstruction (UUO)-induced kidney injury in rats."3.75Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression. ( Cekmen, M; Ilbey, YO; Ozbek, E; Ozbek, M; Simsek, A; Somay, A, 2009)
"The administration of L-NAME inhibited NOS activity, increased conjugated dienes concentration, elevated blood pressure and induced LVH and fibrosis (indicated by increased collagenous proteins and hydroxyproline levels)."3.75Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. ( Adamcova, M; Barta, A; Krajcirovicova, K; Paulis, L; Pechanova, O; Pelouch, V; Simko, F; Zicha, J, 2009)
" Melatonin, even at low dose, is an efficient agent in reducing negative parameters of cholestasis."3.73Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats. ( Emre, MH; Esrefoglu, M; Gül, M; Polat, A; Selimoglu, MA, 2005)
" The effects of 900 MHz of radiation on fibrosis, lipid peroxidation, and anti-oxidant enzymes and the ameliorating effects of melatonin (Mel) were evaluated in rat skin."3.72Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin. ( Akturk, O; Altuntas, I; Ayata, A; Mollaoglu, H; Ozguner, F; Yilmaz, HR, 2004)
"We might hypothesize that the high rate of pseudarthrosis after spinal fusion for neurofibromatous scoliosis is related to two factors: the absence of neurofibromin and melatonin deficiency."3.71The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis. ( Abdel-Wanis, ME; Kawahara, N, 2002)
"Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body."2.58Melatonin in Heart Failure: A Promising Therapeutic Strategy? ( Maarman, GJ; Nduhirabandi, F, 2018)
"Fibrosis is a common occurrence following organ injury and failure."2.53Melatonin: the dawning of a treatment for fibrosis? ( Deng, C; Di, S; Fan, C; Hu, W; Jiang, S; Lv, J; Ma, Z; Reiter, RJ; Yan, X; Yang, Y, 2016)
"The hypoxic microenvironment of cryptorchidism is an important factor in the impairment and fibrosis of Sertoli cells which result in blood-testis barrier (BTB) destruction and spermatogenesis loss."1.72Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells. ( Lee, Y; Li, D; Li, X; Wang, W; Wei, H; Wei, J; Xiao, L; Yao, H, 2022)
"Melatonin has received attention as a potential antifibrotic agent due to its anti-proliferative actions on PSCs."1.72Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia. ( Estaras, M; Garcia, A; Gonzalez, A; Iovanna, JL; Martinez, R; Ortiz-Placin, C; Santofimia-Castaño, P, 2022)
"Melatonin has been demonstrated to ameliorate cardiac hypertrophy and its accompanied fibrosis in previous studies."1.56A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy. ( Cao, F; Lei, C; Liu, L; Wang, B; Wang, J; Wang, X; Yang, Q; Yuan, J; Zhang, J; Zhao, X; Zhu, X, 2020)
"Melatonin treatment for 8 weeks markedly attenuated cardiac hypertrophy and restored impaired cardiac function, as indicated by a decreased HW/BW ratio, reduced cell cross-sectional area and fibrosis, downregulated the mRNA levels of ANP, BNP, and β-MHC and ameliorated adverse effects on the LVEF and LVFS."1.56Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway. ( Ding, P; Fan, ZG; Gao, EH; Kong, LH; Liu, Y; Xu, CN; Yang, J; Yang, LF, 2020)
"Melatonin-treated BDL rats received daily melatonin 100 mg/kg/day via intraperitoneal injection."1.40Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats. ( Aktas, C; Erboga, M; Kanter, M; Mete, R; Oran, M, 2014)
"Melatonin (MEL) has been proposed as a therapeutic agent for the oral cavity, due to its antioxidant and anti-inflammatory effects since periodontal diseases are aggravated by free radicals, and by disproportionate immunological response to plaque microorganism."1.39Anti-fibrotic and anti-inflammatory properties of melatonin on human gingival fibroblasts in vitro. ( Gómez-Florit, M; Monjo, M; Ramis, JM, 2013)
"Melatonin treatment increased GSH levels and GSH-Px activity, decreased MDA level in testicular tissue, and increased plasma T level."1.35Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats. ( Cekmen, M; Ilbey, YO; Otunctemur, A; Ozbek, E; Simsek, A; Somay, A, 2009)
"In chronic pancreatitis and pancreatic cancer, progressive fibrosis with the accumulation of extracellular matrix occurs."1.35Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1. ( Aust, S; Jäger, W; Kirschner, H; Klimpfinger, M; Thalhammer, T, 2008)

