| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 4.02 | 13 | 0 |
Burns
Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like. | 0 | 2.41 | 1 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 3.12 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 1 | 5.12 | 1 | 0 |
Sterility, Male
[description not available] | 0 | 2.21 | 1 | 0 |
Infertility, Male
The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility. | 0 | 2.21 | 1 | 0 |
Fatty Liver, Nonalcoholic
[description not available] | 0 | 2.31 | 1 | 0 |
Insulin Sensitivity
[description not available] | 0 | 2.61 | 2 | 0 |
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS. | 0 | 2.61 | 2 | 0 |
Non-alcoholic Fatty Liver Disease
Fatty liver finding without excessive ALCOHOL CONSUMPTION. | 0 | 2.31 | 1 | 0 |
Age-Related Osteoporosis
[description not available] | 0 | 2.15 | 1 | 0 |
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis. | 0 | 2.15 | 1 | 0 |
Abnormality, Heart
[description not available] | 0 | 8.55 | 5 | 1 |
Heart Defects, Congenital
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life. | 0 | 8.55 | 5 | 1 |
Injury, Ischemia-Reperfusion
[description not available] | 0 | 2.99 | 4 | 0 |
Reperfusion Injury
Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA. | 0 | 2.99 | 4 | 0 |
Kidney Failure
A severe irreversible decline in the ability of kidneys to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. | 0 | 2.17 | 1 | 0 |
Renal Insufficiency
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE. | 0 | 2.17 | 1 | 0 |
Adenoma, Prostatic
[description not available] | 0 | 7.46 | 6 | 3 |
Prostatic Hyperplasia
Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both. | 0 | 7.46 | 6 | 3 |
Pulmonary Arterial Hypertension
A progressive rare pulmonary disease characterized by high blood pressure in the PULMONARY ARTERY. | 0 | 4.51 | 1 | 1 |
Acute Kidney Failure
[description not available] | 0 | 2.45 | 2 | 0 |
Acute Kidney Injury
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. | 0 | 2.45 | 2 | 0 |
Impotence
[description not available] | 0 | 13.67 | 43 | 17 |
Erectile Dysfunction
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction. | 1 | 15.67 | 43 | 17 |
Hypotension, Postural
[description not available] | 0 | 3.47 | 1 | 1 |
Hypotension, Orthostatic
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE. | 0 | 3.47 | 1 | 1 |
Constriction, Pathological
[description not available] | 0 | 2.08 | 1 | 0 |
Bilateral Headache
[description not available] | 0 | 2.08 | 1 | 0 |
Hemorrhage, Subarachnoid
[description not available] | 0 | 2.08 | 1 | 0 |
Constriction, Pathologic
The condition of an anatomical structure's being constricted beyond normal dimensions. | 0 | 2.08 | 1 | 0 |
Headache
The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS. | 0 | 2.08 | 1 | 0 |
Subarachnoid Hemorrhage
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status. | 0 | 2.08 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 5.36 | 2 | 2 |
Systolic Heart Failure
[description not available] | 0 | 4.39 | 1 | 1 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 5.36 | 2 | 2 |
Heart Failure, Systolic
Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying. | 1 | 6.39 | 1 | 1 |
Cold Fingers, Hereditary
[description not available] | 0 | 4.4 | 1 | 1 |
Connective Tissue Diseases
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides. | 0 | 4.4 | 1 | 1 |
Raynaud Disease
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress. | 1 | 6.4 | 1 | 1 |
Hyperlipemia
[description not available] | 0 | 2.1 | 1 | 0 |
Hyperlipidemias
Conditions with excess LIPIDS in the blood. | 0 | 2.1 | 1 | 0 |
Testicular Diseases
Pathological processes of the TESTIS. | 0 | 2.1 | 1 | 0 |
Precordial Catch
[description not available] | 0 | 4.4 | 1 | 1 |
Chest Pain
Pressure, burning, or numbness in the chest. | 0 | 4.4 | 1 | 1 |
Alloxan Diabetes
[description not available] | 0 | 3.55 | 8 | 0 |
Complication, Postoperative
[description not available] | 0 | 4.79 | 2 | 1 |
Cancer of Rectum
[description not available] | 0 | 4.41 | 1 | 1 |
Postoperative Complications
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. | 0 | 4.79 | 2 | 1 |
Rectal Neoplasms
Tumors or cancer of the RECTUM. | 0 | 4.41 | 1 | 1 |
Cruveilhier-Baumgarten Syndrome
Liver cirrhosis with intrahepatic portal obstruction, HYPERTENSION, and patent UMBILICAL VEINS. | 0 | 3.86 | 2 | 1 |
Cirrhosis, Liver
[description not available] | 0 | 3.86 | 2 | 1 |
Hypertension, Portal
Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN. | 0 | 3.86 | 2 | 1 |
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. | 0 | 3.86 | 2 | 1 |
Left Ventricular Hypertrophy
[description not available] | 0 | 2.11 | 1 | 0 |
Cirrhosis
[description not available] | 0 | 2.48 | 2 | 0 |
Cardiac Hypertrophy
Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix. | 0 | 2.11 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 5.45 | 5 | 1 |
