isoxazoles has been researched along with Fibrosis in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 13 (59.09) | 24.3611 |
| 2020's | 4 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Cheon, J; Jun, HS; Kim, D; Lee, GH | 1 |
| Bao, X; Feng, Y; Liu, S; Lv, W; Ren, Y; Yi, Z; Zhang, Q | 1 |
| Hirata, T; Miyata, N; Roman, RJ; Smith, SV; Takahashi, T | 1 |
| Cai, W; Chen, S; Du, J; Liu, Y; Lu, Y; Tian, X; Wang, W; Wang, Y; Xiao, Y | 1 |
| Batteux, F; Cerles, O; Chéreau, C; Chouzenoux, S; Kavian, N; Morin, F; Nicco, C | 1 |
| Frangogiannis, NG; Fujikura, K; Garcia, MJ; Palanski, BA; Shinde, AV; Su, Y | 1 |
| Ali, A; Ashraf, M; Hu, H; Maienschein-Cline, M; Tang, Y; Wang, Y; Xuan, W | 1 |
| Bae, EH; Choi, HI; Kim, CS; Kim, DH; Kim, SW; Ma, SK; Park, JS | 1 |
| Jirarattanaphochai, K; Sae-Jung, S | 1 |
| Bascands, JL; Bouloumié, A; Decaunes, P; Gres, S; Langin, D; Rancoule, C; Saulnier-Blache, JS; Valet, P; Viaud, M; Viguerie, N | 1 |
| Ohashi, T; Yamamoto, T | 1 |
| Cheng, E; Huo, X; Park, JY; Souza, RF; Spechler, SJ; Wang, DH; Wilson, KS; Yu, C; Zhang, Q; Zhang, X | 1 |
| Bellamy, CO; Dhaun, N; Kluth, DC; MacIntyre, IM | 1 |
| Derk, CT; Shetty, N | 1 |
| Brandes, RP; Cornitescu, T; Dahal, BK; Davie, N; Ghofrani, HA; Grimminger, F; Janssen, W; Kojonazarov, B; Kosanovic, D; Luitel, H; Schermuly, RT; Seeger, W; Sydykov, A; Weissmann, N | 1 |
| Baldelli, F; Cipriani, S; D'Amore, C; Distrutti, E; Fiorucci, S; Mencarelli, A; Palladino, G; Renga, B | 1 |
| Akhmetshina, A; Allanore, Y; Avouac, J; Beyer, C; Dees, C; Distler, JH; Distler, O; Horn, A; Maurer, B; Palumbo, K; Sadowski, A; Schett, G; Schneider, H; Shiozawa, S; Tomcik, M; Zerr, P | 1 |
| Brizzolara, R; Cutolo, M; Ferrone, C; Montagna, P; Parodio, A; Seriolo, B; Soldano, S; Sulli, A; Villaggio, B | 1 |
| Asari, S; Chiba, A; Fujita, K; Fukuchi, N; Iida, Y; Ijichi, C; Iwayama, S; Kataba, Y; Ohmuta, N; Ohsumi, K; Shoji, M; Yamamoto, T | 1 |
| Bascands, JL; Calise, D; Chun, J; Grès, S; Guigné, C; Klein, J; Neau, E; Pradère, JP; Saulnier-Blache, JS; Schanstra, JP; Valet, P | 1 |
| Liu, X; Lou, TQ; Peng, H; Tang, H; Tang, Y; Wang, C | 1 |
| Bartlett, RR; Dimitrijevic, M; Stosic-Grujicic, S | 1 |
1 review(s) available for isoxazoles and Fibrosis
| Article | Year |
|---|---|
Endothelin receptor antagonists as disease modifiers in systemic sclerosis.
Topics: Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Endothelins; Familial Primary Pulmonary Hypertension; Fibrosis; Humans; Hypertension, Pulmonary; Isoxazoles; Phenylpropionates; Pyridazines; Receptors, Endothelin; Scleroderma, Systemic; Sulfonamides; Thiophenes; Treatment Outcome | 2011 |
1 trial(s) available for isoxazoles and Fibrosis
| Article | Year |
|---|---|
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.