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (19.51)29.6817
2010's14 (34.15)24.3611
2020's19 (46.34)2.80

Authors

AuthorsStudies
Estaras, M1
Martinez, R1
Garcia, A1
Ortiz-Placin, C1
Iovanna, JL1
Santofimia-Castaño, P1
Gonzalez, A1
Wei, H1
Xiao, L1
Yao, H1
Li, X1
Wang, W1
Lee, Y1
Li, D2
Wei, J1
Jiang, W1
Jin, L1
Ju, D1
Lu, Z1
Wang, C1
Guo, X1
Zhao, H1
Shen, S1
Cheng, Z1
Shen, J1
Zong, G1
Chen, J1
Li, K2
Yang, L2
Zhang, Z1
Feng, Y1
Shen, JZ1
Zhang, EE1
Wan, R1
Pan, JH1
Huang, XF1
Liao, YQ1
Ling, YJ1
Luo, JY1
Li, N3
Xiong, R1
Li, G1
Wang, B2
Geng, Q1
Ziegler, KA1
Ahles, A1
Dueck, A1
Esfandyari, D1
Pichler, P1
Weber, K1
Kotschi, S1
Bartelt, A1
Sinicina, I1
Graw, M1
Leonhardt, H1
Weckbach, LT1
Massberg, S1
Schifferer, M1
Simons, M1
Hoeher, L1
Luo, J1
Ertürk, A1
Schiattarella, GG1
Sassi, Y1
Misgeld, T1
Engelhardt, S1
Dong, Y1
Cao, X1
Huang, J1
Hu, Z1
Chen, C1
Chen, M1
Long, Q1
Xu, Z1
Lv, D1
Rong, Y1
Luo, S1
Wang, H2
Deng, W1
Tang, B1
Yang, Z2
He, Y1
Ma, Q1
Zhang, Q1
Che, H1
Wang, Y1
Li, H1
Li, Y1
Sahil, A1
Lv, J2
Liu, Y2
Dong, R1
Xue, H1
Wang, L1
Han, YS2
Lee, JH4
Lee, SH4
Zhao, X1
Wang, X2
Wang, J1
Yuan, J1
Zhang, J2
Zhu, X1
Lei, C1
Yang, Q1
Cao, F1
Liu, L1
Wang, Z1
Gao, F1
Lei, Y1
Li, Z1
Lu, L2
Ma, J1
Sun, M1
Gao, E1
Ren, J1
Yang, J3
Fan, Z1
Qi, X1
Yang, W1
Xia, L1
Wu, Y1
Xu, CN1
Kong, LH1
Ding, P1
Fan, ZG1
Gao, EH1
Yang, LF1
Yoon, YM3
Go, G3
Yun, CW1
Lim, JH2
Jiang, J1
Liang, S1
Du, Z1
Xu, Q1
Duan, J1
Sun, Z1
Yoon, S1
Lee, G1
Wu, N1
Meng, F2
Zhou, T1
Han, Y2
Kennedy, L2
Venter, J2
Francis, H2
DeMorrow, S2
Onori, P2
Invernizzi, P1
Bernuzzi, F1
Mancinelli, R2
Gaudio, E2
Franchitto, A2
Glaser, S2
Alpini, G2
Zhai, M1
Liu, Z1
Zhang, B1
Jing, L1
Li, B1
Chen, X1
Zhang, M1
Yu, B1
Ren, K1
Yang, Y2
Yi, W1
Liu, J1
Yi, D1
Liang, H1
Jin, Z1
Reiter, RJ2
Duan, W1
Yu, S1
Simko, F3
Pechanova, O2
Repova, K1
Aziriova, S1
Krajcirovicova, K2
Celec, P1
Tothova, L1
Vrankova, S1
Balazova, L1
Zorad, S1
Adamcova, M2
Dos Santos, M1
Favero, G1
Bonomini, F1
Stacchiotti, A1
Rodella, LF1
Veronese, FV1
Rezzani, R1
Nduhirabandi, F1
Maarman, GJ1
Li, J1
Yan, S1
Lu, Y1
Miao, X1
Gu, Z1
Shao, Y1
Paulis, L2
Gómez-Florit, M1
Ramis, JM1
Monjo, M1
Ray, D1
Greene, J1
Renzi, A1
Gürses, I1
Özeren, M1
Serin, M1
Yücel, N1
Erkal, HŞ1
Hu, W1
Ma, Z1
Jiang, S1
Fan, C1
Deng, C1
Yan, X1
Di, S1
Ranga Rao, S1
Subbarayan, R1
Ajitkumar, S1
Murugan Girija, D1
Ilbey, YO2
Ozbek, E2
Simsek, A2
Otunctemur, A1
Cekmen, M2
Somay, A2
Aust, S1
Jäger, W1
Kirschner, H1
Klimpfinger, M1
Thalhammer, T1
Ozbek, M1
Zicha, J1
Barta, A1
Pelouch, V1
Erol, FS1
Kavakli, A1
Ilhan, N1
Ozercan, IH1
Sarsilmaz, M1
Aktas, C1
Kanter, M1
Erboga, M1
Mete, R1
Oran, M1
Mizrak, B1
Parlakpinar, H1
Acet, A1
Turkoz, Y1
Ayata, A1
Mollaoglu, H1
Yilmaz, HR1
Akturk, O1
Ozguner, F1
Altuntas, I1
Esrefoglu, M1
Gül, M1
Emre, MH1
Polat, A1
Selimoglu, MA1
Abdel-Wanis, ME1
Kawahara, N1

