Compounds > n-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
Page last updated: 2024-11-12

n-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide

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Description

N-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide: has antineoplastic activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID19582717
CHEMBL ID1222381
CHEBI ID95020
SCHEMBL ID509365
MeSH IDM0559868

Synonyms (45)

Synonym
CHEMBL1222381
n-cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
AKOS004090583
NCGC00182348-01
neuronal differentiation inducer iii
S7914
c11h10n2o2s
BRD-K53903639-001-01-3
SYENTKHGMVKGAQ-UHFFFAOYSA-N
832115-62-5
n-cyclopropyl-5-(thiophen-2-yl)-1,2-oxazole-3-carboxamide
SCHEMBL509365
CS-5072
isx 9
n-cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
HB3401
n-cyclopropyl-5-(2-thienyl)-3-isoxa zolecarboxamide
isx-9
HY-12323
AC-30932
isoxazole 9 (isx-9)
n-cyclopropyl-5-thiophen-2-yl-1,2-oxazole-3-carboxamide
EX-A937
isoxazole 9
FT-0699834
CHEBI:95020
n-cyclopropyl-5-(thiophen-2-yl)-isoxazole-3-carboxamide
F17380
isoxazole 9(isx9)
BCP16038
isx9
DTXSID50880071
Q27166781
n-cyclopropyl-5-thiophen-2-yl-3-isoxazolecarboxamide
neuronal differentiation inducer iii - cas 832115-62-5
Z220650400
mfcd04133937
AS-16612
EN300-141479
HMS3886J19
CCG-266818
BI162774
isx-9 (gmp)
HY-12323G
CS-0622784
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
heteroareneA heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).
aromatic amideAn amide in which the amide linkage is bonded directly to an aromatic system.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency10.69100.007215.758889.3584AID588342
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (69)