Topics: Actins; Adipose Tissue; Animals; Collagen; Enzyme Activators; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Obese; Propionates; Receptors, Lysophosphatidic Acid; Tissue Culture Techniques; Transforming Growth Factor beta | 2014 |
20 other study(ies) available for isoxazoles and Fibrosis
| Article | Year |
|---|---|
Lysophosphatidic Acid Promotes Epithelial-Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy.
Topics: Actins; Animals; Cadherins; Diabetic Nephropathies; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Factor V; Fibronectins; Fibrosis; Glycerophospholipids; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Kruppel-Like Transcription Factors; Lysophospholipids; Mice; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription Factors; Vimentin | 2022 |
Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts.
Topics: Apoptosis; Cells, Cultured; Dermis; Down-Regulation; Fibroblasts; Fibrosis; Guanine Nucleotide Exchange Factors; Humans; Hydrazones; Isoxazoles; Keloid; Primary Cell Culture; Protein Isoforms; Proto-Oncogene Proteins c-akt; Signal Transduction | 2021 |
Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
Topics: Animals; Diabetic Nephropathies; Fibrosis; Hypertension, Renal; Isoxazoles; Kidney; Lysophospholipids; Male; Propionates; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley | 2021 |
A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis.
Topics: Animals; Benzothiazoles; Bile Acids and Salts; Fibrosis; Humans; Isoxazoles; Liver; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease; Swine | 2021 |
Leflunomide prevents ROS-induced systemic fibrosis in mice.
Topics: Animals; Antirheumatic Agents; Autoantibodies; Bleomycin; Cells, Cultured; Disease Models, Animal; Female; Fibrosis; Humans; Hypochlorous Acid; Immunosuppression Therapy; Isoxazoles; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Leflunomide; Lymphocyte Activation; Macrophages; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; Reactive Oxygen Species; Signal Transduction; Skin; STAT6 Transcription Factor | 2017 |
Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload.
Topics: Animals; Cardiomegaly; Collagen; Diastole; Extracellular Matrix; Female; Fibroblasts; Fibrosis; GTP-Binding Proteins; Hypertrophy, Left Ventricular; Isoxazoles; Male; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Pressure; Protein Glutamine gamma Glutamyltransferase 2; Pyrrolidines; Quinolines; Recombinant Proteins; Stroke Volume; Tissue Inhibitor of Metalloproteinases; Transcription, Genetic; Transglutaminases; Up-Regulation; Ventricular Remodeling | 2018 |
Cardiac Progenitors Induced from Human Induced Pluripotent Stem Cells with Cardiogenic Small Molecule Effectively Regenerate Infarcted Hearts and Attenuate Fibrosis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Fibrosis; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Mice; Myocardial Infarction; Myocytes, Cardiac; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Transplantation; Thiophenes | 2018 |
Src-mediated crosstalk between FXR and YAP protects against renal fibrosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Epithelial Cells; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Proto-Oncogene Mas; Receptors, Cytoplasmic and Nuclear; Signal Transduction; src-Family Kinases; YAP-Signaling Proteins | 2019 |
Prevention of peridural fibrosis using a cyclooxygenase-2 inhibitor (nonsteroidal anti-inflammatory drug) soaked in absorbable gelatin sponge: an experimental comparative animal model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Dura Mater; Failed Back Surgery Syndrome; Female; Fibroblasts; Fibrosis; Gelatin Sponge, Absorbable; Humans; Isoxazoles; Laminectomy; Lumbar Vertebrae; Male; Models, Animal; Postoperative Complications; Random Allocation; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2013 |
Antifibrotic effect of lysophosphatidic acid receptors LPA1 and LPA3 antagonist on experimental murine scleroderma induced by bleomycin.