Reviews

3 reviews available for melatonin and Fibrosis

ArticleYear
Effect of melatonin on oxidative stress indicators in animal models of fibrosis: A systematic review and meta-analysis.
    Free radical biology & medicine, 2023, 02-01, Volume: 195

    Topics: Animals; Antioxidants; Catalase; Fibrosis; Glutathione; Glutathione Peroxidase; Humans; Malondialdeh

2023
Melatonin in Heart Failure: A Promising Therapeutic Strategy?
    Molecules (Basel, Switzerland), 2018, Jul-22, Volume: 23, Issue:7

    Topics: Animals; Fibrosis; Heart Failure; Humans; Hypertension; Melatonin

2018
Melatonin: the dawning of a treatment for fibrosis?
    Journal of pineal research, 2016, Volume: 60, Issue:2

    Topics: Animals; Extracellular Matrix; Fibrosis; Heart Diseases; Humans; Kidney Diseases; Liver Cirrhosis; M

2016

Other Studies

38 other studies available for melatonin and Fibrosis

ArticleYear
Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia.
    Biochemical pharmacology, 2022, Volume: 202

    Topics: Actins; Cells, Cultured; Collagen; Fibrosis; Humans; Hypoxia; Melatonin; Pancreas; Pancreatic Stella

2022
Melatonin through blockade of Hif-1α signaling mediates the anti-fibrosis under hypoxia in canine Sertoli cells.
    Reproductive biology, 2022, Volume: 22, Issue:4

    Topics: Acetylserotonin O-Methyltransferase; Animals; Cryptorchidism; Dogs; Fibrosis; Hypoxia; Hypoxia-Induc

2022
The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction.
    Science translational medicine, 2022, 09-28, Volume: 14, Issue:664

    Topics: Animals; ARNTL Transcription Factors; Aryl Hydrocarbon Receptor Nuclear Translocator; Fibrosis; Inte

2022
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis.
    Free radical biology & medicine, 2023, Aug-20, Volume: 205

    Topics: Animals; Cellular Senescence; Ferroptosis; Fibrosis; Lung; Lung Injury; Melatonin; Mice; Particulate

2023
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.
    Science (New York, N.Y.), 2023, 07-21, Volume: 381, Issue:6655

    Topics: Animals; Circadian Rhythm; Fibrosis; Heart Diseases; Humans; Macrophages; Melatonin; Mice; Pineal Gl

2023
Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling.
    Biochimica et biophysica acta. Molecular basis of disease, 2024, Volume: 1870, Issue:1