Assay IDTitleYearJournalArticle
AID500522Induction of C57BL/6 mouse P19CL6 cell differentiation at 50 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500558Induction of NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 24 hrs by RT-PCR analysis in presence of NMDA receptor antagonist MK8012008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500557Induction of L-type calcium channel/NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 24 hrs by RT-PCR analysis in presence of multiple inhibitors2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500527Induction of rat HCN cell differentiation assessed as increase in GluR2 gene expression after 3 hrs by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500578Induction of CAMK-mediated MREx3 activity in rat HCN cells by luciferase reporter gene assay in presence of 200 nM PKC inhibitor Go69762008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500537Induction of rat HCN cell differentiation assessed as increase in NR1 gene expression after 3 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500532Induction of rat HCN cell differentiation assessed as increase in Tuj1 gene expression after 1 day by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500582Induction of rat HCN cell proliferation at 20 uM after 20 days by BrdU incorporation assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500555Induction of NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 3 hrs by RT-PCR analysis in presence of NMDA receptor antagonist MK8012008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500551Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of NMDA receptor antagonist MK8012008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500571Induction of HDAC5 translocation in cytoplasm of rat HCN cells assessed as phosphorylated HDAC5 accumulation2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500577Induction of CAMK-mediated MREx3 activity in rat HCN cells by luciferase reporter gene assay in presence of 2.5 uM CAMK inhibitor KN932008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500549Induction of NMDA receptor-mediated Ca2+ influx in rat HCN cells at 5 uM by Fura-2 imaging analysis in presence of NMDA receptor antagonist MK8012008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500519Inhibition of LIF/BMP2-mediated rat HCN cell differentiation into astrocytes at 25 uM2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500560Induction of rat HCN cell differentiation assessed as induction of induction of MREx3 gene expression by luciferase reporter gene assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500575Induction of HDAC5 translocation in nucleus of rat HCN cells assessed as GFP-HDAC5 fusion protein accumulation at 20 uM by fluorescence assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500548Induction of L-type calcium channel/NMDA receptor-mediated Ca2+ influx in rat HCN cells at 5 uM by Fura-2 imaging analysis in presence of multiple of inhibitors2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500570Induction of HDAC5 translocation in nucleus of rat HCN cells assessed as phosphorylated HDAC5 accumulation2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500517Induction of rat HCN cell differentiation assessed as induction of neuronal reporter neuroD activity by luciferase reporter gene assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500546Induction of NMDA receptor-mediated Ca2+ influx in rat HCN cells in presence of NMDA receptor antagonist MK8012008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500574Effect on subcellular distribution of CREB protein in rat HCN cells after 5 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500525Induction of rat HCN differentiation into Tuj1 neurons at 25 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500524Inhibition of gliogenesis differentiation in rat HCN cells at 25 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500535Induction of rat HCN cell differentiation assessed as increase in GluR2 gene expression after 3 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500583Induction of rat HCN cell differentiation into Tuj1 neurons at 20 uM after 4 days in presence of caspase inhibitor Q-VD-Oph2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500533Induction of rat HCN cell differentiation assessed as increase in NR1 gene expression after 1 day by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500545Induction of L-type calcium channel/NMDA receptor-mediated Ca2+ influx in rat HCN cells in presence multiple inhibitors2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500526Induction of rat HCN cell differentiation assessed as increase in neuroD gene expression after 3 hrs by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500779Induction of HDAC5 translocation in nucleus of rat HCN cells assessed as GFP-HDAC5 S258A S498A mutant fusion protein accumulation at 5 uM by fluorescence assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500544Induction of L-type calcium channel/NMDA receptor-mediated Ca2+ influx in rat HCN cells2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500541Induction of rat HCN cell differentiation assessed as increase in p27Kip1 gene expression after 9 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500563Induction of rat HCN cell differentiation assessed as upregulation of MEF2D expression after 2 to 4 days by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500528Induction of rat HCN cell differentiation assessed as increase in Tuj1 gene expression after 3 hrs by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500581Induction of CAMK-mediated MREx3 activity in rat HCN cells by luciferase reporter gene assay in presence of 2.5 uM potassium channel inhibitor KN922008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500543Induction of LIF/BMP2-mediated rat HCN cell differentiation into Tuj1 neurons after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500580Induction of CAMK2 phosphorylation in rat HCN cells by Western blot analysis in presence of 2.5 uM CAMK inhibitor KN932008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500540Induction of rat HCN cell differentiation assessed as increase in MAP2AB gene expression after 9 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500531Induction of rat HCN cell differentiation assessed as increase in GluR2 gene expression after 1 day by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500520Induction of mouse neuronal progenitor cell differentiation at 25 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500569Induction of HDAC5 phosphorylation in rat HCN cells after 24 hrs2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500539Induction of rat HCN cell differentiation assessed as increase in DCX gene expression after 9 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500536Induction of rat HCN cell differentiation assessed as increase in Tuj1 gene expression after 3 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500523Induction of mouse progenitor cell differentiation into Tuj1 neurons at 20 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500568Induction of HDAC5 phosphorylation in rat HCN cells after 6 hrs2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500564Induction of neurogenesis in undifferentiated rat HCN cells assessed as MEF2A protein level at 8 to 64 uM after 9 hrs by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500538Induction of rat HCN cell differentiation assessed as increase in beta-TUB3 gene expression after 9 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500572Effect on subcellular distribution of MEF2A protein in rat HCN cells after 5 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500566Induction of neurogenesis in undifferentiated rat HCN cells assessed as MAP2AB protein level at 8 to 64 uM after 9 hrs by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500550Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of multiple inhibitors2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500534Induction of rat HCN cell differentiation assessed as increase in neuroD gene expression after 3 days by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500562Induction of rat HCN cell differentiation assessed as upregulation of MEF2A expression after 2 to 4 days by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500565Induction of neurogenesis in undifferentiated rat HCN cells assessed as MEF2C protein level at 8 to 64 uM after 9 hrs by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500552Induction of L-type calcium channel-mediated neuroD gene expression in rat HCN cells after 24 hrs by luciferase reporter gene assay in presence of NMDA receptor antagonist nifedipine2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500554Induction of L-type calcium channel/NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 3 hrs by RT-PCR analysis in presence of multiple inhibitors2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500567Induction of neurogenesis in undifferentiated rat HCN cells assessed as GlR2/3 protein level at 8 to 64 uM after 9 hrs by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500584Cytotoxicity in rat HCN cells at 20 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500521Induction of mouse C57BL/6 P19CL6 cell differentiation assessed as induction of neuronal reporter gluR2 expression by luciferase reporter gene assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500547Induction of L-type calcium channel/NMDA receptor-mediated Ca2+ influx in rat HCN cells at 5 uM by Fura-2 imaging analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500561Induction of rat HCN cell differentiation assessed as upregulation of MEF2C expression after 2 to 4 days by protein blotting analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500529Induction of rat HCN cell differentiation assessed as increase in NR1 gene expression after 3 hrs by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500556Induction of NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 3 hrs by RT-PCR analysis in presence of NMDA receptor antagonist nifedipine2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500553Induction of rat HCN cell differentiation assessed as increase in neuroD gene expression at 10 uM after 3 hrs by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500518Induction of rat HCN cell differentiation assessed as induction of neuronal reporter neuroD activity at 20 uM after 24 hrs by luciferase reporter gene assay2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500573Effect on subcellular distribution of MEF2C protein in rat HCN cells after 5 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500530Induction of rat HCN cell differentiation assessed as increase in neuroD gene expression after 1 day by RT-PCR analysis2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500585Induction of mouse progenitor cell differentiation into Map2ab-positive neurons at 20 uM after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500559Induction of NMDA receptor-mediated neuroD gene expression in rat HCN cells at 50 uM after 24 hrs by RT-PCR analysis in presence of NMDA receptor antagonist nifedipine2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500542Induction of LIF/BMP2-mediated rat HCN cell differentiation into GFAP-positive astrocytes after 4 days2008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
AID500579Induction of CAMK-mediated HDAC5 phosphorylation in rat HCN cells by Western blot analysis in presence of 2.5 uM CAMK inhibitor KN932008Nature chemical biology, Jul, Volume: 4, Issue:7
Small-molecule activation of neuronal cell fate.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's9 (69.23)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.08