Fibrosis
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury. | 0 | 2.48 | 2 | 0 |
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES. | 0 | 2.11 | 1 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 5.45 | 5 | 1 |
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. | 0 | 2.47 | 2 | 0 |
Hypertrophy, Left Ventricular
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality. | 0 | 2.11 | 1 | 0 |
Left Ventricular Dysfunction
[description not available] | 0 | 3.5 | 1 | 1 |
Cardiac Failure
[description not available] | 0 | 3.5 | 1 | 1 |
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | 0 | 3.5 | 1 | 1 |
Ventricular Dysfunction, Left
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall. | 0 | 3.5 | 1 | 1 |
Acute Edematous Pancreatitis
[description not available] | 0 | 4.43 | 2 | 2 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 4.13 | 3 | 1 |
Pancreatitis
INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis. | 0 | 4.43 | 2 | 2 |
Spermatic Cord Torsion
The twisting of the SPERMATIC CORD due to an anatomical abnormality that left the TESTIS mobile and dangling in the SCROTUM. The initial effect of testicular torsion is obstruction of venous return. Depending on the duration and degree of cord rotation, testicular symptoms range from EDEMA to interrupted arterial flow and testicular pain. If blood flow to testis is absent for 4 to 6 h, SPERMATOGENESIS may be permanently lost. | 0 | 2.13 | 1 | 0 |
Chronic Kidney Failure
[description not available] | 0 | 2.13 | 1 | 0 |
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. | 0 | 2.13 | 1 | 0 |
Liver Dysfunction
[description not available] | 0 | 3.51 | 1 | 1 |
Liver Diseases
Pathological processes of the LIVER. | 1 | 5.51 | 1 | 1 |
Cephalgia Syndromes
[description not available] | 0 | 3.51 | 1 | 1 |
Headache Disorders
Various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1) | 0 | 3.51 | 1 | 1 |
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) | 0 | 4.12 | 3 | 1 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 3.27 | 6 | 0 |
Impotence, Arteriogenic
[description not available] | 0 | 5.05 | 3 | 1 |
Prostatism
Lower urinary tract symptom, such as slow urinary stream, associated with PROSTATIC HYPERPLASIA in older men. | 0 | 3.45 | 1 | 1 |
Disease Exacerbation
[description not available] | 0 | 2.06 | 1 | 0 |
Adverse Drug Event
[description not available] | 0 | 2.98 | 1 | 0 |
Drug-Related Side Effects and Adverse Reactions
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals. | 0 | 2.98 | 1 | 0 |
Complications of Diabetes Mellitus
[description not available] | 0 | 3.45 | 1 | 1 |
Sphincter of Oddi Dysfunction
Organic or functional motility disorder involving the SPHINCTER OF ODDI and associated with biliary COLIC. Pathological changes are most often seen in the COMMON BILE DUCT sphincter, and less commonly the PANCREATIC DUCT sphincter. | 0 | 3.45 | 1 | 1 |
Cardiovascular Diseases
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. | 0 | 2.98 | 1 | 0 |
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE. | 0 | 2.98 | 1 | 0 |
Lower Urinary Tract Symptom
[description not available] | 0 | 3.9 | 1 | 0 |
Anterior Ischemic Optic Neuropathy
[description not available] | 0 | 2.07 | 1 | 0 |
Optic Neuropathy, Ischemic
Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135) | 0 | 2.07 | 1 | 0 |
Airflow Obstruction, Chronic
[description not available] | 0 | 4.37 | 1 | 1 |
Pulmonary Hypertension
[description not available] | 0 | 4.74 | 2 | 1 |
Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. | 1 | 6.74 | 2 | 1 |
Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. | 0 | 4.37 | 1 | 1 |
Hypergonadotropic Hypogonadism
[description not available] | 0 | 3.92 | 1 | 0 |
Hypogonadism
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism). | 0 | 3.92 | 1 | 0 |
Injuries, Spinal Cord
[description not available] | 0 | 2.42 | 2 | 0 |
Spinal Cord Injuries
Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.). | 0 | 2.42 | 2 | 0 |
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position. | 0 | 2.02 | 1 | 0 |
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. | 0 | 2.02 | 1 | 0 |
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. | 0 | 2.02 | 1 | 0 |
Marasmus
[description not available] | 0 | 2.02 | 1 | 0 |
Protein-Energy Malnutrition
The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses. | 0 | 2.02 | 1 | 0 |
Apoplexy
[description not available] | 0 | 2.03 | 1 | 0 |
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810) | 0 | 2.03 | 1 | 0 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 2.03 | 1 | 0 |
Dehydration
The condition that results from excessive loss of water from a living organism. | 0 | 2.03 | 1 | 0 |
Elevated Cholesterol
[description not available] | 0 | 2.03 | 1 | 0 |
Hypercholesterolemia
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population. | 0 | 2.03 | 1 | 0 |