    Topics: Animals; Autophagy; Cicatrix, Hypertrophic; Fibroblasts; Fibrosis; Humans; Melatonin; Phosphatidylin

2024
Alleviative effect of melatonin against the nephrotoxicity induced by cadmium exposure through regulating renal oxidative stress, inflammatory reaction, and fibrosis in a mouse model.
    Ecotoxicology and environmental safety, 2023, Oct-15, Volume: 265

    Topics: Animals; Cadmium; Drug-Related Side Effects and Adverse Reactions; Fibrosis; Humans; Inflammation; K

2023
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:4

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Fibrosis; Gene Ex

2020
Melatonin suppresses ischemia-induced fibrosis by regulating miR-149.
    Biochemical and biophysical research communications, 2020, 04-30, Volume: 525, Issue:2

    Topics: Animals; Fibrosis; Inflammation; Ischemia; Melatonin; Mice; MicroRNAs; Myoblasts; Peroxisome Prolife

2020
A Peptide-Functionalized Magnetic Nanoplatform-Loaded Melatonin for Targeted Amelioration of Fibrosis in Pressure Overload-Induced Cardiac Hypertrophy.
    International journal of nanomedicine, 2020, Volume: 15

    Topics: Animals; Cardiomegaly; Disease Models, Animal; Drug Delivery Systems; Ferrosoferric Oxide; Fibrosis;

2020
Melatonin ameliorates renal fibroblast-myofibroblast transdifferentiation and renal fibrosis through miR-21-5p regulation.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:10

    Topics: Actins; Animals; Biomarkers; Cell Survival; Cell Transdifferentiation; Disease Models, Animal; Disea

2020
Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Anisomycin; Apoptosis; Cell Hypoxia; Cell Line; Cytoprotection; Diabetes Mellitus, Experime

2020
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
    Archives of medical research, 2020, Volume: 51, Issue:6

    Topics: Animals; Central Nervous System Depressants; Diabetes Mellitus, Experimental; Diabetic Nephropathies

2020
Melatonin ameliorates pressure overload-induced cardiac hypertrophy by attenuating Atg5-dependent autophagy and activating the Akt/mTOR pathway.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 10-01, Volume: 1866, Issue:10

    Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cardiomegaly; Disease Models, Animal; Fi

2020
Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis.
    International journal of medical sciences, 2020, Volume: 17, Issue:9

    Topics: Blotting, Western; Catalase; Cell Proliferation; Collagen Type I; Fibronectins; Fibrosis; Glucose; H

2020
Melatonin Suppresses Renal Cortical Fibrosis by Inhibiting Cytoskeleton Reorganization and Mitochondrial Dysfunction through Regulation of miR-4516.
    International journal of molecular sciences, 2020, Jul-27, Volume: 21, Issue:15

    Topics: Animals; Cell Line; Cytoskeleton; Fibrosis; Gene Expression Regulation; Kidney Cortex; Male; Melaton

2020
Melatonin ameliorates PM
    Journal of pineal research, 2021, Volume: 70, Issue:1

    Topics: Acetylation; Animals; Antioxidants; Cardiomyopathies; Cardiotoxicity; Cell Line; Disease Models, Ani

2021
Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis.
    Cells, 2021, 07-03, Volume: 10, Issue:7

    Topics: Animals; Cell Line; Disease Models, Animal; Fibrosis; Humans; Kidney; Kidney Function Tests; Male; M

2021
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:10

    Topics: Angiogenesis Inducing Agents; Animals; Cell Proliferation; Cholangitis, Sclerosing; Darkness; Diseas

2017
Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies.
    Journal of pineal research, 2017, Volume: 63, Issue:3

    Topics: Angiotensin II; Animals; Antioxidants; Cardiomegaly; Disease Models, Animal; Drug Evaluation, Precli

2017
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
    International journal of molecular sciences, 2017, Jul-25, Volume: 18, Issue:8

    Topics: Acetylcysteine; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Fibrosis; Heart

2017
Oral supplementation of melatonin protects against lupus nephritis renal injury in a pristane-induced lupus mouse model.
    Life sciences, 2018, Jan-15, Volume: 193

    Topics: Animals; Apoptosis; Autoantibodies; Cytokines; Disease Models, Animal; Female; Fibrosis; Inflammatio

