Protein mono-ADP-ribosyltransferase PARP11

A protein mono-ADP-ribosyltransferase PARP11 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NR21]

EC 2.4.2.-;
ADP-ribosyltransferase diphtheria toxin-like 11;
ARTD11;
Poly [ADP-ribose] polymerase 11;
PARP-11

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3,4-dihydro-5-methyl-1(2h)-isoquinolinone	Homo sapiens (human)	IC50	2.1190	1	2
1-oxo-1,2,3,4-tetrahydroisoquinoline	Homo sapiens (human)	IC50	7.9716	1	2
xav939	Homo sapiens (human)	IC50	5.0119	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rucaparib	Homo sapiens (human)	Kd	10.0000	1	1
niraparib	Homo sapiens (human)	Kd	10.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
NAD+ ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
nucleotidyltransferase activity	molecular function	Catalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
NAD+- protein-cysteine ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]
NAD+- protein-lysine ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide. [PMID:25043379, RHEA:58220]
NAD+-protein ADP-ribosyltransferase activity	molecular function	Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]

This protein is located in 4 target(s):

Target	Category	Definition
nuclear envelope	cellular component	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear body	cellular component	Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

This protein is part of 1 target(s):

Target	Category	Definition
nuclear pore	cellular component	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. [ISBN:0198547684]

This protein is involved in 6 target(s):

Target	Category	Definition
nuclear envelope organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
protein transport	biological process	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
mRNA transport	biological process	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
protein auto-ADP-ribosylation	biological process	The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]