Topics: Animals; Bleomycin; Cell Count; Chemokine CCL3; Collagen Type I; Connective Tissue Growth Factor; Disease Models, Animal; Female; Fibrosis; Hydroxyproline; Interferon-gamma; Isoxazoles; Lung; Mast Cells; Mice; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Scleroderma, Systemic; Skin; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1 | 2015 |
JAK-STAT6 Pathway Inhibitors Block Eotaxin-3 Secretion by Epithelial Cells and Fibroblasts from Esophageal Eosinophilia Patients: Promising Agents to Improve Inflammation and Prevent Fibrosis in EoE.
Topics: Cell Line, Transformed; Chemokine CCL26; Chemokines, CC; Eosinophilic Esophagitis; Eosinophils; Epithelial Cells; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Inflammation; Interleukin-13; Interleukin-4; Isoxazoles; Janus Kinase 1; Leflunomide; Nitriles; Omeprazole; Phosphorylation; Primary Cell Culture; Pyrazoles; Pyrimidines; Signal Transduction; STAT6 Transcription Factor; Th2 Cells | 2016 |
Endothelin receptor antagonism and renin inhibition as treatment options for scleroderma kidney.
Topics: Amides; Antihypertensive Agents; Atrophy; Biomarkers; Biopsy; Endothelin Receptor Antagonists; Female; Fibrosis; Fumarates; Humans; Hypertension, Renal; Isoxazoles; Kidney; Middle Aged; Proteinuria; Pulmonary Fibrosis; Renal Insufficiency, Chronic; Renin; Scleroderma, Systemic; Thiophenes; Treatment Outcome | 2009 |
Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Disease Models, Animal; Echocardiography, Doppler; Endothelin A Receptor Antagonists; Fibrosis; Hemodynamics; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Isoxazoles; Male; Monocrotaline; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Sulfones; Time Factors; Ventricular Function, Right; Ventricular Remodeling | 2011 |
FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity.
Topics: Acyl-CoA Oxidase; Animals; Apoptosis; Bile Acids and Salts; Blood Glucose; Cardiovascular Diseases; Chenodeoxycholic Acid; Dyslipidemias; Fibrosis; Hyperinsulinism; Hyperlipidemias; Insulin Resistance; Isoxazoles; Lipid Metabolism; Liver; Myocardium; Obesity; PPAR alpha; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Risk Factors; RNA, Messenger; Triglycerides | 2013 |
Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.
Topics: Animals; Benzophenones; Bleomycin; Cells, Cultured; Collagen; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Scleroderma, Systemic; Signal Transduction; Transcription Factor AP-1; Transfection; Transforming Growth Factor beta; Up-Regulation | 2012 |
Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients.
Topics: Aged; Bosentan; Cells, Cultured; Collagen Type I; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Extracellular Matrix Proteins; Female; Fibrillin-1; Fibrillins; Fibroblasts; Fibronectins; Fibrosis; Humans; Isoxazoles; Microfilament Proteins; Middle Aged; Primary Cell Culture; Scleroderma, Systemic; Sulfonamides; Thiophenes | 2012 |
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.
Topics: Animals; Cell Proliferation; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Drug Design; Fibrosis; Humans; Inhibitory Concentration 50; Isoxazoles; Liver; Lysophospholipids; Propionates; Rats | 2007 |
LPA1 receptor activation promotes renal interstitial fibrosis.
Topics: Animals; Culture Media, Conditioned; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Propionates; Receptors, Lysophosphatidic Acid; Transforming Growth Factor beta; Ureter | 2007 |
[Study on protective effects and its mechanism of leflunomide on renal tissue in rat IgA nephropathy model].
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Fibrosis; Glomerulonephritis, IGA; Isoxazoles; Kidney; Leflunomide; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1 | 2008 |
Prevention of experimental autoimmune diabetes in mice by treatment with leflunomide.
Topics: Aniline Compounds; Animals; Crotonates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Fibrosis; Hydroxybutyrates; Immunosuppressive Agents; Islets of Langerhans; Isoxazoles; Leflunomide; Male; Mice; Mice, Inbred CBA; Nitriles; Toluidines | 1998 |