2018
Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Diabetes Mellitus, Experimental; Down-Regulation;

2019
Antifibrotic effect of melatonin--perspective protection in hypertensive heart disease.
    International journal of cardiology, 2013, Oct-03, Volume: 168, Issue:3

    Topics: Animals; Cardiomegaly; Fibrosis; Humans; Hypertension; Melatonin; Myocardium

2013
Anti-fibrotic and anti-inflammatory properties of melatonin on human gingival fibroblasts in vitro.
    Biochemical pharmacology, 2013, Dec-15, Volume: 86, Issue:12

    Topics: Anti-Inflammatory Agents; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Fibrosis; Gingiva; Humans;

2013
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Nov-01, Volume: 307, Issue:9

    Topics: Animals; ARNTL Transcription Factors; Arylalkylamine N-Acetyltransferase; Bile Acids and Salts; Bile

2014
Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model.
    Pathology, research and practice, 2014, Volume: 210, Issue:12

    Topics: Animals; Cardiomyopathies; Coronary Artery Disease; Coronary Vessels; Cytoprotection; Fibrosis; Male

2014
4PBA strongly attenuates endoplasmic reticulum stress, fibrosis, and mitochondrial apoptosis markers in cyclosporine treated human gingival fibroblasts.
    Journal of cellular physiology, 2018, Volume: 233, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Cells, Cultured; Cyclosporine; Cytoprotecti

2018
Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats.
    Fertility and sterility, 2009, Volume: 92, Issue:3

    Topics: Animals; Antioxidants; Cisplatin; Cyclophosphamide; Fibrosis; Glutathione; Glutathione Peroxidase; I

2009
Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1.
    Wiener medizinische Wochenschrift (1946), 2008, Volume: 158, Issue:19-20

    Topics: Carcinoma, Pancreatic Ductal; Cell Division; Epithelial Cells; Fibrosis; Humans; Melatonin; Microsco

2008
Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression.
    Journal of endourology, 2009, Volume: 23, Issue:7

    Topics: Animals; Cell Movement; Fibrosis; Glutathione; Immunohistochemistry; Kidney Diseases; Leukocytes; Li

2009
Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 2009, Volume: 27, Issue:6

    Topics: Animals; Blood Pressure; Fibrosis; Free Radical Scavengers; Heart Ventricles; Hemodynamics; Hydroxyp

2009
Efects of melatonin and octreotide on peridural fibrosis in an animal model of laminectomy.
    Turkish neurosurgery, 2010, Volume: 20, Issue:1

    Topics: Animals; Central Nervous System Depressants; Fibrosis; Laminectomy; Lumbar Vertebrae; Male; Melatoni

2010
Melatonin attenuates oxidative stress, liver damage and hepatocyte apoptosis after bile-duct ligation in rats.
    Toxicology and industrial health, 2014, Volume: 30, Issue:9

    Topics: Animals; Apoptosis; Cell Proliferation; Cholestasis; Common Bile Duct; Fibrosis; Glutathione; Hepato

2014
Effects of pinealectomy and exogenous melatonin on rat hearts.
    Acta histochemica, 2004, Volume: 106, Issue:1

    Topics: Animals; Aorta; Cholesterol; Female; Fibrosis; Glutathione; Heart; Heart Valves; Malondialdehyde; Me

2004
Oxidative stress-mediated skin damage in an experimental mobile phone model can be prevented by melatonin.
    The Journal of dermatology, 2004, Volume: 31, Issue:11

    Topics: Animals; Antioxidants; Catalase; Cell Phone; Disease Models, Animal; Fibrosis; Free Radical Scavenge

2004
Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats.
    World journal of gastroenterology, 2005, Apr-07, Volume: 11, Issue:13

    Topics: Animals; Antioxidants; Cholestasis; Cholestasis, Extrahepatic; Common Bile Duct; Dose-Response Relat

2005
The role of neurofibromin and melatonin in pathogenesis of pseudarthrosis after spinal fusion for neurofibromatous scoliosis.
    Medical hypotheses, 2002, Volume: 58, Issue:5

    Topics: Bone and Bones; Fibrosis; Humans; Melatonin; Models, Biological; Neurofibromatosis 1; Neurofibromin

2002