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.08 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.72 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.08)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
corticosterone
[no description available]		2.131011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		4.03120mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
isoxazoles
Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.		4.03120isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazoles
[no description available]		2.17101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
methamphetamine
Methamphetamine: A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.. methamphetamine : A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.		2.1710amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
colforsin
Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.		2.1710acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol		adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.1310cyclodextrin
chir 99021
Chir 99021: structure in first source. CHIR 99021 : A member of the class of aminopyrimidines that is 2-aminopyrimidine substituted at positions N2, 5 and 6 by (5-cyanopyridin-2-yl)ethyl, 4-methylimidazol-2-yl and 2,4-dichlorophenyl groups respectively.		2.1710aminopyridine;
aminopyrimidine;
cyanopyridine;
diamine;
dichlorobenzene;
imidazoles;
secondary amino compound		EC 2.7.11.26 (tau-protein kinase) inhibitor
N-Cyclohexyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
[no description available]		2.0410aromatic amide;
heteroarene
gsk1210151a
GSK1210151A: inhibitor of the BET family of proteins; structure in first source		2.1710imidazoquinoline
ConditionIndicatedRelationship StrengthStudiesTrials
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.		02.4110
Cognitive Decline
[description not available]		02.1510
Akinetic-Rigid Variant of Huntington Disease
[description not available]		02.1510
Huntington Disease
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)		02.1510
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function.		02.1510
Recrudescence
[description not available]		02.1710
Chemical Dependence
[description not available]		02.1710
Substance-Related Disorders
Disorders related to substance use or abuse.		02.1710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1710
Cirrhosis
[description not available]		02.1710
Cardiovascular Stroke
[description not available]		02.1710
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.		02.1710
Myocardial Infarction
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).		02.1710
Benign Neoplasms, Brain
[description not available]		02.1710
Astrocytoma, Grade IV
[description not available]		02.1710
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.		02.1710
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.1710
Alloxan Diabetes
[description not available]		02.1710
Glial Cell Tumors
[description not available]		02.0610
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.0610